Development Level

Tbio 10,361 | 11,651
Tdark 4,064 | 6,593
Tchem 1,268 | 1,388
Tclin 513 | 612

Collection

RFA-RM-18-021 256 | 328
Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 943 | 979
preweaning lethality, incomple... 472 | 499
abnormal behavior 278 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 208 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 189 | 210
decreased vertical activity 172 | 208
abnormal bone structure 167 | 187
increased lean body mass 156 | 172
decreased body weight 152 | 161
abnormal heart morphology 148 | 162
hyperactivity 138 | 148
decreased bone mineral content 134 | 151
decreased lean body mass 121 | 135
increased total body fat amoun... 120 | 134
hypoactivity 119 | 132
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 111 | 122
decreased bone mineral density 110 | 126
male infertility 109 | 123
embryonic growth retardation 102 | 106
decreased grip strength 101 | 116
abnormal seminal vesicle morph... 100 | 114
increased startle reflex 100 | 112
increased bone mineral content 98 | 108
decreased body length 93 | 101
short tibia 91 | 97
increased mean corpuscular vol... 89 | 92
decreased circulating choleste... 88 | 93
increased or absent threshold ... 88 | 101
increased mean corpuscular hem... 87 | 96
prenatal lethality prior to he... 84 | 87
cataract 83 | 92
decreased lymphocyte cell numb... 77 | 83
decreased prepulse inhibition 77 | 82
abnormal lens morphology 74 | 81
decreased circulating serum al... 74 | 82
decreased circulating triglyce... 74 | 79
increased fasted circulating g... 71 | 76
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 69 | 72
decreased circulating insulin ... 68 | 76
decreased startle reflex 68 | 75
improved glucose tolerance 68 | 79
abnormal eye morphology 67 | 68
increased circulating HDL chol... 67 | 80
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
decreased leukocyte cell numbe... 66 | 73
impaired glucose tolerance 66 | 75
small superior vagus ganglion 65 | 74
abnormal sleep behavior 63 | 70
abnormal gait 62 | 69
increased circulating sodium l... 62 | 71
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 61 | 68
abnormal coat-hair pigmentatio... 60 | 64
abnormal behavioral response t... 59 | 66
abnormal kidney morphology 59 | 65
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
decreased erythrocyte cell num... 57 | 62
increased heart weight 57 | 62
edema 54 | 59
small testis 52 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
decreased caudal vertebrae num... 50 | 53
female infertility 49 | 60
decreased mean corpuscular hem... 47 | 50
hydrometra 47 | 53
abnormal skin morphology 46 | 50
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
increased blood urea nitrogen ... 44 | 48
decreased circulating alanine ... 43 | 47
increased neutrophil cell numb... 43 | 46
decreased circulating alkaline... 42 | 46
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
abnormal testis morphology 40 | 43
decreased neutrophil cell numb... 40 | 42
enlarged spleen 39 | 41
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
increased circulating chloride... 37 | 41
increased circulating triglyce... 37 | 42
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
limb grasping 36 | 41
tremors 36 | 39
decreased circulating LDL chol... 35 | 38
decreased circulating creatini... 35 | 39
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,793 | 11,493
ovarian cancer 8,118 | 8,520
osteosarcoma 7,451 | 7,950
psoriasis 5,832 | 6,694
medulloblastoma, large-cell 5,768 | 6,241
glioblastoma 5,429 | 5,792
atypical teratoid / rhabdoid tumor 4,787 | 5,112
lung cancer 4,459 | 4,740
ependymoma 4,326 | 4,679
group 3 medulloblastoma 3,839 | 4,104
adult high grade glioma 3,481 | 3,801
Breast cancer 3,391 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,170 | 3,291
malignant mesothelioma 3,098 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,880 | 2,989
invasive ductal carcinoma 2,866 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,844 | 2,955
Astrocytoma, Pilocytic 2,833 | 3,081
primitive neuroectodermal tumor 2,820 | 3,035
non-small cell lung cancer 2,786 | 2,890
oligodendroglioma 2,619 | 2,850
lung carcinoma 2,618 | 2,843
lung adenocarcinoma 2,557 | 2,716
astrocytic glioma 2,389 | 2,597
pancreatic cancer 2,275 | 2,398
Kidney cancer 2,263 | 2,613
Cancer 2,218 | 2,499
interstitial cystitis 2,178 | 2,312
subependymal giant cell astrocytoma 2,149 | 2,287
tuberculosis 1,906 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,867 | 1,962
pituitary cancer 1,819 | 1,972
Pick disease 1,803 | 1,894
group 4 medulloblastoma 1,753 | 1,855
ulcerative colitis 1,707 | 1,819
ductal carcinoma in situ 1,693 | 1,745
cystic fibrosis 1,616 | 1,696
breast carcinoma 1,588 | 1,638
adrenocortical carcinoma 1,391 | 1,428
colon cancer 1,391 | 1,478
diabetes mellitus 1,352 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,301 | 1,442
juvenile dermatomyositis 1,154 | 1,187
acute quadriplegic myopathy 1,118 | 1,158
astrocytoma 1,099 | 1,146
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
Rheumatoid arthritis 1,082 | 1,191
spina bifida 1,041 | 1,074
cutaneous lupus erythematosus 1,016 | 1,057
pediatric high grade glioma 1,011 | 1,064
Schizophrenia 998 | 1,160
nasopharyngeal carcinoma 990 | 1,058
Intellectual disability 943 | 1,016
dermatomyositis 919 | 966
Atopic dermatitis 909 | 952
active Crohn's disease 869 | 922
non primary Sjogren syndrome sicca 817 | 891
acute myeloid leukemia 774 | 783
gastric carcinoma 768 | 807
Waldenstrons macroglobulinemia 756 | 765
Liver Cirrhosis, Experimental 720 | 769
Epilepsy 715 | 792
esophageal adenocarcinoma 709 | 737
primary Sjogren syndrome 703 | 735
active ulcerative colitis 701 | 764
medulloblastoma 673 | 720
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 642 | 665
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Alzheimer's disease 594 | 658
Obesity 590 | 678
Duchenne muscular dystrophy 576 | 601
Cognitive delay 571 | 608
Global developmental delay 571 | 608
Mental and motor retardation 571 | 608
Bipolar Disorder 564 | 666
Seizures 548 | 596
Melanoma 543 | 711
Muscle hypotonia 543 | 571
pancreatic carcinoma 542 | 562
hepatocellular carcinoma 535 | 547
fibroadenoma 534 | 559
Endometriosis 501 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 510
Liver cancer 493 | 604
Short stature 491 | 531
Down syndrome 466 | 499
chronic rhinosinusitis 466 | 512
Prostatic Neoplasms 460 | 495
mucosa-associated lymphoid tissue lymphoma 449 | 484
posterior fossa group A ependymoma 447 | 468
gastric cancer 446 | 459
Multiple Sclerosis 444 | 540
sonic hedgehog group medulloblastoma 435 | 467
Amyotrophic lateral sclerosis 426 | 451

Tissue

Skin and soft tissues 16,206 | 17,230
Endocrine System 16,105 | 18,159
Female tissues 16,033 | 17,400
Digestive Tract 16,016 | 17,369
Male tissues 15,868 | 17,142
Blood and immune system 15,867 | 16,909
Liver and Pancreas 15,736 | 16,750
Urinary Tract 15,672 | 16,678
Nervous System 15,623 | 16,725
Respiratory system 15,542 | 16,393
Cardiovascular System 14,719 | 15,192

Target Family

Non-IDG 9,422 | 12,091
Enzyme 3,745 | 4,145
Transcription Factor 1,205 | 1,400
Kinase 596 | 634
Transporter 392 | 473
GPCR 268 | 408
Ion Channel 255 | 344
Epigenetic 228 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 35 | 38
oGPCR 17 | 421

HPA RNA Tissue

skin 16,206 | 16,206
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115