Development Level

Tbio 7,918 | 10,625
Tdark 3,303 | 7,003
Tchem 1,366 | 1,890
Tclin 325 | 602

Collection

Eligible Kinase Proteins 95 | 134
Eligible Ion Channel Proteins 39 | 117
Eligible non-olfactory GPCR Proteins 30 | 143

IMPC Term

preweaning lethality, complete... 567 | 633
preweaning lethality, incomple... 211 | 260
abnormal behavior 181 | 226
embryonic lethality prior to t... 175 | 187
decreased total body fat amoun... 159 | 186
decreased lean body mass 157 | 195
decreased body weight 146 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 125 | 157
increased circulating alkaline... 103 | 119
abnormal bone structure 97 | 131
abnormal embryo size 97 | 112
decreased bone mineral density 97 | 126
increased or absent threshold ... 97 | 128
decreased circulating glucose ... 96 | 121
decreased body length 91 | 108
decreased grip strength 90 | 123
abnormal retina morphology 87 | 100
increased lean body mass 86 | 107
hyperactivity 84 | 108
increased mean corpuscular hem... 84 | 93
enlarged heart 80 | 111
increased bone mineral content 79 | 92
increased mean corpuscular vol... 79 | 91
decreased circulating choleste... 73 | 85
short tibia 71 | 82
decreased circulating HDL chol... 68 | 77
hypoactivity 68 | 89
decreased circulating serum al... 67 | 79
decreased circulating triglyce... 67 | 83
increased grip strength 65 | 83
abnormal lens morphology 59 | 73
increased fasted circulating g... 58 | 68
prenatal lethality prior to he... 58 | 64
abnormal retinal pigmentation 55 | 61
decreased circulating insulin ... 55 | 75
decreased lumbar vertebrae num... 54 | 62
increased sacral vertebrae num... 51 | 62
decreased rib number 50 | 59
increased circulating sodium l... 49 | 71
abnormal sleep behavior 47 | 63
male infertility 47 | 62
abnormal coat/hair pigmentatio... 46 | 54
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
decreased hemoglobin content 44 | 53
improved glucose tolerance 44 | 56
abnormal bone mineralization 43 | 55
decreased prepulse inhibition 43 | 52
increased bone mineral density 43 | 52
increased circulating HDL chol... 43 | 63
increased exploration in new e... 41 | 56
abnormal gait 40 | 51
increased circulating choleste... 40 | 53
abnormal behavioral response t... 39 | 52
decreased circulating alanine ... 39 | 53
impaired glucose tolerance 39 | 52
decreased caudal vertebrae num... 38 | 49
decreased erythrocyte cell num... 38 | 43
decreased startle reflex 38 | 48
increased total body fat amoun... 38 | 57
thrombocytopenia 38 | 46
decreased circulating total pr... 37 | 41
decreased fasted circulating g... 37 | 49
increased blood urea nitrogen ... 37 | 44
increased hemoglobin content 36 | 45
decreased eosinophil cell numb... 35 | 41
decreased heart weight 34 | 44
increased body weight 34 | 42
increased rib number 34 | 41
abnormal eye morphology 33 | 38
abnormal neural tube closure 33 | 37
decreased circulating LDL chol... 33 | 37
abnormal heart morphology 32 | 51
decreased neutrophil cell numb... 32 | 37
decreased circulating alkaline... 31 | 41
increased circulating chloride... 31 | 43
abnormal seminal vesicle morph... 30 | 47
decreased circulating free fat... 30 | 39
decreased mean corpuscular hem... 30 | 34
increased hematocrit 29 | 36
increased leukocyte cell numbe... 29 | 37
tremors 29 | 34
abnormal spleen morphology 28 | 36
decreased circulating fructosa... 28 | 31
increased startle reflex 28 | 38
small testis 28 | 37
abnormal cranium morphology 27 | 32
decreased circulating calcium ... 27 | 33
embryonic growth retardation 27 | 28
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
decreased NK T cell number 25 | 28
decreased T cell number 25 | 31
decreased circulating chloride... 25 | 32
cardiovascular system phenotyp... 24 | 35
decreased blood urea nitrogen ... 24 | 31
decreased circulating creatini... 24 | 31
increased circulating calcium ... 24 | 32
limb grasping 24 | 35

Disease

ovarian cancer 7,327 | 8,484
osteosarcoma 6,459 | 7,933
medulloblastoma, large-cell 4,830 | 6,234
psoriasis 4,683 | 6,685
glioblastoma 4,427 | 5,572
lung cancer 3,791 | 4,466
atypical teratoid / rhabdoid tumor 3,373 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,806 | 3,289
malignant mesothelioma 2,668 | 3,162
Breast cancer 2,606 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,514 | 2,988
invasive ductal carcinoma 2,509 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,473 | 2,956
non-small cell lung cancer 2,324 | 2,798
primitive neuroectodermal tumor 2,305 | 3,031
pilocytic astrocytoma 2,216 | 3,086
oligodendroglioma 2,139 | 2,849
lung adenocarcinoma 2,119 | 2,713
pediatric high grade glioma 2,096 | 2,712
ependymoma 2,008 | 2,514
lung carcinoma 2,007 | 2,844
pancreatic cancer 1,920 | 2,300
subependymal giant cell astrocytoma 1,834 | 2,287
group 3 medulloblastoma 1,819 | 2,254
Cancer 1,769 | 2,346
interstitial cystitis 1,725 | 2,299
astrocytic glioma 1,716 | 2,241
ulcerative colitis 1,669 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 1,569 | 1,795
adult high grade glioma 1,560 | 2,148
Pick disease 1,559 | 1,893
group 4 medulloblastoma 1,535 | 1,875
ductal carcinoma in situ 1,449 | 1,745
pituitary cancer 1,420 | 1,972
Carcinoma 1,377 | 2,147
breast carcinoma 1,372 | 1,614
cystic fibrosis 1,297 | 1,665
tuberculosis 1,290 | 1,557
Multiple myeloma 1,289 | 1,327
astrocytoma 1,241 | 1,493
adrenocortical carcinoma 1,215 | 1,427
colon cancer 1,174 | 1,475
sonic hedgehog group medulloblastoma 1,154 | 1,482
primary pancreatic ductal adenocarcinoma 1,144 | 1,271
medulloblastoma 1,119 | 1,524
juvenile dermatomyositis 1,099 | 1,189
posterior fossa group A ependymoma 1,092 | 1,511
diabetes mellitus 1,088 | 1,663
acute quadriplegic myopathy 1,056 | 1,157
posterior fossa group B ependymoma 1,050 | 1,530
spina bifida 952 | 1,064
Rheumatoid Arthritis 939 | 1,160
dermatomyositis 890 | 933
atypical teratoid/rhabdoid tumor 846 | 1,095
cutaneous lupus erythematosus 830 | 1,056
nasopharyngeal carcinoma 793 | 1,056
Atopic dermatitis 787 | 944
Waldenstrons macroglobulinemia 736 | 765
active Crohn's disease 728 | 918
acute myeloid leukemia 715 | 780
gastric carcinoma 697 | 832
non primary Sjogren syndrome sicca 658 | 840
primary Sjogren syndrome 652 | 789
esophageal adenocarcinoma 641 | 737
tuberculosis and treatment for 6 months 620 | 686
progressive supranuclear palsy 591 | 674
aldosterone-producing adenoma 571 | 664
Duchenne muscular dystrophy 538 | 602
pancreatic carcinoma 480 | 567
Alzheimer's disease 467 | 644
hepatocellular carcinoma 465 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 457 | 499
Down syndrome 454 | 548
Intellectual disability 453 | 573
fibroadenoma 434 | 557
Obesity 413 | 616
IGA Glomerulonephritis 405 | 454
Endometriosis 403 | 535
Prostatic Neoplasms 373 | 471
gastric cancer 362 | 430
Amyotrophic Lateral Sclerosis 354 | 431
active ulcerative colitis 354 | 477
chronic rhinosinusitis 346 | 512
mucosa-associated lymphoid tissue lymphoma 340 | 480
Mammary Neoplasms 327 | 410
Neurodegenerative disease 326 | 383
inflammatory breast cancer 325 | 404
Multiple Sclerosis 305 | 498
Schizophrenia 303 | 501
hereditary spastic paraplegia 301 | 313
tuberculosis and treatment for 3 months 282 | 327
sarcoidosis 278 | 358
glioblastoma multiforme 267 | 347
Polycystic Ovary Syndrome 264 | 332
non-small cell lung carcinoma 254 | 413
Parkinson's disease 249 | 364
urothelial carcinoma 248 | 318
interstitial lung disease 245 | 291
Kidney disease 234 | 396
Stomach Neoplasms 232 | 282

Tissue

Skin and soft tissues 12,912 | 18,115
Digestive Tract 12,908 | 18,473
Endocrine System 12,906 | 18,512
Female tissues 12,904 | 18,647
Nervous System 12,903 | 18,561
Urinary Tract 12,896 | 18,444
Blood and immune system 12,890 | 17,995
Liver and Pancreas 12,886 | 18,136
Cardiovascular System 12,880 | 17,958
Male tissues 12,873 | 17,969
Respiratory system 12,857 | 17,484

Target Family

Non-IDG 7,467 | 11,971
Enzyme 3,179 | 4,146
Transcription Factor 958 | 1,400
Kinase 506 | 634
Transporter 297 | 473
Epigenetic 209 | 242
GPCR 123 | 406
Ion Channel 112 | 341
TF/Epigenetic 30 | 38
Nuclear Receptor 29 | 48
oGPCR 2 | 421

HPA RNA Tissue

skin 12,912 | 12,912
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108