Development Level

Tbio 8,792 | 11,178
Tdark 3,333 | 6,569
Tchem 1,473 | 1,885
Tclin 413 | 612

Collection

Kinase: IDG Consortium (Target... 100 | 125
Ion Channel: IDG Consortium (T... 55 | 99
GPCR: IDG Consortium (Targets) 34 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 911 | 979
preweaning lethality, incomple... 428 | 499
embryonic lethality prior to t... 260 | 278
abnormal behavior 254 | 298
embryonic lethality prior to o... 226 | 239
abnormal embryo size 201 | 220
decreased total body fat amoun... 175 | 207
abnormal bone structure 161 | 187
enlarged heart 161 | 210
decreased vertical activity 147 | 208
decreased body weight 146 | 161
increased lean body mass 143 | 172
decreased bone mineral content 128 | 151
abnormal heart morphology 123 | 162
hyperactivity 119 | 148
decreased lean body mass 111 | 135
increased total body fat amoun... 108 | 134
hypoactivity 107 | 132
decreased bone mineral density 104 | 126
decreased circulating glucose ... 104 | 126
increased circulating alkaline... 103 | 122
embryonic growth retardation 97 | 106
male infertility 96 | 123
increased startle reflex 95 | 112
decreased grip strength 92 | 116
increased bone mineral content 91 | 108
decreased body length 88 | 101
increased mean corpuscular hem... 83 | 96
increased mean corpuscular vol... 83 | 92
abnormal seminal vesicle morph... 82 | 114
decreased circulating choleste... 81 | 93
increased or absent threshold ... 80 | 101
cataract 78 | 92
prenatal lethality prior to he... 78 | 87
short tibia 78 | 97
abnormal lens morphology 71 | 81
decreased circulating serum al... 69 | 82
decreased prepulse inhibition 68 | 82
decreased mean corpuscular vol... 66 | 79
decreased circulating triglyce... 65 | 79
decreased leukocyte cell numbe... 65 | 73
increased bone mineral density 65 | 72
decreased lymphocyte cell numb... 63 | 83
decreased startle reflex 63 | 75
improved glucose tolerance 63 | 79
increased fasted circulating g... 63 | 76
abnormal retina morphology 60 | 71
abnormal sleep behavior 60 | 70
impaired glucose tolerance 60 | 75
increased circulating HDL chol... 60 | 80
abnormal eye morphology 59 | 68
decreased circulating HDL chol... 58 | 68
decreased circulating insulin ... 58 | 76
increased circulating sodium l... 58 | 71
edema 56 | 59
small superior vagus ganglion 56 | 74
abnormal gait 55 | 69
decreased erythrocyte cell num... 55 | 62
decreased hemoglobin content 55 | 68
increased circulating choleste... 55 | 66
abnormal behavioral response t... 54 | 66
abnormal coat-hair pigmentatio... 54 | 64
decreased fasted circulating g... 52 | 65
abnormal kidney morphology 50 | 65
decreased caudal vertebrae num... 49 | 53
increased monocyte cell number 47 | 63
thrombocytopenia 47 | 56
decreased circulating total pr... 46 | 49
increased heart weight 46 | 62
small testis 45 | 58
decreased mean corpuscular hem... 44 | 50
increased hematocrit 44 | 46
abnormal neural tube closure 43 | 46
female infertility 43 | 60
abnormal spleen morphology 42 | 55
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 41 | 48
abnormal skin morphology 40 | 50
decreased blood urea nitrogen ... 40 | 51
decreased circulating alkaline... 38 | 46
decreased hematocrit 38 | 46
enlarged spleen 38 | 41
hydrometra 38 | 53
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased leukocyte cell numbe... 36 | 47
increased neutrophil cell numb... 36 | 46
increased circulating triglyce... 35 | 42
increased mean platelet volume 35 | 45
tremors 35 | 39
abnormal bone mineralization 34 | 38
decreased red blood cell distr... 34 | 41
increased erythrocyte cell num... 34 | 39
abnormal cranium morphology 33 | 36
increased grip strength 33 | 41
abnormal testis morphology 32 | 43
enlarged lymph nodes 32 | 37
increased circulating chloride... 32 | 41
pallor 31 | 34

Disease

Carcinoma 8,362 | 11,192
ovarian cancer 7,385 | 8,297
osteosarcoma 6,698 | 7,766
medulloblastoma, large-cell 5,083 | 6,086
psoriasis 4,808 | 6,514
glioblastoma 4,786 | 5,635
atypical teratoid / rhabdoid tumor 4,150 | 4,971
lung cancer 3,956 | 4,607
ependymoma 3,703 | 4,559
group 3 medulloblastoma 3,338 | 4,002
adult high grade glioma 2,944 | 3,701
Breast cancer 2,943 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 2,784 | 3,204
malignant mesothelioma 2,754 | 3,135
invasive ductal carcinoma 2,545 | 2,867
intraductal papillary-mucinous carcinoma (IPMC) 2,525 | 2,902
intraductal papillary-mucinous adenoma (IPMA) 2,518 | 2,872
primitive neuroectodermal tumor 2,442 | 2,957
Astrocytoma, Pilocytic 2,404 | 3,006
non-small cell lung cancer 2,369 | 2,799
oligodendroglioma 2,271 | 2,768
lung carcinoma 2,167 | 2,755
lung adenocarcinoma 2,149 | 2,627
astrocytic glioma 2,102 | 2,530
subependymal giant cell astrocytoma 1,959 | 2,230
Kidney cancer 1,945 | 2,548
pancreatic cancer 1,920 | 2,322
Cancer 1,876 | 2,388
interstitial cystitis 1,772 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,720 | 1,911
tuberculosis 1,699 | 1,963
Pick disease 1,630 | 1,856
group 4 medulloblastoma 1,594 | 1,806
pituitary cancer 1,535 | 1,915
ulcerative colitis 1,477 | 1,765
ductal carcinoma in situ 1,456 | 1,686
breast carcinoma 1,395 | 1,589
cystic fibrosis 1,359 | 1,629
Multiple myeloma 1,255 | 1,296
adrenocortical carcinoma 1,213 | 1,385
colon cancer 1,188 | 1,428
diabetes mellitus 1,173 | 1,683
Autosomal recessive predisposition 1,137 | 1,407
acute quadriplegic myopathy 1,119 | 1,133
juvenile dermatomyositis 1,116 | 1,147
astrocytoma 1,006 | 1,113
primary pancreatic ductal adenocarcinoma 967 | 1,071
Rheumatoid arthritis 964 | 1,156
spina bifida 922 | 1,053
pediatric high grade glioma 921 | 1,035
dermatomyositis 890 | 941
cutaneous lupus erythematosus 847 | 1,016
Intellectual disability 842 | 998
Schizophrenia 797 | 1,136
nasopharyngeal carcinoma 753 | 1,024
Waldenstrons macroglobulinemia 718 | 742
non primary Sjogren syndrome sicca 712 | 861
active Crohn's disease 711 | 882
acute myeloid leukemia 711 | 760
Atopic dermatitis 706 | 915
gastric carcinoma 697 | 781
Liver Cirrhosis, Experimental 637 | 733
primary Sjogren syndrome 619 | 710
Epilepsy 616 | 775
medulloblastoma 598 | 702
aldosterone-producing adenoma 594 | 646
progressive supranuclear palsy 593 | 656
active ulcerative colitis 588 | 736
esophageal adenocarcinoma 585 | 696
Duchenne muscular dystrophy 574 | 587
Dull intelligence 541 | 634
Low intelligence 541 | 634
Mental Retardation 541 | 634
Mental deficiency 541 | 634
Poor school performance 541 | 634
Cognitive delay 526 | 596
Global developmental delay 526 | 596
Mental and motor retardation 526 | 596
Muscle hypotonia 512 | 562
Alzheimer's disease 509 | 640
pancreatic carcinoma 502 | 555
hepatocellular carcinoma 493 | 536
Obesity 490 | 655
Seizures 490 | 584
autosomal dominant Emery-Dreifuss muscular dystrophy 484 | 492
fibroadenoma 460 | 538
Short stature 443 | 514
Bipolar Disorder 440 | 646
Down syndrome 426 | 480
Melanoma 418 | 689
gastric cancer 409 | 445
Amyotrophic lateral sclerosis 407 | 437
sonic hedgehog group medulloblastoma 402 | 459
Prostatic Neoplasms 396 | 472
tuberculosis and treatment for 6 months 393 | 399
Liver cancer 391 | 589
Endometriosis 386 | 521
posterior fossa group A ependymoma 382 | 456
mucosa-associated lymphoid tissue lymphoma 379 | 473
chronic rhinosinusitis 372 | 505

Tissue

Skin and soft tissues 14,011 | 17,230
Endocrine System 13,980 | 18,159
Digestive Tract 13,953 | 17,369
Female tissues 13,935 | 17,400
Male tissues 13,916 | 17,142
Blood and immune system 13,867 | 16,909
Liver and Pancreas 13,833 | 16,750
Urinary Tract 13,828 | 16,678
Nervous System 13,815 | 16,725
Respiratory system 13,774 | 16,393
Cardiovascular System 13,619 | 15,192

Target Family

Non-IDG 8,075 | 12,091
Enzyme 3,355 | 4,145
Transcription Factor 1,062 | 1,400
Kinase 541 | 634
Transporter 330 | 473
Epigenetic 222 | 242
GPCR 183 | 408
Ion Channel 169 | 344
Nuclear Receptor 38 | 48
TF/Epigenetic 31 | 38
oGPCR 5 | 421

HPA RNA Tissue

skeletal muscle 14,011 | 14,011
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Vascular endothelial zinc finger 1 VEZF1 Tbio Transcription Factor -2.04566 107.4 83
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Dystroglycan DAG1 Tbio Enzyme -2.77503 560.0 254