Development Level

Tbio 9,161 | 11,651
Tdark 3,345 | 6,593
Tchem 1,092 | 1,388
Tclin 413 | 612

Collection

RFA-RM-18-021 189 | 328
Kinase: IDG Consortium (Target... 100 | 125
Ion Channel: IDG Consortium (T... 55 | 99
GPCR: IDG Consortium (Targets) 34 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 911 | 979
preweaning lethality, incomple... 428 | 499
embryonic lethality prior to t... 260 | 278
abnormal behavior 254 | 298
embryonic lethality prior to o... 226 | 239
abnormal embryo size 201 | 220
decreased total body fat amoun... 175 | 207
abnormal bone structure 161 | 187
enlarged heart 161 | 210
decreased vertical activity 147 | 208
decreased body weight 146 | 161
increased lean body mass 143 | 172
decreased bone mineral content 128 | 151
abnormal heart morphology 123 | 162
hyperactivity 119 | 148
decreased lean body mass 111 | 135
increased total body fat amoun... 108 | 134
hypoactivity 107 | 132
decreased bone mineral density 104 | 126
decreased circulating glucose ... 104 | 126
increased circulating alkaline... 103 | 122
embryonic growth retardation 97 | 106
male infertility 96 | 123
increased startle reflex 95 | 112
decreased grip strength 92 | 116
increased bone mineral content 91 | 108
decreased body length 88 | 101
increased mean corpuscular hem... 83 | 96
increased mean corpuscular vol... 83 | 92
abnormal seminal vesicle morph... 82 | 114
decreased circulating choleste... 81 | 93
increased or absent threshold ... 80 | 101
cataract 78 | 92
prenatal lethality prior to he... 78 | 87
short tibia 78 | 97
abnormal lens morphology 71 | 81
decreased circulating serum al... 69 | 82
decreased prepulse inhibition 68 | 82
decreased mean corpuscular vol... 66 | 79
decreased circulating triglyce... 65 | 79
decreased leukocyte cell numbe... 65 | 73
increased bone mineral density 65 | 72
decreased lymphocyte cell numb... 63 | 83
decreased startle reflex 63 | 75
improved glucose tolerance 63 | 79
increased fasted circulating g... 63 | 76
abnormal retina morphology 60 | 71
abnormal sleep behavior 60 | 70
impaired glucose tolerance 60 | 75
increased circulating HDL chol... 60 | 80
abnormal eye morphology 59 | 68
decreased circulating HDL chol... 58 | 68
decreased circulating insulin ... 58 | 76
increased circulating sodium l... 58 | 71
edema 56 | 59
small superior vagus ganglion 56 | 74
abnormal gait 55 | 69
decreased erythrocyte cell num... 55 | 62
decreased hemoglobin content 55 | 68
increased circulating choleste... 55 | 66
abnormal behavioral response t... 54 | 66
abnormal coat-hair pigmentatio... 54 | 64
decreased fasted circulating g... 52 | 65
abnormal kidney morphology 50 | 65
decreased caudal vertebrae num... 49 | 53
increased monocyte cell number 47 | 63
thrombocytopenia 47 | 56
decreased circulating total pr... 46 | 49
increased heart weight 46 | 62
small testis 45 | 58
decreased mean corpuscular hem... 44 | 50
increased hematocrit 44 | 46
abnormal neural tube closure 43 | 46
female infertility 43 | 60
abnormal spleen morphology 42 | 55
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 41 | 48
abnormal skin morphology 40 | 50
decreased blood urea nitrogen ... 40 | 51
decreased circulating alkaline... 38 | 46
decreased hematocrit 38 | 46
enlarged spleen 38 | 41
hydrometra 38 | 53
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
increased leukocyte cell numbe... 36 | 47
increased neutrophil cell numb... 36 | 46
increased circulating triglyce... 35 | 42
increased mean platelet volume 35 | 45
tremors 35 | 39
abnormal bone mineralization 34 | 38
decreased red blood cell distr... 34 | 41
increased erythrocyte cell num... 34 | 39
abnormal cranium morphology 33 | 36
increased grip strength 33 | 41
abnormal testis morphology 32 | 43
enlarged lymph nodes 32 | 37
increased circulating chloride... 32 | 41
pallor 31 | 34

Disease

Carcinoma 8,552 | 11,493
ovarian cancer 7,573 | 8,520
osteosarcoma 6,847 | 7,950
medulloblastoma, large-cell 5,205 | 6,241
psoriasis 4,926 | 6,694
glioblastoma 4,910 | 5,792
atypical teratoid / rhabdoid tumor 4,262 | 5,112
lung cancer 4,059 | 4,740
ependymoma 3,796 | 4,679
group 3 medulloblastoma 3,415 | 4,104
Breast cancer 3,023 | 3,578
adult high grade glioma 3,019 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 2,850 | 3,291
malignant mesothelioma 2,833 | 3,232
invasive ductal carcinoma 2,613 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,592 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,581 | 2,955
primitive neuroectodermal tumor 2,503 | 3,035
Astrocytoma, Pilocytic 2,463 | 3,081
non-small cell lung cancer 2,429 | 2,890
oligodendroglioma 2,337 | 2,850
lung carcinoma 2,236 | 2,843
lung adenocarcinoma 2,210 | 2,716
astrocytic glioma 2,153 | 2,597
subependymal giant cell astrocytoma 2,007 | 2,287
Kidney cancer 1,980 | 2,613
pancreatic cancer 1,969 | 2,398
Cancer 1,953 | 2,499
interstitial cystitis 1,825 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,761 | 1,962
tuberculosis 1,740 | 2,010
Pick disease 1,659 | 1,894
group 4 medulloblastoma 1,634 | 1,855
pituitary cancer 1,583 | 1,972
ulcerative colitis 1,512 | 1,819
ductal carcinoma in situ 1,499 | 1,745
breast carcinoma 1,433 | 1,638
cystic fibrosis 1,402 | 1,696
Multiple myeloma 1,291 | 1,332
adrenocortical carcinoma 1,252 | 1,428
colon cancer 1,222 | 1,478
diabetes mellitus 1,206 | 1,728
Autosomal recessive predisposition 1,162 | 1,442
juvenile dermatomyositis 1,155 | 1,187
acute quadriplegic myopathy 1,144 | 1,158
astrocytoma 1,034 | 1,146
primary pancreatic ductal adenocarcinoma 999 | 1,109
Rheumatoid arthritis 990 | 1,191
pediatric high grade glioma 944 | 1,064
spina bifida 936 | 1,074
dermatomyositis 915 | 966
cutaneous lupus erythematosus 872 | 1,057
Intellectual disability 854 | 1,016
Schizophrenia 811 | 1,160
nasopharyngeal carcinoma 777 | 1,058
Waldenstrons macroglobulinemia 740 | 765
active Crohn's disease 736 | 922
non primary Sjogren syndrome sicca 735 | 891
Atopic dermatitis 733 | 952
acute myeloid leukemia 733 | 783
gastric carcinoma 720 | 807
Liver Cirrhosis, Experimental 666 | 769
primary Sjogren syndrome 639 | 735
Epilepsy 628 | 792
esophageal adenocarcinoma 614 | 737
medulloblastoma 613 | 720
aldosterone-producing adenoma 610 | 665
progressive supranuclear palsy 609 | 676
active ulcerative colitis 606 | 764
Duchenne muscular dystrophy 588 | 601
Dull intelligence 548 | 645
Low intelligence 548 | 645
Mental Retardation 548 | 645
Mental deficiency 548 | 645
Poor school performance 548 | 645
Cognitive delay 531 | 608
Global developmental delay 531 | 608
Mental and motor retardation 531 | 608
Alzheimer's disease 523 | 658
Muscle hypotonia 517 | 571
pancreatic carcinoma 508 | 562
hepatocellular carcinoma 504 | 547
Obesity 503 | 678
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Seizures 497 | 596
fibroadenoma 475 | 559
Bipolar Disorder 453 | 666
Short stature 451 | 531
Down syndrome 441 | 499
Melanoma 429 | 711
gastric cancer 423 | 459
Amyotrophic lateral sclerosis 420 | 451
Prostatic Neoplasms 412 | 495
sonic hedgehog group medulloblastoma 410 | 467
tuberculosis and treatment for 6 months 403 | 409
Endometriosis 399 | 540
Liver cancer 397 | 604
posterior fossa group A ependymoma 394 | 468
mucosa-associated lymphoid tissue lymphoma 386 | 484
chronic rhinosinusitis 378 | 512

Tissue

Skin and soft tissues 14,011 | 17,230
Endocrine System 13,980 | 18,159
Digestive Tract 13,953 | 17,369
Female tissues 13,935 | 17,400
Male tissues 13,916 | 17,142
Blood and immune system 13,867 | 16,909
Liver and Pancreas 13,833 | 16,750
Urinary Tract 13,828 | 16,678
Nervous System 13,815 | 16,725
Respiratory system 13,774 | 16,393
Cardiovascular System 13,619 | 15,192

Target Family

Non-IDG 8,075 | 12,091
Enzyme 3,355 | 4,145
Transcription Factor 1,062 | 1,400
Kinase 541 | 634
Transporter 330 | 473
Epigenetic 222 | 242
GPCR 183 | 408
Ion Channel 169 | 344
Nuclear Receptor 38 | 48
TF/Epigenetic 31 | 38
oGPCR 5 | 421

HPA RNA Tissue

skeletal muscle 14,011 | 14,011
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50