Development Level

Tbio 6,842 | 10,625
Tdark 2,754 | 7,003
Tchem 1,161 | 1,890
Tclin 273 | 602

Collection

Eligible Kinase Proteins 88 | 134
Eligible Ion Channel Proteins 32 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 540 | 633
preweaning lethality, incomple... 192 | 260
abnormal behavior 168 | 226
embryonic lethality prior to t... 168 | 187
decreased lean body mass 147 | 195
decreased total body fat amoun... 145 | 186
embryonic lethality prior to o... 139 | 148
decreased body weight 129 | 174
decreased bone mineral content 119 | 157
abnormal bone structure 95 | 131
abnormal embryo size 95 | 112
decreased bone mineral density 91 | 126
increased circulating alkaline... 91 | 119
decreased circulating glucose ... 86 | 121
increased or absent threshold ... 85 | 128
decreased body length 82 | 108
decreased grip strength 81 | 123
abnormal retina morphology 79 | 100
hyperactivity 78 | 108
increased lean body mass 75 | 107
increased mean corpuscular hem... 73 | 93
increased mean corpuscular vol... 72 | 91
increased bone mineral content 70 | 92
enlarged heart 65 | 111
decreased circulating serum al... 64 | 79
decreased circulating choleste... 62 | 85
short tibia 62 | 82
hypoactivity 61 | 89
decreased circulating HDL chol... 60 | 77
increased grip strength 59 | 83
abnormal lens morphology 55 | 73
prenatal lethality prior to he... 55 | 64
decreased circulating triglyce... 52 | 83
decreased lumbar vertebrae num... 49 | 62
increased fasted circulating g... 47 | 68
abnormal retinal pigmentation 46 | 61
increased sacral vertebrae num... 46 | 62
decreased circulating insulin ... 45 | 75
decreased leukocyte cell numbe... 44 | 54
increased circulating sodium l... 44 | 71
decreased mean corpuscular vol... 43 | 50
abnormal coat/hair pigmentatio... 41 | 54
abnormal sleep behavior 41 | 63
decreased rib number 41 | 59
male infertility 41 | 62
abnormal bone mineralization 39 | 55
decreased hemoglobin content 39 | 53
impaired glucose tolerance 39 | 52
increased circulating choleste... 39 | 53
decreased circulating total pr... 38 | 41
improved glucose tolerance 37 | 56
increased bone mineral density 37 | 52
increased exploration in new e... 37 | 56
increased circulating HDL chol... 36 | 63
increased total body fat amoun... 36 | 57
decreased erythrocyte cell num... 35 | 43
decreased prepulse inhibition 35 | 52
abnormal gait 34 | 51
abnormal behavioral response t... 33 | 52
decreased caudal vertebrae num... 33 | 49
decreased fasted circulating g... 33 | 49
decreased circulating alanine ... 32 | 53
decreased eosinophil cell numb... 32 | 41
decreased heart weight 32 | 44
decreased startle reflex 32 | 48
increased hemoglobin content 32 | 45
decreased circulating LDL chol... 31 | 37
increased body weight 31 | 42
abnormal neural tube closure 30 | 37
increased blood urea nitrogen ... 29 | 44
thrombocytopenia 29 | 46
abnormal eye morphology 28 | 38
decreased circulating fructosa... 28 | 31
decreased circulating alkaline... 27 | 41
increased leukocyte cell numbe... 27 | 37
increased rib number 27 | 41
increased startle reflex 27 | 38
small testis 27 | 37
abnormal cranium morphology 26 | 32
cardiovascular system phenotyp... 26 | 35
decreased T cell number 26 | 31
abnormal heart morphology 25 | 51
decreased mean corpuscular hem... 25 | 34
increased hematocrit 25 | 36
abnormal seminal vesicle morph... 24 | 47
decreased circulating free fat... 24 | 39
decreased neutrophil cell numb... 24 | 37
increased circulating chloride... 24 | 43
limb grasping 24 | 35
increased heart weight 23 | 37
decreased CD8-positive, alpha-... 22 | 26
decreased circulating calcium ... 22 | 33
decreased circulating chloride... 22 | 32
decreased circulating creatini... 22 | 31
embryonic growth retardation 22 | 28
enlarged spleen 22 | 26
increased circulating potassiu... 22 | 31
abnormal spleen morphology 21 | 36
decreased NK T cell number 21 | 28
tremors 21 | 34

Disease

ovarian cancer 6,486 | 8,484
osteosarcoma 5,616 | 7,933
medulloblastoma, large-cell 4,162 | 6,234
psoriasis 3,828 | 6,685
glioblastoma 3,784 | 5,572
lung cancer 3,206 | 4,466
atypical teratoid / rhabdoid tumor 2,914 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,266 | 3,289
malignant mesothelioma 2,207 | 3,162
Breast cancer 2,107 | 3,094
invasive ductal carcinoma 2,032 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,017 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,010 | 2,988
primitive neuroectodermal tumor 1,896 | 3,031
oligodendroglioma 1,859 | 2,849
pilocytic astrocytoma 1,817 | 3,086
ependymoma 1,803 | 2,514
non-small cell lung cancer 1,766 | 2,798
pediatric high grade glioma 1,698 | 2,712
lung adenocarcinoma 1,671 | 2,713
subependymal giant cell astrocytoma 1,583 | 2,287
lung carcinoma 1,557 | 2,844
astrocytic glioma 1,525 | 2,241
group 3 medulloblastoma 1,524 | 2,254
pancreatic cancer 1,477 | 2,300
Cancer 1,436 | 2,346
Pick disease 1,426 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,423 | 1,795
adult high grade glioma 1,350 | 2,148
group 4 medulloblastoma 1,344 | 1,875
ulcerative colitis 1,319 | 2,087
Multiple myeloma 1,248 | 1,327
interstitial cystitis 1,200 | 2,299
Carcinoma 1,183 | 2,147
pituitary cancer 1,180 | 1,972
astrocytoma 1,120 | 1,493
breast carcinoma 1,114 | 1,614
ductal carcinoma in situ 1,096 | 1,745
acute quadriplegic myopathy 1,090 | 1,157
juvenile dermatomyositis 1,067 | 1,189
tuberculosis 1,054 | 1,557
medulloblastoma 1,005 | 1,524
diabetes mellitus 1,000 | 1,663
primary pancreatic ductal adenocarcinoma 993 | 1,271
cystic fibrosis 980 | 1,665
sonic hedgehog group medulloblastoma 959 | 1,482
adrenocortical carcinoma 947 | 1,427
colon cancer 946 | 1,475
dermatomyositis 884 | 933
posterior fossa group B ependymoma 866 | 1,530
posterior fossa group A ependymoma 834 | 1,511
Rheumatoid Arthritis 808 | 1,160
spina bifida 719 | 1,064
atypical teratoid/rhabdoid tumor 693 | 1,095
Waldenstrons macroglobulinemia 682 | 765
acute myeloid leukemia 633 | 780
gastric carcinoma 595 | 832
non primary Sjogren syndrome sicca 583 | 840
tuberculosis and treatment for 6 months 567 | 686
cutaneous lupus erythematosus 559 | 1,056
Duchenne muscular dystrophy 541 | 602
progressive supranuclear palsy 540 | 674
active Crohn's disease 535 | 918
nasopharyngeal carcinoma 532 | 1,056
aldosterone-producing adenoma 510 | 664
Atopic dermatitis 486 | 944
primary Sjogren syndrome 483 | 789
esophageal adenocarcinoma 479 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 447 | 499
Down syndrome 413 | 548
Intellectual disability 412 | 573
Alzheimer's disease 411 | 644
hepatocellular carcinoma 401 | 532
pancreatic carcinoma 400 | 567
Amyotrophic Lateral Sclerosis 368 | 431
fibroadenoma 355 | 557
Obesity 348 | 616
Prostatic Neoplasms 318 | 471
gastric cancer 311 | 430
hereditary spastic paraplegia 304 | 313
Neurodegenerative disease 300 | 383
IGA Glomerulonephritis 299 | 454
chronic rhinosinusitis 272 | 512
active ulcerative colitis 270 | 477
mucosa-associated lymphoid tissue lymphoma 269 | 480
Endometriosis 265 | 535
Mammary Neoplasms 263 | 410
Schizophrenia 246 | 501
inflammatory breast cancer 245 | 404
Multiple Sclerosis 228 | 498
tuberculosis and treatment for 3 months 227 | 327
Polycystic Ovary Syndrome 220 | 332
glioblastoma multiforme 219 | 347
Parkinson's disease 212 | 364
sarcoidosis 209 | 358
interstitial lung disease 202 | 291
Kidney disease 190 | 396
Stomach Neoplasms 189 | 282
non-small cell lung carcinoma 187 | 413
Epilepsy 181 | 346

Tissue

Skin and soft tissues 11,030 | 18,115
Nervous System 11,029 | 18,561
Endocrine System 11,027 | 18,512
Female tissues 11,027 | 18,647
Digestive Tract 11,026 | 18,473
Cardiovascular System 11,024 | 17,958
Urinary Tract 11,022 | 18,444
Liver and Pancreas 11,021 | 18,136
Male tissues 11,019 | 17,969
Blood and immune system 11,018 | 17,995
Respiratory system 11,007 | 17,484

Target Family

Non-IDG 6,328 | 11,971
Enzyme 2,820 | 4,146
Transcription Factor 788 | 1,400
Kinase 437 | 634
Transporter 235 | 473
Epigenetic 203 | 242
Ion Channel 101 | 341
GPCR 62 | 406
Nuclear Receptor 29 | 48
TF/Epigenetic 27 | 38

HPA RNA Tissue

skeletal muscle 11,030 | 11,030
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Zinc finger protein 485 ZNF485 Tdark Transcription Factor 0.00000 48
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
ATP synthase F(0) complex subunit C3, mitochondrial ATP5G3 Tdark Enzyme -1.10871 11.9 27