Development Level

Tbio 10,255 | 11,651
Tdark 3,927 | 6,593
Tchem 1,235 | 1,388
Tclin 501 | 612

Collection

RFA-RM-18-021 253 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 950 | 979
preweaning lethality, incomple... 466 | 499
embryonic lethality prior to t... 275 | 278
abnormal behavior 273 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 192 | 210
decreased vertical activity 183 | 208
abnormal bone structure 166 | 187
increased lean body mass 159 | 172
abnormal heart morphology 150 | 162
decreased body weight 147 | 161
decreased bone mineral content 136 | 151
hyperactivity 135 | 148
decreased lean body mass 125 | 135
increased total body fat amoun... 122 | 134
decreased circulating glucose ... 118 | 126
hypoactivity 116 | 132
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 122
male infertility 107 | 123
decreased grip strength 105 | 116
abnormal seminal vesicle morph... 103 | 114
increased startle reflex 103 | 112
embryonic growth retardation 102 | 106
increased bone mineral content 98 | 108
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 88 | 96
prenatal lethality prior to he... 86 | 87
cataract 84 | 92
decreased lymphocyte cell numb... 80 | 83
abnormal lens morphology 75 | 81
decreased circulating triglyce... 75 | 79
decreased circulating serum al... 74 | 82
decreased prepulse inhibition 73 | 82
decreased circulating insulin ... 71 | 76
decreased leukocyte cell numbe... 71 | 73
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 71 | 75
increased fasted circulating g... 70 | 76
improved glucose tolerance 69 | 79
increased bone mineral density 69 | 72
small superior vagus ganglion 69 | 74
impaired glucose tolerance 68 | 75
abnormal eye morphology 67 | 68
increased circulating HDL chol... 67 | 80
abnormal retina morphology 65 | 71
decreased circulating HDL chol... 65 | 68
abnormal sleep behavior 64 | 70
increased circulating sodium l... 63 | 71
abnormal coat-hair pigmentatio... 61 | 64
abnormal gait 61 | 69
decreased hemoglobin content 60 | 68
increased monocyte cell number 60 | 63
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 58 | 65
increased circulating choleste... 58 | 66
increased heart weight 57 | 62
edema 56 | 59
small testis 54 | 58
decreased caudal vertebrae num... 53 | 53
abnormal spleen morphology 51 | 55
thrombocytopenia 51 | 56
abnormal skin morphology 49 | 50
hydrometra 49 | 53
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
female infertility 48 | 60
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 44 | 46
decreased hematocrit 43 | 46
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
decreased circulating alanine ... 41 | 47
increased mean platelet volume 41 | 45
abnormal testis morphology 40 | 43
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 38 | 41
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
abnormal epididymis morphology 37 | 42
increased circulating triglyce... 37 | 42
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
tremors 36 | 39
abnormal bone mineralization 35 | 38
increased grip strength 35 | 41
decreased circulating creatini... 34 | 39

Disease

Carcinoma 9,716 | 11,493
ovarian cancer 8,092 | 8,520
osteosarcoma 7,413 | 7,950
medulloblastoma, large-cell 5,796 | 6,241
psoriasis 5,715 | 6,694
glioblastoma 5,500 | 5,792
atypical teratoid / rhabdoid tumor 4,820 | 5,112
lung cancer 4,457 | 4,740
ependymoma 4,406 | 4,679
group 3 medulloblastoma 3,873 | 4,104
adult high grade glioma 3,523 | 3,801
Breast cancer 3,393 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,159 | 3,291
malignant mesothelioma 3,097 | 3,232
Astrocytoma, Pilocytic 2,885 | 3,081
primitive neuroectodermal tumor 2,878 | 3,035
invasive ductal carcinoma 2,877 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,872 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,846 | 2,955
non-small cell lung cancer 2,769 | 2,890
oligodendroglioma 2,687 | 2,850
lung carcinoma 2,660 | 2,843
lung adenocarcinoma 2,565 | 2,716
astrocytic glioma 2,454 | 2,597
Kidney cancer 2,302 | 2,613
pancreatic cancer 2,263 | 2,398
interstitial cystitis 2,209 | 2,312
Cancer 2,194 | 2,499
subependymal giant cell astrocytoma 2,177 | 2,287
tuberculosis 1,902 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,862 | 1,962
pituitary cancer 1,849 | 1,972
Pick disease 1,831 | 1,894
group 4 medulloblastoma 1,769 | 1,855
ulcerative colitis 1,712 | 1,819
ductal carcinoma in situ 1,696 | 1,745
cystic fibrosis 1,610 | 1,696
breast carcinoma 1,575 | 1,638
colon cancer 1,405 | 1,478
adrenocortical carcinoma 1,386 | 1,428
diabetes mellitus 1,308 | 1,728
Multiple myeloma 1,306 | 1,332
Autosomal recessive predisposition 1,274 | 1,442
juvenile dermatomyositis 1,160 | 1,187
acute quadriplegic myopathy 1,128 | 1,158
astrocytoma 1,106 | 1,146
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
Rheumatoid arthritis 1,074 | 1,191
pediatric high grade glioma 1,022 | 1,064
spina bifida 1,021 | 1,074
cutaneous lupus erythematosus 996 | 1,057
Schizophrenia 982 | 1,160
nasopharyngeal carcinoma 980 | 1,058
Intellectual disability 941 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 873 | 922
Atopic dermatitis 845 | 952
non primary Sjogren syndrome sicca 825 | 891
gastric carcinoma 773 | 807
acute myeloid leukemia 767 | 783
Waldenstrons macroglobulinemia 755 | 765
Liver Cirrhosis, Experimental 719 | 769
Epilepsy 718 | 792
active ulcerative colitis 714 | 764
primary Sjogren syndrome 709 | 735
esophageal adenocarcinoma 688 | 737
medulloblastoma 681 | 720
progressive supranuclear palsy 655 | 676
aldosterone-producing adenoma 649 | 665
Alzheimer's disease 601 | 658
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Obesity 575 | 678
Duchenne muscular dystrophy 573 | 601
Cognitive delay 572 | 608
Global developmental delay 572 | 608
Mental and motor retardation 572 | 608
Bipolar Disorder 569 | 666
Melanoma 556 | 711
Seizures 547 | 596
pancreatic carcinoma 546 | 562
fibroadenoma 545 | 559
Muscle hypotonia 540 | 571
hepatocellular carcinoma 527 | 547
Endometriosis 509 | 540
Liver cancer 507 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 495 | 510
Short stature 488 | 531
chronic rhinosinusitis 485 | 512
Down syndrome 473 | 499
Prostatic Neoplasms 458 | 495
Multiple Sclerosis 452 | 540
gastric cancer 446 | 459
mucosa-associated lymphoid tissue lymphoma 443 | 484
posterior fossa group A ependymoma 441 | 468
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 430 | 451

Tissue

Male tissues 15,918 | 17,142
Endocrine System 15,878 | 18,159
Female tissues 15,830 | 17,400
Digestive Tract 15,792 | 17,369
Skin and soft tissues 15,766 | 17,230
Urinary Tract 15,628 | 16,678
Liver and Pancreas 15,607 | 16,750
Blood and immune system 15,571 | 16,909
Nervous System 15,525 | 16,725
Respiratory system 15,472 | 16,393
Cardiovascular System 14,684 | 15,192

Target Family

Non-IDG 9,249 | 12,091
Enzyme 3,690 | 4,145
Transcription Factor 1,172 | 1,400
Kinase 594 | 634
Transporter 381 | 473
GPCR 261 | 408
Ion Channel 250 | 344
Epigenetic 229 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 35 | 38
oGPCR 16 | 421

HPA RNA Tissue

seminal vesicle 15,918 | 15,918
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50