Development Level

Tbio 9,788 | 11,651
Tdark 3,568 | 6,593
Tchem 1,172 | 1,388
Tclin 453 | 612

Collection

RFA-RM-18-021 222 | 328
Kinase: IDG Consortium (Target... 107 | 125
Ion Channel: IDG Consortium (T... 60 | 99
GPCR: IDG Consortium (Targets) 56 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 938 | 979
preweaning lethality, incomple... 443 | 499
embryonic lethality prior to t... 268 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 206 | 220
decreased total body fat amoun... 186 | 207
enlarged heart 175 | 210
decreased vertical activity 163 | 208
abnormal bone structure 157 | 187
increased lean body mass 155 | 172
decreased body weight 144 | 161
abnormal heart morphology 138 | 162
decreased bone mineral content 127 | 151
hyperactivity 125 | 148
decreased lean body mass 117 | 135
increased total body fat amoun... 113 | 134
hypoactivity 111 | 132
decreased circulating glucose ... 110 | 126
decreased bone mineral density 106 | 126
increased circulating alkaline... 102 | 122
embryonic growth retardation 101 | 106
increased startle reflex 98 | 112
decreased grip strength 96 | 116
increased bone mineral content 94 | 108
male infertility 94 | 123
abnormal seminal vesicle morph... 92 | 114
decreased body length 89 | 101
increased or absent threshold ... 87 | 101
increased mean corpuscular hem... 86 | 96
cataract 85 | 92
short tibia 85 | 97
decreased circulating choleste... 84 | 93
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 82 | 87
abnormal lens morphology 75 | 81
decreased circulating serum al... 74 | 82
decreased lymphocyte cell numb... 71 | 83
decreased prepulse inhibition 70 | 82
increased bone mineral density 69 | 72
decreased circulating triglyce... 68 | 79
increased circulating HDL chol... 68 | 80
decreased mean corpuscular vol... 66 | 79
decreased startle reflex 66 | 75
decreased leukocyte cell numbe... 65 | 73
impaired glucose tolerance 65 | 75
increased fasted circulating g... 65 | 76
improved glucose tolerance 64 | 79
abnormal eye morphology 62 | 68
abnormal retina morphology 62 | 71
abnormal sleep behavior 61 | 70
decreased circulating HDL chol... 61 | 68
decreased circulating insulin ... 61 | 76
small superior vagus ganglion 60 | 74
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
abnormal behavioral response t... 57 | 66
increased circulating sodium l... 57 | 71
increased circulating choleste... 55 | 66
abnormal gait 54 | 69
edema 54 | 59
increased monocyte cell number 54 | 63
increased heart weight 53 | 62
abnormal kidney morphology 52 | 65
small testis 52 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
decreased caudal vertebrae num... 49 | 53
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 44 | 46
decreased blood urea nitrogen ... 44 | 51
decreased hematocrit 44 | 46
female infertility 44 | 60
abnormal skin morphology 43 | 50
hydrometra 43 | 53
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 42 | 46
increased neutrophil cell numb... 42 | 46
increased blood urea nitrogen ... 41 | 48
increased hematocrit 41 | 46
increased mean platelet volume 40 | 45
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
increased leukocyte cell numbe... 38 | 47
abnormal testis morphology 37 | 43
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 35 | 42
tremors 35 | 39
abnormal bone mineralization 34 | 38
abnormal cranium morphology 34 | 36
increased circulating chloride... 34 | 41
increased grip strength 34 | 41
increased circulating triglyce... 33 | 42
increased erythrocyte cell num... 33 | 39
decreased circulating aspartat... 32 | 34
increased mean corpuscular hem... 32 | 36

Disease

Carcinoma 9,154 | 11,493
ovarian cancer 7,904 | 8,520
osteosarcoma 7,228 | 7,950
medulloblastoma, large-cell 5,505 | 6,241
psoriasis 5,390 | 6,694
glioblastoma 5,208 | 5,792
atypical teratoid / rhabdoid tumor 4,540 | 5,112
lung cancer 4,329 | 4,740
ependymoma 4,101 | 4,679
group 3 medulloblastoma 3,668 | 4,104
Breast cancer 3,288 | 3,578
adult high grade glioma 3,268 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 3,095 | 3,291
malignant mesothelioma 2,994 | 3,232
invasive ductal carcinoma 2,843 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,805 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,789 | 2,955
primitive neuroectodermal tumor 2,682 | 3,035
Astrocytoma, Pilocytic 2,677 | 3,081
non-small cell lung cancer 2,671 | 2,890
oligodendroglioma 2,511 | 2,850
lung carcinoma 2,483 | 2,843
lung adenocarcinoma 2,451 | 2,716
astrocytic glioma 2,294 | 2,597
pancreatic cancer 2,195 | 2,398
Kidney cancer 2,126 | 2,613
interstitial cystitis 2,115 | 2,312
Cancer 2,098 | 2,499
subependymal giant cell astrocytoma 2,095 | 2,287
tuberculosis 1,870 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,826 | 1,962
Pick disease 1,742 | 1,894
pituitary cancer 1,738 | 1,972
group 4 medulloblastoma 1,698 | 1,855
ductal carcinoma in situ 1,674 | 1,745
ulcerative colitis 1,669 | 1,819
breast carcinoma 1,561 | 1,638
cystic fibrosis 1,542 | 1,696
adrenocortical carcinoma 1,350 | 1,428
colon cancer 1,341 | 1,478
Multiple myeloma 1,300 | 1,332
diabetes mellitus 1,268 | 1,728
Autosomal recessive predisposition 1,217 | 1,442
juvenile dermatomyositis 1,151 | 1,187
acute quadriplegic myopathy 1,115 | 1,158
astrocytoma 1,084 | 1,146
primary pancreatic ductal adenocarcinoma 1,070 | 1,109
Rheumatoid arthritis 1,060 | 1,191
spina bifida 1,007 | 1,074
pediatric high grade glioma 985 | 1,064
cutaneous lupus erythematosus 964 | 1,057
nasopharyngeal carcinoma 920 | 1,058
dermatomyositis 917 | 966
Schizophrenia 903 | 1,160
Intellectual disability 900 | 1,016
active Crohn's disease 839 | 922
Atopic dermatitis 819 | 952
non primary Sjogren syndrome sicca 778 | 891
acute myeloid leukemia 765 | 783
Waldenstrons macroglobulinemia 758 | 765
gastric carcinoma 750 | 807
primary Sjogren syndrome 708 | 735
Liver Cirrhosis, Experimental 691 | 769
active ulcerative colitis 684 | 764
esophageal adenocarcinoma 683 | 737
Epilepsy 672 | 792
medulloblastoma 642 | 720
progressive supranuclear palsy 640 | 676
aldosterone-producing adenoma 634 | 665
Duchenne muscular dystrophy 574 | 601
Dull intelligence 571 | 645
Low intelligence 571 | 645
Mental Retardation 571 | 645
Mental deficiency 571 | 645
Poor school performance 571 | 645
Alzheimer's disease 560 | 658
Cognitive delay 559 | 608
Global developmental delay 559 | 608
Mental and motor retardation 559 | 608
Obesity 540 | 678
pancreatic carcinoma 537 | 562
fibroadenoma 530 | 559
hepatocellular carcinoma 526 | 547
Muscle hypotonia 521 | 571
Seizures 515 | 596
Bipolar Disorder 512 | 666
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 510
Melanoma 484 | 711
Short stature 470 | 531
Endometriosis 466 | 540
Down syndrome 458 | 499
Liver cancer 451 | 604
chronic rhinosinusitis 451 | 512
Prostatic Neoplasms 450 | 495
gastric cancer 444 | 459
mucosa-associated lymphoid tissue lymphoma 432 | 484
Multiple Sclerosis 426 | 540
posterior fossa group A ependymoma 426 | 468
sonic hedgehog group medulloblastoma 422 | 467
Amyotrophic lateral sclerosis 415 | 451

Tissue

Digestive Tract 14,981 | 17,369
Endocrine System 14,966 | 18,159
Female tissues 14,956 | 17,400
Skin and soft tissues 14,919 | 17,230
Male tissues 14,904 | 17,142
Liver and Pancreas 14,858 | 16,750
Blood and immune system 14,854 | 16,909
Urinary Tract 14,835 | 16,678
Respiratory system 14,781 | 16,393
Nervous System 14,722 | 16,725
Cardiovascular System 14,309 | 15,192

Target Family

Non-IDG 8,686 | 12,091
Enzyme 3,559 | 4,145
Transcription Factor 1,099 | 1,400
Kinase 571 | 634
Transporter 348 | 473
Epigenetic 224 | 242
GPCR 214 | 408
Ion Channel 204 | 344
Nuclear Receptor 38 | 48
TF/Epigenetic 32 | 38
oGPCR 6 | 421

HPA RNA Tissue

salivary gland 14,981 | 14,981
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50