Development Level

Tbio 7,902 | 10,625
Tdark 3,237 | 7,003
Tchem 1,353 | 1,890
Tclin 347 | 602

Collection

Kinase: IDG Consortium (Targets) 90 | 125
Ion Channel: IDG Consortium (Targets) 42 | 102
GPCR: IDG Consortium (Targets) 35 | 128
Kinase: IDG Consortium (Complete/Control) 30 | 37
GPCR: IDG Consortium (Complete/Control) 10 | 24

IMPC Phenotype

preweaning lethality, complete... 563 | 633
preweaning lethality, incomple... 213 | 260
abnormal behavior 184 | 226
embryonic lethality prior to t... 171 | 187
decreased lean body mass 160 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 147 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 124 | 157
decreased bone mineral density 103 | 126
increased circulating alkaline... 100 | 119
abnormal bone structure 98 | 131
abnormal embryo size 98 | 112
increased or absent threshold ... 95 | 128
decreased circulating glucose ... 93 | 121
decreased body length 90 | 108
decreased grip strength 89 | 123
increased lean body mass 89 | 107
abnormal retina morphology 87 | 100
hyperactivity 85 | 108
increased mean corpuscular hem... 80 | 93
enlarged heart 79 | 111
increased bone mineral content 79 | 92
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 71 | 85
short tibia 71 | 82
hypoactivity 68 | 89
decreased circulating HDL chol... 65 | 77
decreased circulating serum al... 65 | 79
decreased circulating triglyce... 65 | 83
abnormal lens morphology 62 | 73
increased grip strength 62 | 83
prenatal lethality prior to he... 58 | 64
increased fasted circulating g... 55 | 68
decreased lumbar vertebrae num... 53 | 62
abnormal retinal pigmentation 51 | 61
decreased circulating insulin ... 51 | 75
increased sacral vertebrae num... 51 | 62
increased circulating sodium l... 49 | 71
decreased rib number 47 | 59
abnormal bone mineralization 46 | 55
abnormal coat-hair pigmentatio... 46 | 54
decreased leukocyte cell numbe... 46 | 54
abnormal sleep behavior 45 | 63
decreased mean corpuscular vol... 45 | 50
increased bone mineral density 45 | 52
increased circulating HDL chol... 45 | 63
increased circulating choleste... 43 | 53
increased total body fat amoun... 43 | 57
male infertility 43 | 62
decreased hemoglobin content 42 | 53
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 41 | 52
decreased fasted circulating g... 40 | 49
abnormal gait 39 | 51
improved glucose tolerance 39 | 56
increased exploration in new e... 39 | 56
decreased caudal vertebrae num... 38 | 49
decreased circulating total pr... 38 | 41
decreased erythrocyte cell num... 38 | 43
thrombocytopenia 38 | 46
abnormal behavioral response t... 36 | 52
increased blood urea nitrogen ... 36 | 44
decreased circulating alanine ... 35 | 53
increased body weight 35 | 42
increased hemoglobin content 35 | 45
decreased heart weight 34 | 44
decreased eosinophil cell numb... 33 | 41
decreased startle reflex 33 | 48
increased rib number 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
abnormal eye morphology 31 | 38
decreased circulating LDL chol... 31 | 37
decreased circulating alkaline... 31 | 41
decreased circulating free fat... 31 | 39
abnormal seminal vesicle morph... 30 | 47
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
increased startle reflex 29 | 38
tremors 29 | 34
abnormal cranium morphology 28 | 32
cardiovascular system phenotyp... 28 | 35
decreased T cell number 28 | 31
decreased circulating calcium ... 28 | 33
decreased circulating fructosa... 28 | 31
increased leukocyte cell numbe... 28 | 37
abnormal spleen morphology 27 | 36
decreased mean corpuscular hem... 27 | 34
increased circulating chloride... 27 | 43
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
small testis 26 | 37
decreased B cell number 25 | 30
decreased circulating chloride... 25 | 32
decreased circulating creatini... 25 | 31
increased circulating iron lev... 25 | 25
abnormal cornea morphology 24 | 24
embryonic growth retardation 24 | 28
increased circulating calcium ... 24 | 32

Disease

ovarian cancer 7,300 | 8,491
osteosarcoma 6,506 | 7,933
medulloblastoma, large-cell 4,804 | 6,234
psoriasis 4,625 | 6,685
glioblastoma 4,390 | 5,572
lung cancer 3,804 | 4,473
atypical teratoid / rhabdoid tumor 3,349 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,796 | 3,289
malignant mesothelioma 2,635 | 3,163
Breast cancer 2,612 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 2,565 | 2,956
invasive ductal carcinoma 2,559 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,531 | 2,988
non-small cell lung cancer 2,275 | 2,798
pilocytic astrocytoma 2,264 | 3,086
primitive neuroectodermal tumor 2,262 | 3,031
oligodendroglioma 2,186 | 2,849
lung carcinoma 2,117 | 2,844
lung adenocarcinoma 2,098 | 2,714
pediatric high grade glioma 2,059 | 2,712
ependymoma 2,028 | 2,514
pancreatic cancer 1,919 | 2,300
subependymal giant cell astrocytoma 1,882 | 2,287
interstitial cystitis 1,808 | 2,299
group 3 medulloblastoma 1,783 | 2,254
astrocytic glioma 1,759 | 2,241
Cancer 1,744 | 2,346
ulcerative colitis 1,737 | 2,087
Pick disease 1,594 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,589 | 1,795
adult high grade glioma 1,587 | 2,148
group 4 medulloblastoma 1,565 | 1,875
pituitary cancer 1,496 | 1,972
ductal carcinoma in situ 1,460 | 1,745
Carcinoma 1,387 | 2,147
breast carcinoma 1,382 | 1,614
cystic fibrosis 1,330 | 1,670
tuberculosis 1,310 | 1,563
Multiple myeloma 1,289 | 1,327
astrocytoma 1,257 | 1,493
colon cancer 1,171 | 1,475
primary pancreatic ductal adenocarcinoma 1,171 | 1,271
adrenocortical carcinoma 1,170 | 1,427
medulloblastoma 1,141 | 1,524
sonic hedgehog group medulloblastoma 1,128 | 1,482
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,097 | 1,663
posterior fossa group B ependymoma 1,091 | 1,530
acute quadriplegic myopathy 1,066 | 1,157
posterior fossa group A ependymoma 1,059 | 1,511
Rheumatoid Arthritis 952 | 1,170
spina bifida 938 | 1,064
dermatomyositis 900 | 966
atypical teratoid/rhabdoid tumor 861 | 1,095
cutaneous lupus erythematosus 839 | 1,056
nasopharyngeal carcinoma 763 | 1,056
active Crohn's disease 746 | 918
Waldenstrons macroglobulinemia 740 | 764
gastric carcinoma 727 | 832
acute myeloid leukemia 719 | 785
primary Sjogren syndrome 683 | 788
non primary Sjogren syndrome sicca 664 | 840
Atopic dermatitis 653 | 944
tuberculosis and treatment for 6 months 638 | 686
esophageal adenocarcinoma 622 | 737
progressive supranuclear palsy 598 | 674
aldosterone-producing adenoma 585 | 664
Duchenne muscular dystrophy 553 | 602
hepatocellular carcinoma 495 | 550
pancreatic carcinoma 489 | 567
Alzheimer's disease 483 | 644
fibroadenoma 469 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 499
Down syndrome 462 | 548
Intellectual disability 452 | 573
Obesity 418 | 616
Prostatic Neoplasms 384 | 471
gastric cancer 380 | 436
IGA Glomerulonephritis 374 | 454
active ulcerative colitis 373 | 477
chronic rhinosinusitis 373 | 512
Amyotrophic Lateral Sclerosis 366 | 432
Endometriosis 363 | 535
mucosa-associated lymphoid tissue lymphoma 362 | 480
Neurodegenerative disease 327 | 383
Mammary Neoplasms 323 | 410
inflammatory breast cancer 321 | 404
Multiple Sclerosis 319 | 498
Schizophrenia 318 | 503
hereditary spastic paraplegia 301 | 313
tuberculosis and treatment for 3 months 289 | 327
sarcoidosis 283 | 368
glioblastoma multiforme 269 | 347
urothelial carcinoma 264 | 318
Parkinson's disease 260 | 364
non-small cell lung carcinoma 255 | 413
Kidney disease 252 | 397
Polycystic Ovary Syndrome 251 | 334
interstitial lung disease 248 | 292
nephrosclerosis 244 | 329

Tissue

Digestive Tract 12,839 | 18,472
Endocrine System 12,837 | 18,511
Female tissues 12,834 | 18,646
Nervous System 12,833 | 18,560
Liver and Pancreas 12,832 | 18,135
Skin and soft tissues 12,830 | 18,114
Urinary Tract 12,830 | 18,443
Blood and immune system 12,823 | 17,994
Male tissues 12,819 | 17,968
Cardiovascular System 12,818 | 17,957
Respiratory system 12,813 | 17,483

Target Family

Non-IDG 7,383 | 11,969
Enzyme 3,212 | 4,146
Transcription Factor 922 | 1,400
Kinase 509 | 634
Transporter 296 | 473
Epigenetic 207 | 242
Ion Channel 125 | 341
GPCR 124 | 408
Nuclear Receptor 30 | 48
TF/Epigenetic 30 | 38
oGPCR 1 | 421

HPA RNA Tissue

salivary gland 12,839 | 12,839
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90