Development Level

Tbio 7,902 | 10,625
Tdark 3,237 | 7,003
Tchem 1,354 | 1,890
Tclin 347 | 602

Collection

Eligible Kinase Proteins 95 | 134
Eligible Ion Channel Proteins 42 | 117
Eligible non-olfactory GPCR Proteins 34 | 143

IMPC Term

preweaning lethality, complete... 563 | 633
preweaning lethality, incomple... 213 | 260
abnormal behavior 184 | 226
embryonic lethality prior to t... 171 | 187
decreased lean body mass 160 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 147 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 124 | 157
decreased bone mineral density 103 | 126
increased circulating alkaline... 100 | 119
abnormal bone structure 98 | 131
abnormal embryo size 98 | 112
increased or absent threshold ... 95 | 128
decreased circulating glucose ... 93 | 121
decreased body length 90 | 108
decreased grip strength 89 | 123
increased lean body mass 89 | 107
abnormal retina morphology 87 | 100
hyperactivity 85 | 108
increased mean corpuscular hem... 80 | 93
enlarged heart 79 | 111
increased bone mineral content 79 | 92
increased mean corpuscular vol... 76 | 91
decreased circulating choleste... 71 | 85
short tibia 71 | 82
hypoactivity 68 | 89
decreased circulating HDL chol... 65 | 77
decreased circulating serum al... 65 | 79
decreased circulating triglyce... 65 | 83
abnormal lens morphology 62 | 73
increased grip strength 62 | 83
prenatal lethality prior to he... 58 | 64
increased fasted circulating g... 55 | 68
decreased lumbar vertebrae num... 53 | 62
abnormal retinal pigmentation 51 | 61
decreased circulating insulin ... 51 | 75
increased sacral vertebrae num... 51 | 62
increased circulating sodium l... 49 | 71
decreased rib number 47 | 59
abnormal bone mineralization 46 | 55
abnormal coat/hair pigmentatio... 46 | 54
decreased leukocyte cell numbe... 46 | 54
abnormal sleep behavior 45 | 63
decreased mean corpuscular vol... 45 | 50
increased bone mineral density 45 | 52
increased circulating HDL chol... 45 | 63
increased circulating choleste... 43 | 53
increased total body fat amoun... 43 | 57
male infertility 43 | 62
decreased hemoglobin content 42 | 53
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 41 | 52
decreased fasted circulating g... 40 | 49
abnormal gait 39 | 51
improved glucose tolerance 39 | 56
increased exploration in new e... 39 | 56
decreased caudal vertebrae num... 38 | 49
decreased circulating total pr... 38 | 41
decreased erythrocyte cell num... 38 | 43
thrombocytopenia 38 | 46
abnormal behavioral response t... 36 | 52
increased blood urea nitrogen ... 36 | 44
decreased circulating alanine ... 35 | 53
increased body weight 35 | 42
increased hemoglobin content 35 | 45
decreased heart weight 34 | 44
decreased eosinophil cell numb... 33 | 41
decreased startle reflex 33 | 48
increased rib number 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
abnormal eye morphology 31 | 38
decreased circulating LDL chol... 31 | 37
decreased circulating alkaline... 31 | 41
decreased circulating free fat... 31 | 39
abnormal seminal vesicle morph... 30 | 47
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
increased startle reflex 29 | 38
tremors 29 | 34
abnormal cranium morphology 28 | 32
cardiovascular system phenotyp... 28 | 35
decreased T cell number 28 | 31
decreased circulating calcium ... 28 | 33
decreased circulating fructosa... 28 | 31
increased leukocyte cell numbe... 28 | 37
abnormal spleen morphology 27 | 36
decreased mean corpuscular hem... 27 | 34
increased circulating chloride... 27 | 43
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
small testis 26 | 37
decreased B cell number 25 | 30
decreased circulating chloride... 25 | 32
decreased circulating creatini... 25 | 31
increased circulating iron lev... 25 | 25
abnormal cornea morphology 24 | 24
embryonic growth retardation 24 | 28
increased circulating calcium ... 24 | 32

Disease

ovarian cancer 7,296 | 8,484
osteosarcoma 6,506 | 7,933
medulloblastoma, large-cell 4,804 | 6,234
psoriasis 4,625 | 6,685
glioblastoma 4,390 | 5,572
lung cancer 3,800 | 4,466
atypical teratoid / rhabdoid tumor 3,349 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,796 | 3,289
malignant mesothelioma 2,634 | 3,162
Breast cancer 2,610 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 2,565 | 2,956
invasive ductal carcinoma 2,559 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,531 | 2,988
non-small cell lung cancer 2,275 | 2,798
pilocytic astrocytoma 2,264 | 3,086
primitive neuroectodermal tumor 2,262 | 3,031
oligodendroglioma 2,186 | 2,849
lung carcinoma 2,117 | 2,844
lung adenocarcinoma 2,097 | 2,713
pediatric high grade glioma 2,059 | 2,712
ependymoma 2,028 | 2,514
pancreatic cancer 1,919 | 2,300
subependymal giant cell astrocytoma 1,882 | 2,287
interstitial cystitis 1,808 | 2,299
group 3 medulloblastoma 1,783 | 2,254
astrocytic glioma 1,759 | 2,241
Cancer 1,744 | 2,346
ulcerative colitis 1,737 | 2,087
Pick disease 1,594 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,589 | 1,795
adult high grade glioma 1,587 | 2,148
group 4 medulloblastoma 1,565 | 1,875
pituitary cancer 1,496 | 1,972
ductal carcinoma in situ 1,460 | 1,745
Carcinoma 1,387 | 2,147
breast carcinoma 1,382 | 1,614
cystic fibrosis 1,327 | 1,665
tuberculosis 1,306 | 1,557
Multiple myeloma 1,290 | 1,327
astrocytoma 1,257 | 1,493
colon cancer 1,171 | 1,475
primary pancreatic ductal adenocarcinoma 1,171 | 1,271
adrenocortical carcinoma 1,170 | 1,427
medulloblastoma 1,141 | 1,524
sonic hedgehog group medulloblastoma 1,128 | 1,482
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,097 | 1,663
posterior fossa group B ependymoma 1,091 | 1,530
acute quadriplegic myopathy 1,066 | 1,157
posterior fossa group A ependymoma 1,059 | 1,511
Rheumatoid Arthritis 953 | 1,160
spina bifida 938 | 1,064
dermatomyositis 900 | 933
atypical teratoid/rhabdoid tumor 861 | 1,095
cutaneous lupus erythematosus 839 | 1,056
nasopharyngeal carcinoma 763 | 1,056
active Crohn's disease 746 | 918
Waldenstrons macroglobulinemia 741 | 765
gastric carcinoma 727 | 832
acute myeloid leukemia 715 | 780
primary Sjogren syndrome 684 | 789
non primary Sjogren syndrome sicca 664 | 840
Atopic dermatitis 653 | 944
tuberculosis and treatment for 6 months 638 | 686
esophageal adenocarcinoma 622 | 737
progressive supranuclear palsy 598 | 674
aldosterone-producing adenoma 585 | 664
Duchenne muscular dystrophy 553 | 602
pancreatic carcinoma 489 | 567
Alzheimer's disease 483 | 644
hepatocellular carcinoma 479 | 532
fibroadenoma 469 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 468 | 499
Down syndrome 462 | 548
Intellectual disability 452 | 573
Obesity 418 | 616
Prostatic Neoplasms 384 | 471
IGA Glomerulonephritis 374 | 454
gastric cancer 374 | 430
active ulcerative colitis 373 | 477
chronic rhinosinusitis 373 | 512
Amyotrophic Lateral Sclerosis 366 | 431
Endometriosis 363 | 535
mucosa-associated lymphoid tissue lymphoma 362 | 480
Neurodegenerative disease 327 | 383
Mammary Neoplasms 323 | 410
inflammatory breast cancer 321 | 404
Multiple Sclerosis 319 | 498
Schizophrenia 316 | 501
hereditary spastic paraplegia 301 | 313
tuberculosis and treatment for 3 months 289 | 327
sarcoidosis 283 | 358
glioblastoma multiforme 269 | 347
urothelial carcinoma 264 | 318
Parkinson's disease 260 | 364
non-small cell lung carcinoma 255 | 413
Polycystic Ovary Syndrome 252 | 332
Kidney disease 251 | 396
interstitial lung disease 247 | 291
nephrosclerosis 244 | 329

Tissue

Digestive Tract 12,840 | 18,473
Endocrine System 12,838 | 18,512
Female tissues 12,835 | 18,647
Nervous System 12,834 | 18,561
Liver and Pancreas 12,833 | 18,136
Skin and soft tissues 12,831 | 18,115
Urinary Tract 12,831 | 18,444
Blood and immune system 12,824 | 17,995
Male tissues 12,820 | 17,969
Cardiovascular System 12,819 | 17,958
Respiratory system 12,814 | 17,484

Target Family

Non-IDG 7,383 | 11,971
Enzyme 3,213 | 4,146
Transcription Factor 922 | 1,400
Kinase 509 | 634
Transporter 296 | 473
Epigenetic 207 | 242
Ion Channel 125 | 341
GPCR 124 | 406
Nuclear Receptor 30 | 48
TF/Epigenetic 30 | 38
oGPCR 1 | 421

HPA RNA Tissue

salivary gland 12,840 | 12,840
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345