Development Level

Tbio 8,170 | 10,625
Tdark 3,348 | 7,003
Tchem 1,463 | 1,890
Tclin 382 | 602

Collection

Eligible Kinase Proteins 100 | 134
Eligible Ion Channel Proteins 41 | 117
Eligible non-olfactory GPCR Proteins 37 | 143

IMPC Term

preweaning lethality, complete... 579 | 633
preweaning lethality, incomple... 217 | 260
abnormal behavior 185 | 226
embryonic lethality prior to t... 179 | 187
decreased lean body mass 164 | 195
decreased total body fat amoun... 159 | 186
decreased body weight 153 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 127 | 157
increased or absent threshold ... 105 | 128
increased circulating alkaline... 101 | 119
abnormal embryo size 100 | 112
abnormal bone structure 98 | 131
decreased bone mineral density 98 | 126
decreased grip strength 97 | 123
decreased circulating glucose ... 95 | 121
decreased body length 93 | 108
increased lean body mass 89 | 107
abnormal retina morphology 87 | 100
hyperactivity 84 | 108
increased bone mineral content 82 | 92
increased mean corpuscular hem... 82 | 93
enlarged heart 81 | 111
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 73 | 85
short tibia 72 | 82
hypoactivity 70 | 89
decreased circulating serum al... 69 | 79
decreased circulating HDL chol... 68 | 77
decreased circulating triglyce... 67 | 83
increased grip strength 65 | 83
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 59 | 64
increased fasted circulating g... 56 | 68
decreased circulating insulin ... 55 | 75
decreased lumbar vertebrae num... 53 | 62
abnormal retinal pigmentation 52 | 61
increased circulating sodium l... 52 | 71
increased sacral vertebrae num... 52 | 62
abnormal coat/hair pigmentatio... 48 | 54
decreased rib number 48 | 59
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
increased circulating HDL chol... 47 | 63
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 46 | 52
abnormal bone mineralization 45 | 55
male infertility 45 | 62
improved glucose tolerance 44 | 56
increased circulating choleste... 44 | 53
increased total body fat amoun... 44 | 57
decreased circulating alanine ... 43 | 53
decreased hemoglobin content 43 | 53
decreased prepulse inhibition 43 | 52
impaired glucose tolerance 42 | 52
abnormal gait 40 | 51
increased exploration in new e... 40 | 56
decreased caudal vertebrae num... 39 | 49
decreased circulating total pr... 38 | 41
decreased erythrocyte cell num... 38 | 43
decreased fasted circulating g... 38 | 49
increased blood urea nitrogen ... 38 | 44
increased body weight 38 | 42
thrombocytopenia 38 | 46
abnormal behavioral response t... 37 | 52
decreased startle reflex 37 | 48
decreased eosinophil cell numb... 35 | 41
increased hemoglobin content 35 | 45
abnormal heart morphology 34 | 51
decreased circulating LDL chol... 34 | 37
decreased heart weight 34 | 44
increased rib number 34 | 41
abnormal neural tube closure 33 | 37
increased startle reflex 32 | 38
abnormal eye morphology 31 | 38
abnormal seminal vesicle morph... 31 | 47
decreased circulating alkaline... 31 | 41
decreased circulating free fat... 31 | 39
decreased circulating fructosa... 30 | 31
decreased neutrophil cell numb... 30 | 37
increased circulating chloride... 30 | 43
increased leukocyte cell numbe... 30 | 37
cardiovascular system phenotyp... 29 | 35
decreased T cell number 29 | 31
decreased mean corpuscular hem... 29 | 34
increased hematocrit 29 | 36
abnormal spleen morphology 28 | 36
small testis 28 | 37
tremors 28 | 34
abnormal cranium morphology 27 | 32
decreased circulating calcium ... 27 | 33
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
limb grasping 27 | 35
decreased circulating creatini... 25 | 31
increased circulating calcium ... 25 | 32
abnormal cornea morphology 24 | 24
abnormal epididymis morphology 24 | 31
increased circulating potassiu... 24 | 31

Disease

ovarian cancer 7,529 | 8,484
osteosarcoma 6,762 | 7,933
medulloblastoma, large-cell 5,061 | 6,234
psoriasis 4,871 | 6,685
glioblastoma 4,650 | 5,572
lung cancer 4,037 | 4,466
atypical teratoid / rhabdoid tumor 3,567 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,996 | 3,289
malignant mesothelioma 2,804 | 3,162
Breast cancer 2,729 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,717 | 2,988
invasive ductal carcinoma 2,685 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,667 | 2,956
primitive neuroectodermal tumor 2,455 | 3,031
non-small cell lung cancer 2,436 | 2,798
pilocytic astrocytoma 2,398 | 3,086
oligodendroglioma 2,303 | 2,849
lung carcinoma 2,298 | 2,844
lung adenocarcinoma 2,276 | 2,713
pediatric high grade glioma 2,235 | 2,712
ependymoma 2,088 | 2,514
pancreatic cancer 2,020 | 2,300
interstitial cystitis 1,984 | 2,299
ulcerative colitis 1,939 | 2,087
subependymal giant cell astrocytoma 1,936 | 2,287
group 3 medulloblastoma 1,878 | 2,254
Cancer 1,858 | 2,346
astrocytic glioma 1,833 | 2,241
Pick disease 1,664 | 1,893
adult high grade glioma 1,651 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,633 | 1,795
group 4 medulloblastoma 1,604 | 1,875
pituitary cancer 1,564 | 1,972
ductal carcinoma in situ 1,558 | 1,745
Carcinoma 1,461 | 2,147
breast carcinoma 1,426 | 1,614
cystic fibrosis 1,399 | 1,665
tuberculosis 1,373 | 1,557
colon cancer 1,357 | 1,475
astrocytoma 1,300 | 1,493
Multiple myeloma 1,295 | 1,327
adrenocortical carcinoma 1,291 | 1,427
medulloblastoma 1,215 | 1,524
sonic hedgehog group medulloblastoma 1,197 | 1,482
primary pancreatic ductal adenocarcinoma 1,187 | 1,271
posterior fossa group A ependymoma 1,178 | 1,511
posterior fossa group B ependymoma 1,132 | 1,530
diabetes mellitus 1,131 | 1,663
juvenile dermatomyositis 1,121 | 1,189
acute quadriplegic myopathy 1,073 | 1,157
Rheumatoid Arthritis 1,003 | 1,160
spina bifida 930 | 1,064
cutaneous lupus erythematosus 910 | 1,056
dermatomyositis 894 | 933
atypical teratoid/rhabdoid tumor 883 | 1,095
active Crohn's disease 848 | 918
nasopharyngeal carcinoma 838 | 1,056
Atopic dermatitis 754 | 944
gastric carcinoma 748 | 832
primary Sjogren syndrome 746 | 789
Waldenstrons macroglobulinemia 741 | 765
acute myeloid leukemia 735 | 780
non primary Sjogren syndrome sicca 674 | 840
tuberculosis and treatment for 6 months 652 | 686
esophageal adenocarcinoma 642 | 737
aldosterone-producing adenoma 608 | 664
progressive supranuclear palsy 607 | 674
Duchenne muscular dystrophy 553 | 602
Alzheimer's disease 514 | 644
pancreatic carcinoma 506 | 567
hepatocellular carcinoma 490 | 532
Down syndrome 479 | 548
fibroadenoma 474 | 557
Intellectual disability 471 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 467 | 499
Obesity 445 | 616
Endometriosis 440 | 535
IGA Glomerulonephritis 428 | 454
active ulcerative colitis 416 | 477
Prostatic Neoplasms 401 | 471
gastric cancer 388 | 430
mucosa-associated lymphoid tissue lymphoma 386 | 480
chronic rhinosinusitis 381 | 512
Amyotrophic Lateral Sclerosis 372 | 431
Mammary Neoplasms 349 | 410
Schizophrenia 342 | 501
inflammatory breast cancer 338 | 404
Multiple Sclerosis 335 | 498
Neurodegenerative disease 332 | 383
sarcoidosis 318 | 358
hereditary spastic paraplegia 304 | 313
tuberculosis and treatment for 3 months 303 | 327
non-small cell lung carcinoma 300 | 413
glioblastoma multiforme 287 | 347
urothelial carcinoma 279 | 318
Parkinson's disease 272 | 364
Kidney disease 269 | 396
Polycystic Ovary Syndrome 265 | 332
interstitial lung disease 260 | 291
nephrosclerosis 258 | 329

Tissue

Digestive Tract 13,363 | 18,473
Endocrine System 13,360 | 18,512
Female tissues 13,358 | 18,647
Skin and soft tissues 13,358 | 18,115
Nervous System 13,355 | 18,561
Urinary Tract 13,355 | 18,444
Liver and Pancreas 13,354 | 18,136
Blood and immune system 13,338 | 17,995
Cardiovascular System 13,335 | 17,958
Male tissues 13,334 | 17,969
Respiratory system 13,330 | 17,484

Target Family

Non-IDG 7,679 | 11,971
Enzyme 3,283 | 4,146
Transcription Factor 985 | 1,400
Kinase 541 | 634
Transporter 309 | 473
Epigenetic 210 | 242
GPCR 147 | 406
Ion Channel 138 | 341
Nuclear Receptor 36 | 48
TF/Epigenetic 32 | 38
oGPCR 3 | 421

HPA RNA Tissue

rectum 13,363 | 13,363
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345