Development Level

Tbio 9,976 | 11,445
Tdark 3,796 | 6,588
Tchem 1,423 | 1,598
Tclin 510 | 613

Collection

RFA-RM-18-021 239 | 328
Kinase: IDG Consortium (Target... 107 | 125
GPCR: IDG Consortium (Targets) 67 | 126
Ion Channel: IDG Consortium (T... 67 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 458 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 184 | 210
decreased vertical activity 170 | 208
abnormal bone structure 167 | 187
increased lean body mass 159 | 172
decreased body weight 147 | 161
abnormal heart morphology 143 | 162
decreased bone mineral content 135 | 151
hyperactivity 135 | 148
decreased lean body mass 125 | 135
increased total body fat amoun... 119 | 134
decreased bone mineral density 116 | 126
hypoactivity 115 | 132
decreased circulating glucose ... 112 | 126
increased circulating alkaline... 110 | 122
decreased grip strength 103 | 116
increased startle reflex 103 | 112
embryonic growth retardation 101 | 106
increased bone mineral content 98 | 108
male infertility 97 | 123
abnormal seminal vesicle morph... 95 | 114
decreased body length 93 | 101
increased or absent threshold ... 93 | 101
short tibia 92 | 97
increased mean corpuscular vol... 89 | 92
increased mean corpuscular hem... 87 | 96
decreased circulating choleste... 86 | 93
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 78 | 83
decreased circulating serum al... 77 | 82
abnormal lens morphology 76 | 81
decreased prepulse inhibition 74 | 82
decreased circulating triglyce... 70 | 79
decreased mean corpuscular vol... 70 | 79
impaired glucose tolerance 70 | 75
increased fasted circulating g... 69 | 76
decreased leukocyte cell numbe... 68 | 73
increased bone mineral density 67 | 72
increased circulating HDL chol... 67 | 80
decreased startle reflex 66 | 75
improved glucose tolerance 66 | 79
small superior vagus ganglion 66 | 74
abnormal eye morphology 65 | 68
abnormal retina morphology 65 | 71
decreased circulating HDL chol... 64 | 68
decreased circulating insulin ... 64 | 76
abnormal gait 63 | 69
abnormal sleep behavior 63 | 70
increased circulating sodium l... 62 | 71
abnormal behavioral response t... 59 | 66
abnormal kidney morphology 59 | 65
decreased fasted circulating g... 59 | 65
decreased hemoglobin content 59 | 68
increased monocyte cell number 59 | 63
decreased erythrocyte cell num... 58 | 62
abnormal coat-hair pigmentatio... 57 | 64
increased circulating choleste... 56 | 66
edema 55 | 59
decreased caudal vertebrae num... 53 | 53
increased heart weight 53 | 62
thrombocytopenia 53 | 56
small testis 52 | 58
abnormal spleen morphology 50 | 55
abnormal skin morphology 48 | 50
female infertility 48 | 60
decreased circulating total pr... 47 | 49
hydrometra 46 | 53
decreased blood urea nitrogen ... 45 | 51
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
decreased circulating alanine ... 43 | 47
increased blood urea nitrogen ... 43 | 48
increased neutrophil cell numb... 43 | 46
decreased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 40 | 45
increased hematocrit 39 | 46
abnormal testis morphology 38 | 43
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
decreased circulating LDL chol... 37 | 38
increased circulating triglyce... 37 | 42
limb grasping 37 | 41
abnormal cranium morphology 36 | 36
increased circulating chloride... 36 | 41
tremors 36 | 39
abnormal bone mineralization 35 | 38
abnormal epididymis morphology 35 | 42
increased erythrocyte cell num... 35 | 39
increased grip strength 34 | 41

Disease

Carcinoma 9,619 | 11,493
ovarian cancer 8,089 | 8,520
osteosarcoma 7,413 | 7,950
medulloblastoma, large-cell 5,757 | 6,241
psoriasis 5,669 | 6,694
glioblastoma 5,468 | 5,792
atypical teratoid / rhabdoid tumor 4,786 | 5,112
lung cancer 4,455 | 4,740
ependymoma 4,349 | 4,679
group 3 medulloblastoma 3,846 | 4,104
adult high grade glioma 3,499 | 3,801
Breast cancer 3,370 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,190 | 3,291
malignant mesothelioma 3,092 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,908 | 2,989
invasive ductal carcinoma 2,880 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,867 | 2,955
Astrocytoma, Pilocytic 2,862 | 3,081
primitive neuroectodermal tumor 2,855 | 3,035
non-small cell lung cancer 2,751 | 2,890
oligodendroglioma 2,667 | 2,850
lung carcinoma 2,656 | 2,843
lung adenocarcinoma 2,564 | 2,716
astrocytic glioma 2,448 | 2,597
pancreatic cancer 2,271 | 2,398
Kidney cancer 2,267 | 2,613
Cancer 2,209 | 2,499
interstitial cystitis 2,206 | 2,312
subependymal giant cell astrocytoma 2,170 | 2,287
tuberculosis 1,916 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,872 | 1,962
pituitary cancer 1,835 | 1,972
Pick disease 1,827 | 1,894
ulcerative colitis 1,762 | 1,819
group 4 medulloblastoma 1,749 | 1,855
ductal carcinoma in situ 1,693 | 1,745
cystic fibrosis 1,592 | 1,696
breast carcinoma 1,571 | 1,638
colon cancer 1,438 | 1,478
adrenocortical carcinoma 1,391 | 1,428
diabetes mellitus 1,326 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,257 | 1,442
juvenile dermatomyositis 1,163 | 1,187
acute quadriplegic myopathy 1,123 | 1,158
astrocytoma 1,100 | 1,146
Rheumatoid arthritis 1,084 | 1,191
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
pediatric high grade glioma 1,018 | 1,064
spina bifida 1,013 | 1,074
cutaneous lupus erythematosus 999 | 1,057
Schizophrenia 983 | 1,160
nasopharyngeal carcinoma 961 | 1,058
Intellectual disability 929 | 1,016
dermatomyositis 917 | 966
active Crohn's disease 901 | 922
Atopic dermatitis 854 | 952
non primary Sjogren syndrome sicca 812 | 891
gastric carcinoma 776 | 807
acute myeloid leukemia 770 | 783
Waldenstrons macroglobulinemia 757 | 765
active ulcerative colitis 739 | 764
Liver Cirrhosis, Experimental 723 | 769
Epilepsy 720 | 792
primary Sjogren syndrome 719 | 735
esophageal adenocarcinoma 691 | 737
medulloblastoma 672 | 720
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 642 | 665
Alzheimer's disease 600 | 658
Dull intelligence 588 | 645
Low intelligence 588 | 645
Mental Retardation 588 | 645
Mental deficiency 588 | 645
Poor school performance 588 | 645
Obesity 577 | 678
Duchenne muscular dystrophy 575 | 601
Cognitive delay 566 | 608
Global developmental delay 566 | 608
Mental and motor retardation 566 | 608
Bipolar Disorder 561 | 666
Melanoma 558 | 711
Seizures 548 | 596
pancreatic carcinoma 546 | 562
fibroadenoma 543 | 559
Muscle hypotonia 534 | 571
hepatocellular carcinoma 531 | 547
Endometriosis 498 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 510
Liver cancer 494 | 604
Short stature 480 | 531
Down syndrome 474 | 499
Prostatic Neoplasms 462 | 495
chronic rhinosinusitis 457 | 512
Multiple Sclerosis 446 | 540
gastric cancer 446 | 459
mucosa-associated lymphoid tissue lymphoma 445 | 484
posterior fossa group A ependymoma 444 | 468
sonic hedgehog group medulloblastoma 438 | 467
Amyotrophic lateral sclerosis 431 | 451

Tissue

Digestive Tract 15,705 | 17,369
Endocrine System 15,652 | 18,159
Female tissues 15,617 | 17,400
Skin and soft tissues 15,596 | 17,230
Male tissues 15,561 | 17,142
Liver and Pancreas 15,518 | 16,750
Urinary Tract 15,475 | 16,678
Blood and immune system 15,445 | 16,909
Respiratory system 15,334 | 16,393
Nervous System 15,331 | 16,725
Cardiovascular System 14,589 | 15,192

Target Family

Non-IDG 9,113 | 12,091
Enzyme 3,635 | 4,145
Transcription Factor 1,157 | 1,400
Kinase 586 | 634
Transporter 388 | 473
GPCR 266 | 408
Ion Channel 241 | 344
Epigenetic 228 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 34 | 38
oGPCR 14 | 421

HPA RNA Tissue

rectum 15,705 | 15,705
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39