Development Level

Tbio 8,312 | 10,625
Tdark 3,506 | 7,003
Tchem 1,419 | 1,890
Tclin 392 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible Ion Channel Proteins 54 | 117
Eligible non-olfactory GPCR Proteins 34 | 143

IMPC Term

preweaning lethality, complete... 583 | 633
preweaning lethality, incomple... 224 | 260
abnormal behavior 195 | 226
embryonic lethality prior to t... 176 | 187
decreased lean body mass 168 | 195
decreased total body fat amoun... 164 | 186
decreased body weight 152 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 130 | 157
increased or absent threshold ... 106 | 128
decreased bone mineral density 105 | 126
increased circulating alkaline... 105 | 119
abnormal embryo size 103 | 112
abnormal bone structure 102 | 131
decreased grip strength 99 | 123
decreased body length 97 | 108
decreased circulating glucose ... 93 | 121
hyperactivity 92 | 108
increased lean body mass 92 | 107
abnormal retina morphology 90 | 100
enlarged heart 86 | 111
increased mean corpuscular hem... 84 | 93
increased bone mineral content 83 | 92
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 76 | 85
short tibia 73 | 82
hypoactivity 72 | 89
decreased circulating triglyce... 70 | 83
decreased circulating serum al... 69 | 79
decreased circulating HDL chol... 67 | 77
increased grip strength 66 | 83
abnormal lens morphology 61 | 73
prenatal lethality prior to he... 57 | 64
increased fasted circulating g... 56 | 68
decreased lumbar vertebrae num... 55 | 62
decreased circulating insulin ... 54 | 75
increased sacral vertebrae num... 54 | 62
increased circulating sodium l... 53 | 71
abnormal retinal pigmentation 52 | 61
decreased rib number 49 | 59
decreased mean corpuscular vol... 48 | 50
abnormal bone mineralization 47 | 55
abnormal coat/hair pigmentatio... 47 | 54
abnormal sleep behavior 47 | 63
decreased leukocyte cell numbe... 47 | 54
increased total body fat amoun... 47 | 57
increased circulating HDL chol... 46 | 63
male infertility 46 | 62
decreased hemoglobin content 45 | 53
increased bone mineral density 45 | 52
decreased prepulse inhibition 44 | 52
abnormal gait 42 | 51
decreased caudal vertebrae num... 42 | 49
decreased fasted circulating g... 42 | 49
increased circulating choleste... 42 | 53
impaired glucose tolerance 41 | 52
improved glucose tolerance 41 | 56
increased exploration in new e... 41 | 56
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
abnormal behavioral response t... 38 | 52
decreased circulating alanine ... 38 | 53
decreased circulating total pr... 38 | 41
increased blood urea nitrogen ... 38 | 44
increased rib number 37 | 41
thrombocytopenia 37 | 46
abnormal heart morphology 36 | 51
increased body weight 36 | 42
increased hemoglobin content 36 | 45
decreased circulating LDL chol... 35 | 37
decreased eosinophil cell numb... 35 | 41
decreased heart weight 35 | 44
abnormal eye morphology 34 | 38
abnormal neural tube closure 34 | 37
abnormal seminal vesicle morph... 33 | 47
decreased circulating alkaline... 33 | 41
decreased neutrophil cell numb... 33 | 37
increased startle reflex 33 | 38
increased hematocrit 32 | 36
decreased circulating free fat... 31 | 39
small testis 31 | 37
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
increased leukocyte cell numbe... 30 | 37
abnormal cranium morphology 29 | 32
cardiovascular system phenotyp... 28 | 35
decreased T cell number 28 | 31
increased circulating chloride... 28 | 43
increased circulating potassiu... 28 | 31
tremors 28 | 34
decreased blood urea nitrogen ... 27 | 31
limb grasping 27 | 35
abnormal spleen morphology 26 | 36
decreased threshold for audito... 26 | 32
increased circulating calcium ... 26 | 32
increased heart weight 26 | 37
abnormal testis morphology 25 | 30
decreased circulating creatini... 25 | 31
decreased circulating aspartat... 24 | 27

Disease

ovarian cancer 7,562 | 8,484
osteosarcoma 6,747 | 7,933
medulloblastoma, large-cell 5,164 | 6,234
psoriasis 4,885 | 6,685
glioblastoma 4,748 | 5,572
lung cancer 3,987 | 4,466
atypical teratoid / rhabdoid tumor 3,660 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,932 | 3,289
malignant mesothelioma 2,802 | 3,162
Breast cancer 2,760 | 3,094
invasive ductal carcinoma 2,674 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,672 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,656 | 2,988
pilocytic astrocytoma 2,516 | 3,086
primitive neuroectodermal tumor 2,487 | 3,031
non-small cell lung cancer 2,406 | 2,798
oligodendroglioma 2,372 | 2,849
lung carcinoma 2,311 | 2,844
pediatric high grade glioma 2,258 | 2,712
lung adenocarcinoma 2,252 | 2,713
ependymoma 2,164 | 2,514
subependymal giant cell astrocytoma 1,992 | 2,287
pancreatic cancer 1,981 | 2,300
interstitial cystitis 1,963 | 2,299
astrocytic glioma 1,912 | 2,241
group 3 medulloblastoma 1,884 | 2,254
Cancer 1,819 | 2,346
ulcerative colitis 1,792 | 2,087
adult high grade glioma 1,738 | 2,148
Pick disease 1,694 | 1,893
group 4 medulloblastoma 1,662 | 1,875
pituitary cancer 1,649 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,630 | 1,795
Carcinoma 1,545 | 2,147
ductal carcinoma in situ 1,539 | 1,745
breast carcinoma 1,442 | 1,614
cystic fibrosis 1,437 | 1,665
tuberculosis 1,336 | 1,557
astrocytoma 1,325 | 1,493
Multiple myeloma 1,296 | 1,327
medulloblastoma 1,265 | 1,524
adrenocortical carcinoma 1,261 | 1,427
colon cancer 1,250 | 1,475
sonic hedgehog group medulloblastoma 1,236 | 1,482
posterior fossa group B ependymoma 1,217 | 1,530
primary pancreatic ductal adenocarcinoma 1,195 | 1,271
posterior fossa group A ependymoma 1,182 | 1,511
juvenile dermatomyositis 1,145 | 1,189
diabetes mellitus 1,127 | 1,663
acute quadriplegic myopathy 1,124 | 1,157
Rheumatoid Arthritis 984 | 1,160
spina bifida 954 | 1,064
atypical teratoid/rhabdoid tumor 906 | 1,095
dermatomyositis 906 | 933
cutaneous lupus erythematosus 868 | 1,056
nasopharyngeal carcinoma 831 | 1,056
active Crohn's disease 785 | 918
gastric carcinoma 759 | 832
acute myeloid leukemia 736 | 780
Waldenstrons macroglobulinemia 734 | 765
Atopic dermatitis 711 | 944
non primary Sjogren syndrome sicca 700 | 840
primary Sjogren syndrome 690 | 789
tuberculosis and treatment for 6 months 647 | 686
esophageal adenocarcinoma 640 | 737
aldosterone-producing adenoma 617 | 664
progressive supranuclear palsy 617 | 674
Duchenne muscular dystrophy 576 | 602
Alzheimer's disease 517 | 644
pancreatic carcinoma 501 | 567
fibroadenoma 494 | 557
Intellectual disability 483 | 573
hepatocellular carcinoma 483 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 479 | 499
Down syndrome 478 | 548
Obesity 448 | 616
chronic rhinosinusitis 414 | 512
Prostatic Neoplasms 407 | 471
Endometriosis 404 | 535
Amyotrophic Lateral Sclerosis 393 | 431
IGA Glomerulonephritis 391 | 454
active ulcerative colitis 385 | 477
gastric cancer 381 | 430
mucosa-associated lymphoid tissue lymphoma 362 | 480
Mammary Neoplasms 343 | 410
Multiple Sclerosis 337 | 498
Neurodegenerative disease 337 | 383
Schizophrenia 337 | 501
inflammatory breast cancer 336 | 404
hereditary spastic paraplegia 311 | 313
sarcoidosis 298 | 358
glioblastoma multiforme 297 | 347
tuberculosis and treatment for 3 months 291 | 327
non-small cell lung carcinoma 289 | 413
urothelial carcinoma 287 | 318
Parkinson's disease 275 | 364
Polycystic Ovary Syndrome 269 | 332
interstitial lung disease 262 | 291
nephrosclerosis 259 | 329
Kidney disease 257 | 396

Tissue

Male tissues 13,629 | 17,969
Digestive Tract 13,628 | 18,473
Endocrine System 13,627 | 18,512
Female tissues 13,626 | 18,647
Skin and soft tissues 13,624 | 18,115
Nervous System 13,621 | 18,561
Urinary Tract 13,620 | 18,444
Liver and Pancreas 13,615 | 18,136
Cardiovascular System 13,608 | 17,958
Blood and immune system 13,606 | 17,995
Respiratory system 13,596 | 17,484

Target Family

Non-IDG 7,861 | 11,971
Enzyme 3,310 | 4,146
Transcription Factor 1,027 | 1,400
Kinase 539 | 634
Transporter 305 | 473
Epigenetic 215 | 242
Ion Channel 163 | 341
GPCR 139 | 406
Nuclear Receptor 34 | 48
TF/Epigenetic 32 | 38
oGPCR 4 | 421

HPA RNA Tissue

prostate 13,629 | 13,629
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345