Development Level

Tbio 10,348 | 11,445
Tdark 4,096 | 6,588
Tchem 1,463 | 1,598
Tclin 553 | 613

Collection

RFA-RM-18-021 267 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 83 | 99
GPCR: IDG Consortium (Targets) 72 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 956 | 979
preweaning lethality, incomple... 474 | 499
abnormal behavior 278 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 196 | 207
enlarged heart 195 | 210
decreased vertical activity 183 | 208
abnormal bone structure 172 | 187
increased lean body mass 160 | 172
decreased body weight 153 | 161
abnormal heart morphology 151 | 162
decreased bone mineral content 139 | 151
hyperactivity 138 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 124 | 134
decreased bone mineral density 118 | 126
hypoactivity 118 | 132
decreased circulating glucose ... 117 | 126
increased circulating alkaline... 112 | 122
male infertility 108 | 123
increased startle reflex 104 | 112
abnormal seminal vesicle morph... 103 | 114
decreased grip strength 103 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 99 | 108
increased or absent threshold ... 96 | 101
decreased body length 95 | 101
short tibia 94 | 97
increased mean corpuscular hem... 92 | 96
increased mean corpuscular vol... 90 | 92
cataract 87 | 92
decreased circulating choleste... 86 | 93
prenatal lethality prior to he... 85 | 87
decreased circulating serum al... 79 | 82
decreased lymphocyte cell numb... 79 | 83
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 76 | 79
decreased mean corpuscular vol... 74 | 79
decreased leukocyte cell numbe... 71 | 73
decreased startle reflex 71 | 75
increased fasted circulating g... 71 | 76
small superior vagus ganglion 70 | 74
impaired glucose tolerance 69 | 75
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
decreased circulating insulin ... 68 | 76
improved glucose tolerance 68 | 79
abnormal eye morphology 67 | 68
abnormal sleep behavior 67 | 70
abnormal retina morphology 65 | 71
abnormal behavioral response t... 63 | 66
abnormal gait 63 | 69
decreased circulating HDL chol... 63 | 68
increased circulating sodium l... 63 | 71
decreased hemoglobin content 62 | 68
abnormal coat-hair pigmentatio... 61 | 64
abnormal kidney morphology 61 | 65
decreased erythrocyte cell num... 60 | 62
decreased fasted circulating g... 60 | 65
increased circulating choleste... 60 | 66
increased monocyte cell number 59 | 63
edema 57 | 59
increased heart weight 56 | 62
small testis 54 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
female infertility 52 | 60
hydrometra 50 | 53
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
increased hematocrit 46 | 46
increased blood urea nitrogen ... 45 | 48
decreased circulating alkaline... 44 | 46
decreased circulating alanine ... 43 | 47
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased hemoglobin content 42 | 45
increased leukocyte cell numbe... 42 | 47
increased circulating triglyce... 41 | 42
increased mean platelet volume 41 | 45
abnormal testis morphology 40 | 43
enlarged spleen 40 | 41
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 38 | 41
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
tremors 37 | 39
abnormal cranium morphology 36 | 36
abnormal epididymis morphology 36 | 42
increased circulating chloride... 36 | 41
limb grasping 36 | 41
increased grip strength 35 | 41

Disease

Carcinoma 10,039 | 11,493
ovarian cancer 8,187 | 8,520
osteosarcoma 7,520 | 7,950
psoriasis 5,910 | 6,694
medulloblastoma, large-cell 5,884 | 6,241
glioblastoma 5,568 | 5,792
atypical teratoid / rhabdoid tumor 4,884 | 5,112
lung cancer 4,536 | 4,740
ependymoma 4,456 | 4,679
group 3 medulloblastoma 3,922 | 4,104
adult high grade glioma 3,590 | 3,801
Breast cancer 3,448 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,198 | 3,291
malignant mesothelioma 3,136 | 3,232
Astrocytoma, Pilocytic 2,931 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,913 | 2,989
primitive neuroectodermal tumor 2,913 | 3,035
invasive ductal carcinoma 2,903 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,882 | 2,955
non-small cell lung cancer 2,809 | 2,890
oligodendroglioma 2,716 | 2,850
lung carcinoma 2,715 | 2,843
lung adenocarcinoma 2,609 | 2,716
astrocytic glioma 2,490 | 2,597
Kidney cancer 2,371 | 2,613
pancreatic cancer 2,300 | 2,398
Cancer 2,253 | 2,499
interstitial cystitis 2,248 | 2,312
subependymal giant cell astrocytoma 2,197 | 2,287
tuberculosis 1,919 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,896 | 1,962
pituitary cancer 1,876 | 1,972
Pick disease 1,838 | 1,894
group 4 medulloblastoma 1,788 | 1,855
ulcerative colitis 1,741 | 1,819
ductal carcinoma in situ 1,713 | 1,745
cystic fibrosis 1,627 | 1,696
breast carcinoma 1,597 | 1,638
colon cancer 1,426 | 1,478
adrenocortical carcinoma 1,407 | 1,428
diabetes mellitus 1,365 | 1,728
Autosomal recessive predisposition 1,330 | 1,442
Multiple myeloma 1,307 | 1,332
juvenile dermatomyositis 1,169 | 1,187
acute quadriplegic myopathy 1,148 | 1,158
astrocytoma 1,112 | 1,146
Rheumatoid arthritis 1,096 | 1,191
primary pancreatic ductal adenocarcinoma 1,092 | 1,109
spina bifida 1,038 | 1,074
pediatric high grade glioma 1,033 | 1,064
Schizophrenia 1,030 | 1,160
cutaneous lupus erythematosus 1,023 | 1,057
nasopharyngeal carcinoma 993 | 1,058
Intellectual disability 961 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 889 | 922
Atopic dermatitis 872 | 952
non primary Sjogren syndrome sicca 834 | 891
gastric carcinoma 781 | 807
acute myeloid leukemia 776 | 783
Waldenstrons macroglobulinemia 759 | 765
Epilepsy 739 | 792
Liver Cirrhosis, Experimental 733 | 769
active ulcerative colitis 728 | 764
primary Sjogren syndrome 720 | 735
esophageal adenocarcinoma 707 | 737
medulloblastoma 689 | 720
progressive supranuclear palsy 658 | 676
aldosterone-producing adenoma 656 | 665
Alzheimer's disease 609 | 658
Dull intelligence 608 | 645
Low intelligence 608 | 645
Mental Retardation 608 | 645
Mental deficiency 608 | 645
Poor school performance 608 | 645
Melanoma 605 | 711
Obesity 604 | 678
Bipolar Disorder 593 | 666
Duchenne muscular dystrophy 587 | 601
Cognitive delay 577 | 608
Global developmental delay 577 | 608
Mental and motor retardation 577 | 608
Seizures 561 | 596
pancreatic carcinoma 547 | 562
Muscle hypotonia 545 | 571
fibroadenoma 545 | 559
Liver cancer 534 | 604
hepatocellular carcinoma 532 | 547
Endometriosis 514 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 504 | 510
Short stature 500 | 531
chronic rhinosinusitis 485 | 512
Down syndrome 479 | 499
Prostatic Neoplasms 477 | 495
Multiple Sclerosis 466 | 540
posterior fossa group A ependymoma 453 | 468
mucosa-associated lymphoid tissue lymphoma 451 | 484
gastric cancer 447 | 459
sonic hedgehog group medulloblastoma 446 | 467
Amyotrophic lateral sclerosis 438 | 451

Tissue

Male tissues 16,460 | 17,142
Endocrine System 16,407 | 18,159
Digestive Tract 16,337 | 17,369
Female tissues 16,323 | 17,400
Skin and soft tissues 16,278 | 17,230
Urinary Tract 16,050 | 16,678
Liver and Pancreas 16,044 | 16,750
Blood and immune system 16,039 | 16,909
Nervous System 15,941 | 16,725
Respiratory system 15,865 | 16,393
Cardiovascular System 14,948 | 15,192

Target Family

Non-IDG 9,574 | 12,091
Enzyme 3,780 | 4,145
Transcription Factor 1,214 | 1,400
Kinase 603 | 634
Transporter 400 | 473
GPCR 283 | 408
Ion Channel 274 | 344
Epigenetic 231 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 34 | 38
oGPCR 23 | 421

HPA RNA Tissue

prostate 16,460 | 16,460
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93