Development Level

Tbio 10,276 | 11,651
Tdark 3,902 | 6,593
Tchem 1,249 | 1,388
Tclin 510 | 612

Collection

RFA-RM-18-021 251 | 328
Kinase: IDG Consortium (Target... 110 | 125
GPCR: IDG Consortium (Targets) 73 | 126
Ion Channel: IDG Consortium (T... 73 | 99
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 951 | 979
preweaning lethality, incomple... 467 | 499
embryonic lethality prior to t... 275 | 278
abnormal behavior 268 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 214 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 187 | 210
decreased vertical activity 172 | 208
abnormal bone structure 162 | 187
increased lean body mass 155 | 172
decreased body weight 152 | 161
abnormal heart morphology 145 | 162
decreased bone mineral content 135 | 151
hyperactivity 129 | 148
decreased lean body mass 123 | 135
increased total body fat amoun... 120 | 134
hypoactivity 115 | 132
decreased bone mineral density 112 | 126
decreased circulating glucose ... 111 | 126
increased circulating alkaline... 109 | 122
male infertility 105 | 123
abnormal seminal vesicle morph... 104 | 114
embryonic growth retardation 103 | 106
increased startle reflex 103 | 112
decreased grip strength 97 | 116
increased bone mineral content 96 | 108
decreased body length 93 | 101
short tibia 93 | 97
increased or absent threshold ... 90 | 101
cataract 89 | 92
increased mean corpuscular vol... 89 | 92
increased mean corpuscular hem... 88 | 96
decreased circulating choleste... 85 | 93
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 78 | 81
decreased circulating serum al... 77 | 82
decreased lymphocyte cell numb... 77 | 83
decreased circulating triglyce... 74 | 79
decreased mean corpuscular vol... 72 | 79
decreased prepulse inhibition 70 | 82
decreased startle reflex 70 | 75
increased bone mineral density 70 | 72
increased circulating HDL chol... 69 | 80
small superior vagus ganglion 69 | 74
decreased leukocyte cell numbe... 68 | 73
decreased circulating insulin ... 67 | 76
improved glucose tolerance 67 | 79
increased fasted circulating g... 67 | 76
abnormal eye morphology 66 | 68
impaired glucose tolerance 66 | 75
abnormal retina morphology 65 | 71
abnormal sleep behavior 62 | 70
decreased circulating HDL chol... 62 | 68
abnormal coat-hair pigmentatio... 60 | 64
abnormal gait 60 | 69
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
increased circulating sodium l... 59 | 71
increased monocyte cell number 59 | 63
decreased hemoglobin content 58 | 68
increased circulating choleste... 58 | 66
abnormal behavioral response t... 57 | 66
edema 57 | 59
increased heart weight 56 | 62
decreased fasted circulating g... 55 | 65
small testis 53 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
decreased caudal vertebrae num... 50 | 53
female infertility 49 | 60
hydrometra 49 | 53
abnormal skin morphology 47 | 50
decreased circulating total pr... 47 | 49
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
decreased mean corpuscular hem... 45 | 50
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
decreased hematocrit 41 | 46
increased leukocyte cell numbe... 41 | 47
abnormal testis morphology 40 | 43
enlarged spleen 40 | 41
increased mean platelet volume 40 | 45
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 38 | 41
increased hemoglobin content 38 | 45
abnormal bone mineralization 37 | 38
increased circulating triglyce... 37 | 42
decreased circulating LDL chol... 36 | 38
decreased circulating creatini... 35 | 39
increased erythrocyte cell num... 35 | 39
tremors 35 | 39
abnormal cranium morphology 34 | 36
abnormal epididymis morphology 34 | 42
decreased circulating aspartat... 33 | 34
pallor 33 | 34

Disease

Carcinoma 9,690 | 11,493
ovarian cancer 8,072 | 8,520
osteosarcoma 7,445 | 7,950
medulloblastoma, large-cell 5,712 | 6,241
psoriasis 5,674 | 6,694
glioblastoma 5,386 | 5,792
atypical teratoid / rhabdoid tumor 4,722 | 5,112
lung cancer 4,456 | 4,740
ependymoma 4,262 | 4,679
group 3 medulloblastoma 3,783 | 4,104
adult high grade glioma 3,423 | 3,801
Breast cancer 3,365 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,147 | 3,291
malignant mesothelioma 3,119 | 3,232
invasive ductal carcinoma 2,868 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,866 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,829 | 2,955
primitive neuroectodermal tumor 2,795 | 3,035
non-small cell lung cancer 2,780 | 2,890
Astrocytoma, Pilocytic 2,778 | 3,081
lung carcinoma 2,605 | 2,843
oligodendroglioma 2,585 | 2,850
lung adenocarcinoma 2,560 | 2,716
astrocytic glioma 2,368 | 2,597
pancreatic cancer 2,271 | 2,398
Kidney cancer 2,254 | 2,613
Cancer 2,212 | 2,499
interstitial cystitis 2,192 | 2,312
subependymal giant cell astrocytoma 2,121 | 2,287
tuberculosis 1,919 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,866 | 1,962
pituitary cancer 1,807 | 1,972
Pick disease 1,776 | 1,894
group 4 medulloblastoma 1,747 | 1,855
ulcerative colitis 1,724 | 1,819
ductal carcinoma in situ 1,689 | 1,745
cystic fibrosis 1,607 | 1,696
breast carcinoma 1,570 | 1,638
adrenocortical carcinoma 1,390 | 1,428
colon cancer 1,386 | 1,478
diabetes mellitus 1,332 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,278 | 1,442
juvenile dermatomyositis 1,156 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
astrocytoma 1,094 | 1,146
primary pancreatic ductal adenocarcinoma 1,084 | 1,109
Rheumatoid arthritis 1,083 | 1,191
spina bifida 1,020 | 1,074
pediatric high grade glioma 1,008 | 1,064
cutaneous lupus erythematosus 1,001 | 1,057
nasopharyngeal carcinoma 980 | 1,058
Schizophrenia 967 | 1,160
Intellectual disability 923 | 1,016
dermatomyositis 918 | 966
active Crohn's disease 865 | 922
Atopic dermatitis 858 | 952
non primary Sjogren syndrome sicca 814 | 891
acute myeloid leukemia 776 | 783
gastric carcinoma 765 | 807
Waldenstrons macroglobulinemia 760 | 765
Liver Cirrhosis, Experimental 721 | 769
primary Sjogren syndrome 712 | 735
Epilepsy 704 | 792
active ulcerative colitis 702 | 764
esophageal adenocarcinoma 691 | 737
medulloblastoma 667 | 720
aldosterone-producing adenoma 643 | 665
progressive supranuclear palsy 638 | 676
Alzheimer's disease 593 | 658
Dull intelligence 588 | 645
Low intelligence 588 | 645
Mental Retardation 588 | 645
Mental deficiency 588 | 645
Poor school performance 588 | 645
Obesity 585 | 678
Duchenne muscular dystrophy 577 | 601
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
pancreatic carcinoma 549 | 562
Bipolar Disorder 548 | 666
Melanoma 546 | 711
Seizures 540 | 596
fibroadenoma 536 | 559
hepatocellular carcinoma 535 | 547
Muscle hypotonia 530 | 571
Endometriosis 504 | 540
Liver cancer 500 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Short stature 483 | 531
chronic rhinosinusitis 474 | 512
Down syndrome 470 | 499
Prostatic Neoplasms 460 | 495
mucosa-associated lymphoid tissue lymphoma 460 | 484
gastric cancer 449 | 459
posterior fossa group A ependymoma 443 | 468
Multiple Sclerosis 442 | 540
sonic hedgehog group medulloblastoma 439 | 467
Amyotrophic lateral sclerosis 429 | 451

Tissue

Female tissues 15,937 | 17,400
Endocrine System 15,889 | 18,159
Digestive Tract 15,776 | 17,369
Skin and soft tissues 15,743 | 17,230
Male tissues 15,673 | 17,142
Blood and immune system 15,663 | 16,909
Liver and Pancreas 15,580 | 16,750
Urinary Tract 15,543 | 16,678
Respiratory system 15,474 | 16,393
Nervous System 15,445 | 16,725
Cardiovascular System 14,680 | 15,192

Target Family

Non-IDG 9,276 | 12,091
Enzyme 3,684 | 4,145
Transcription Factor 1,167 | 1,400
Kinase 583 | 634
Transporter 375 | 473
GPCR 275 | 408
Ion Channel 251 | 344
Epigenetic 227 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 35 | 38
oGPCR 24 | 421

HPA RNA Tissue

placenta 15,937 | 15,937
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50