Development Level

Tbio 8,014 | 10,625
Tdark 3,219 | 7,003
Tchem 1,413 | 1,890
Tclin 365 | 602

Collection

Eligible Kinase Proteins 94 | 134
Eligible Ion Channel Proteins 42 | 117
Eligible non-olfactory GPCR Proteins 39 | 143

IMPC Term

preweaning lethality, complete... 585 | 633
preweaning lethality, incomple... 209 | 260
abnormal behavior 186 | 226
embryonic lethality prior to t... 180 | 187
decreased lean body mass 162 | 195
decreased total body fat amoun... 157 | 186
decreased body weight 147 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 123 | 157
abnormal embryo size 104 | 112
increased circulating alkaline... 100 | 119
decreased circulating glucose ... 99 | 121
decreased bone mineral density 98 | 126
increased or absent threshold ... 97 | 128
abnormal bone structure 96 | 131
decreased body length 92 | 108
decreased grip strength 90 | 123
abnormal retina morphology 87 | 100
hyperactivity 85 | 108
enlarged heart 83 | 111
increased mean corpuscular hem... 82 | 93
increased lean body mass 81 | 107
increased mean corpuscular vol... 81 | 91
increased bone mineral content 78 | 92
decreased circulating choleste... 69 | 85
short tibia 69 | 82
hypoactivity 68 | 89
decreased circulating triglyce... 67 | 83
increased grip strength 67 | 83
decreased circulating HDL chol... 63 | 77
decreased circulating serum al... 63 | 79
abnormal lens morphology 60 | 73
prenatal lethality prior to he... 59 | 64
decreased lumbar vertebrae num... 55 | 62
increased fasted circulating g... 55 | 68
abnormal retinal pigmentation 54 | 61
increased sacral vertebrae num... 54 | 62
decreased circulating insulin ... 53 | 75
increased circulating sodium l... 52 | 71
decreased rib number 51 | 59
abnormal sleep behavior 49 | 63
increased circulating HDL chol... 47 | 63
decreased leukocyte cell numbe... 46 | 54
abnormal coat/hair pigmentatio... 45 | 54
decreased mean corpuscular vol... 45 | 50
abnormal bone mineralization 44 | 55
male infertility 44 | 62
decreased hemoglobin content 43 | 53
improved glucose tolerance 43 | 56
increased bone mineral density 42 | 52
increased circulating choleste... 42 | 53
increased total body fat amoun... 42 | 57
decreased circulating alanine ... 41 | 53
decreased erythrocyte cell num... 41 | 43
decreased prepulse inhibition 41 | 52
abnormal gait 40 | 51
increased exploration in new e... 40 | 56
abnormal behavioral response t... 39 | 52
impaired glucose tolerance 39 | 52
thrombocytopenia 39 | 46
decreased caudal vertebrae num... 38 | 49
decreased circulating total pr... 37 | 41
decreased eosinophil cell numb... 36 | 41
increased body weight 36 | 42
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
decreased fasted circulating g... 35 | 49
decreased startle reflex 35 | 48
increased blood urea nitrogen ... 35 | 44
increased hemoglobin content 35 | 45
abnormal heart morphology 34 | 51
decreased heart weight 34 | 44
increased rib number 34 | 41
abnormal eye morphology 33 | 38
abnormal seminal vesicle morph... 32 | 47
decreased circulating LDL chol... 32 | 37
decreased neutrophil cell numb... 31 | 37
decreased circulating alkaline... 30 | 41
decreased mean corpuscular hem... 30 | 34
increased circulating chloride... 30 | 43
increased leukocyte cell numbe... 30 | 37
increased startle reflex 30 | 38
small testis 29 | 37
decreased circulating calcium ... 28 | 33
decreased circulating fructosa... 28 | 31
embryonic growth retardation 28 | 28
increased hematocrit 28 | 36
tremors 28 | 34
abnormal cranium morphology 27 | 32
cardiovascular system phenotyp... 27 | 35
decreased circulating creatini... 27 | 31
decreased T cell number 26 | 31
decreased circulating chloride... 26 | 32
abnormal spleen morphology 25 | 36
decreased blood urea nitrogen ... 25 | 31
increased circulating potassiu... 25 | 31
decreased NK T cell number 24 | 28
increased circulating calcium ... 24 | 32
increased circulating iron lev... 24 | 25
increased heart weight 24 | 37

Disease

ovarian cancer 7,438 | 8,484
osteosarcoma 6,622 | 7,933
medulloblastoma, large-cell 4,906 | 6,234
psoriasis 4,669 | 6,685
glioblastoma 4,505 | 5,572
lung cancer 3,943 | 4,466
atypical teratoid / rhabdoid tumor 3,439 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,847 | 3,289
malignant mesothelioma 2,774 | 3,162
Breast cancer 2,625 | 3,094
invasive ductal carcinoma 2,609 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,580 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,518 | 2,956
non-small cell lung cancer 2,417 | 2,798
primitive neuroectodermal tumor 2,340 | 3,031
pilocytic astrocytoma 2,266 | 3,086
lung adenocarcinoma 2,201 | 2,713
oligodendroglioma 2,169 | 2,849
pediatric high grade glioma 2,135 | 2,712
lung carcinoma 2,128 | 2,844
ependymoma 2,019 | 2,514
pancreatic cancer 1,970 | 2,300
subependymal giant cell astrocytoma 1,865 | 2,287
group 3 medulloblastoma 1,838 | 2,254
interstitial cystitis 1,827 | 2,299
Cancer 1,805 | 2,346
ulcerative colitis 1,771 | 2,087
astrocytic glioma 1,733 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,589 | 1,795
Pick disease 1,586 | 1,893
group 4 medulloblastoma 1,585 | 1,875
adult high grade glioma 1,583 | 2,148
ductal carcinoma in situ 1,493 | 1,745
pituitary cancer 1,483 | 1,972
Carcinoma 1,433 | 2,147
breast carcinoma 1,386 | 1,614
cystic fibrosis 1,383 | 1,665
tuberculosis 1,367 | 1,557
Multiple myeloma 1,294 | 1,327
adrenocortical carcinoma 1,271 | 1,427
astrocytoma 1,254 | 1,493
colon cancer 1,209 | 1,475
primary pancreatic ductal adenocarcinoma 1,171 | 1,271
sonic hedgehog group medulloblastoma 1,160 | 1,482
medulloblastoma 1,156 | 1,524
posterior fossa group A ependymoma 1,126 | 1,511
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,112 | 1,663
posterior fossa group B ependymoma 1,067 | 1,530
acute quadriplegic myopathy 1,065 | 1,157
Rheumatoid Arthritis 971 | 1,160
spina bifida 914 | 1,064
dermatomyositis 895 | 933
atypical teratoid/rhabdoid tumor 864 | 1,095
cutaneous lupus erythematosus 827 | 1,056
nasopharyngeal carcinoma 780 | 1,056
Waldenstrons macroglobulinemia 745 | 765
active Crohn's disease 745 | 918
acute myeloid leukemia 723 | 780
gastric carcinoma 720 | 832
Atopic dermatitis 709 | 944
primary Sjogren syndrome 689 | 789
non primary Sjogren syndrome sicca 655 | 840
tuberculosis and treatment for 6 months 648 | 686
esophageal adenocarcinoma 616 | 737
aldosterone-producing adenoma 591 | 664
progressive supranuclear palsy 587 | 674
Duchenne muscular dystrophy 540 | 602
pancreatic carcinoma 506 | 567
Alzheimer's disease 496 | 644
hepatocellular carcinoma 486 | 532
Down syndrome 475 | 548
Intellectual disability 465 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 461 | 499
fibroadenoma 446 | 557
Endometriosis 426 | 535
IGA Glomerulonephritis 425 | 454
Obesity 421 | 616
mucosa-associated lymphoid tissue lymphoma 407 | 480
Prostatic Neoplasms 390 | 471
gastric cancer 379 | 430
Amyotrophic Lateral Sclerosis 370 | 431
chronic rhinosinusitis 362 | 512
active ulcerative colitis 356 | 477
Mammary Neoplasms 353 | 410
inflammatory breast cancer 333 | 404
Multiple Sclerosis 328 | 498
Schizophrenia 324 | 501
Neurodegenerative disease 319 | 383
sarcoidosis 309 | 358
hereditary spastic paraplegia 295 | 313
tuberculosis and treatment for 3 months 290 | 327
non-small cell lung carcinoma 278 | 413
glioblastoma multiforme 276 | 347
Polycystic Ovary Syndrome 267 | 332
Kidney disease 263 | 396
Parkinson's disease 253 | 364
urothelial carcinoma 251 | 318
interstitial lung disease 245 | 291
Stomach Neoplasms 244 | 282

Tissue

Female tissues 13,011 | 18,647
Endocrine System 13,009 | 18,512
Nervous System 13,005 | 18,561
Digestive Tract 13,003 | 18,473
Skin and soft tissues 13,000 | 18,115
Liver and Pancreas 12,997 | 18,136
Urinary Tract 12,997 | 18,444
Cardiovascular System 12,985 | 17,958
Male tissues 12,980 | 17,969
Blood and immune system 12,975 | 17,995
Respiratory system 12,967 | 17,484

Target Family

Non-IDG 7,476 | 11,971
Enzyme 3,196 | 4,146
Transcription Factor 976 | 1,400
Kinase 507 | 634
Transporter 289 | 473
Epigenetic 213 | 242
GPCR 155 | 406
Ion Channel 133 | 341
Nuclear Receptor 31 | 48
TF/Epigenetic 31 | 38
oGPCR 4 | 421

HPA RNA Tissue

placenta 13,011 | 13,011
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248