Development Level

Tbio 9,388 | 11,445
Tdark 3,636 | 6,588
Tchem 1,301 | 1,598
Tclin 444 | 613

Collection

Kinase: IDG Consortium (Target... 107 | 125
Ion Channel: IDG Consortium (T... 63 | 99
GPCR: IDG Consortium (Targets) 61 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 930 | 979
preweaning lethality, incomple... 436 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 264 | 278
embryonic lethality prior to o... 235 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 169 | 210
abnormal bone structure 161 | 187
increased lean body mass 152 | 172
decreased vertical activity 150 | 208
decreased body weight 146 | 161
abnormal heart morphology 136 | 162
decreased bone mineral content 127 | 151
hyperactivity 125 | 148
decreased lean body mass 118 | 135
hypoactivity 112 | 132
increased total body fat amoun... 110 | 134
decreased circulating glucose ... 109 | 126
increased circulating alkaline... 106 | 122
decreased bone mineral density 105 | 126
embryonic growth retardation 101 | 106
male infertility 99 | 123
decreased grip strength 96 | 116
increased bone mineral content 96 | 108
increased startle reflex 96 | 112
decreased body length 91 | 101
abnormal seminal vesicle morph... 88 | 114
decreased circulating choleste... 87 | 93
increased mean corpuscular vol... 86 | 92
increased or absent threshold ... 85 | 101
increased mean corpuscular hem... 83 | 96
short tibia 83 | 97
cataract 82 | 92
prenatal lethality prior to he... 81 | 87
abnormal lens morphology 75 | 81
decreased lymphocyte cell numb... 74 | 83
decreased circulating triglyce... 72 | 79
decreased prepulse inhibition 72 | 82
decreased mean corpuscular vol... 71 | 79
decreased circulating serum al... 70 | 82
increased circulating HDL chol... 67 | 80
decreased leukocyte cell numbe... 66 | 73
increased bone mineral density 66 | 72
increased fasted circulating g... 66 | 76
decreased circulating HDL chol... 65 | 68
improved glucose tolerance 65 | 79
decreased circulating insulin ... 64 | 76
decreased startle reflex 63 | 75
abnormal eye morphology 62 | 68
abnormal retina morphology 62 | 71
impaired glucose tolerance 62 | 75
abnormal sleep behavior 60 | 70
decreased hemoglobin content 60 | 68
small superior vagus ganglion 60 | 74
abnormal coat-hair pigmentatio... 56 | 64
abnormal gait 56 | 69
decreased erythrocyte cell num... 56 | 62
increased circulating sodium l... 56 | 71
increased monocyte cell number 56 | 63
abnormal behavioral response t... 55 | 66
decreased fasted circulating g... 55 | 65
edema 55 | 59
increased circulating choleste... 55 | 66
abnormal kidney morphology 54 | 65
increased heart weight 53 | 62
decreased caudal vertebrae num... 50 | 53
thrombocytopenia 50 | 56
small testis 49 | 58
decreased circulating total pr... 48 | 49
abnormal spleen morphology 47 | 55
female infertility 47 | 60
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 44 | 46
decreased blood urea nitrogen ... 44 | 51
abnormal skin morphology 43 | 50
hydrometra 43 | 53
decreased circulating alkaline... 42 | 46
increased blood urea nitrogen ... 42 | 48
decreased circulating alanine ... 41 | 47
decreased hematocrit 41 | 46
increased hematocrit 40 | 46
increased mean platelet volume 40 | 45
increased leukocyte cell numbe... 39 | 47
increased neutrophil cell numb... 39 | 46
enlarged spleen 38 | 41
increased hemoglobin content 37 | 45
abnormal testis morphology 36 | 43
decreased circulating LDL chol... 36 | 38
decreased red blood cell distr... 36 | 41
tremors 36 | 39
abnormal bone mineralization 35 | 38
abnormal cranium morphology 34 | 36
decreased neutrophil cell numb... 34 | 42
increased circulating chloride... 34 | 41
limb grasping 34 | 41
decreased circulating creatini... 33 | 39
enlarged lymph nodes 33 | 37
increased circulating triglyce... 33 | 42
pallor 33 | 34

Disease

Carcinoma 9,061 | 11,493
ovarian cancer 7,824 | 8,520
osteosarcoma 7,121 | 7,950
medulloblastoma, large-cell 5,462 | 6,241
psoriasis 5,212 | 6,694
glioblastoma 5,157 | 5,792
atypical teratoid / rhabdoid tumor 4,524 | 5,112
lung cancer 4,263 | 4,740
ependymoma 4,082 | 4,679
group 3 medulloblastoma 3,627 | 4,104
adult high grade glioma 3,231 | 3,801
Breast cancer 3,204 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,012 | 3,291
malignant mesothelioma 2,968 | 3,232
invasive ductal carcinoma 2,784 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,748 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,707 | 2,955
primitive neuroectodermal tumor 2,667 | 3,035
Astrocytoma, Pilocytic 2,621 | 3,081
non-small cell lung cancer 2,599 | 2,890
oligodendroglioma 2,466 | 2,850
lung carcinoma 2,457 | 2,843
lung adenocarcinoma 2,386 | 2,716
astrocytic glioma 2,271 | 2,597
pancreatic cancer 2,114 | 2,398
Kidney cancer 2,112 | 2,613
subependymal giant cell astrocytoma 2,051 | 2,287
Cancer 2,045 | 2,499
interstitial cystitis 1,994 | 2,312
tuberculosis 1,826 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,812 | 1,962
Pick disease 1,731 | 1,894
pituitary cancer 1,694 | 1,972
group 4 medulloblastoma 1,684 | 1,855
ductal carcinoma in situ 1,632 | 1,745
ulcerative colitis 1,604 | 1,819
breast carcinoma 1,493 | 1,638
cystic fibrosis 1,468 | 1,696
adrenocortical carcinoma 1,347 | 1,428
colon cancer 1,313 | 1,478
Multiple myeloma 1,299 | 1,332
diabetes mellitus 1,232 | 1,728
Autosomal recessive predisposition 1,201 | 1,442
juvenile dermatomyositis 1,143 | 1,187
acute quadriplegic myopathy 1,111 | 1,158
astrocytoma 1,068 | 1,146
primary pancreatic ductal adenocarcinoma 1,046 | 1,109
Rheumatoid arthritis 1,024 | 1,191
pediatric high grade glioma 972 | 1,064
spina bifida 960 | 1,074
dermatomyositis 911 | 966
nasopharyngeal carcinoma 909 | 1,058
cutaneous lupus erythematosus 906 | 1,057
Intellectual disability 898 | 1,016
Schizophrenia 884 | 1,160
active Crohn's disease 805 | 922
Atopic dermatitis 788 | 952
non primary Sjogren syndrome sicca 773 | 891
acute myeloid leukemia 749 | 783
gastric carcinoma 748 | 807
Waldenstrons macroglobulinemia 744 | 765
Liver Cirrhosis, Experimental 690 | 769
primary Sjogren syndrome 682 | 735
Epilepsy 672 | 792
active ulcerative colitis 661 | 764
medulloblastoma 644 | 720
aldosterone-producing adenoma 630 | 665
progressive supranuclear palsy 628 | 676
esophageal adenocarcinoma 624 | 737
Dull intelligence 571 | 645
Low intelligence 571 | 645
Mental Retardation 571 | 645
Mental deficiency 571 | 645
Poor school performance 571 | 645
Duchenne muscular dystrophy 568 | 601
Cognitive delay 555 | 608
Global developmental delay 555 | 608
Mental and motor retardation 555 | 608
Alzheimer's disease 549 | 658
pancreatic carcinoma 526 | 562
Muscle hypotonia 522 | 571
Obesity 521 | 678
hepatocellular carcinoma 517 | 547
Seizures 514 | 596
fibroadenoma 506 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 495 | 510
Bipolar Disorder 491 | 666
Short stature 464 | 531
Endometriosis 463 | 540
Melanoma 461 | 711
Down syndrome 457 | 499
Liver cancer 451 | 604
chronic rhinosinusitis 442 | 512
Prostatic Neoplasms 433 | 495
gastric cancer 430 | 459
posterior fossa group A ependymoma 423 | 468
sonic hedgehog group medulloblastoma 415 | 467
mucosa-associated lymphoid tissue lymphoma 411 | 484
Amyotrophic lateral sclerosis 408 | 451
tuberculosis and treatment for 6 months 406 | 409

Tissue

Endocrine System 14,769 | 18,159
Female tissues 14,715 | 17,400
Digestive Tract 14,698 | 17,369
Skin and soft tissues 14,688 | 17,230
Male tissues 14,675 | 17,142
Blood and immune system 14,596 | 16,909
Liver and Pancreas 14,587 | 16,750
Urinary Tract 14,577 | 16,678
Nervous System 14,549 | 16,725
Respiratory system 14,531 | 16,393
Cardiovascular System 14,029 | 15,192

Target Family

Non-IDG 8,556 | 12,091
Enzyme 3,459 | 4,145
Transcription Factor 1,120 | 1,400
Kinase 564 | 634
Transporter 341 | 473
Epigenetic 224 | 242
GPCR 219 | 408
Ion Channel 206 | 344
Nuclear Receptor 37 | 48
TF/Epigenetic 33 | 38
oGPCR 10 | 421

HPA RNA Tissue

parathyroid gland 14,769 | 14,769
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Retinoic acid receptor responder protein 3 RARRES3 Tbio Non-IDG -1.84020 71.0 164
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90