Development Level

Tbio 7,436 | 10,625
Tdark 2,954 | 7,003
Tchem 1,291 | 1,890
Tclin 314 | 602

Collection

Eligible Kinase Proteins 90 | 134
Eligible Ion Channel Proteins 27 | 117
Eligible non-olfactory GPCR Proteins 20 | 143

IMPC Term

preweaning lethality, complete... 548 | 633
preweaning lethality, incomple... 200 | 260
abnormal behavior 172 | 226
embryonic lethality prior to t... 168 | 187
decreased lean body mass 158 | 195
decreased total body fat amoun... 151 | 186
decreased body weight 146 | 174
embryonic lethality prior to o... 140 | 148
decreased bone mineral content 124 | 157
decreased bone mineral density 101 | 126
abnormal bone structure 99 | 131
increased circulating alkaline... 98 | 119
abnormal embryo size 95 | 112
increased or absent threshold ... 94 | 128
decreased body length 92 | 108
decreased circulating glucose ... 88 | 121
decreased grip strength 87 | 123
hyperactivity 81 | 108
enlarged heart 78 | 111
increased lean body mass 78 | 107
increased mean corpuscular hem... 78 | 93
abnormal retina morphology 77 | 100
increased bone mineral content 77 | 92
decreased circulating choleste... 74 | 85
increased mean corpuscular vol... 71 | 91
hypoactivity 68 | 89
decreased circulating HDL chol... 66 | 77
decreased circulating serum al... 66 | 79
decreased circulating triglyce... 66 | 83
short tibia 64 | 82
increased grip strength 58 | 83
prenatal lethality prior to he... 57 | 64
abnormal lens morphology 53 | 73
decreased circulating insulin ... 50 | 75
decreased lumbar vertebrae num... 50 | 62
increased fasted circulating g... 50 | 68
increased sacral vertebrae num... 48 | 62
abnormal bone mineralization 47 | 55
abnormal retinal pigmentation 47 | 61
decreased rib number 46 | 59
increased circulating sodium l... 46 | 71
decreased leukocyte cell numbe... 45 | 54
decreased mean corpuscular vol... 44 | 50
male infertility 44 | 62
abnormal coat/hair pigmentatio... 43 | 54
impaired glucose tolerance 43 | 52
increased circulating HDL chol... 43 | 63
increased circulating choleste... 43 | 53
decreased hemoglobin content 42 | 53
decreased prepulse inhibition 42 | 52
increased bone mineral density 41 | 52
decreased caudal vertebrae num... 39 | 49
improved glucose tolerance 39 | 56
abnormal sleep behavior 38 | 63
decreased erythrocyte cell num... 37 | 43
increased total body fat amoun... 37 | 57
abnormal gait 36 | 51
decreased circulating total pr... 36 | 41
increased blood urea nitrogen ... 36 | 44
increased exploration in new e... 36 | 56
thrombocytopenia 35 | 46
decreased fasted circulating g... 34 | 49
increased body weight 34 | 42
abnormal behavioral response t... 33 | 52
decreased circulating LDL chol... 33 | 37
decreased circulating alanine ... 33 | 53
decreased heart weight 33 | 44
increased rib number 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
decreased startle reflex 32 | 48
increased hemoglobin content 32 | 45
abnormal eye morphology 31 | 38
abnormal seminal vesicle morph... 29 | 47
decreased circulating alkaline... 29 | 41
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased hematocrit 29 | 36
decreased circulating free fat... 28 | 39
decreased eosinophil cell numb... 28 | 41
increased startle reflex 28 | 38
decreased T cell number 27 | 31
decreased neutrophil cell numb... 27 | 37
tremors 27 | 34
decreased circulating calcium ... 26 | 33
increased leukocyte cell numbe... 26 | 37
small testis 26 | 37
abnormal cranium morphology 25 | 32
decreased mean corpuscular hem... 25 | 34
increased heart weight 25 | 37
decreased circulating chloride... 24 | 32
decreased circulating creatini... 24 | 31
increased circulating potassiu... 24 | 31
decreased circulating aspartat... 23 | 27
increased circulating calcium ... 23 | 32
increased circulating phosphat... 23 | 24
limb grasping 23 | 35
abnormal cornea morphology 22 | 24
abnormal spleen morphology 22 | 36
cardiovascular system phenotyp... 22 | 35

Disease

ovarian cancer 7,004 | 8,484
osteosarcoma 6,058 | 7,933
medulloblastoma, large-cell 4,539 | 6,234
psoriasis 4,248 | 6,685
glioblastoma 4,163 | 5,572
lung cancer 3,615 | 4,466
atypical teratoid / rhabdoid tumor 3,181 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,736 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 2,522 | 2,956
malignant mesothelioma 2,493 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 2,464 | 2,988
Breast cancer 2,359 | 3,094
invasive ductal carcinoma 2,299 | 2,950
primitive neuroectodermal tumor 2,096 | 3,031
pilocytic astrocytoma 2,086 | 3,086
oligodendroglioma 2,057 | 2,849
non-small cell lung cancer 2,050 | 2,798
lung carcinoma 1,975 | 2,844
pediatric high grade glioma 1,945 | 2,712
lung adenocarcinoma 1,938 | 2,713
ependymoma 1,934 | 2,514
pancreatic cancer 1,843 | 2,300
subependymal giant cell astrocytoma 1,776 | 2,287
astrocytic glioma 1,658 | 2,241
group 3 medulloblastoma 1,647 | 2,254
Cancer 1,631 | 2,346
ulcerative colitis 1,582 | 2,087
interstitial cystitis 1,563 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 1,559 | 1,795
Pick disease 1,545 | 1,893
group 4 medulloblastoma 1,496 | 1,875
adult high grade glioma 1,476 | 2,148
pituitary cancer 1,385 | 1,972
ductal carcinoma in situ 1,292 | 1,745
Carcinoma 1,278 | 2,147
Multiple myeloma 1,275 | 1,327
breast carcinoma 1,240 | 1,614
astrocytoma 1,230 | 1,493
tuberculosis 1,198 | 1,557
cystic fibrosis 1,188 | 1,665
primary pancreatic ductal adenocarcinoma 1,167 | 1,271
adrenocortical carcinoma 1,091 | 1,427
juvenile dermatomyositis 1,089 | 1,189
medulloblastoma 1,087 | 1,524
diabetes mellitus 1,082 | 1,663
colon cancer 1,081 | 1,475
sonic hedgehog group medulloblastoma 1,072 | 1,482
acute quadriplegic myopathy 1,047 | 1,157
posterior fossa group B ependymoma 1,014 | 1,530
posterior fossa group A ependymoma 990 | 1,511
Rheumatoid Arthritis 899 | 1,160
dermatomyositis 881 | 933
spina bifida 869 | 1,064
atypical teratoid/rhabdoid tumor 795 | 1,095
Waldenstrons macroglobulinemia 718 | 765
cutaneous lupus erythematosus 712 | 1,056
gastric carcinoma 712 | 832
active Crohn's disease 683 | 918
acute myeloid leukemia 682 | 780
nasopharyngeal carcinoma 665 | 1,056
non primary Sjogren syndrome sicca 631 | 840
tuberculosis and treatment for 6 months 609 | 686
esophageal adenocarcinoma 577 | 737
aldosterone-producing adenoma 574 | 664
Atopic dermatitis 572 | 944
progressive supranuclear palsy 570 | 674
primary Sjogren syndrome 558 | 789
Duchenne muscular dystrophy 525 | 602
Alzheimer's disease 460 | 644
hepatocellular carcinoma 453 | 532
Down syndrome 451 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 444 | 499
pancreatic carcinoma 444 | 567
Intellectual disability 443 | 573
Obesity 411 | 616
fibroadenoma 407 | 557
Prostatic Neoplasms 375 | 471
active ulcerative colitis 354 | 477
Amyotrophic Lateral Sclerosis 351 | 431
IGA Glomerulonephritis 348 | 454
gastric cancer 344 | 430
chronic rhinosinusitis 337 | 512
Endometriosis 331 | 535
mucosa-associated lymphoid tissue lymphoma 324 | 480
Neurodegenerative disease 316 | 383
Mammary Neoplasms 305 | 410
inflammatory breast cancer 297 | 404
hereditary spastic paraplegia 295 | 313
Schizophrenia 286 | 501
Multiple Sclerosis 276 | 498
tuberculosis and treatment for 3 months 260 | 327
glioblastoma multiforme 252 | 347
Parkinson's disease 246 | 364
Polycystic Ovary Syndrome 245 | 332
urothelial carcinoma 243 | 318
sarcoidosis 241 | 358
nephrosclerosis 240 | 329
interstitial lung disease 237 | 291
Kidney disease 236 | 396
non-small cell lung carcinoma 233 | 413

Tissue

Digestive Tract 11,995 | 18,473
Liver and Pancreas 11,995 | 18,136
Endocrine System 11,994 | 18,512
Female tissues 11,993 | 18,647
Nervous System 11,991 | 18,561
Skin and soft tissues 11,985 | 18,115
Urinary Tract 11,985 | 18,444
Cardiovascular System 11,978 | 17,958
Male tissues 11,978 | 17,969
Blood and immune system 11,972 | 17,995
Respiratory system 11,963 | 17,484

Target Family

Non-IDG 6,879 | 11,971
Enzyme 3,072 | 4,146
Transcription Factor 828 | 1,400
Kinase 485 | 634
Transporter 273 | 473
Epigenetic 205 | 242
Ion Channel 102 | 341
GPCR 88 | 406
Nuclear Receptor 33 | 48
TF/Epigenetic 29 | 38
oGPCR 1 | 421

HPA RNA Tissue

pancreas 11,995 | 11,995
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108