Development Level

Tbio 7,617 | 10,625
Tdark 3,269 | 7,003
Tchem 1,317 | 1,890
Tclin 336 | 602

Collection

Eligible Kinase Proteins 95 | 134
Eligible Ion Channel Proteins 34 | 117
Eligible non-olfactory GPCR Proteins 29 | 143

IMPC Term

preweaning lethality, complete... 561 | 633
preweaning lethality, incomple... 206 | 260
abnormal behavior 186 | 226
embryonic lethality prior to t... 169 | 187
decreased lean body mass 164 | 195
decreased total body fat amoun... 156 | 186
decreased body weight 146 | 174
embryonic lethality prior to o... 140 | 148
decreased bone mineral content 130 | 157
abnormal bone structure 102 | 131
decreased bone mineral density 102 | 126
increased circulating alkaline... 102 | 119
abnormal embryo size 97 | 112
increased or absent threshold ... 96 | 128
decreased body length 94 | 108
decreased grip strength 92 | 123
decreased circulating glucose ... 89 | 121
increased lean body mass 86 | 107
hyperactivity 85 | 108
abnormal retina morphology 83 | 100
increased mean corpuscular hem... 81 | 93
increased bone mineral content 80 | 92
enlarged heart 75 | 111
decreased circulating choleste... 74 | 85
increased mean corpuscular vol... 72 | 91
hypoactivity 70 | 89
short tibia 70 | 82
decreased circulating HDL chol... 68 | 77
decreased circulating serum al... 68 | 79
increased grip strength 65 | 83
decreased circulating triglyce... 64 | 83
abnormal lens morphology 59 | 73
prenatal lethality prior to he... 56 | 64
increased fasted circulating g... 55 | 68
decreased circulating insulin ... 52 | 75
decreased lumbar vertebrae num... 52 | 62
abnormal retinal pigmentation 50 | 61
increased sacral vertebrae num... 50 | 62
abnormal sleep behavior 48 | 63
increased circulating sodium l... 47 | 71
increased total body fat amoun... 47 | 57
male infertility 47 | 62
abnormal bone mineralization 46 | 55
decreased rib number 46 | 59
decreased leukocyte cell numbe... 45 | 54
decreased mean corpuscular vol... 44 | 50
increased bone mineral density 44 | 52
increased circulating HDL chol... 44 | 63
increased circulating choleste... 44 | 53
abnormal coat/hair pigmentatio... 43 | 54
decreased hemoglobin content 42 | 53
impaired glucose tolerance 40 | 52
abnormal gait 39 | 51
decreased prepulse inhibition 39 | 52
decreased caudal vertebrae num... 38 | 49
decreased circulating total pr... 38 | 41
decreased erythrocyte cell num... 38 | 43
improved glucose tolerance 38 | 56
abnormal behavioral response t... 37 | 52
decreased circulating alanine ... 37 | 53
decreased fasted circulating g... 37 | 49
increased exploration in new e... 36 | 56
decreased circulating LDL chol... 35 | 37
decreased eosinophil cell numb... 35 | 41
decreased startle reflex 35 | 48
increased blood urea nitrogen ... 35 | 44
decreased heart weight 34 | 44
increased hemoglobin content 34 | 45
thrombocytopenia 34 | 46
abnormal neural tube closure 33 | 37
increased body weight 33 | 42
decreased neutrophil cell numb... 32 | 37
increased rib number 32 | 41
abnormal heart morphology 31 | 51
increased startle reflex 31 | 38
abnormal eye morphology 30 | 38
abnormal seminal vesicle morph... 30 | 47
decreased circulating alkaline... 30 | 41
decreased circulating free fat... 30 | 39
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
abnormal cranium morphology 28 | 32
increased circulating potassiu... 28 | 31
increased hematocrit 28 | 36
increased leukocyte cell numbe... 28 | 37
small testis 28 | 37
cardiovascular system phenotyp... 27 | 35
decreased mean corpuscular hem... 27 | 34
increased heart weight 27 | 37
tremors 27 | 34
increased circulating chloride... 26 | 43
abnormal spleen morphology 25 | 36
decreased T cell number 25 | 31
increased circulating calcium ... 25 | 32
decreased circulating chloride... 24 | 32
decreased circulating creatini... 24 | 31
abnormal testis morphology 23 | 30
decreased circulating aspartat... 23 | 27
embryonic growth retardation 23 | 28
female infertility 23 | 34

Disease

ovarian cancer 7,212 | 8,484
osteosarcoma 6,317 | 7,933
medulloblastoma, large-cell 4,803 | 6,234
glioblastoma 4,409 | 5,572
psoriasis 4,338 | 6,685
lung cancer 3,710 | 4,466
atypical teratoid / rhabdoid tumor 3,398 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,666 | 3,289
malignant mesothelioma 2,577 | 3,162
Breast cancer 2,502 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,432 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,430 | 2,956
invasive ductal carcinoma 2,427 | 2,950
primitive neuroectodermal tumor 2,287 | 3,031
pilocytic astrocytoma 2,242 | 3,086
oligodendroglioma 2,189 | 2,849
non-small cell lung cancer 2,107 | 2,798
pediatric high grade glioma 2,066 | 2,712
lung carcinoma 2,054 | 2,844
ependymoma 2,035 | 2,514
lung adenocarcinoma 1,951 | 2,713
subependymal giant cell astrocytoma 1,873 | 2,287
group 3 medulloblastoma 1,785 | 2,254
astrocytic glioma 1,758 | 2,241
pancreatic cancer 1,752 | 2,300
Cancer 1,645 | 2,346
Pick disease 1,613 | 1,893
ulcerative colitis 1,601 | 2,087
group 4 medulloblastoma 1,586 | 1,875
interstitial cystitis 1,566 | 2,299
adult high grade glioma 1,556 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,535 | 1,795
pituitary cancer 1,481 | 1,972
Carcinoma 1,437 | 2,147
ductal carcinoma in situ 1,339 | 1,745
Multiple myeloma 1,286 | 1,327
breast carcinoma 1,277 | 1,614
astrocytoma 1,263 | 1,493
cystic fibrosis 1,257 | 1,665
tuberculosis 1,252 | 1,557
adrenocortical carcinoma 1,205 | 1,427
medulloblastoma 1,171 | 1,524
sonic hedgehog group medulloblastoma 1,125 | 1,482
colon cancer 1,121 | 1,475
primary pancreatic ductal adenocarcinoma 1,119 | 1,271
juvenile dermatomyositis 1,100 | 1,189
posterior fossa group B ependymoma 1,100 | 1,530
acute quadriplegic myopathy 1,062 | 1,157
diabetes mellitus 1,059 | 1,663
posterior fossa group A ependymoma 1,046 | 1,511
Rheumatoid Arthritis 929 | 1,160
dermatomyositis 888 | 933
atypical teratoid/rhabdoid tumor 806 | 1,095
spina bifida 805 | 1,064
cutaneous lupus erythematosus 756 | 1,056
Waldenstrons macroglobulinemia 716 | 765
gastric carcinoma 713 | 832
acute myeloid leukemia 706 | 780
nasopharyngeal carcinoma 689 | 1,056
active Crohn's disease 675 | 918
non primary Sjogren syndrome sicca 636 | 840
tuberculosis and treatment for 6 months 626 | 686
primary Sjogren syndrome 623 | 789
Atopic dermatitis 600 | 944
aldosterone-producing adenoma 599 | 664
progressive supranuclear palsy 590 | 674
Duchenne muscular dystrophy 538 | 602
esophageal adenocarcinoma 537 | 737
Alzheimer's disease 488 | 644
Intellectual disability 468 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 461 | 499
hepatocellular carcinoma 461 | 532
pancreatic carcinoma 457 | 567
Down syndrome 452 | 548
fibroadenoma 412 | 557
Obesity 406 | 616
Amyotrophic Lateral Sclerosis 372 | 431
chronic rhinosinusitis 371 | 512
IGA Glomerulonephritis 363 | 454
Prostatic Neoplasms 357 | 471
gastric cancer 353 | 430
Endometriosis 350 | 535
mucosa-associated lymphoid tissue lymphoma 341 | 480
active ulcerative colitis 330 | 477
Neurodegenerative disease 320 | 383
Mammary Neoplasms 314 | 410
Schizophrenia 314 | 501
hereditary spastic paraplegia 298 | 313
inflammatory breast cancer 296 | 404
Multiple Sclerosis 294 | 498
sarcoidosis 274 | 358
glioblastoma multiforme 271 | 347
tuberculosis and treatment for 3 months 269 | 327
Polycystic Ovary Syndrome 255 | 332
Parkinson's disease 250 | 364
non-small cell lung carcinoma 244 | 413
Kidney disease 238 | 396
interstitial lung disease 233 | 291
urothelial carcinoma 232 | 318
nephrosclerosis 219 | 329

Tissue

Endocrine System 12,539 | 18,512
Female tissues 12,539 | 18,647
Digestive Tract 12,535 | 18,473
Liver and Pancreas 12,532 | 18,136
Nervous System 12,532 | 18,561
Skin and soft tissues 12,530 | 18,115
Urinary Tract 12,530 | 18,444
Blood and immune system 12,529 | 17,995
Male tissues 12,527 | 17,969
Cardiovascular System 12,526 | 17,958
Respiratory system 12,517 | 17,484

Target Family

Non-IDG 7,199 | 11,971
Enzyme 3,119 | 4,146
Transcription Factor 941 | 1,400
Kinase 501 | 634
Transporter 269 | 473
Epigenetic 213 | 242
Ion Channel 115 | 341
GPCR 114 | 406
Nuclear Receptor 34 | 48
TF/Epigenetic 32 | 38
oGPCR 2 | 421

HPA RNA Tissue

ovary 12,539 | 12,539
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248