Development Level

Tbio 9,983 | 11,445
Tdark 3,925 | 6,588
Tchem 1,429 | 1,598
Tclin 496 | 613

Collection

RFA-RM-18-021 238 | 328
Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 943 | 979
preweaning lethality, incomple... 468 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 188 | 210
decreased vertical activity 167 | 208
abnormal bone structure 166 | 187
increased lean body mass 157 | 172
decreased body weight 151 | 161
abnormal heart morphology 147 | 162
decreased bone mineral content 136 | 151
hyperactivity 130 | 148
decreased lean body mass 124 | 135
increased total body fat amoun... 121 | 134
decreased circulating glucose ... 116 | 126
decreased bone mineral density 115 | 126
hypoactivity 115 | 132
increased circulating alkaline... 109 | 122
decreased grip strength 103 | 116
embryonic growth retardation 102 | 106
male infertility 102 | 123
increased startle reflex 101 | 112
abnormal seminal vesicle morph... 100 | 114
increased bone mineral content 96 | 108
decreased body length 93 | 101
short tibia 91 | 97
increased or absent threshold ... 89 | 101
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 88 | 92
cataract 87 | 92
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 74 | 79
decreased prepulse inhibition 74 | 82
decreased mean corpuscular vol... 71 | 79
increased bone mineral density 70 | 72
decreased leukocyte cell numbe... 69 | 73
increased circulating HDL chol... 68 | 80
increased fasted circulating g... 68 | 76
decreased startle reflex 67 | 75
improved glucose tolerance 67 | 79
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
small superior vagus ganglion 66 | 74
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
impaired glucose tolerance 65 | 75
abnormal sleep behavior 64 | 70
increased circulating sodium l... 64 | 71
abnormal coat-hair pigmentatio... 60 | 64
abnormal gait 60 | 69
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
decreased hemoglobin content 57 | 68
increased circulating choleste... 57 | 66
increased monocyte cell number 57 | 63
edema 56 | 59
increased heart weight 56 | 62
abnormal kidney morphology 54 | 65
female infertility 52 | 60
small testis 52 | 58
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 51 | 56
abnormal spleen morphology 49 | 55
decreased circulating total pr... 48 | 49
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
decreased mean corpuscular hem... 45 | 50
increased neutrophil cell numb... 45 | 46
abnormal skin morphology 44 | 50
hydrometra 44 | 53
increased leukocyte cell numbe... 44 | 47
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
decreased hematocrit 41 | 46
abnormal testis morphology 40 | 43
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
enlarged spleen 38 | 41
increased circulating chloride... 38 | 41
increased circulating triglyce... 38 | 42
decreased neutrophil cell numb... 37 | 42
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
decreased red blood cell distr... 36 | 41
increased erythrocyte cell num... 36 | 39
tremors 36 | 39
abnormal cranium morphology 35 | 36
enlarged lymph nodes 34 | 37
increased grip strength 34 | 41
increased mean corpuscular hem... 33 | 36

Disease

Carcinoma 9,599 | 11,493
ovarian cancer 8,042 | 8,520
osteosarcoma 7,436 | 7,950
medulloblastoma, large-cell 5,694 | 6,241
psoriasis 5,583 | 6,694
glioblastoma 5,369 | 5,792
atypical teratoid / rhabdoid tumor 4,707 | 5,112
lung cancer 4,435 | 4,740
ependymoma 4,253 | 4,679
group 3 medulloblastoma 3,782 | 4,104
adult high grade glioma 3,420 | 3,801
Breast cancer 3,322 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,135 | 3,291
malignant mesothelioma 3,081 | 3,232
invasive ductal carcinoma 2,863 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,861 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,815 | 2,955
primitive neuroectodermal tumor 2,783 | 3,035
Astrocytoma, Pilocytic 2,779 | 3,081
non-small cell lung cancer 2,720 | 2,890
oligodendroglioma 2,592 | 2,850
lung carcinoma 2,585 | 2,843
lung adenocarcinoma 2,518 | 2,716
astrocytic glioma 2,369 | 2,597
pancreatic cancer 2,222 | 2,398
Kidney cancer 2,212 | 2,613
Cancer 2,188 | 2,499
interstitial cystitis 2,137 | 2,312
subependymal giant cell astrocytoma 2,127 | 2,287
tuberculosis 1,926 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,870 | 1,962
Pick disease 1,785 | 1,894
pituitary cancer 1,783 | 1,972
group 4 medulloblastoma 1,747 | 1,855
ulcerative colitis 1,725 | 1,819
ductal carcinoma in situ 1,681 | 1,745
cystic fibrosis 1,569 | 1,696
breast carcinoma 1,562 | 1,638
colon cancer 1,393 | 1,478
adrenocortical carcinoma 1,372 | 1,428
diabetes mellitus 1,336 | 1,728
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,273 | 1,442
juvenile dermatomyositis 1,159 | 1,187
acute quadriplegic myopathy 1,127 | 1,158
astrocytoma 1,092 | 1,146
Rheumatoid arthritis 1,082 | 1,191
primary pancreatic ductal adenocarcinoma 1,076 | 1,109
pediatric high grade glioma 1,004 | 1,064
cutaneous lupus erythematosus 994 | 1,057
spina bifida 992 | 1,074
Schizophrenia 975 | 1,160
nasopharyngeal carcinoma 953 | 1,058
Intellectual disability 923 | 1,016
dermatomyositis 916 | 966
active Crohn's disease 863 | 922
Atopic dermatitis 842 | 952
non primary Sjogren syndrome sicca 812 | 891
acute myeloid leukemia 778 | 783
Waldenstrons macroglobulinemia 761 | 765
gastric carcinoma 761 | 807
Liver Cirrhosis, Experimental 729 | 769
primary Sjogren syndrome 717 | 735
Epilepsy 704 | 792
active ulcerative colitis 696 | 764
esophageal adenocarcinoma 667 | 737
medulloblastoma 663 | 720
progressive supranuclear palsy 646 | 676
aldosterone-producing adenoma 635 | 665
Alzheimer's disease 593 | 658
Dull intelligence 592 | 645
Low intelligence 592 | 645
Mental Retardation 592 | 645
Mental deficiency 592 | 645
Poor school performance 592 | 645
Obesity 582 | 678
Duchenne muscular dystrophy 576 | 601
Cognitive delay 569 | 608
Global developmental delay 569 | 608
Mental and motor retardation 569 | 608
Bipolar Disorder 549 | 666
Seizures 544 | 596
pancreatic carcinoma 544 | 562
Muscle hypotonia 537 | 571
hepatocellular carcinoma 537 | 547
fibroadenoma 532 | 559
Melanoma 521 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 496 | 510
Endometriosis 489 | 540
Short stature 480 | 531
Liver cancer 468 | 604
Down syndrome 467 | 499
mucosa-associated lymphoid tissue lymphoma 456 | 484
chronic rhinosinusitis 454 | 512
Multiple Sclerosis 450 | 540
Prostatic Neoplasms 449 | 495
gastric cancer 447 | 459
posterior fossa group A ependymoma 440 | 468
sonic hedgehog group medulloblastoma 431 | 467
Amyotrophic lateral sclerosis 421 | 451

Tissue

Blood and immune system 15,833 | 16,909
Endocrine System 15,796 | 18,159
Digestive Tract 15,761 | 17,369
Female tissues 15,714 | 17,400
Skin and soft tissues 15,683 | 17,230
Male tissues 15,611 | 17,142
Liver and Pancreas 15,571 | 16,750
Urinary Tract 15,512 | 16,678
Respiratory system 15,442 | 16,393
Nervous System 15,425 | 16,725
Cardiovascular System 14,633 | 15,192

Target Family

Non-IDG 9,210 | 12,091
Enzyme 3,664 | 4,145
Transcription Factor 1,168 | 1,400
Kinase 588 | 634
Transporter 380 | 473
GPCR 258 | 408
Ion Channel 237 | 344
Epigenetic 227 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 36 | 38
oGPCR 22 | 421

HPA RNA Tissue

lymph node 15,833 | 15,833
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39