Development Level

Tbio 7,820 | 10,625
Tdark 3,204 | 7,003
Tchem 1,390 | 1,890
Tclin 354 | 602

Collection

Eligible Kinase Proteins 92 | 134
Eligible Ion Channel Proteins 33 | 117
Eligible non-olfactory GPCR Proteins 33 | 145

IMPC Term

preweaning lethality, complete... 577 | 633
preweaning lethality, incomple... 209 | 260
abnormal behavior 182 | 226
embryonic lethality prior to t... 177 | 187
decreased lean body mass 160 | 195
decreased total body fat amoun... 154 | 186
decreased body weight 147 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 122 | 157
increased circulating alkaline... 104 | 119
decreased bone mineral density 100 | 126
abnormal embryo size 97 | 112
increased or absent threshold ... 96 | 128
abnormal bone structure 95 | 131
decreased circulating glucose ... 93 | 121
decreased grip strength 91 | 123
decreased body length 89 | 108
abnormal retina morphology 83 | 100
increased mean corpuscular hem... 83 | 93
enlarged heart 80 | 111
hyperactivity 80 | 108
increased lean body mass 79 | 107
increased mean corpuscular vol... 79 | 91
increased bone mineral content 78 | 92
hypoactivity 70 | 89
decreased circulating choleste... 69 | 85
short tibia 69 | 82
decreased circulating serum al... 66 | 79
increased grip strength 66 | 83
decreased circulating triglyce... 65 | 83
decreased circulating HDL chol... 64 | 77
abnormal lens morphology 58 | 73
prenatal lethality prior to he... 58 | 64
increased fasted circulating g... 56 | 68
decreased lumbar vertebrae num... 53 | 62
increased sacral vertebrae num... 51 | 62
abnormal retinal pigmentation 50 | 61
decreased circulating insulin ... 50 | 75
increased circulating sodium l... 50 | 71
decreased rib number 48 | 59
abnormal sleep behavior 46 | 63
decreased leukocyte cell numbe... 46 | 54
abnormal bone mineralization 45 | 55
abnormal coat/hair pigmentatio... 45 | 54
decreased hemoglobin content 45 | 53
increased bone mineral density 45 | 52
male infertility 45 | 62
decreased mean corpuscular vol... 44 | 50
increased circulating HDL chol... 44 | 63
increased circulating choleste... 42 | 53
decreased erythrocyte cell num... 40 | 43
decreased prepulse inhibition 40 | 52
impaired glucose tolerance 40 | 52
increased total body fat amoun... 40 | 57
decreased circulating alanine ... 39 | 53
increased exploration in new e... 39 | 56
abnormal gait 38 | 51
decreased circulating total pr... 38 | 41
thrombocytopenia 38 | 46
decreased caudal vertebrae num... 37 | 49
decreased startle reflex 37 | 48
decreased fasted circulating g... 36 | 49
improved glucose tolerance 36 | 56
increased blood urea nitrogen ... 36 | 44
abnormal behavioral response t... 35 | 52
increased body weight 34 | 42
decreased circulating free fat... 33 | 39
decreased heart weight 33 | 44
increased hemoglobin content 33 | 45
abnormal heart morphology 32 | 51
abnormal seminal vesicle morph... 32 | 47
decreased circulating LDL chol... 32 | 37
abnormal eye morphology 31 | 38
abnormal neural tube closure 31 | 37
decreased eosinophil cell numb... 31 | 41
increased leukocyte cell numbe... 31 | 37
increased rib number 31 | 41
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
decreased circulating alkaline... 29 | 41
decreased circulating fructosa... 29 | 31
decreased mean corpuscular hem... 29 | 34
increased circulating chloride... 29 | 43
abnormal cranium morphology 28 | 32
decreased T cell number 28 | 31
decreased circulating calcium ... 28 | 33
small testis 28 | 37
decreased circulating creatini... 27 | 31
embryonic growth retardation 27 | 28
increased startle reflex 27 | 38
abnormal spleen morphology 26 | 36
cardiovascular system phenotyp... 26 | 35
tremors 26 | 34
increased circulating potassiu... 25 | 31
increased heart weight 25 | 37
decreased blood urea nitrogen ... 24 | 31
decreased circulating chloride... 24 | 32
increased circulating iron lev... 24 | 25
decreased circulating aspartat... 23 | 27
female infertility 23 | 34

Disease

ovarian cancer 7,285 | 8,492
osteosarcoma 6,580 | 7,933
medulloblastoma, large-cell 4,814 | 6,234
psoriasis 4,531 | 6,685
glioblastoma 4,432 | 5,572
lung cancer 3,855 | 4,473
atypical teratoid / rhabdoid tumor 3,379 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,761 | 3,289
malignant mesothelioma 2,675 | 3,163
Breast cancer 2,555 | 3,099
invasive ductal carcinoma 2,520 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,490 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,418 | 2,956
primitive neuroectodermal tumor 2,296 | 3,031
non-small cell lung cancer 2,275 | 2,798
pilocytic astrocytoma 2,217 | 3,086
oligodendroglioma 2,110 | 2,849
pediatric high grade glioma 2,100 | 2,712
lung adenocarcinoma 2,080 | 2,714
lung carcinoma 2,059 | 2,844
ependymoma 1,983 | 2,514
pancreatic cancer 1,860 | 2,300
subependymal giant cell astrocytoma 1,834 | 2,287
group 3 medulloblastoma 1,815 | 2,254
Cancer 1,790 | 2,346
interstitial cystitis 1,754 | 2,299
ulcerative colitis 1,736 | 2,087
astrocytic glioma 1,687 | 2,241
Pick disease 1,563 | 1,893
adult high grade glioma 1,555 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 1,547 | 1,795
group 4 medulloblastoma 1,537 | 1,875
pituitary cancer 1,425 | 1,972
ductal carcinoma in situ 1,410 | 1,745
tuberculosis 1,392 | 1,563
Carcinoma 1,378 | 2,147
breast carcinoma 1,340 | 1,614
Multiple myeloma 1,291 | 1,328
cystic fibrosis 1,264 | 1,670
astrocytoma 1,249 | 1,493
adrenocortical carcinoma 1,235 | 1,427
colon cancer 1,167 | 1,475
medulloblastoma 1,146 | 1,524
primary pancreatic ductal adenocarcinoma 1,128 | 1,271
sonic hedgehog group medulloblastoma 1,122 | 1,482
juvenile dermatomyositis 1,117 | 1,189
diabetes mellitus 1,099 | 1,663
posterior fossa group A ependymoma 1,084 | 1,511
acute quadriplegic myopathy 1,067 | 1,157
posterior fossa group B ependymoma 1,047 | 1,530
Rheumatoid Arthritis 1,003 | 1,171
dermatomyositis 899 | 967
cutaneous lupus erythematosus 859 | 1,056
spina bifida 835 | 1,064
atypical teratoid/rhabdoid tumor 826 | 1,095
nasopharyngeal carcinoma 750 | 1,056
Waldenstrons macroglobulinemia 749 | 765
primary Sjogren syndrome 746 | 789
acute myeloid leukemia 731 | 785
active Crohn's disease 726 | 918
gastric carcinoma 706 | 832
Atopic dermatitis 685 | 944
tuberculosis and treatment for 6 months 663 | 686
non primary Sjogren syndrome sicca 656 | 840
progressive supranuclear palsy 585 | 674
aldosterone-producing adenoma 572 | 664
esophageal adenocarcinoma 572 | 737
Duchenne muscular dystrophy 540 | 602
hepatocellular carcinoma 512 | 550
pancreatic carcinoma 512 | 567
Alzheimer's disease 480 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 457 | 499
Down syndrome 451 | 548
Intellectual disability 451 | 573
IGA Glomerulonephritis 424 | 454
Obesity 414 | 616
fibroadenoma 413 | 557
gastric cancer 402 | 436
Endometriosis 396 | 535
mucosa-associated lymphoid tissue lymphoma 390 | 480
Prostatic Neoplasms 365 | 471
Amyotrophic Lateral Sclerosis 363 | 432
Multiple Sclerosis 349 | 498
active ulcerative colitis 343 | 477
Mammary Neoplasms 336 | 410
chronic rhinosinusitis 334 | 512
inflammatory breast cancer 324 | 404
sarcoidosis 312 | 368
Neurodegenerative disease 309 | 383
Schizophrenia 309 | 503
tuberculosis and treatment for 3 months 304 | 327
hereditary spastic paraplegia 295 | 313
non-small cell lung carcinoma 268 | 413
Polycystic Ovary Syndrome 262 | 335
glioblastoma multiforme 262 | 347
Kidney disease 258 | 397
Parkinson's disease 250 | 364
interstitial lung disease 249 | 292
Crohn's disease 245 | 304
urothelial carcinoma 237 | 318

Tissue

Blood and immune system 12,768 | 17,995
Digestive Tract 12,768 | 18,473
Endocrine System 12,765 | 18,512
Female tissues 12,765 | 18,647
Nervous System 12,762 | 18,561
Skin and soft tissues 12,762 | 18,115
Urinary Tract 12,762 | 18,444
Liver and Pancreas 12,760 | 18,136
Respiratory system 12,753 | 17,484
Male tissues 12,751 | 17,969
Cardiovascular System 12,746 | 17,958

Target Family

Non-IDG 7,364 | 11,969
Enzyme 3,130 | 4,146
Transcription Factor 962 | 1,400
Kinase 506 | 634
Transporter 282 | 473
Epigenetic 210 | 242
GPCR 141 | 408
Ion Channel 109 | 341
TF/Epigenetic 32 | 38
Nuclear Receptor 31 | 48
oGPCR 1 | 421

HPA RNA Tissue

lymph node 12,768 | 12,768
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11