Development Level

Tbio 8,246 | 10,625
Tdark 3,541 | 7,003
Tchem 1,479 | 1,890
Tclin 388 | 602

Collection

Eligible Kinase Proteins 102 | 134
Eligible Ion Channel Proteins 46 | 117
Eligible non-olfactory GPCR Proteins 39 | 143

IMPC Term

preweaning lethality, complete... 585 | 633
preweaning lethality, incomple... 218 | 260
abnormal behavior 184 | 226
embryonic lethality prior to t... 182 | 187
decreased lean body mass 167 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 151 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 130 | 157
abnormal embryo size 103 | 112
decreased bone mineral density 103 | 126
increased circulating alkaline... 103 | 119
abnormal bone structure 102 | 131
increased or absent threshold ... 101 | 128
decreased circulating glucose ... 99 | 121
decreased grip strength 95 | 123
decreased body length 93 | 108
increased lean body mass 90 | 107
enlarged heart 87 | 111
hyperactivity 86 | 108
abnormal retina morphology 83 | 100
increased mean corpuscular hem... 83 | 93
increased bone mineral content 79 | 92
increased mean corpuscular vol... 79 | 91
decreased circulating choleste... 71 | 85
decreased circulating triglyce... 71 | 83
short tibia 71 | 82
decreased circulating serum al... 70 | 79
hypoactivity 70 | 89
increased grip strength 68 | 83
decreased circulating HDL chol... 66 | 77
abnormal lens morphology 61 | 73
decreased circulating insulin ... 58 | 75
prenatal lethality prior to he... 58 | 64
decreased lumbar vertebrae num... 56 | 62
increased fasted circulating g... 56 | 68
increased sacral vertebrae num... 55 | 62
increased circulating sodium l... 53 | 71
abnormal retinal pigmentation 52 | 61
abnormal sleep behavior 50 | 63
decreased rib number 49 | 59
male infertility 49 | 62
increased circulating HDL chol... 48 | 63
increased total body fat amoun... 47 | 57
abnormal bone mineralization 46 | 55
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
abnormal coat/hair pigmentatio... 45 | 54
decreased hemoglobin content 45 | 53
increased bone mineral density 45 | 52
decreased circulating alanine ... 43 | 53
decreased prepulse inhibition 43 | 52
improved glucose tolerance 43 | 56
increased circulating choleste... 43 | 53
decreased caudal vertebrae num... 42 | 49
increased exploration in new e... 41 | 56
impaired glucose tolerance 40 | 52
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
decreased fasted circulating g... 38 | 49
increased blood urea nitrogen ... 38 | 44
abnormal gait 37 | 51
abnormal heart morphology 37 | 51
thrombocytopenia 37 | 46
abnormal behavioral response t... 36 | 52
decreased eosinophil cell numb... 36 | 41
increased body weight 36 | 42
increased rib number 36 | 41
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
increased hemoglobin content 35 | 45
abnormal seminal vesicle morph... 34 | 47
decreased heart weight 34 | 44
decreased circulating free fat... 33 | 39
decreased neutrophil cell numb... 32 | 37
abnormal eye morphology 30 | 38
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
increased startle reflex 30 | 38
decreased circulating alkaline... 29 | 41
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
small testis 28 | 37
abnormal cranium morphology 27 | 32
cardiovascular system phenotyp... 27 | 35
decreased T cell number 27 | 31
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
decreased circulating chloride... 26 | 32
decreased circulating creatini... 26 | 31
increased circulating potassiu... 26 | 31
tremors 26 | 34
enlarged spleen 25 | 26
increased circulating calcium ... 25 | 32
limb grasping 25 | 35

Disease

ovarian cancer 7,576 | 8,484
osteosarcoma 6,854 | 7,933
medulloblastoma, large-cell 5,063 | 6,234
psoriasis 4,887 | 6,685
glioblastoma 4,648 | 5,572
lung cancer 4,061 | 4,466
atypical teratoid / rhabdoid tumor 3,572 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,946 | 3,289
malignant mesothelioma 2,796 | 3,162
Breast cancer 2,721 | 3,094
invasive ductal carcinoma 2,685 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,664 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,659 | 2,988
non-small cell lung cancer 2,494 | 2,798
primitive neuroectodermal tumor 2,418 | 3,031
lung carcinoma 2,415 | 2,844
pilocytic astrocytoma 2,407 | 3,086
lung adenocarcinoma 2,402 | 2,713
oligodendroglioma 2,286 | 2,849
pediatric high grade glioma 2,202 | 2,712
ependymoma 2,103 | 2,514
pancreatic cancer 2,022 | 2,300
interstitial cystitis 1,986 | 2,299
subependymal giant cell astrocytoma 1,944 | 2,287
group 3 medulloblastoma 1,872 | 2,254
Cancer 1,865 | 2,346
ulcerative colitis 1,840 | 2,087
astrocytic glioma 1,839 | 2,241
adult high grade glioma 1,673 | 2,148
Pick disease 1,646 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,633 | 1,795
group 4 medulloblastoma 1,626 | 1,875
pituitary cancer 1,600 | 1,972
ductal carcinoma in situ 1,538 | 1,745
Carcinoma 1,518 | 2,147
tuberculosis 1,423 | 1,557
breast carcinoma 1,417 | 1,614
cystic fibrosis 1,416 | 1,665
Multiple myeloma 1,301 | 1,327
astrocytoma 1,301 | 1,493
posterior fossa group B ependymoma 1,292 | 1,530
adrenocortical carcinoma 1,258 | 1,427
colon cancer 1,256 | 1,475
medulloblastoma 1,219 | 1,524
primary pancreatic ductal adenocarcinoma 1,196 | 1,271
sonic hedgehog group medulloblastoma 1,193 | 1,482
posterior fossa group A ependymoma 1,156 | 1,511
diabetes mellitus 1,133 | 1,663
juvenile dermatomyositis 1,126 | 1,189
acute quadriplegic myopathy 1,081 | 1,157
Rheumatoid Arthritis 1,017 | 1,160
spina bifida 939 | 1,064
nasopharyngeal carcinoma 917 | 1,056
cutaneous lupus erythematosus 911 | 1,056
dermatomyositis 903 | 933
atypical teratoid/rhabdoid tumor 892 | 1,095
active Crohn's disease 800 | 918
gastric carcinoma 749 | 832
Waldenstrons macroglobulinemia 742 | 765
acute myeloid leukemia 733 | 780
primary Sjogren syndrome 732 | 789
Atopic dermatitis 722 | 944
non primary Sjogren syndrome sicca 683 | 840
tuberculosis and treatment for 6 months 663 | 686
esophageal adenocarcinoma 644 | 737
progressive supranuclear palsy 609 | 674
aldosterone-producing adenoma 608 | 664
Duchenne muscular dystrophy 556 | 602
pancreatic carcinoma 522 | 567
Alzheimer's disease 506 | 644
hepatocellular carcinoma 500 | 532
fibroadenoma 472 | 557
Down syndrome 471 | 548
Intellectual disability 471 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
chronic rhinosinusitis 459 | 512
Obesity 447 | 616
Endometriosis 439 | 535
mucosa-associated lymphoid tissue lymphoma 416 | 480
IGA Glomerulonephritis 413 | 454
gastric cancer 401 | 430
Prostatic Neoplasms 397 | 471
active ulcerative colitis 394 | 477
Amyotrophic Lateral Sclerosis 384 | 431
Multiple Sclerosis 360 | 498
Mammary Neoplasms 353 | 410
non-small cell lung carcinoma 347 | 413
Schizophrenia 341 | 501
inflammatory breast cancer 336 | 404
Neurodegenerative disease 334 | 383
sarcoidosis 327 | 358
tuberculosis and treatment for 3 months 308 | 327
hereditary spastic paraplegia 302 | 313
glioblastoma multiforme 286 | 347
urothelial carcinoma 280 | 318
Polycystic Ovary Syndrome 273 | 332
Parkinson's disease 271 | 364
interstitial lung disease 270 | 291
Kidney disease 269 | 396
nephrosclerosis 262 | 329

Tissue

Respiratory system 13,654 | 17,484
Female tissues 13,652 | 18,647
Digestive Tract 13,651 | 18,473
Endocrine System 13,651 | 18,512
Skin and soft tissues 13,647 | 18,115
Nervous System 13,646 | 18,561
Liver and Pancreas 13,645 | 18,136
Urinary Tract 13,645 | 18,444
Male tissues 13,633 | 17,969
Cardiovascular System 13,627 | 17,958
Blood and immune system 13,626 | 17,995

Target Family

Non-IDG 7,939 | 11,971
Enzyme 3,298 | 4,146
Transcription Factor 989 | 1,400
Kinase 533 | 634
Transporter 304 | 473
Epigenetic 211 | 242
GPCR 166 | 406
Ion Channel 145 | 341
Nuclear Receptor 35 | 48
TF/Epigenetic 33 | 38
oGPCR 1 | 421

HPA RNA Tissue

lung 13,654 | 13,654
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248