Development Level

Tbio 10,421 | 11,651
Tdark 4,082 | 6,593
Tchem 1,277 | 1,388
Tclin 532 | 612

Collection

RFA-RM-18-021 259 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 949 | 979
preweaning lethality, incomple... 474 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 215 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 193 | 210
decreased vertical activity 178 | 208
abnormal bone structure 170 | 187
increased lean body mass 157 | 172
abnormal heart morphology 151 | 162
decreased body weight 151 | 161
decreased bone mineral content 138 | 151
hyperactivity 134 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 122 | 134
hypoactivity 118 | 132
decreased bone mineral density 117 | 126
decreased circulating glucose ... 115 | 126
increased circulating alkaline... 113 | 122
male infertility 107 | 123
decreased grip strength 105 | 116
embryonic growth retardation 104 | 106
increased startle reflex 104 | 112
abnormal seminal vesicle morph... 102 | 114
increased bone mineral content 101 | 108
decreased body length 94 | 101
increased or absent threshold ... 92 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
increased mean corpuscular hem... 88 | 96
cataract 87 | 92
decreased circulating choleste... 87 | 93
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 79 | 83
decreased circulating serum al... 78 | 82
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 73 | 79
decreased startle reflex 71 | 75
increased bone mineral density 71 | 72
decreased mean corpuscular vol... 70 | 79
decreased leukocyte cell numbe... 69 | 73
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
increased fasted circulating g... 69 | 76
small superior vagus ganglion 69 | 74
increased circulating HDL chol... 68 | 80
decreased circulating insulin ... 67 | 76
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
abnormal sleep behavior 65 | 70
decreased circulating HDL chol... 64 | 68
abnormal behavioral response t... 62 | 66
abnormal coat-hair pigmentatio... 62 | 64
increased circulating sodium l... 62 | 71
abnormal gait 61 | 69
decreased fasted circulating g... 61 | 65
abnormal kidney morphology 59 | 65
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
decreased hemoglobin content 58 | 68
increased circulating choleste... 58 | 66
edema 56 | 59
increased heart weight 55 | 62
small testis 53 | 58
abnormal spleen morphology 51 | 55
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 51 | 56
female infertility 49 | 60
abnormal skin morphology 48 | 50
hydrometra 48 | 53
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 45 | 50
decreased circulating alanine ... 44 | 47
increased neutrophil cell numb... 44 | 46
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
increased leukocyte cell numbe... 42 | 47
decreased hematocrit 41 | 46
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
decreased circulating LDL chol... 38 | 38
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
abnormal bone mineralization 37 | 38
increased erythrocyte cell num... 37 | 39
increased grip strength 36 | 41
tremors 36 | 39
abnormal epididymis morphology 35 | 42
decreased circulating creatini... 35 | 39
limb grasping 35 | 41
increased circulating chloride... 34 | 41

Disease

Carcinoma 9,911 | 11,493
ovarian cancer 8,183 | 8,519
osteosarcoma 7,527 | 7,950
medulloblastoma, large-cell 5,836 | 6,241
psoriasis 5,829 | 6,694
glioblastoma 5,513 | 5,792
atypical teratoid / rhabdoid tumor 4,841 | 5,112
lung cancer 4,517 | 4,740
ependymoma 4,427 | 4,679
group 3 medulloblastoma 3,891 | 4,104
adult high grade glioma 3,533 | 3,801
Breast cancer 3,424 | 3,577
intraductal papillary-mucinous neoplasm (IPMN) 3,200 | 3,290
malignant mesothelioma 3,133 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,911 | 2,988
invasive ductal carcinoma 2,898 | 2,950
Astrocytoma, Pilocytic 2,884 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,884 | 2,954
primitive neuroectodermal tumor 2,882 | 3,035
non-small cell lung cancer 2,818 | 2,890
lung carcinoma 2,746 | 2,843
oligodendroglioma 2,684 | 2,850
lung adenocarcinoma 2,645 | 2,716
astrocytic glioma 2,453 | 2,597
Kidney cancer 2,340 | 2,613
pancreatic cancer 2,306 | 2,398
Cancer 2,252 | 2,499
interstitial cystitis 2,230 | 2,312
subependymal giant cell astrocytoma 2,181 | 2,287
tuberculosis 1,940 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,884 | 1,962
pituitary cancer 1,866 | 1,972
Pick disease 1,829 | 1,894
group 4 medulloblastoma 1,777 | 1,855
ulcerative colitis 1,742 | 1,819
ductal carcinoma in situ 1,709 | 1,744
cystic fibrosis 1,622 | 1,695
breast carcinoma 1,594 | 1,637
colon cancer 1,416 | 1,478
adrenocortical carcinoma 1,398 | 1,428
diabetes mellitus 1,352 | 1,728
Multiple myeloma 1,309 | 1,332
Autosomal recessive predisposition 1,304 | 1,442
juvenile dermatomyositis 1,162 | 1,187
acute quadriplegic myopathy 1,130 | 1,158
astrocytoma 1,106 | 1,146
Rheumatoid arthritis 1,092 | 1,191
primary pancreatic ductal adenocarcinoma 1,087 | 1,108
pediatric high grade glioma 1,030 | 1,064
spina bifida 1,030 | 1,074
nasopharyngeal carcinoma 1,025 | 1,058
cutaneous lupus erythematosus 1,015 | 1,057
Schizophrenia 1,007 | 1,160
Intellectual disability 940 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 878 | 922
Atopic dermatitis 869 | 952
non primary Sjogren syndrome sicca 825 | 891
acute myeloid leukemia 779 | 783
gastric carcinoma 778 | 807
Waldenstrons macroglobulinemia 761 | 765
Liver Cirrhosis, Experimental 732 | 769
active ulcerative colitis 722 | 764
Epilepsy 720 | 792
primary Sjogren syndrome 718 | 735
esophageal adenocarcinoma 704 | 737
medulloblastoma 680 | 720
aldosterone-producing adenoma 651 | 665
progressive supranuclear palsy 651 | 676
Alzheimer's disease 610 | 658
Obesity 603 | 678
Dull intelligence 594 | 645
Low intelligence 594 | 645
Mental Retardation 594 | 645
Mental deficiency 594 | 645
Poor school performance 594 | 645
Melanoma 585 | 711
Duchenne muscular dystrophy 578 | 601
Bipolar Disorder 577 | 666
Cognitive delay 575 | 608
Global developmental delay 575 | 608
Mental and motor retardation 575 | 608
Seizures 553 | 596
pancreatic carcinoma 553 | 562
fibroadenoma 544 | 559
Muscle hypotonia 540 | 571
hepatocellular carcinoma 537 | 547
Liver cancer 533 | 604
Endometriosis 522 | 540
chronic rhinosinusitis 500 | 512
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Short stature 495 | 531
Down syndrome 472 | 499
Prostatic Neoplasms 467 | 495
mucosa-associated lymphoid tissue lymphoma 463 | 484
Multiple Sclerosis 457 | 540
gastric cancer 452 | 459
posterior fossa group A ependymoma 449 | 468
sonic hedgehog group medulloblastoma 441 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Respiratory system 16,312 | 16,393
Endocrine System 16,270 | 18,159
Female tissues 16,210 | 17,400
Digestive Tract 16,191 | 17,369
Skin and soft tissues 16,113 | 17,230
Male tissues 16,071 | 17,142
Blood and immune system 16,017 | 16,909
Liver and Pancreas 15,966 | 16,750
Urinary Tract 15,923 | 16,678
Nervous System 15,790 | 16,725
Cardiovascular System 14,871 | 15,192

Target Family

Non-IDG 9,543 | 12,091
Enzyme 3,741 | 4,145
Transcription Factor 1,169 | 1,400
Kinase 597 | 634
Transporter 395 | 473
GPCR 280 | 408
Ion Channel 261 | 344
Epigenetic 231 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 34 | 38
oGPCR 15 | 421

HPA RNA Tissue

lung 16,312 | 16,312
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50