Development Level

Tbio 8,246 | 10,625
Tdark 3,541 | 7,003
Tchem 1,478 | 1,890
Tclin 388 | 602

Collection

Kinase: IDG Consortium (Targets) 96 | 125
Ion Channel: IDG Consortium (Targets) 46 | 102
GPCR: IDG Consortium (Targets) 38 | 127
Kinase: IDG Consortium (Complete/Control) 30 | 37
GPCR: IDG Consortium (Complete/Control) 12 | 26

IMPC Phenotype

preweaning lethality, complete... 585 | 633
preweaning lethality, incomple... 218 | 260
abnormal behavior 184 | 226
embryonic lethality prior to t... 182 | 187
decreased lean body mass 167 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 151 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 130 | 157
abnormal embryo size 103 | 112
decreased bone mineral density 103 | 126
increased circulating alkaline... 103 | 119
abnormal bone structure 102 | 131
increased or absent threshold ... 101 | 128
decreased circulating glucose ... 99 | 121
decreased grip strength 95 | 123
decreased body length 93 | 108
increased lean body mass 90 | 107
enlarged heart 87 | 111
hyperactivity 86 | 108
abnormal retina morphology 83 | 100
increased mean corpuscular hem... 83 | 93
increased bone mineral content 79 | 92
increased mean corpuscular vol... 79 | 91
decreased circulating choleste... 71 | 85
decreased circulating triglyce... 71 | 83
short tibia 71 | 82
decreased circulating serum al... 70 | 79
hypoactivity 70 | 89
increased grip strength 68 | 83
decreased circulating HDL chol... 66 | 77
abnormal lens morphology 61 | 73
decreased circulating insulin ... 58 | 75
prenatal lethality prior to he... 58 | 64
decreased lumbar vertebrae num... 56 | 62
increased fasted circulating g... 56 | 68
increased sacral vertebrae num... 55 | 62
increased circulating sodium l... 53 | 71
abnormal retinal pigmentation 52 | 61
abnormal sleep behavior 50 | 63
decreased rib number 49 | 59
male infertility 49 | 62
increased circulating HDL chol... 48 | 63
increased total body fat amoun... 47 | 57
abnormal bone mineralization 46 | 55
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
abnormal coat-hair pigmentatio... 45 | 54
decreased hemoglobin content 45 | 53
increased bone mineral density 45 | 52
decreased circulating alanine ... 43 | 53
decreased prepulse inhibition 43 | 52
improved glucose tolerance 43 | 56
increased circulating choleste... 43 | 53
decreased caudal vertebrae num... 42 | 49
increased exploration in new e... 41 | 56
impaired glucose tolerance 40 | 52
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
decreased fasted circulating g... 38 | 49
increased blood urea nitrogen ... 38 | 44
abnormal gait 37 | 51
abnormal heart morphology 37 | 51
thrombocytopenia 37 | 46
abnormal behavioral response t... 36 | 52
decreased eosinophil cell numb... 36 | 41
increased body weight 36 | 42
increased rib number 36 | 41
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
increased hemoglobin content 35 | 45
abnormal seminal vesicle morph... 34 | 47
decreased heart weight 34 | 44
decreased circulating free fat... 33 | 39
decreased neutrophil cell numb... 32 | 37
abnormal eye morphology 30 | 38
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
increased startle reflex 30 | 38
decreased circulating alkaline... 29 | 41
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
small testis 28 | 37
abnormal cranium morphology 27 | 32
cardiovascular system phenotyp... 27 | 35
decreased T cell number 27 | 31
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
decreased circulating chloride... 26 | 32
decreased circulating creatini... 26 | 31
increased circulating potassiu... 26 | 31
tremors 26 | 34
enlarged spleen 25 | 26
increased circulating calcium ... 25 | 32
limb grasping 25 | 35

Disease

ovarian cancer 7,580 | 8,491
osteosarcoma 6,854 | 7,933
medulloblastoma, large-cell 5,063 | 6,234
psoriasis 4,887 | 6,685
glioblastoma 4,648 | 5,572
lung cancer 4,067 | 4,473
atypical teratoid / rhabdoid tumor 3,572 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,946 | 3,289
malignant mesothelioma 2,797 | 3,163
Breast cancer 2,724 | 3,098
invasive ductal carcinoma 2,685 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,664 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,659 | 2,988
non-small cell lung cancer 2,494 | 2,798
primitive neuroectodermal tumor 2,418 | 3,031
lung carcinoma 2,415 | 2,844
pilocytic astrocytoma 2,407 | 3,086
lung adenocarcinoma 2,403 | 2,714
oligodendroglioma 2,286 | 2,849
pediatric high grade glioma 2,202 | 2,712
ependymoma 2,103 | 2,514
pancreatic cancer 2,022 | 2,300
interstitial cystitis 1,986 | 2,299
subependymal giant cell astrocytoma 1,944 | 2,287
group 3 medulloblastoma 1,872 | 2,254
Cancer 1,865 | 2,346
ulcerative colitis 1,840 | 2,087
astrocytic glioma 1,839 | 2,241
adult high grade glioma 1,673 | 2,148
Pick disease 1,646 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,633 | 1,795
group 4 medulloblastoma 1,626 | 1,875
pituitary cancer 1,600 | 1,972
ductal carcinoma in situ 1,538 | 1,745
Carcinoma 1,518 | 2,147
tuberculosis 1,427 | 1,563
cystic fibrosis 1,420 | 1,670
breast carcinoma 1,417 | 1,614
astrocytoma 1,301 | 1,493
Multiple myeloma 1,300 | 1,327
posterior fossa group B ependymoma 1,292 | 1,530
adrenocortical carcinoma 1,258 | 1,427
colon cancer 1,256 | 1,475
medulloblastoma 1,219 | 1,524
primary pancreatic ductal adenocarcinoma 1,196 | 1,271
sonic hedgehog group medulloblastoma 1,193 | 1,482
posterior fossa group A ependymoma 1,156 | 1,511
diabetes mellitus 1,133 | 1,663
juvenile dermatomyositis 1,126 | 1,189
acute quadriplegic myopathy 1,081 | 1,157
Rheumatoid Arthritis 1,017 | 1,170
spina bifida 939 | 1,064
nasopharyngeal carcinoma 917 | 1,056
cutaneous lupus erythematosus 911 | 1,056
dermatomyositis 903 | 966
atypical teratoid/rhabdoid tumor 892 | 1,095
active Crohn's disease 800 | 918
gastric carcinoma 749 | 832
Waldenstrons macroglobulinemia 741 | 764
acute myeloid leukemia 738 | 785
primary Sjogren syndrome 731 | 788
Atopic dermatitis 722 | 944
non primary Sjogren syndrome sicca 683 | 840
tuberculosis and treatment for 6 months 663 | 686
esophageal adenocarcinoma 644 | 737
progressive supranuclear palsy 609 | 674
aldosterone-producing adenoma 608 | 664
Duchenne muscular dystrophy 556 | 602
pancreatic carcinoma 522 | 567
hepatocellular carcinoma 517 | 550
Alzheimer's disease 506 | 644
fibroadenoma 472 | 557
Down syndrome 471 | 548
Intellectual disability 471 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 499
chronic rhinosinusitis 459 | 512
Obesity 447 | 616
Endometriosis 439 | 535
mucosa-associated lymphoid tissue lymphoma 416 | 480
IGA Glomerulonephritis 413 | 454
gastric cancer 407 | 436
Prostatic Neoplasms 397 | 471
active ulcerative colitis 394 | 477
Amyotrophic Lateral Sclerosis 384 | 432
Multiple Sclerosis 360 | 498
Mammary Neoplasms 353 | 410
non-small cell lung carcinoma 347 | 413
Schizophrenia 343 | 503
inflammatory breast cancer 336 | 404
Neurodegenerative disease 334 | 383
sarcoidosis 327 | 368
tuberculosis and treatment for 3 months 308 | 327
hereditary spastic paraplegia 302 | 313
glioblastoma multiforme 286 | 347
urothelial carcinoma 280 | 318
Polycystic Ovary Syndrome 272 | 334
Parkinson's disease 271 | 364
interstitial lung disease 271 | 292
Kidney disease 270 | 397
nephrosclerosis 262 | 329

Tissue

Respiratory system 13,653 | 17,483
Female tissues 13,651 | 18,646
Digestive Tract 13,650 | 18,472
Endocrine System 13,650 | 18,511
Skin and soft tissues 13,646 | 18,114
Nervous System 13,645 | 18,560
Liver and Pancreas 13,644 | 18,135
Urinary Tract 13,644 | 18,443
Male tissues 13,632 | 17,968
Cardiovascular System 13,626 | 17,957
Blood and immune system 13,625 | 17,994

Target Family

Non-IDG 7,939 | 11,969
Enzyme 3,297 | 4,146
Transcription Factor 989 | 1,400
Kinase 533 | 634
Transporter 304 | 473
Epigenetic 211 | 242
GPCR 166 | 408
Ion Channel 145 | 341
Nuclear Receptor 35 | 48
TF/Epigenetic 33 | 38
oGPCR 1 | 421

HPA RNA Tissue

lung 13,653 | 13,653
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90