Development Level

Tbio 9,401 | 11,445
Tdark 3,395 | 6,588
Tchem 1,356 | 1,598
Tclin 435 | 613

Collection

RFA-RM-18-021 193 | 328
Kinase: IDG Consortium (Target... 99 | 125
GPCR: IDG Consortium (Targets) 51 | 126
Ion Channel: IDG Consortium (T... 43 | 99
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 921 | 979
preweaning lethality, incomple... 438 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 256 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 174 | 210
decreased vertical activity 154 | 208
abnormal bone structure 153 | 187
increased lean body mass 153 | 172
decreased body weight 147 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 122 | 151
hyperactivity 121 | 148
decreased lean body mass 114 | 135
increased total body fat amoun... 109 | 134
hypoactivity 108 | 132
decreased circulating glucose ... 107 | 126
decreased bone mineral density 105 | 126
increased circulating alkaline... 103 | 122
embryonic growth retardation 101 | 106
increased startle reflex 97 | 112
increased bone mineral content 95 | 108
decreased grip strength 93 | 116
male infertility 92 | 123
abnormal seminal vesicle morph... 91 | 114
short tibia 89 | 97
increased mean corpuscular vol... 87 | 92
increased or absent threshold ... 87 | 101
decreased body length 85 | 101
increased mean corpuscular hem... 85 | 96
decreased circulating choleste... 84 | 93
prenatal lethality prior to he... 81 | 87
cataract 80 | 92
abnormal lens morphology 74 | 81
decreased lymphocyte cell numb... 72 | 83
decreased prepulse inhibition 72 | 82
decreased circulating serum al... 71 | 82
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 69 | 72
decreased circulating triglyce... 67 | 79
improved glucose tolerance 66 | 79
increased fasted circulating g... 66 | 76
decreased leukocyte cell numbe... 65 | 73
decreased startle reflex 64 | 75
increased circulating HDL chol... 64 | 80
decreased circulating HDL chol... 63 | 68
impaired glucose tolerance 63 | 75
abnormal eye morphology 62 | 68
abnormal retina morphology 62 | 71
small superior vagus ganglion 62 | 74
abnormal sleep behavior 59 | 70
decreased circulating insulin ... 58 | 76
decreased hemoglobin content 58 | 68
increased circulating sodium l... 58 | 71
abnormal coat-hair pigmentatio... 57 | 64
decreased erythrocyte cell num... 57 | 62
decreased fasted circulating g... 57 | 65
abnormal gait 56 | 69
abnormal kidney morphology 55 | 65
increased circulating choleste... 54 | 66
edema 53 | 59
increased heart weight 53 | 62
abnormal behavioral response t... 52 | 66
increased monocyte cell number 52 | 63
thrombocytopenia 51 | 56
small testis 50 | 58
decreased caudal vertebrae num... 48 | 53
abnormal spleen morphology 46 | 55
abnormal neural tube closure 45 | 46
abnormal skin morphology 45 | 50
decreased blood urea nitrogen ... 44 | 51
decreased circulating total pr... 44 | 49
decreased mean corpuscular hem... 44 | 50
female infertility 44 | 60
hydrometra 44 | 53
increased blood urea nitrogen ... 44 | 48
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 41 | 46
increased hematocrit 41 | 46
increased neutrophil cell numb... 40 | 46
decreased hematocrit 39 | 46
enlarged spleen 38 | 41
increased leukocyte cell numbe... 38 | 47
abnormal testis morphology 37 | 43
increased circulating triglyce... 37 | 42
increased hemoglobin content 37 | 45
tremors 37 | 39
decreased circulating LDL chol... 35 | 38
decreased red blood cell distr... 35 | 41
increased mean platelet volume 35 | 45
abnormal bone mineralization 34 | 38
decreased neutrophil cell numb... 34 | 42
increased circulating chloride... 34 | 41
increased circulating creatini... 34 | 38
increased erythrocyte cell num... 34 | 39
abnormal cranium morphology 33 | 36
decreased circulating creatini... 33 | 39
pallor 33 | 34

Disease

Carcinoma 8,954 | 11,493
ovarian cancer 7,803 | 8,520
osteosarcoma 7,101 | 7,950
medulloblastoma, large-cell 5,324 | 6,241
psoriasis 5,199 | 6,694
glioblastoma 5,043 | 5,792
atypical teratoid / rhabdoid tumor 4,380 | 5,112
lung cancer 4,292 | 4,740
ependymoma 3,909 | 4,679
group 3 medulloblastoma 3,519 | 4,104
Breast cancer 3,172 | 3,578
adult high grade glioma 3,130 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 3,042 | 3,291
malignant mesothelioma 2,941 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,764 | 2,989
invasive ductal carcinoma 2,761 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,743 | 2,955
non-small cell lung cancer 2,613 | 2,890
primitive neuroectodermal tumor 2,573 | 3,035
Astrocytoma, Pilocytic 2,522 | 3,081
lung carcinoma 2,416 | 2,843
lung adenocarcinoma 2,395 | 2,716
oligodendroglioma 2,389 | 2,850
astrocytic glioma 2,194 | 2,597
pancreatic cancer 2,174 | 2,398
Cancer 2,115 | 2,499
Kidney cancer 2,058 | 2,613
interstitial cystitis 2,051 | 2,312
subependymal giant cell astrocytoma 2,003 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,928 | 1,962
tuberculosis 1,880 | 2,010
ulcerative colitis 1,684 | 1,819
Pick disease 1,675 | 1,894
pituitary cancer 1,663 | 1,972
group 4 medulloblastoma 1,652 | 1,855
ductal carcinoma in situ 1,601 | 1,745
breast carcinoma 1,491 | 1,638
cystic fibrosis 1,483 | 1,696
adrenocortical carcinoma 1,338 | 1,428
colon cancer 1,326 | 1,478
Multiple myeloma 1,302 | 1,332
diabetes mellitus 1,272 | 1,728
Autosomal recessive predisposition 1,218 | 1,442
juvenile dermatomyositis 1,145 | 1,187
acute quadriplegic myopathy 1,108 | 1,158
Rheumatoid arthritis 1,065 | 1,191
astrocytoma 1,057 | 1,146
primary pancreatic ductal adenocarcinoma 1,054 | 1,109
spina bifida 976 | 1,074
pediatric high grade glioma 963 | 1,064
cutaneous lupus erythematosus 945 | 1,057
dermatomyositis 911 | 966
nasopharyngeal carcinoma 885 | 1,058
Schizophrenia 883 | 1,160
Intellectual disability 868 | 1,016
active Crohn's disease 825 | 922
Atopic dermatitis 793 | 952
non primary Sjogren syndrome sicca 770 | 891
acute myeloid leukemia 759 | 783
Waldenstrons macroglobulinemia 757 | 765
gastric carcinoma 749 | 807
Liver Cirrhosis, Experimental 740 | 769
primary Sjogren syndrome 702 | 735
active ulcerative colitis 671 | 764
esophageal adenocarcinoma 655 | 737
Epilepsy 654 | 792
progressive supranuclear palsy 630 | 676
medulloblastoma 626 | 720
aldosterone-producing adenoma 619 | 665
Duchenne muscular dystrophy 571 | 601
Alzheimer's disease 555 | 658
Dull intelligence 555 | 645
Low intelligence 555 | 645
Mental Retardation 555 | 645
Mental deficiency 555 | 645
Poor school performance 555 | 645
Cognitive delay 549 | 608
Global developmental delay 549 | 608
Mental and motor retardation 549 | 608
Obesity 542 | 678
pancreatic carcinoma 537 | 562
hepatocellular carcinoma 535 | 547
Muscle hypotonia 513 | 571
Seizures 506 | 596
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 510
fibroadenoma 489 | 559
Bipolar Disorder 483 | 666
Melanoma 482 | 711
Endometriosis 463 | 540
Short stature 450 | 531
Down syndrome 449 | 499
Prostatic Neoplasms 447 | 495
gastric cancer 445 | 459
mucosa-associated lymphoid tissue lymphoma 443 | 484
chronic rhinosinusitis 426 | 512
Liver cancer 421 | 604
posterior fossa group A ependymoma 415 | 468
Amyotrophic lateral sclerosis 411 | 451
Multiple Sclerosis 411 | 540
tuberculosis and treatment for 6 months 408 | 409

Tissue

Liver and Pancreas 14,587 | 16,750
Endocrine System 14,543 | 18,159
Digestive Tract 14,514 | 17,369
Female tissues 14,502 | 17,400
Skin and soft tissues 14,486 | 17,230
Urinary Tract 14,463 | 16,678
Male tissues 14,440 | 17,142
Blood and immune system 14,411 | 16,909
Respiratory system 14,324 | 16,393
Nervous System 14,296 | 16,725
Cardiovascular System 13,901 | 15,192

Target Family

Non-IDG 8,442 | 12,091
Enzyme 3,530 | 4,145
Transcription Factor 1,035 | 1,400
Kinase 555 | 634
Transporter 354 | 473
Epigenetic 223 | 242
GPCR 204 | 408
Ion Channel 169 | 344
Nuclear Receptor 40 | 48
TF/Epigenetic 31 | 38
oGPCR 4 | 421

HPA RNA Tissue

liver 14,587 | 14,587
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29