Development Level

Tbio 7,500 | 10,625
Tdark 2,881 | 7,003
Tchem 1,359 | 1,890
Tclin 343 | 602

Collection

Eligible Kinase Proteins 82 | 134
Eligible non-olfactory GPCR Proteins 27 | 143
Eligible Ion Channel Proteins 23 | 117

IMPC Term

preweaning lethality, complete... 556 | 633
preweaning lethality, incomple... 200 | 260
abnormal behavior 170 | 226
embryonic lethality prior to t... 170 | 187
decreased total body fat amoun... 153 | 186
decreased lean body mass 152 | 195
decreased body weight 145 | 174
embryonic lethality prior to o... 139 | 148
decreased bone mineral content 122 | 157
decreased bone mineral density 97 | 126
increased circulating alkaline... 96 | 119
abnormal embryo size 95 | 112
abnormal bone structure 93 | 131
increased or absent threshold ... 93 | 128
decreased body length 87 | 108
decreased circulating glucose ... 86 | 121
decreased grip strength 83 | 123
abnormal retina morphology 82 | 100
increased lean body mass 80 | 107
enlarged heart 79 | 111
increased mean corpuscular hem... 79 | 93
hyperactivity 77 | 108
increased mean corpuscular vol... 76 | 91
increased bone mineral content 74 | 92
decreased circulating choleste... 71 | 85
short tibia 67 | 82
decreased circulating HDL chol... 66 | 77
hypoactivity 66 | 89
decreased circulating serum al... 65 | 79
decreased circulating triglyce... 61 | 83
increased grip strength 57 | 83
abnormal lens morphology 56 | 73
prenatal lethality prior to he... 55 | 64
increased fasted circulating g... 52 | 68
decreased lumbar vertebrae num... 50 | 62
abnormal retinal pigmentation 48 | 61
increased sacral vertebrae num... 48 | 62
decreased circulating insulin ... 47 | 75
decreased rib number 46 | 59
increased circulating sodium l... 46 | 71
decreased leukocyte cell numbe... 45 | 54
abnormal bone mineralization 43 | 55
abnormal sleep behavior 43 | 63
decreased hemoglobin content 43 | 53
decreased mean corpuscular vol... 43 | 50
abnormal coat/hair pigmentatio... 42 | 54
decreased prepulse inhibition 40 | 52
impaired glucose tolerance 40 | 52
increased bone mineral density 40 | 52
increased circulating choleste... 40 | 53
increased exploration in new e... 40 | 56
male infertility 40 | 62
decreased circulating alanine ... 39 | 53
increased circulating HDL chol... 39 | 63
increased total body fat amoun... 39 | 57
improved glucose tolerance 38 | 56
decreased erythrocyte cell num... 37 | 43
abnormal behavioral response t... 36 | 52
abnormal gait 36 | 51
thrombocytopenia 36 | 46
decreased caudal vertebrae num... 35 | 49
decreased circulating total pr... 35 | 41
increased body weight 35 | 42
decreased fasted circulating g... 34 | 49
increased hemoglobin content 34 | 45
decreased circulating LDL chol... 33 | 37
increased rib number 33 | 41
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
abnormal seminal vesicle morph... 31 | 47
decreased startle reflex 31 | 48
increased blood urea nitrogen ... 31 | 44
increased hematocrit 31 | 36
decreased heart weight 30 | 44
abnormal eye morphology 29 | 38
decreased circulating fructosa... 29 | 31
decreased circulating alkaline... 28 | 41
decreased circulating creatini... 28 | 31
decreased eosinophil cell numb... 28 | 41
decreased T cell number 27 | 31
decreased circulating free fat... 27 | 39
decreased mean corpuscular hem... 27 | 34
increased circulating chloride... 27 | 43
increased heart weight 27 | 37
increased leukocyte cell numbe... 27 | 37
decreased neutrophil cell numb... 26 | 37
tremors 26 | 34
abnormal cranium morphology 25 | 32
cardiovascular system phenotyp... 25 | 35
decreased circulating calcium ... 25 | 33
increased circulating potassiu... 25 | 31
abnormal spleen morphology 24 | 36
embryonic growth retardation 24 | 28
increased circulating calcium ... 24 | 32
increased startle reflex 24 | 38
small testis 24 | 37
decreased circulating chloride... 23 | 32
decreased hematocrit 23 | 25
increased circulating iron lev... 23 | 25
limb grasping 23 | 35

Disease

ovarian cancer 7,029 | 8,484
osteosarcoma 6,178 | 7,933
medulloblastoma, large-cell 4,471 | 6,234
psoriasis 4,301 | 6,685
glioblastoma 4,105 | 5,572
lung cancer 3,667 | 4,466
atypical teratoid / rhabdoid tumor 3,121 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,631 | 3,289
malignant mesothelioma 2,496 | 3,162
Breast cancer 2,359 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,350 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,340 | 2,956
invasive ductal carcinoma 2,329 | 2,950
non-small cell lung cancer 2,119 | 2,798
primitive neuroectodermal tumor 2,087 | 3,031
pilocytic astrocytoma 2,015 | 3,086
oligodendroglioma 1,965 | 2,849
lung carcinoma 1,954 | 2,844
lung adenocarcinoma 1,934 | 2,713
pediatric high grade glioma 1,908 | 2,712
ependymoma 1,884 | 2,514
pancreatic cancer 1,806 | 2,300
subependymal giant cell astrocytoma 1,740 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,711 | 1,795
Cancer 1,707 | 2,346
ulcerative colitis 1,690 | 2,087
group 3 medulloblastoma 1,660 | 2,254
interstitial cystitis 1,612 | 2,299
astrocytic glioma 1,587 | 2,241
Pick disease 1,472 | 1,893
group 4 medulloblastoma 1,448 | 1,875
adult high grade glioma 1,446 | 2,148
pituitary cancer 1,310 | 1,972
ductal carcinoma in situ 1,301 | 1,745
Multiple myeloma 1,283 | 1,327
tuberculosis 1,283 | 1,557
Carcinoma 1,259 | 2,147
breast carcinoma 1,220 | 1,614
astrocytoma 1,197 | 1,493
cystic fibrosis 1,179 | 1,665
adrenocortical carcinoma 1,121 | 1,427
primary pancreatic ductal adenocarcinoma 1,110 | 1,271
diabetes mellitus 1,087 | 1,663
juvenile dermatomyositis 1,087 | 1,189
colon cancer 1,084 | 1,475
medulloblastoma 1,065 | 1,524
sonic hedgehog group medulloblastoma 1,035 | 1,482
acute quadriplegic myopathy 1,028 | 1,157
posterior fossa group A ependymoma 982 | 1,511
Rheumatoid Arthritis 960 | 1,160
posterior fossa group B ependymoma 931 | 1,530
dermatomyositis 882 | 933
spina bifida 844 | 1,064
cutaneous lupus erythematosus 790 | 1,056
atypical teratoid/rhabdoid tumor 748 | 1,095
Waldenstrons macroglobulinemia 730 | 765
gastric carcinoma 700 | 832
active Crohn's disease 696 | 918
acute myeloid leukemia 696 | 780
nasopharyngeal carcinoma 683 | 1,056
primary Sjogren syndrome 654 | 789
tuberculosis and treatment for 6 months 628 | 686
non primary Sjogren syndrome sicca 625 | 840
Atopic dermatitis 589 | 944
esophageal adenocarcinoma 575 | 737
progressive supranuclear palsy 564 | 674
aldosterone-producing adenoma 560 | 664
Duchenne muscular dystrophy 501 | 602
pancreatic carcinoma 475 | 567
hepatocellular carcinoma 474 | 532
Alzheimer's disease 464 | 644
Down syndrome 450 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 438 | 499
Intellectual disability 435 | 573
Obesity 419 | 616
IGA Glomerulonephritis 389 | 454
Prostatic Neoplasms 382 | 471
fibroadenoma 381 | 557
mucosa-associated lymphoid tissue lymphoma 379 | 480
gastric cancer 358 | 430
Amyotrophic Lateral Sclerosis 350 | 431
Endometriosis 346 | 535
active ulcerative colitis 338 | 477
chronic rhinosinusitis 329 | 512
Mammary Neoplasms 328 | 410
Neurodegenerative disease 305 | 383
Multiple Sclerosis 302 | 498
Schizophrenia 296 | 501
inflammatory breast cancer 294 | 404
hereditary spastic paraplegia 289 | 313
sarcoidosis 283 | 358
tuberculosis and treatment for 3 months 281 | 327
nephrosclerosis 271 | 329
Kidney disease 255 | 396
Polycystic Ovary Syndrome 254 | 332
Parkinson's disease 250 | 364
glioblastoma multiforme 246 | 347
non-small cell lung carcinoma 239 | 413
interstitial lung disease 235 | 291
urothelial carcinoma 232 | 318

Tissue

Liver and Pancreas 12,083 | 18,136
Digestive Tract 12,081 | 18,473
Urinary Tract 12,079 | 18,444
Endocrine System 12,076 | 18,512
Skin and soft tissues 12,076 | 18,115
Female tissues 12,075 | 18,647
Nervous System 12,075 | 18,561
Blood and immune system 12,067 | 17,995
Cardiovascular System 12,059 | 17,958
Male tissues 12,051 | 17,969
Respiratory system 12,049 | 17,484

Target Family

Non-IDG 6,934 | 11,971
Enzyme 3,123 | 4,146
Transcription Factor 792 | 1,400
Kinase 479 | 634
Transporter 292 | 473
Epigenetic 207 | 242
GPCR 102 | 406
Ion Channel 89 | 341
Nuclear Receptor 36 | 48
TF/Epigenetic 28 | 38
oGPCR 1 | 421

HPA RNA Tissue

liver 12,083 | 12,083
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160