Development Level

Tbio 8,073 | 10,625
Tdark 3,465 | 7,003
Tchem 1,421 | 1,890
Tclin 382 | 602

Collection

Kinase: IDG Consortium (Targets) 97 | 125
Ion Channel: IDG Consortium (Targets) 42 | 102
GPCR: IDG Consortium (Targets) 33 | 127
Kinase: IDG Consortium (Complete/Control) 31 | 37
GPCR: IDG Consortium (Complete/Control) 10 | 26

IMPC Phenotype

preweaning lethality, complete... 579 | 633
preweaning lethality, incomple... 216 | 260
abnormal behavior 192 | 226
embryonic lethality prior to t... 173 | 187
decreased lean body mass 169 | 195
decreased total body fat amoun... 166 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 142 | 148
decreased bone mineral content 135 | 157
decreased bone mineral density 107 | 126
abnormal bone structure 105 | 131
increased or absent threshold ... 104 | 128
increased circulating alkaline... 103 | 119
abnormal embryo size 101 | 112
decreased circulating glucose ... 98 | 121
decreased body length 96 | 108
decreased grip strength 96 | 123
increased lean body mass 91 | 107
abnormal retina morphology 89 | 100
hyperactivity 87 | 108
increased mean corpuscular hem... 86 | 93
enlarged heart 82 | 111
increased bone mineral content 81 | 92
increased mean corpuscular vol... 80 | 91
decreased circulating choleste... 77 | 85
hypoactivity 74 | 89
decreased circulating serum al... 70 | 79
short tibia 70 | 82
decreased circulating HDL chol... 69 | 77
decreased circulating triglyce... 69 | 83
increased grip strength 67 | 83
abnormal lens morphology 60 | 73
decreased circulating insulin ... 58 | 75
increased fasted circulating g... 57 | 68
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 54 | 62
abnormal retinal pigmentation 52 | 61
increased circulating sodium l... 52 | 71
increased sacral vertebrae num... 52 | 62
abnormal sleep behavior 50 | 63
decreased rib number 48 | 59
male infertility 48 | 62
decreased hemoglobin content 47 | 53
decreased leukocyte cell numbe... 47 | 54
increased total body fat amoun... 47 | 57
abnormal coat-hair pigmentatio... 46 | 54
decreased mean corpuscular vol... 46 | 50
abnormal bone mineralization 45 | 55
increased bone mineral density 45 | 52
decreased prepulse inhibition 44 | 52
increased circulating HDL chol... 44 | 63
increased circulating choleste... 42 | 53
decreased startle reflex 41 | 48
improved glucose tolerance 41 | 56
increased exploration in new e... 41 | 56
abnormal gait 40 | 51
decreased caudal vertebrae num... 40 | 49
impaired glucose tolerance 40 | 52
increased blood urea nitrogen ... 40 | 44
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
abnormal behavioral response t... 38 | 52
decreased circulating total pr... 38 | 41
decreased circulating alanine ... 37 | 53
increased body weight 37 | 42
thrombocytopenia 37 | 46
increased hemoglobin content 36 | 45
abnormal heart morphology 35 | 51
decreased circulating LDL chol... 35 | 37
decreased eosinophil cell numb... 35 | 41
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
increased rib number 33 | 41
abnormal eye morphology 32 | 38
decreased circulating alkaline... 32 | 41
decreased circulating free fat... 32 | 39
decreased neutrophil cell numb... 31 | 37
increased startle reflex 31 | 38
abnormal seminal vesicle morph... 30 | 47
decreased circulating calcium ... 30 | 33
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased leukocyte cell numbe... 29 | 37
small testis 29 | 37
tremors 29 | 34
cardiovascular system phenotyp... 28 | 35
decreased T cell number 27 | 31
increased circulating potassiu... 27 | 31
increased heart weight 27 | 37
limb grasping 27 | 35
increased circulating calcium ... 26 | 32
abnormal spleen morphology 25 | 36
decreased circulating creatini... 25 | 31
decreased threshold for audito... 25 | 32
corneal opacity 24 | 25
embryonic growth retardation 24 | 28
increased circulating iron lev... 24 | 25

Disease

ovarian cancer 7,478 | 8,491
osteosarcoma 6,618 | 7,933
medulloblastoma, large-cell 4,993 | 6,234
psoriasis 4,704 | 6,685
glioblastoma 4,593 | 5,572
lung cancer 3,897 | 4,473
atypical teratoid / rhabdoid tumor 3,528 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,892 | 3,289
malignant mesothelioma 2,732 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 2,641 | 2,956
Breast cancer 2,630 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,614 | 2,988
invasive ductal carcinoma 2,569 | 2,950
pilocytic astrocytoma 2,396 | 3,086
primitive neuroectodermal tumor 2,391 | 3,031
non-small cell lung cancer 2,321 | 2,798
oligodendroglioma 2,276 | 2,849
lung carcinoma 2,228 | 2,844
pediatric high grade glioma 2,177 | 2,712
lung adenocarcinoma 2,164 | 2,714
ependymoma 2,098 | 2,514
pancreatic cancer 1,950 | 2,300
subependymal giant cell astrocytoma 1,936 | 2,287
astrocytic glioma 1,836 | 2,241
group 3 medulloblastoma 1,831 | 2,254
interstitial cystitis 1,815 | 2,299
Cancer 1,776 | 2,346
ulcerative colitis 1,770 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 1,665 | 1,795
Pick disease 1,650 | 1,893
adult high grade glioma 1,650 | 2,148
group 4 medulloblastoma 1,620 | 1,875
pituitary cancer 1,564 | 1,972
Carcinoma 1,474 | 2,147
ductal carcinoma in situ 1,455 | 1,745
cystic fibrosis 1,379 | 1,670
breast carcinoma 1,346 | 1,614
tuberculosis 1,322 | 1,563
astrocytoma 1,294 | 1,493
Multiple myeloma 1,284 | 1,327
adrenocortical carcinoma 1,230 | 1,427
colon cancer 1,219 | 1,475
medulloblastoma 1,205 | 1,524
sonic hedgehog group medulloblastoma 1,201 | 1,482
posterior fossa group B ependymoma 1,190 | 1,530
primary pancreatic ductal adenocarcinoma 1,190 | 1,271
posterior fossa group A ependymoma 1,138 | 1,511
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,116 | 1,663
acute quadriplegic myopathy 1,076 | 1,157
Rheumatoid Arthritis 973 | 1,170
spina bifida 927 | 1,064
dermatomyositis 892 | 966
atypical teratoid/rhabdoid tumor 879 | 1,095
cutaneous lupus erythematosus 819 | 1,056
nasopharyngeal carcinoma 789 | 1,056
active Crohn's disease 776 | 918
gastric carcinoma 756 | 832
Waldenstrons macroglobulinemia 734 | 764
acute myeloid leukemia 719 | 785
non primary Sjogren syndrome sicca 682 | 840
Atopic dermatitis 657 | 944
primary Sjogren syndrome 646 | 788
tuberculosis and treatment for 6 months 636 | 686
aldosterone-producing adenoma 611 | 664
esophageal adenocarcinoma 604 | 737
progressive supranuclear palsy 599 | 674
Duchenne muscular dystrophy 545 | 602
Alzheimer's disease 507 | 644
pancreatic carcinoma 492 | 567
hepatocellular carcinoma 491 | 550
Down syndrome 481 | 548
Intellectual disability 468 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 499
fibroadenoma 459 | 557
Obesity 446 | 616
chronic rhinosinusitis 397 | 512
Prostatic Neoplasms 395 | 471
Endometriosis 391 | 535
active ulcerative colitis 389 | 477
gastric cancer 379 | 436
Amyotrophic Lateral Sclerosis 374 | 432
IGA Glomerulonephritis 373 | 454
mucosa-associated lymphoid tissue lymphoma 371 | 480
Mammary Neoplasms 334 | 410
Neurodegenerative disease 331 | 383
Schizophrenia 329 | 503
inflammatory breast cancer 321 | 404
nephrosclerosis 319 | 329
Multiple Sclerosis 316 | 498
hereditary spastic paraplegia 302 | 313
Kidney disease 294 | 397
tuberculosis and treatment for 3 months 290 | 327
sarcoidosis 289 | 368
non-small cell lung carcinoma 276 | 413
urothelial carcinoma 276 | 318
glioblastoma multiforme 273 | 347
Parkinson's disease 271 | 364
Polycystic Ovary Syndrome 259 | 334
interstitial lung disease 252 | 292

Tissue

Urinary Tract 13,341 | 18,443
Endocrine System 13,336 | 18,511
Digestive Tract 13,333 | 18,472
Nervous System 13,332 | 18,560
Female tissues 13,331 | 18,646
Liver and Pancreas 13,331 | 18,135
Skin and soft tissues 13,330 | 18,114
Male tissues 13,312 | 17,968
Cardiovascular System 13,311 | 17,957
Blood and immune system 13,306 | 17,994
Respiratory system 13,284 | 17,483

Target Family

Non-IDG 7,614 | 11,969
Enzyme 3,308 | 4,146
Transcription Factor 987 | 1,400
Kinase 532 | 634
Transporter 348 | 473
Epigenetic 213 | 242
Ion Channel 139 | 341
GPCR 130 | 408
Nuclear Receptor 37 | 48
TF/Epigenetic 30 | 38
oGPCR 3 | 421

HPA RNA Tissue

kidney 13,341 | 13,341
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Zinc finger protein 214 ZNF214 Tdark Transcription Factor -0.49369 2.48 88