Development Level

Tbio 10,230 | 11,651
Tdark 3,919 | 6,593
Tchem 1,253 | 1,388
Tclin 515 | 612

Collection

RFA-RM-18-021 242 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 68 | 99
GPCR: IDG Consortium (Targets) 60 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 954 | 979
preweaning lethality, incomple... 467 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 197 | 207
enlarged heart 189 | 210
decreased vertical activity 173 | 208
abnormal bone structure 168 | 187
increased lean body mass 164 | 172
decreased body weight 151 | 161
abnormal heart morphology 147 | 162
decreased bone mineral content 137 | 151
hyperactivity 131 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 124 | 134
decreased circulating glucose ... 119 | 126
decreased bone mineral density 113 | 126
hypoactivity 113 | 132
increased circulating alkaline... 109 | 122
decreased grip strength 105 | 116
male infertility 104 | 123
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
increased bone mineral content 100 | 108
abnormal seminal vesicle morph... 97 | 114
decreased body length 95 | 101
short tibia 94 | 97
increased mean corpuscular vol... 91 | 92
increased or absent threshold ... 91 | 101
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 87 | 96
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 80 | 83
decreased circulating serum al... 76 | 82
decreased circulating triglyce... 76 | 79
abnormal lens morphology 75 | 81
decreased prepulse inhibition 74 | 82
decreased mean corpuscular vol... 73 | 79
decreased circulating insulin ... 71 | 76
improved glucose tolerance 70 | 79
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
increased bone mineral density 69 | 72
decreased leukocyte cell numbe... 68 | 73
abnormal retina morphology 67 | 71
decreased startle reflex 67 | 75
abnormal eye morphology 64 | 68
decreased circulating HDL chol... 64 | 68
impaired glucose tolerance 64 | 75
small superior vagus ganglion 64 | 74
abnormal sleep behavior 63 | 70
decreased fasted circulating g... 62 | 65
decreased hemoglobin content 62 | 68
abnormal gait 61 | 69
increased circulating sodium l... 61 | 71
abnormal coat-hair pigmentatio... 60 | 64
increased circulating choleste... 60 | 66
abnormal behavioral response t... 59 | 66
abnormal kidney morphology 59 | 65
decreased erythrocyte cell num... 59 | 62
edema 57 | 59
increased monocyte cell number 57 | 63
increased heart weight 54 | 62
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 53 | 56
abnormal spleen morphology 50 | 55
female infertility 50 | 60
decreased circulating total pr... 48 | 49
abnormal skin morphology 47 | 50
decreased blood urea nitrogen ... 46 | 51
increased blood urea nitrogen ... 46 | 48
abnormal neural tube closure 45 | 46
decreased circulating alkaline... 45 | 46
decreased mean corpuscular hem... 45 | 50
hydrometra 44 | 53
increased neutrophil cell numb... 44 | 46
decreased circulating alanine ... 43 | 47
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
increased hemoglobin content 40 | 45
decreased red blood cell distr... 39 | 41
abnormal testis morphology 38 | 43
decreased circulating LDL chol... 38 | 38
increased circulating triglyce... 38 | 42
enlarged spleen 37 | 41
increased circulating creatini... 37 | 38
increased mean platelet volume 37 | 45
limb grasping 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
cardiovascular system phenotyp... 36 | 36
decreased neutrophil cell numb... 36 | 42
increased grip strength 36 | 41
increased erythrocyte cell num... 35 | 39

Disease

Carcinoma 9,735 | 11,493
ovarian cancer 8,105 | 8,520
osteosarcoma 7,371 | 7,950
medulloblastoma, large-cell 5,747 | 6,241
psoriasis 5,676 | 6,694
glioblastoma 5,432 | 5,792
atypical teratoid / rhabdoid tumor 4,754 | 5,112
lung cancer 4,468 | 4,740
ependymoma 4,334 | 4,679
group 3 medulloblastoma 3,825 | 4,104
adult high grade glioma 3,475 | 3,801
Breast cancer 3,368 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,181 | 3,291
malignant mesothelioma 3,093 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,899 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,874 | 2,955
invasive ductal carcinoma 2,869 | 2,951
Astrocytoma, Pilocytic 2,835 | 3,081
primitive neuroectodermal tumor 2,819 | 3,035
non-small cell lung cancer 2,746 | 2,890
lung carcinoma 2,669 | 2,843
oligodendroglioma 2,643 | 2,850
lung adenocarcinoma 2,557 | 2,716
astrocytic glioma 2,421 | 2,597
Kidney cancer 2,294 | 2,613
pancreatic cancer 2,270 | 2,398
interstitial cystitis 2,196 | 2,312
Cancer 2,192 | 2,499
subependymal giant cell astrocytoma 2,156 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,925 | 1,962
tuberculosis 1,892 | 2,010
pituitary cancer 1,825 | 1,972
Pick disease 1,819 | 1,894
group 4 medulloblastoma 1,759 | 1,855
ulcerative colitis 1,722 | 1,819
ductal carcinoma in situ 1,687 | 1,745
cystic fibrosis 1,582 | 1,696
breast carcinoma 1,568 | 1,638
colon cancer 1,411 | 1,478
adrenocortical carcinoma 1,387 | 1,428
diabetes mellitus 1,335 | 1,728
Multiple myeloma 1,303 | 1,332
Autosomal recessive predisposition 1,300 | 1,442
juvenile dermatomyositis 1,160 | 1,187
acute quadriplegic myopathy 1,131 | 1,158
astrocytoma 1,100 | 1,146
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
Rheumatoid arthritis 1,076 | 1,191
spina bifida 1,011 | 1,074
pediatric high grade glioma 1,008 | 1,064
cutaneous lupus erythematosus 993 | 1,057
Schizophrenia 984 | 1,160
nasopharyngeal carcinoma 961 | 1,058
Intellectual disability 940 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 881 | 922
Atopic dermatitis 841 | 952
non primary Sjogren syndrome sicca 808 | 891
gastric carcinoma 781 | 807
acute myeloid leukemia 765 | 783
Waldenstrons macroglobulinemia 751 | 765
Liver Cirrhosis, Experimental 743 | 769
active ulcerative colitis 716 | 764
Epilepsy 715 | 792
primary Sjogren syndrome 708 | 735
esophageal adenocarcinoma 686 | 737
medulloblastoma 674 | 720
progressive supranuclear palsy 651 | 676
aldosterone-producing adenoma 649 | 665
Alzheimer's disease 602 | 658
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Obesity 589 | 678
Duchenne muscular dystrophy 577 | 601
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Melanoma 573 | 711
Mental and motor retardation 573 | 608
Bipolar Disorder 558 | 666
Seizures 546 | 596
fibroadenoma 542 | 559
pancreatic carcinoma 540 | 562
Muscle hypotonia 532 | 571
hepatocellular carcinoma 532 | 547
Liver cancer 504 | 604
Endometriosis 503 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Short stature 485 | 531
chronic rhinosinusitis 474 | 512
Down syndrome 470 | 499
Prostatic Neoplasms 459 | 495
Multiple Sclerosis 447 | 540
posterior fossa group A ependymoma 447 | 468
gastric cancer 445 | 459
mucosa-associated lymphoid tissue lymphoma 443 | 484
sonic hedgehog group medulloblastoma 438 | 467
Amyotrophic lateral sclerosis 429 | 451

Tissue

Urinary Tract 15,917 | 16,678
Endocrine System 15,857 | 18,159
Digestive Tract 15,776 | 17,369
Female tissues 15,773 | 17,400
Male tissues 15,732 | 17,142
Skin and soft tissues 15,727 | 17,230
Liver and Pancreas 15,643 | 16,750
Blood and immune system 15,544 | 16,909
Nervous System 15,499 | 16,725
Respiratory system 15,445 | 16,393
Cardiovascular System 14,706 | 15,192

Target Family

Non-IDG 9,236 | 12,091
Enzyme 3,710 | 4,145
Transcription Factor 1,145 | 1,400
Kinase 594 | 634
Transporter 411 | 473
GPCR 253 | 408
Ion Channel 244 | 344
Epigenetic 230 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 14 | 421

HPA RNA Tissue

kidney 15,917 | 15,917
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50