Development Level

Tbio 8,073 | 10,625
Tdark 3,465 | 7,003
Tchem 1,422 | 1,890
Tclin 382 | 602

Collection

Eligible Kinase Proteins 102 | 134
Eligible Ion Channel Proteins 42 | 117
Eligible non-olfactory GPCR Proteins 33 | 143

IMPC Term

preweaning lethality, complete... 579 | 633
preweaning lethality, incomple... 216 | 260
abnormal behavior 192 | 226
embryonic lethality prior to t... 173 | 187
decreased lean body mass 169 | 195
decreased total body fat amoun... 166 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 142 | 148
decreased bone mineral content 135 | 157
decreased bone mineral density 107 | 126
abnormal bone structure 105 | 131
increased or absent threshold ... 104 | 128
increased circulating alkaline... 103 | 119
abnormal embryo size 101 | 112
decreased circulating glucose ... 98 | 121
decreased body length 96 | 108
decreased grip strength 96 | 123
increased lean body mass 91 | 107
abnormal retina morphology 89 | 100
hyperactivity 87 | 108
increased mean corpuscular hem... 86 | 93
enlarged heart 82 | 111
increased bone mineral content 81 | 92
increased mean corpuscular vol... 80 | 91
decreased circulating choleste... 77 | 85
hypoactivity 74 | 89
decreased circulating serum al... 70 | 79
short tibia 70 | 82
decreased circulating HDL chol... 69 | 77
decreased circulating triglyce... 69 | 83
increased grip strength 67 | 83
abnormal lens morphology 60 | 73
decreased circulating insulin ... 58 | 75
increased fasted circulating g... 57 | 68
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 54 | 62
abnormal retinal pigmentation 52 | 61
increased circulating sodium l... 52 | 71
increased sacral vertebrae num... 52 | 62
abnormal sleep behavior 50 | 63
decreased rib number 48 | 59
male infertility 48 | 62
decreased hemoglobin content 47 | 53
decreased leukocyte cell numbe... 47 | 54
increased total body fat amoun... 47 | 57
abnormal coat/hair pigmentatio... 46 | 54
decreased mean corpuscular vol... 46 | 50
abnormal bone mineralization 45 | 55
increased bone mineral density 45 | 52
decreased prepulse inhibition 44 | 52
increased circulating HDL chol... 44 | 63
increased circulating choleste... 42 | 53
decreased startle reflex 41 | 48
improved glucose tolerance 41 | 56
increased exploration in new e... 41 | 56
abnormal gait 40 | 51
decreased caudal vertebrae num... 40 | 49
impaired glucose tolerance 40 | 52
increased blood urea nitrogen ... 40 | 44
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
abnormal behavioral response t... 38 | 52
decreased circulating total pr... 38 | 41
decreased circulating alanine ... 37 | 53
increased body weight 37 | 42
thrombocytopenia 37 | 46
increased hemoglobin content 36 | 45
abnormal heart morphology 35 | 51
decreased circulating LDL chol... 35 | 37
decreased eosinophil cell numb... 35 | 41
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
increased rib number 33 | 41
abnormal eye morphology 32 | 38
decreased circulating alkaline... 32 | 41
decreased circulating free fat... 32 | 39
decreased neutrophil cell numb... 31 | 37
increased startle reflex 31 | 38
abnormal seminal vesicle morph... 30 | 47
decreased circulating calcium ... 30 | 33
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased leukocyte cell numbe... 29 | 37
small testis 29 | 37
tremors 29 | 34
cardiovascular system phenotyp... 28 | 35
decreased T cell number 27 | 31
increased circulating potassiu... 27 | 31
increased heart weight 27 | 37
limb grasping 27 | 35
increased circulating calcium ... 26 | 32
abnormal spleen morphology 25 | 36
decreased circulating creatini... 25 | 31
decreased threshold for audito... 25 | 32
corneal opacity 24 | 25
embryonic growth retardation 24 | 28
increased circulating iron lev... 24 | 25

Disease

ovarian cancer 7,473 | 8,484
osteosarcoma 6,618 | 7,933
medulloblastoma, large-cell 4,993 | 6,234
psoriasis 4,704 | 6,685
glioblastoma 4,593 | 5,572
lung cancer 3,893 | 4,466
atypical teratoid / rhabdoid tumor 3,528 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,892 | 3,289
malignant mesothelioma 2,731 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 2,641 | 2,956
Breast cancer 2,627 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,614 | 2,988
invasive ductal carcinoma 2,569 | 2,950
pilocytic astrocytoma 2,396 | 3,086
primitive neuroectodermal tumor 2,391 | 3,031
non-small cell lung cancer 2,321 | 2,798
oligodendroglioma 2,276 | 2,849
lung carcinoma 2,228 | 2,844
pediatric high grade glioma 2,177 | 2,712
lung adenocarcinoma 2,163 | 2,713
ependymoma 2,098 | 2,514
pancreatic cancer 1,950 | 2,300
subependymal giant cell astrocytoma 1,936 | 2,287
astrocytic glioma 1,836 | 2,241
group 3 medulloblastoma 1,831 | 2,254
interstitial cystitis 1,815 | 2,299
Cancer 1,776 | 2,346
ulcerative colitis 1,770 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 1,665 | 1,795
Pick disease 1,650 | 1,893
adult high grade glioma 1,650 | 2,148
group 4 medulloblastoma 1,620 | 1,875
pituitary cancer 1,564 | 1,972
Carcinoma 1,474 | 2,147
ductal carcinoma in situ 1,455 | 1,745
cystic fibrosis 1,376 | 1,665
breast carcinoma 1,346 | 1,614
tuberculosis 1,317 | 1,557
astrocytoma 1,294 | 1,493
Multiple myeloma 1,285 | 1,327
adrenocortical carcinoma 1,230 | 1,427
colon cancer 1,219 | 1,475
medulloblastoma 1,205 | 1,524
sonic hedgehog group medulloblastoma 1,201 | 1,482
posterior fossa group B ependymoma 1,190 | 1,530
primary pancreatic ductal adenocarcinoma 1,190 | 1,271
posterior fossa group A ependymoma 1,138 | 1,511
juvenile dermatomyositis 1,120 | 1,189
diabetes mellitus 1,116 | 1,663
acute quadriplegic myopathy 1,076 | 1,157
Rheumatoid Arthritis 973 | 1,160
spina bifida 927 | 1,064
dermatomyositis 892 | 933
atypical teratoid/rhabdoid tumor 879 | 1,095
cutaneous lupus erythematosus 819 | 1,056
nasopharyngeal carcinoma 789 | 1,056
active Crohn's disease 776 | 918
gastric carcinoma 756 | 832
Waldenstrons macroglobulinemia 735 | 765
acute myeloid leukemia 715 | 780
non primary Sjogren syndrome sicca 682 | 840
Atopic dermatitis 657 | 944
primary Sjogren syndrome 647 | 789
tuberculosis and treatment for 6 months 636 | 686
aldosterone-producing adenoma 611 | 664
esophageal adenocarcinoma 604 | 737
progressive supranuclear palsy 599 | 674
Duchenne muscular dystrophy 545 | 602
Alzheimer's disease 507 | 644
pancreatic carcinoma 492 | 567
Down syndrome 481 | 548
hepatocellular carcinoma 474 | 532
Intellectual disability 468 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 466 | 499
fibroadenoma 459 | 557
Obesity 446 | 616
chronic rhinosinusitis 397 | 512
Prostatic Neoplasms 395 | 471
Endometriosis 391 | 535
active ulcerative colitis 389 | 477
Amyotrophic Lateral Sclerosis 374 | 431
IGA Glomerulonephritis 373 | 454
gastric cancer 373 | 430
mucosa-associated lymphoid tissue lymphoma 371 | 480
Mammary Neoplasms 334 | 410
Neurodegenerative disease 331 | 383
Schizophrenia 327 | 501
inflammatory breast cancer 321 | 404
nephrosclerosis 319 | 329
Multiple Sclerosis 316 | 498
hereditary spastic paraplegia 302 | 313
Kidney disease 293 | 396
tuberculosis and treatment for 3 months 290 | 327
sarcoidosis 289 | 358
non-small cell lung carcinoma 276 | 413
urothelial carcinoma 276 | 318
glioblastoma multiforme 273 | 347
Parkinson's disease 271 | 364
Polycystic Ovary Syndrome 260 | 332
interstitial lung disease 251 | 291

Tissue

Urinary Tract 13,342 | 18,444
Endocrine System 13,337 | 18,512
Digestive Tract 13,334 | 18,473
Nervous System 13,333 | 18,561
Female tissues 13,332 | 18,647
Liver and Pancreas 13,332 | 18,136
Skin and soft tissues 13,331 | 18,115
Male tissues 13,313 | 17,969
Cardiovascular System 13,312 | 17,958
Blood and immune system 13,307 | 17,995
Respiratory system 13,285 | 17,484

Target Family

Non-IDG 7,614 | 11,971
Enzyme 3,309 | 4,146
Transcription Factor 987 | 1,400
Kinase 532 | 634
Transporter 348 | 473
Epigenetic 213 | 242
Ion Channel 139 | 341
GPCR 130 | 406
Nuclear Receptor 37 | 48
TF/Epigenetic 30 | 38
oGPCR 3 | 421

HPA RNA Tissue

kidney 13,342 | 13,342
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108