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Target Filters...

Development Level

Tbio 7,698 | 10,625
Tdark 3,197 | 7,003
Tchem 1,352 | 1,890
Tclin 355 | 602

Collection

Eligible Kinase Proteins 97 | 134
Eligible Ion Channel Proteins 36 | 117
Eligible non-olfactory GPCR Proteins 25 | 145

IMPC Term

preweaning lethality, complete... 561 | 633
preweaning lethality, incomple... 205 | 260
abnormal behavior 192 | 226
embryonic lethality prior to t... 171 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 159 | 186
decreased body weight 148 | 174
embryonic lethality prior to o... 139 | 148
decreased bone mineral content 129 | 157
abnormal bone structure 104 | 131
decreased bone mineral density 101 | 126
increased circulating alkaline... 101 | 119
abnormal embryo size 98 | 112
decreased body length 95 | 108
increased or absent threshold ... 94 | 128
decreased grip strength 93 | 123
hyperactivity 92 | 108
decreased circulating glucose ... 90 | 121
increased lean body mass 89 | 107
abnormal retina morphology 84 | 100
increased bone mineral content 80 | 92
increased mean corpuscular hem... 79 | 93
increased mean corpuscular vol... 79 | 91
enlarged heart 74 | 111
short tibia 72 | 82
decreased circulating choleste... 70 | 85
hypoactivity 69 | 89
decreased circulating HDL chol... 68 | 77
decreased circulating serum al... 68 | 79
increased grip strength 66 | 83
decreased circulating triglyce... 64 | 83
abnormal lens morphology 58 | 73
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 55 | 62
increased fasted circulating g... 51 | 68
increased sacral vertebrae num... 51 | 62
decreased circulating insulin ... 50 | 75
abnormal retinal pigmentation 48 | 61
abnormal sleep behavior 47 | 63
decreased rib number 47 | 59
increased circulating sodium l... 47 | 71
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
increased total body fat amoun... 45 | 57
decreased hemoglobin content 44 | 53
male infertility 44 | 62
abnormal bone mineralization 43 | 55
increased bone mineral density 43 | 52
improved glucose tolerance 42 | 56
increased circulating choleste... 42 | 53
abnormal coat/hair pigmentatio... 41 | 54
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 41 | 52
increased circulating HDL chol... 41 | 63
abnormal gait 40 | 51
decreased circulating alanine ... 40 | 53
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
decreased caudal vertebrae num... 38 | 49
increased exploration in new e... 38 | 56
decreased circulating total pr... 37 | 41
thrombocytopenia 37 | 46
abnormal behavioral response t... 36 | 52
decreased startle reflex 36 | 48
increased blood urea nitrogen ... 36 | 44
increased body weight 35 | 42
decreased heart weight 34 | 44
increased hemoglobin content 34 | 45
increased rib number 34 | 41
decreased circulating LDL chol... 33 | 37
abnormal neural tube closure 32 | 37
decreased eosinophil cell numb... 31 | 41
abnormal eye morphology 30 | 38
decreased circulating free fat... 30 | 39
decreased mean corpuscular hem... 30 | 34
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
abnormal heart morphology 29 | 51
decreased circulating alkaline... 29 | 41
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased startle reflex 29 | 38
abnormal seminal vesicle morph... 28 | 47
decreased T cell number 28 | 31
increased heart weight 28 | 37
increased leukocyte cell numbe... 28 | 37
tremors 28 | 34
cardiovascular system phenotyp... 27 | 35
decreased circulating calcium ... 27 | 33
decreased circulating creatini... 27 | 31
abnormal cranium morphology 26 | 32
limb grasping 26 | 35
small testis 26 | 37
increased circulating potassiu... 25 | 31
decreased circulating chloride... 24 | 32
decreased threshold for audito... 24 | 32
abnormal rib morphology 23 | 28
abnormal spleen morphology 23 | 36
decreased circulating aspartat... 23 | 27
embryonic growth retardation 23 | 28

Disease

ovarian cancer 7,222 | 8,492
osteosarcoma 6,362 | 7,933
medulloblastoma, large-cell 4,827 | 6,234
glioblastoma 4,445 | 5,572
psoriasis 4,424 | 6,685
lung cancer 3,762 | 4,473
atypical teratoid / rhabdoid tumor 3,422 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,690 | 3,289
malignant mesothelioma 2,609 | 3,163
Breast cancer 2,501 | 3,099
intraductal papillary-mucinous adenoma (IPMA) 2,465 | 2,956
invasive ductal carcinoma 2,463 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,451 | 2,988
pilocytic astrocytoma 2,301 | 3,086
primitive neuroectodermal tumor 2,292 | 3,031
oligodendroglioma 2,216 | 2,849
non-small cell lung cancer 2,160 | 2,798
lung carcinoma 2,101 | 2,844
pediatric high grade glioma 2,090 | 2,712
ependymoma 2,053 | 2,514
lung adenocarcinoma 2,012 | 2,714
subependymal giant cell astrocytoma 1,916 | 2,287
pancreatic cancer 1,791 | 2,300
astrocytic glioma 1,785 | 2,241
group 3 medulloblastoma 1,769 | 2,254
Cancer 1,659 | 2,346
interstitial cystitis 1,652 | 2,299
Pick disease 1,634 | 1,893
ulcerative colitis 1,624 | 2,087
adult high grade glioma 1,590 | 2,148
group 4 medulloblastoma 1,579 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,542 | 1,795
pituitary cancer 1,476 | 1,972
Carcinoma 1,433 | 2,147
ductal carcinoma in situ 1,359 | 1,745
breast carcinoma 1,298 | 1,614
Multiple myeloma 1,286 | 1,328
cystic fibrosis 1,284 | 1,670
tuberculosis 1,279 | 1,563
astrocytoma 1,276 | 1,493
adrenocortical carcinoma 1,180 | 1,427
medulloblastoma 1,166 | 1,524
sonic hedgehog group medulloblastoma 1,159 | 1,482
colon cancer 1,149 | 1,475
primary pancreatic ductal adenocarcinoma 1,139 | 1,271
juvenile dermatomyositis 1,124 | 1,189
acute quadriplegic myopathy 1,104 | 1,157
posterior fossa group B ependymoma 1,096 | 1,530
diabetes mellitus 1,089 | 1,663
posterior fossa group A ependymoma 1,075 | 1,511
Rheumatoid Arthritis 944 | 1,171
dermatomyositis 903 | 967
atypical teratoid/rhabdoid tumor 829 | 1,095
spina bifida 826 | 1,064
cutaneous lupus erythematosus 765 | 1,056
Waldenstrons macroglobulinemia 730 | 765
gastric carcinoma 724 | 832
acute myeloid leukemia 715 | 785
nasopharyngeal carcinoma 681 | 1,056
active Crohn's disease 676 | 918
non primary Sjogren syndrome sicca 639 | 840
primary Sjogren syndrome 636 | 789
tuberculosis and treatment for 6 months 629 | 686
Atopic dermatitis 621 | 944
aldosterone-producing adenoma 601 | 664
progressive supranuclear palsy 595 | 674
Duchenne muscular dystrophy 566 | 602
esophageal adenocarcinoma 552 | 737
Alzheimer's disease 500 | 644
hepatocellular carcinoma 487 | 550
pancreatic carcinoma 479 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 499
Down syndrome 462 | 548
Intellectual disability 453 | 573
fibroadenoma 432 | 557
Obesity 425 | 616
Amyotrophic Lateral Sclerosis 381 | 432
gastric cancer 367 | 436
IGA Glomerulonephritis 361 | 454
Prostatic Neoplasms 359 | 471
mucosa-associated lymphoid tissue lymphoma 357 | 480
chronic rhinosinusitis 354 | 512
active ulcerative colitis 333 | 477
Neurodegenerative disease 331 | 383
Endometriosis 329 | 535
Schizophrenia 322 | 503
Mammary Neoplasms 312 | 410
hereditary spastic paraplegia 309 | 313
Multiple Sclerosis 308 | 498
inflammatory breast cancer 303 | 404
sarcoidosis 277 | 368
tuberculosis and treatment for 3 months 272 | 327
glioblastoma multiforme 268 | 347
Parkinson's disease 260 | 364
Polycystic Ovary Syndrome 253 | 335
non-small cell lung carcinoma 253 | 413
Kidney disease 248 | 397
urothelial carcinoma 244 | 318
interstitial lung disease 243 | 292
Stomach Neoplasms 229 | 282

Tissue

Cardiovascular System 12,602 | 17,958
Endocrine System 12,601 | 18,512
Female tissues 12,601 | 18,647
Digestive Tract 12,599 | 18,473
Nervous System 12,599 | 18,561
Liver and Pancreas 12,597 | 18,136
Skin and soft tissues 12,596 | 18,115
Urinary Tract 12,593 | 18,444
Male tissues 12,585 | 17,969
Blood and immune system 12,584 | 17,995
Respiratory system 12,580 | 17,484

Target Family

Non-IDG 7,256 | 11,969
Enzyme 3,122 | 4,146
Transcription Factor 906 | 1,400
Kinase 505 | 634
Transporter 279 | 473
Epigenetic 212 | 242
Ion Channel 131 | 341
GPCR 124 | 408
Nuclear Receptor 35 | 48
TF/Epigenetic 31 | 38
oGPCR 1 | 421

HPA RNA Tissue

heart muscle 12,602 | 12,602
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11