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Development Level

Tbio 9,732 | 11,651
Tdark 3,587 | 6,593
Tchem 1,184 | 1,388
Tclin 469 | 612

Collection

RFA-RM-18-021 224 | 328
Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 58 | 99
GPCR: IDG Consortium (Targets) 53 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 932 | 979
preweaning lethality, incomple... 439 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 266 | 298
embryonic lethality prior to o... 234 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 184 | 207
enlarged heart 169 | 210
abnormal bone structure 163 | 187
decreased vertical activity 160 | 208
increased lean body mass 154 | 172
decreased body weight 145 | 161
abnormal heart morphology 135 | 162
decreased bone mineral content 134 | 151
hyperactivity 131 | 148
decreased lean body mass 121 | 135
increased total body fat amoun... 117 | 134
hypoactivity 114 | 132
decreased bone mineral density 108 | 126
decreased circulating glucose ... 107 | 126
increased circulating alkaline... 105 | 122
embryonic growth retardation 101 | 106
decreased grip strength 98 | 116
increased startle reflex 98 | 112
male infertility 97 | 123
abnormal seminal vesicle morph... 94 | 114
increased bone mineral content 94 | 108
decreased body length 90 | 101
increased mean corpuscular vol... 89 | 92
short tibia 88 | 97
increased mean corpuscular hem... 84 | 96
increased or absent threshold ... 84 | 101
decreased circulating choleste... 83 | 93
cataract 82 | 92
prenatal lethality prior to he... 80 | 87
abnormal lens morphology 73 | 81
decreased lymphocyte cell numb... 73 | 83
decreased circulating serum al... 71 | 82
decreased prepulse inhibition 71 | 82
decreased mean corpuscular vol... 70 | 79
increased bone mineral density 70 | 72
improved glucose tolerance 69 | 79
decreased circulating triglyce... 68 | 79
decreased startle reflex 67 | 75
decreased leukocyte cell numbe... 65 | 73
impaired glucose tolerance 65 | 75
increased circulating HDL chol... 65 | 80
increased fasted circulating g... 64 | 76
abnormal retina morphology 63 | 71
decreased circulating HDL chol... 62 | 68
abnormal eye morphology 61 | 68
abnormal gait 61 | 69
decreased circulating insulin ... 61 | 76
small superior vagus ganglion 60 | 74
abnormal sleep behavior 59 | 70
decreased fasted circulating g... 59 | 65
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
decreased hemoglobin content 58 | 68
increased circulating sodium l... 57 | 71
abnormal kidney morphology 56 | 65
edema 55 | 59
increased circulating choleste... 55 | 66
increased monocyte cell number 55 | 63
abnormal behavioral response t... 54 | 66
increased heart weight 53 | 62
decreased caudal vertebrae num... 51 | 53
small testis 50 | 58
thrombocytopenia 50 | 56
abnormal spleen morphology 47 | 55
decreased circulating total pr... 47 | 49
female infertility 47 | 60
abnormal skin morphology 45 | 50
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 43 | 46
decreased circulating alanine ... 43 | 47
increased hematocrit 43 | 46
decreased blood urea nitrogen ... 42 | 51
decreased circulating alkaline... 42 | 46
decreased hematocrit 42 | 46
hydrometra 41 | 53
increased blood urea nitrogen ... 40 | 48
increased leukocyte cell numbe... 40 | 47
increased neutrophil cell numb... 40 | 46
decreased neutrophil cell numb... 38 | 42
increased hemoglobin content 38 | 45
abnormal testis morphology 37 | 43
decreased circulating LDL chol... 37 | 38
enlarged spleen 37 | 41
increased circulating triglyce... 37 | 42
increased mean platelet volume 37 | 45
decreased red blood cell distr... 36 | 41
tremors 36 | 39
abnormal bone mineralization 34 | 38
abnormal epididymis morphology 34 | 42
decreased circulating creatini... 34 | 39
increased circulating chloride... 34 | 41
increased grip strength 34 | 41
increased erythrocyte cell num... 33 | 39
pallor 33 | 34

Disease

Carcinoma 9,172 | 11,493
ovarian cancer 7,909 | 8,520
osteosarcoma 7,199 | 7,950
medulloblastoma, large-cell 5,545 | 6,241
psoriasis 5,318 | 6,694
glioblastoma 5,255 | 5,792
atypical teratoid / rhabdoid tumor 4,599 | 5,112
lung cancer 4,339 | 4,740
ependymoma 4,153 | 4,679
group 3 medulloblastoma 3,691 | 4,104
adult high grade glioma 3,321 | 3,801
Breast cancer 3,241 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,053 | 3,291
malignant mesothelioma 3,004 | 3,232
invasive ductal carcinoma 2,807 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,788 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,750 | 2,955
primitive neuroectodermal tumor 2,734 | 3,035
Astrocytoma, Pilocytic 2,701 | 3,081
non-small cell lung cancer 2,638 | 2,890
oligodendroglioma 2,528 | 2,850
lung carcinoma 2,523 | 2,843
lung adenocarcinoma 2,423 | 2,716
astrocytic glioma 2,324 | 2,597
pancreatic cancer 2,171 | 2,398
Kidney cancer 2,163 | 2,613
subependymal giant cell astrocytoma 2,105 | 2,287
Cancer 2,090 | 2,499
interstitial cystitis 2,074 | 2,312
tuberculosis 1,865 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,822 | 1,962
Pick disease 1,759 | 1,894
pituitary cancer 1,744 | 1,972
group 4 medulloblastoma 1,709 | 1,855
ulcerative colitis 1,649 | 1,819
ductal carcinoma in situ 1,646 | 1,745
breast carcinoma 1,526 | 1,638
cystic fibrosis 1,524 | 1,696
adrenocortical carcinoma 1,356 | 1,428
colon cancer 1,339 | 1,478
Multiple myeloma 1,298 | 1,332
diabetes mellitus 1,268 | 1,728
Autosomal recessive predisposition 1,212 | 1,442
juvenile dermatomyositis 1,155 | 1,187
acute quadriplegic myopathy 1,129 | 1,158
astrocytoma 1,083 | 1,146
primary pancreatic ductal adenocarcinoma 1,066 | 1,109
Rheumatoid arthritis 1,050 | 1,191
pediatric high grade glioma 984 | 1,064
spina bifida 978 | 1,074
cutaneous lupus erythematosus 952 | 1,057
dermatomyositis 918 | 966
Schizophrenia 916 | 1,160
nasopharyngeal carcinoma 894 | 1,058
Intellectual disability 893 | 1,016
active Crohn's disease 817 | 922
Atopic dermatitis 808 | 952
non primary Sjogren syndrome sicca 781 | 891
acute myeloid leukemia 763 | 783
Waldenstrons macroglobulinemia 755 | 765
gastric carcinoma 752 | 807
Liver Cirrhosis, Experimental 704 | 769
primary Sjogren syndrome 703 | 735
Epilepsy 679 | 792
active ulcerative colitis 652 | 764
medulloblastoma 649 | 720
esophageal adenocarcinoma 643 | 737
progressive supranuclear palsy 638 | 676
aldosterone-producing adenoma 635 | 665
Alzheimer's disease 579 | 658
Duchenne muscular dystrophy 578 | 601
Dull intelligence 569 | 645
Low intelligence 569 | 645
Mental Retardation 569 | 645
Mental deficiency 569 | 645
Poor school performance 569 | 645
Cognitive delay 557 | 608
Global developmental delay 557 | 608
Mental and motor retardation 557 | 608
Obesity 548 | 678
pancreatic carcinoma 536 | 562
hepatocellular carcinoma 527 | 547
fibroadenoma 524 | 559
Muscle hypotonia 523 | 571
Seizures 518 | 596
Bipolar Disorder 516 | 666
Melanoma 508 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Liver cancer 468 | 604
Short stature 467 | 531
Endometriosis 464 | 540
Down syndrome 458 | 499
gastric cancer 444 | 459
mucosa-associated lymphoid tissue lymphoma 435 | 484
Prostatic Neoplasms 431 | 495
chronic rhinosinusitis 431 | 512
Multiple Sclerosis 430 | 540
sonic hedgehog group medulloblastoma 428 | 467
Amyotrophic lateral sclerosis 420 | 451
posterior fossa group A ependymoma 420 | 468

Tissue

Cardiovascular System 14,972 | 15,192
Endocrine System 14,958 | 18,159
Digestive Tract 14,929 | 17,369
Female tissues 14,924 | 17,400
Skin and soft tissues 14,919 | 17,230
Male tissues 14,873 | 17,142
Liver and Pancreas 14,858 | 16,750
Urinary Tract 14,818 | 16,678
Blood and immune system 14,808 | 16,909
Nervous System 14,744 | 16,725
Respiratory system 14,737 | 16,393

Target Family

Non-IDG 8,708 | 12,091
Enzyme 3,506 | 4,145
Transcription Factor 1,080 | 1,400
Kinase 577 | 634
Transporter 350 | 473
Epigenetic 228 | 242
GPCR 225 | 408
Ion Channel 212 | 344
Nuclear Receptor 41 | 48
TF/Epigenetic 34 | 38
oGPCR 11 | 421

HPA RNA Tissue

heart muscle 14,972 | 14,972
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50