1. Home
  2. Targets
Target Filters...

Development Level

Tbio 7,698 | 10,625
Tdark 3,197 | 7,003
Tchem 1,351 | 1,890
Tclin 355 | 602

Collection

Kinase: IDG Consortium (Targets) 91 | 125
Ion Channel: IDG Consortium (Targets) 37 | 102
Kinase: IDG Consortium (Complete/Control) 28 | 37
GPCR: IDG Consortium (Targets) 24 | 128
GPCR: IDG Consortium (Complete/Control) 9 | 24

IMPC Phenotype

preweaning lethality, complete... 561 | 633
preweaning lethality, incomple... 205 | 260
abnormal behavior 192 | 226
embryonic lethality prior to t... 171 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 159 | 186
decreased body weight 148 | 174
embryonic lethality prior to o... 139 | 148
decreased bone mineral content 129 | 157
abnormal bone structure 104 | 131
decreased bone mineral density 101 | 126
increased circulating alkaline... 101 | 119
abnormal embryo size 98 | 112
decreased body length 95 | 108
increased or absent threshold ... 94 | 128
decreased grip strength 93 | 123
hyperactivity 92 | 108
decreased circulating glucose ... 90 | 121
increased lean body mass 89 | 107
abnormal retina morphology 84 | 100
increased bone mineral content 80 | 92
increased mean corpuscular hem... 79 | 93
increased mean corpuscular vol... 79 | 91
enlarged heart 74 | 111
short tibia 72 | 82
decreased circulating choleste... 70 | 85
hypoactivity 69 | 89
decreased circulating HDL chol... 68 | 77
decreased circulating serum al... 68 | 79
increased grip strength 66 | 83
decreased circulating triglyce... 64 | 83
abnormal lens morphology 58 | 73
prenatal lethality prior to he... 57 | 64
decreased lumbar vertebrae num... 55 | 62
increased fasted circulating g... 51 | 68
increased sacral vertebrae num... 51 | 62
decreased circulating insulin ... 50 | 75
abnormal retinal pigmentation 48 | 61
abnormal sleep behavior 47 | 63
decreased rib number 47 | 59
increased circulating sodium l... 47 | 71
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
increased total body fat amoun... 45 | 57
decreased hemoglobin content 44 | 53
male infertility 44 | 62
abnormal bone mineralization 43 | 55
increased bone mineral density 43 | 52
improved glucose tolerance 42 | 56
increased circulating choleste... 42 | 53
abnormal coat-hair pigmentatio... 41 | 54
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 41 | 52
increased circulating HDL chol... 41 | 63
abnormal gait 40 | 51
decreased circulating alanine ... 40 | 53
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
decreased caudal vertebrae num... 38 | 49
increased exploration in new e... 38 | 56
decreased circulating total pr... 37 | 41
thrombocytopenia 37 | 46
abnormal behavioral response t... 36 | 52
decreased startle reflex 36 | 48
increased blood urea nitrogen ... 36 | 44
increased body weight 35 | 42
decreased heart weight 34 | 44
increased hemoglobin content 34 | 45
increased rib number 34 | 41
decreased circulating LDL chol... 33 | 37
abnormal neural tube closure 32 | 37
decreased eosinophil cell numb... 31 | 41
abnormal eye morphology 30 | 38
decreased circulating free fat... 30 | 39
decreased mean corpuscular hem... 30 | 34
decreased neutrophil cell numb... 30 | 37
increased hematocrit 30 | 36
abnormal heart morphology 29 | 51
decreased circulating alkaline... 29 | 41
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased startle reflex 29 | 38
abnormal seminal vesicle morph... 28 | 47
decreased T cell number 28 | 31
increased heart weight 28 | 37
increased leukocyte cell numbe... 28 | 37
tremors 28 | 34
cardiovascular system phenotyp... 27 | 35
decreased circulating calcium ... 27 | 33
decreased circulating creatini... 27 | 31
abnormal cranium morphology 26 | 32
limb grasping 26 | 35
small testis 26 | 37
increased circulating potassiu... 25 | 31
decreased circulating chloride... 24 | 32
decreased threshold for audito... 24 | 32
abnormal rib morphology 23 | 28
abnormal spleen morphology 23 | 36
decreased circulating aspartat... 23 | 27
embryonic growth retardation 23 | 28

Disease

ovarian cancer 7,221 | 8,491
osteosarcoma 6,362 | 7,933
medulloblastoma, large-cell 4,827 | 6,234
glioblastoma 4,445 | 5,572
psoriasis 4,424 | 6,685
lung cancer 3,762 | 4,473
atypical teratoid / rhabdoid tumor 3,422 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,690 | 3,289
malignant mesothelioma 2,609 | 3,163
Breast cancer 2,500 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 2,465 | 2,956
invasive ductal carcinoma 2,463 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,451 | 2,988
pilocytic astrocytoma 2,301 | 3,086
primitive neuroectodermal tumor 2,292 | 3,031
oligodendroglioma 2,216 | 2,849
non-small cell lung cancer 2,160 | 2,798
lung carcinoma 2,101 | 2,844
pediatric high grade glioma 2,090 | 2,712
ependymoma 2,053 | 2,514
lung adenocarcinoma 2,012 | 2,714
subependymal giant cell astrocytoma 1,916 | 2,287
pancreatic cancer 1,791 | 2,300
astrocytic glioma 1,785 | 2,241
group 3 medulloblastoma 1,769 | 2,254
Cancer 1,659 | 2,346
interstitial cystitis 1,652 | 2,299
Pick disease 1,634 | 1,893
ulcerative colitis 1,624 | 2,087
adult high grade glioma 1,590 | 2,148
group 4 medulloblastoma 1,579 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,542 | 1,795
pituitary cancer 1,476 | 1,972
Carcinoma 1,433 | 2,147
ductal carcinoma in situ 1,359 | 1,745
breast carcinoma 1,298 | 1,614
Multiple myeloma 1,285 | 1,327
cystic fibrosis 1,284 | 1,670
tuberculosis 1,279 | 1,563
astrocytoma 1,276 | 1,493
adrenocortical carcinoma 1,180 | 1,427
medulloblastoma 1,166 | 1,524
sonic hedgehog group medulloblastoma 1,159 | 1,482
colon cancer 1,149 | 1,475
primary pancreatic ductal adenocarcinoma 1,139 | 1,271
juvenile dermatomyositis 1,124 | 1,189
acute quadriplegic myopathy 1,104 | 1,157
posterior fossa group B ependymoma 1,096 | 1,530
diabetes mellitus 1,089 | 1,663
posterior fossa group A ependymoma 1,075 | 1,511
Rheumatoid Arthritis 943 | 1,170
dermatomyositis 902 | 966
atypical teratoid/rhabdoid tumor 829 | 1,095
spina bifida 826 | 1,064
cutaneous lupus erythematosus 765 | 1,056
Waldenstrons macroglobulinemia 729 | 764
gastric carcinoma 724 | 832
acute myeloid leukemia 715 | 785
nasopharyngeal carcinoma 681 | 1,056
active Crohn's disease 676 | 918
non primary Sjogren syndrome sicca 639 | 840
primary Sjogren syndrome 635 | 788
tuberculosis and treatment for 6 months 629 | 686
Atopic dermatitis 621 | 944
aldosterone-producing adenoma 601 | 664
progressive supranuclear palsy 595 | 674
Duchenne muscular dystrophy 566 | 602
esophageal adenocarcinoma 552 | 737
Alzheimer's disease 500 | 644
hepatocellular carcinoma 487 | 550
pancreatic carcinoma 479 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 499
Down syndrome 462 | 548
Intellectual disability 453 | 573
fibroadenoma 432 | 557
Obesity 425 | 616
Amyotrophic Lateral Sclerosis 381 | 432
gastric cancer 367 | 436
IGA Glomerulonephritis 361 | 454
Prostatic Neoplasms 359 | 471
mucosa-associated lymphoid tissue lymphoma 357 | 480
chronic rhinosinusitis 354 | 512
active ulcerative colitis 333 | 477
Neurodegenerative disease 331 | 383
Endometriosis 329 | 535
Schizophrenia 322 | 503
Mammary Neoplasms 312 | 410
hereditary spastic paraplegia 309 | 313
Multiple Sclerosis 308 | 498
inflammatory breast cancer 303 | 404
sarcoidosis 277 | 368
tuberculosis and treatment for 3 months 272 | 327
glioblastoma multiforme 268 | 347
Parkinson's disease 260 | 364
non-small cell lung carcinoma 253 | 413
Polycystic Ovary Syndrome 252 | 334
Kidney disease 248 | 397
urothelial carcinoma 244 | 318
interstitial lung disease 243 | 292
Stomach Neoplasms 229 | 282

Tissue

Cardiovascular System 12,601 | 17,957
Endocrine System 12,600 | 18,511
Female tissues 12,600 | 18,646
Digestive Tract 12,598 | 18,472
Nervous System 12,598 | 18,560
Liver and Pancreas 12,596 | 18,135
Skin and soft tissues 12,595 | 18,114
Urinary Tract 12,592 | 18,443
Male tissues 12,584 | 17,968
Blood and immune system 12,583 | 17,994
Respiratory system 12,579 | 17,483

Target Family

Non-IDG 7,256 | 11,969
Enzyme 3,121 | 4,146
Transcription Factor 906 | 1,400
Kinase 505 | 634
Transporter 279 | 473
Epigenetic 212 | 242
Ion Channel 131 | 341
GPCR 124 | 408
Nuclear Receptor 35 | 48
TF/Epigenetic 31 | 38
oGPCR 1 | 421

HPA RNA Tissue

heart muscle 12,601 | 12,601
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
adipose tissue 12,955 | 12,955
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160