Development Level

Tbio 8,378 | 10,625
Tdark 3,454 | 7,003
Tchem 1,503 | 1,890
Tclin 399 | 602

Collection

Eligible Kinase Proteins 106 | 134
Eligible Ion Channel Proteins 46 | 117
Eligible non-olfactory GPCR Proteins 41 | 143

IMPC Term

preweaning lethality, complete... 580 | 633
preweaning lethality, incomple... 221 | 260
abnormal behavior 193 | 226
embryonic lethality prior to t... 178 | 187
decreased lean body mass 173 | 195
decreased total body fat amoun... 163 | 186
decreased body weight 155 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 133 | 157
abnormal bone structure 106 | 131
increased or absent threshold ... 105 | 128
decreased bone mineral density 104 | 126
increased circulating alkaline... 104 | 119
decreased circulating glucose ... 100 | 121
decreased grip strength 99 | 123
abnormal embryo size 98 | 112
decreased body length 97 | 108
increased lean body mass 93 | 107
enlarged heart 89 | 111
hyperactivity 89 | 108
abnormal retina morphology 86 | 100
increased bone mineral content 84 | 92
increased mean corpuscular hem... 83 | 93
increased mean corpuscular vol... 83 | 91
decreased circulating choleste... 75 | 85
decreased circulating serum al... 72 | 79
decreased circulating triglyce... 72 | 83
hypoactivity 72 | 89
decreased circulating HDL chol... 71 | 77
short tibia 70 | 82
increased grip strength 68 | 83
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 59 | 64
decreased circulating insulin ... 57 | 75
increased fasted circulating g... 57 | 68
decreased lumbar vertebrae num... 56 | 62
increased circulating sodium l... 54 | 71
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 52 | 61
abnormal sleep behavior 48 | 63
decreased rib number 48 | 59
increased bone mineral density 47 | 52
increased circulating HDL chol... 47 | 63
increased total body fat amoun... 47 | 57
abnormal bone mineralization 46 | 55
abnormal coat/hair pigmentatio... 46 | 54
decreased leukocyte cell numbe... 46 | 54
decreased hemoglobin content 45 | 53
improved glucose tolerance 45 | 56
male infertility 45 | 62
decreased mean corpuscular vol... 44 | 50
decreased prepulse inhibition 43 | 52
increased circulating choleste... 43 | 53
decreased circulating alanine ... 42 | 53
impaired glucose tolerance 42 | 52
increased exploration in new e... 42 | 56
abnormal gait 41 | 51
decreased caudal vertebrae num... 41 | 49
decreased fasted circulating g... 41 | 49
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased startle reflex 39 | 48
abnormal heart morphology 38 | 51
increased body weight 38 | 42
thrombocytopenia 38 | 46
abnormal behavioral response t... 37 | 52
increased blood urea nitrogen ... 37 | 44
increased rib number 37 | 41
decreased heart weight 36 | 44
decreased eosinophil cell numb... 35 | 41
abnormal seminal vesicle morph... 34 | 47
decreased circulating LDL chol... 34 | 37
abnormal eye morphology 33 | 38
abnormal neural tube closure 33 | 37
decreased circulating free fat... 33 | 39
decreased neutrophil cell numb... 33 | 37
increased hemoglobin content 33 | 45
decreased circulating alkaline... 32 | 41
increased hematocrit 31 | 36
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
increased circulating chloride... 30 | 43
increased startle reflex 30 | 38
small testis 30 | 37
decreased T cell number 29 | 31
increased leukocyte cell numbe... 29 | 37
limb grasping 29 | 35
tremors 29 | 34
abnormal cranium morphology 28 | 32
cardiovascular system phenotyp... 28 | 35
decreased circulating creatini... 27 | 31
increased circulating calcium ... 27 | 32
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased circulating chloride... 26 | 32
decreased blood urea nitrogen ... 25 | 31
embryonic growth retardation 25 | 28
increased circulating creatini... 25 | 29
increased circulating potassiu... 25 | 31

Disease

ovarian cancer 7,638 | 8,484
osteosarcoma 6,883 | 7,933
medulloblastoma, large-cell 5,144 | 6,234
psoriasis 4,945 | 6,685
glioblastoma 4,736 | 5,572
lung cancer 4,070 | 4,466
atypical teratoid / rhabdoid tumor 3,643 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,033 | 3,289
malignant mesothelioma 2,832 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 2,762 | 2,956
Breast cancer 2,756 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,750 | 2,988
invasive ductal carcinoma 2,733 | 2,950
non-small cell lung cancer 2,476 | 2,798
primitive neuroectodermal tumor 2,475 | 3,031
pilocytic astrocytoma 2,470 | 3,086
lung carcinoma 2,381 | 2,844
oligodendroglioma 2,353 | 2,849
lung adenocarcinoma 2,345 | 2,713
pediatric high grade glioma 2,244 | 2,712
ependymoma 2,146 | 2,514
pancreatic cancer 2,096 | 2,300
interstitial cystitis 2,056 | 2,299
subependymal giant cell astrocytoma 1,987 | 2,287
ulcerative colitis 1,914 | 2,087
Cancer 1,902 | 2,346
group 3 medulloblastoma 1,896 | 2,254
astrocytic glioma 1,882 | 2,241
adult high grade glioma 1,724 | 2,148
Pick disease 1,678 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,670 | 1,795
group 4 medulloblastoma 1,647 | 1,875
pituitary cancer 1,637 | 1,972
ductal carcinoma in situ 1,585 | 1,745
Carcinoma 1,544 | 2,147
cystic fibrosis 1,454 | 1,665
breast carcinoma 1,453 | 1,614
tuberculosis 1,421 | 1,557
colon cancer 1,317 | 1,475
astrocytoma 1,315 | 1,493
Multiple myeloma 1,297 | 1,327
adrenocortical carcinoma 1,288 | 1,427
medulloblastoma 1,248 | 1,524
sonic hedgehog group medulloblastoma 1,233 | 1,482
primary pancreatic ductal adenocarcinoma 1,222 | 1,271
posterior fossa group B ependymoma 1,204 | 1,530
posterior fossa group A ependymoma 1,202 | 1,511
diabetes mellitus 1,146 | 1,663
juvenile dermatomyositis 1,129 | 1,189
acute quadriplegic myopathy 1,083 | 1,157
Rheumatoid Arthritis 1,024 | 1,160
spina bifida 945 | 1,064
cutaneous lupus erythematosus 922 | 1,056
atypical teratoid/rhabdoid tumor 911 | 1,095
dermatomyositis 901 | 933
nasopharyngeal carcinoma 863 | 1,056
active Crohn's disease 813 | 918
gastric carcinoma 760 | 832
Atopic dermatitis 748 | 944
primary Sjogren syndrome 746 | 789
Waldenstrons macroglobulinemia 745 | 765
acute myeloid leukemia 739 | 780
non primary Sjogren syndrome sicca 702 | 840
tuberculosis and treatment for 6 months 662 | 686
esophageal adenocarcinoma 651 | 737
progressive supranuclear palsy 619 | 674
aldosterone-producing adenoma 617 | 664
Duchenne muscular dystrophy 556 | 602
Alzheimer's disease 534 | 644
pancreatic carcinoma 520 | 567
hepatocellular carcinoma 500 | 532
fibroadenoma 493 | 557
Down syndrome 484 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 474 | 499
Intellectual disability 473 | 573
Obesity 468 | 616
Endometriosis 434 | 535
mucosa-associated lymphoid tissue lymphoma 418 | 480
IGA Glomerulonephritis 416 | 454
Prostatic Neoplasms 415 | 471
chronic rhinosinusitis 414 | 512
active ulcerative colitis 408 | 477
gastric cancer 400 | 430
Amyotrophic Lateral Sclerosis 377 | 431
Mammary Neoplasms 361 | 410
Multiple Sclerosis 358 | 498
Schizophrenia 352 | 501
inflammatory breast cancer 342 | 404
Neurodegenerative disease 338 | 383
sarcoidosis 325 | 358
non-small cell lung carcinoma 311 | 413
tuberculosis and treatment for 3 months 311 | 327
hereditary spastic paraplegia 304 | 313
glioblastoma multiforme 294 | 347
Kidney disease 284 | 396
nephrosclerosis 283 | 329
urothelial carcinoma 283 | 318
Parkinson's disease 273 | 364
Polycystic Ovary Syndrome 271 | 332
interstitial lung disease 271 | 291

Tissue

Liver and Pancreas 13,734 | 18,136
Digestive Tract 13,733 | 18,473
Female tissues 13,731 | 18,647
Urinary Tract 13,730 | 18,444
Endocrine System 13,729 | 18,512
Skin and soft tissues 13,728 | 18,115
Nervous System 13,725 | 18,561
Blood and immune system 13,710 | 17,995
Cardiovascular System 13,708 | 17,958
Male tissues 13,707 | 17,969
Respiratory system 13,705 | 17,484

Target Family

Non-IDG 7,925 | 11,971
Enzyme 3,344 | 4,146
Transcription Factor 988 | 1,400
Kinase 540 | 634
Transporter 328 | 473
Epigenetic 211 | 242
GPCR 170 | 406
Ion Channel 153 | 341
Nuclear Receptor 40 | 48
TF/Epigenetic 33 | 38
oGPCR 2 | 421

HPA RNA Tissue

gallbladder 13,734 | 13,734
testis 14,883 | 14,883
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160