Development Level

Tbio 10,457 | 11,651
Tdark 4,060 | 6,593
Tchem 1,279 | 1,388
Tclin 537 | 612

Collection

RFA-RM-18-021 263 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 71 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 947 | 979
preweaning lethality, incomple... 473 | 499
abnormal behavior 281 | 298
embryonic lethality prior to t... 273 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 197 | 207
enlarged heart 190 | 210
decreased vertical activity 179 | 208
abnormal bone structure 171 | 187
increased lean body mass 163 | 172
decreased body weight 154 | 161
abnormal heart morphology 149 | 162
decreased bone mineral content 140 | 151
hyperactivity 140 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 126 | 134
hypoactivity 119 | 132
decreased bone mineral density 118 | 126
decreased circulating glucose ... 117 | 126
increased circulating alkaline... 112 | 122
male infertility 105 | 123
increased startle reflex 104 | 112
decreased grip strength 102 | 116
embryonic growth retardation 101 | 106
abnormal seminal vesicle morph... 98 | 114
increased bone mineral content 98 | 108
increased or absent threshold ... 96 | 101
decreased body length 95 | 101
short tibia 92 | 97
increased mean corpuscular hem... 91 | 96
increased mean corpuscular vol... 91 | 92
decreased circulating choleste... 89 | 93
cataract 88 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 78 | 81
decreased circulating serum al... 78 | 82
decreased prepulse inhibition 77 | 82
decreased circulating triglyce... 75 | 79
decreased mean corpuscular vol... 75 | 79
improved glucose tolerance 72 | 79
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 71 | 76
decreased leukocyte cell numbe... 70 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
impaired glucose tolerance 68 | 75
abnormal eye morphology 67 | 68
decreased circulating insulin ... 67 | 76
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
small superior vagus ganglion 66 | 74
abnormal gait 65 | 69
increased circulating sodium l... 65 | 71
abnormal sleep behavior 64 | 70
decreased hemoglobin content 63 | 68
decreased fasted circulating g... 62 | 65
abnormal coat-hair pigmentatio... 61 | 64
abnormal behavioral response t... 60 | 66
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
increased circulating choleste... 60 | 66
increased monocyte cell number 59 | 63
increased heart weight 56 | 62
edema 55 | 59
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 53 | 56
abnormal spleen morphology 52 | 55
female infertility 50 | 60
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
hydrometra 47 | 53
abnormal neural tube closure 46 | 46
decreased mean corpuscular hem... 46 | 50
increased blood urea nitrogen ... 46 | 48
decreased circulating alanine ... 45 | 47
increased leukocyte cell numbe... 45 | 47
increased hematocrit 44 | 46
decreased circulating alkaline... 43 | 46
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
decreased red blood cell distr... 40 | 41
increased circulating triglyce... 40 | 42
increased hemoglobin content 40 | 45
abnormal testis morphology 39 | 43
increased circulating chloride... 39 | 41
increased mean platelet volume 39 | 45
decreased circulating LDL chol... 38 | 38
abnormal bone mineralization 37 | 38
decreased circulating creatini... 37 | 39
limb grasping 37 | 41
tremors 37 | 39
abnormal cranium morphology 36 | 36
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 9,966 | 11,493
ovarian cancer 8,172 | 8,520
osteosarcoma 7,527 | 7,950
psoriasis 5,865 | 6,694
medulloblastoma, large-cell 5,837 | 6,241
glioblastoma 5,521 | 5,792
atypical teratoid / rhabdoid tumor 4,848 | 5,112
lung cancer 4,511 | 4,740
ependymoma 4,421 | 4,679
group 3 medulloblastoma 3,903 | 4,104
adult high grade glioma 3,541 | 3,801
Breast cancer 3,422 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,221 | 3,291
malignant mesothelioma 3,126 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,925 | 2,989
invasive ductal carcinoma 2,901 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,894 | 2,955
primitive neuroectodermal tumor 2,888 | 3,035
Astrocytoma, Pilocytic 2,887 | 3,081
non-small cell lung cancer 2,794 | 2,890
lung carcinoma 2,700 | 2,843
oligodendroglioma 2,686 | 2,850
lung adenocarcinoma 2,604 | 2,716
astrocytic glioma 2,454 | 2,597
Kidney cancer 2,350 | 2,613
pancreatic cancer 2,326 | 2,398
Cancer 2,248 | 2,499
interstitial cystitis 2,224 | 2,312
subependymal giant cell astrocytoma 2,177 | 2,287
tuberculosis 1,937 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,913 | 1,962
pituitary cancer 1,867 | 1,972
Pick disease 1,829 | 1,894
group 4 medulloblastoma 1,771 | 1,855
ulcerative colitis 1,755 | 1,819
ductal carcinoma in situ 1,716 | 1,745
cystic fibrosis 1,627 | 1,696
breast carcinoma 1,591 | 1,638
colon cancer 1,434 | 1,478
adrenocortical carcinoma 1,401 | 1,428
diabetes mellitus 1,356 | 1,728
Autosomal recessive predisposition 1,336 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,163 | 1,187
acute quadriplegic myopathy 1,129 | 1,158
astrocytoma 1,110 | 1,146
Rheumatoid arthritis 1,093 | 1,191
primary pancreatic ductal adenocarcinoma 1,090 | 1,109
spina bifida 1,038 | 1,074
pediatric high grade glioma 1,029 | 1,064
Schizophrenia 1,016 | 1,160
cutaneous lupus erythematosus 1,015 | 1,057
nasopharyngeal carcinoma 1,003 | 1,058
Intellectual disability 955 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 885 | 922
Atopic dermatitis 876 | 952
non primary Sjogren syndrome sicca 833 | 891
gastric carcinoma 780 | 807
acute myeloid leukemia 776 | 783
Waldenstrons macroglobulinemia 760 | 765
Liver Cirrhosis, Experimental 738 | 769
Epilepsy 736 | 792
active ulcerative colitis 727 | 764
primary Sjogren syndrome 717 | 735
esophageal adenocarcinoma 714 | 737
medulloblastoma 681 | 720
progressive supranuclear palsy 658 | 676
aldosterone-producing adenoma 651 | 665
Alzheimer's disease 606 | 658
Dull intelligence 604 | 645
Low intelligence 604 | 645
Mental Retardation 604 | 645
Mental deficiency 604 | 645
Poor school performance 604 | 645
Obesity 603 | 678
Melanoma 592 | 711
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Bipolar Disorder 579 | 666
Duchenne muscular dystrophy 577 | 601
Seizures 564 | 596
pancreatic carcinoma 553 | 562
fibroadenoma 549 | 559
Muscle hypotonia 546 | 571
hepatocellular carcinoma 539 | 547
Liver cancer 525 | 604
Endometriosis 515 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Short stature 493 | 531
chronic rhinosinusitis 479 | 512
Down syndrome 477 | 499
Prostatic Neoplasms 471 | 495
Multiple Sclerosis 461 | 540
mucosa-associated lymphoid tissue lymphoma 457 | 484
gastric cancer 450 | 459
posterior fossa group A ependymoma 447 | 468
sonic hedgehog group medulloblastoma 444 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Liver and Pancreas 16,333 | 16,750
Endocrine System 16,277 | 18,159
Digestive Tract 16,235 | 17,369
Female tissues 16,220 | 17,400
Skin and soft tissues 16,181 | 17,230
Male tissues 16,095 | 17,142
Urinary Tract 16,010 | 16,678
Blood and immune system 16,009 | 16,909
Respiratory system 15,828 | 16,393
Nervous System 15,813 | 16,725
Cardiovascular System 14,929 | 15,192

Target Family

Non-IDG 9,518 | 12,091
Enzyme 3,758 | 4,145
Transcription Factor 1,178 | 1,400
Kinase 599 | 634
Transporter 407 | 473
GPCR 284 | 408
Ion Channel 263 | 344
Epigenetic 231 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 35 | 38
oGPCR 16 | 421

HPA RNA Tissue

gallbladder 16,333 | 16,333
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50