Development Level

Tbio 8,255 | 10,625
Tdark 3,630 | 7,003
Tchem 1,441 | 1,890
Tclin 383 | 602

Collection

Eligible Kinase Proteins 103 | 134
Eligible Ion Channel Proteins 50 | 117
Eligible non-olfactory GPCR Proteins 43 | 143

IMPC Term

preweaning lethality, complete... 575 | 633
preweaning lethality, incomple... 225 | 260
abnormal behavior 199 | 226
embryonic lethality prior to t... 177 | 187
decreased lean body mass 171 | 195
decreased total body fat amoun... 163 | 186
decreased body weight 152 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 132 | 157
increased or absent threshold ... 105 | 128
increased circulating alkaline... 104 | 119
abnormal bone structure 103 | 131
decreased bone mineral density 103 | 126
decreased grip strength 101 | 123
abnormal embryo size 100 | 112
decreased circulating glucose ... 99 | 121
decreased body length 97 | 108
hyperactivity 93 | 108
increased lean body mass 91 | 107
abnormal retina morphology 87 | 100
enlarged heart 86 | 111
increased mean corpuscular hem... 85 | 93
increased mean corpuscular vol... 82 | 91
increased bone mineral content 80 | 92
decreased circulating choleste... 74 | 85
short tibia 74 | 82
hypoactivity 71 | 89
decreased circulating serum al... 70 | 79
decreased circulating triglyce... 70 | 83
decreased circulating HDL chol... 68 | 77
increased grip strength 67 | 83
abnormal lens morphology 61 | 73
prenatal lethality prior to he... 58 | 64
decreased circulating insulin ... 57 | 75
decreased lumbar vertebrae num... 57 | 62
increased fasted circulating g... 57 | 68
increased sacral vertebrae num... 56 | 62
abnormal retinal pigmentation 55 | 61
increased circulating sodium l... 55 | 71
abnormal coat/hair pigmentatio... 50 | 54
male infertility 50 | 62
abnormal sleep behavior 49 | 63
decreased rib number 49 | 59
decreased mean corpuscular vol... 47 | 50
increased circulating HDL chol... 47 | 63
increased total body fat amoun... 47 | 57
abnormal bone mineralization 46 | 55
increased bone mineral density 46 | 52
decreased hemoglobin content 45 | 53
decreased leukocyte cell numbe... 45 | 54
abnormal gait 44 | 51
decreased caudal vertebrae num... 44 | 49
decreased prepulse inhibition 44 | 52
improved glucose tolerance 44 | 56
decreased circulating alanine ... 42 | 53
increased circulating choleste... 42 | 53
increased exploration in new e... 42 | 56
decreased fasted circulating g... 41 | 49
decreased erythrocyte cell num... 39 | 43
impaired glucose tolerance 39 | 52
increased blood urea nitrogen ... 39 | 44
abnormal behavioral response t... 38 | 52
decreased circulating total pr... 38 | 41
decreased eosinophil cell numb... 38 | 41
decreased startle reflex 38 | 48
increased rib number 38 | 41
thrombocytopenia 37 | 46
abnormal heart morphology 36 | 51
decreased circulating LDL chol... 36 | 37
increased body weight 35 | 42
increased hemoglobin content 35 | 45
abnormal neural tube closure 34 | 37
decreased heart weight 34 | 44
abnormal seminal vesicle morph... 33 | 47
decreased neutrophil cell numb... 33 | 37
abnormal eye morphology 32 | 38
increased circulating chloride... 32 | 43
decreased circulating alkaline... 31 | 41
decreased circulating free fat... 31 | 39
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased startle reflex 30 | 38
tremors 30 | 34
cardiovascular system phenotyp... 29 | 35
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
increased leukocyte cell numbe... 29 | 37
small testis 29 | 37
abnormal cranium morphology 28 | 32
abnormal spleen morphology 27 | 36
decreased T cell number 27 | 31
limb grasping 27 | 35
decreased circulating chloride... 26 | 32
decreased circulating creatini... 26 | 31
embryonic growth retardation 26 | 28
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
decreased blood urea nitrogen ... 25 | 31
decreased threshold for audito... 25 | 32
increased circulating calcium ... 25 | 32

Disease

ovarian cancer 7,601 | 8,484
osteosarcoma 6,811 | 7,933
medulloblastoma, large-cell 5,135 | 6,234
psoriasis 4,870 | 6,685
glioblastoma 4,714 | 5,572
lung cancer 3,988 | 4,466
atypical teratoid / rhabdoid tumor 3,639 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,961 | 3,289
malignant mesothelioma 2,785 | 3,162
Breast cancer 2,742 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 2,679 | 2,956
invasive ductal carcinoma 2,678 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,670 | 2,988
primitive neuroectodermal tumor 2,487 | 3,031
pilocytic astrocytoma 2,466 | 3,086
non-small cell lung cancer 2,420 | 2,798
lung carcinoma 2,365 | 2,844
oligodendroglioma 2,342 | 2,849
lung adenocarcinoma 2,298 | 2,713
pediatric high grade glioma 2,241 | 2,712
ependymoma 2,153 | 2,514
pancreatic cancer 2,017 | 2,300
subependymal giant cell astrocytoma 1,981 | 2,287
interstitial cystitis 1,920 | 2,299
group 3 medulloblastoma 1,902 | 2,254
astrocytic glioma 1,878 | 2,241
Cancer 1,825 | 2,346
ulcerative colitis 1,794 | 2,087
adult high grade glioma 1,709 | 2,148
Pick disease 1,677 | 1,893
group 4 medulloblastoma 1,649 | 1,875
pituitary cancer 1,646 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,625 | 1,795
Carcinoma 1,549 | 2,147
ductal carcinoma in situ 1,540 | 1,745
breast carcinoma 1,417 | 1,614
cystic fibrosis 1,403 | 1,665
tuberculosis 1,359 | 1,557
posterior fossa group B ependymoma 1,332 | 1,530
astrocytoma 1,317 | 1,493
Multiple myeloma 1,296 | 1,327
adrenocortical carcinoma 1,257 | 1,427
colon cancer 1,251 | 1,475
medulloblastoma 1,247 | 1,524
sonic hedgehog group medulloblastoma 1,237 | 1,482
primary pancreatic ductal adenocarcinoma 1,189 | 1,271
posterior fossa group A ependymoma 1,184 | 1,511
juvenile dermatomyositis 1,127 | 1,189
diabetes mellitus 1,104 | 1,663
acute quadriplegic myopathy 1,080 | 1,157
Rheumatoid Arthritis 983 | 1,160
spina bifida 946 | 1,064
nasopharyngeal carcinoma 914 | 1,056
atypical teratoid/rhabdoid tumor 905 | 1,095
dermatomyositis 901 | 933
cutaneous lupus erythematosus 876 | 1,056
active Crohn's disease 776 | 918
gastric carcinoma 756 | 832
Waldenstrons macroglobulinemia 736 | 765
acute myeloid leukemia 734 | 780
Atopic dermatitis 715 | 944
primary Sjogren syndrome 694 | 789
non primary Sjogren syndrome sicca 684 | 840
esophageal adenocarcinoma 651 | 737
tuberculosis and treatment for 6 months 648 | 686
progressive supranuclear palsy 613 | 674
aldosterone-producing adenoma 612 | 664
Duchenne muscular dystrophy 556 | 602
Alzheimer's disease 523 | 644
pancreatic carcinoma 508 | 567
Intellectual disability 484 | 573
hepatocellular carcinoma 483 | 532
fibroadenoma 480 | 557
Down syndrome 479 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
chronic rhinosinusitis 470 | 512
Obesity 447 | 616
Endometriosis 433 | 535
IGA Glomerulonephritis 398 | 454
Prostatic Neoplasms 395 | 471
mucosa-associated lymphoid tissue lymphoma 395 | 480
active ulcerative colitis 387 | 477
Amyotrophic Lateral Sclerosis 382 | 431
gastric cancer 379 | 430
Schizophrenia 349 | 501
Mammary Neoplasms 346 | 410
Neurodegenerative disease 344 | 383
Multiple Sclerosis 339 | 498
inflammatory breast cancer 335 | 404
non-small cell lung carcinoma 309 | 413
hereditary spastic paraplegia 304 | 313
sarcoidosis 298 | 358
tuberculosis and treatment for 3 months 295 | 327
glioblastoma multiforme 292 | 347
urothelial carcinoma 276 | 318
Parkinson's disease 272 | 364
Polycystic Ovary Syndrome 263 | 332
interstitial lung disease 257 | 291
nephrosclerosis 255 | 329
Kidney disease 253 | 396

Tissue

Female tissues 13,709 | 18,647
Endocrine System 13,706 | 18,512
Digestive Tract 13,704 | 18,473
Nervous System 13,703 | 18,561
Urinary Tract 13,701 | 18,444
Skin and soft tissues 13,698 | 18,115
Liver and Pancreas 13,692 | 18,136
Respiratory system 13,690 | 17,484
Male tissues 13,686 | 17,969
Blood and immune system 13,679 | 17,995
Cardiovascular System 13,674 | 17,958

Target Family

Non-IDG 7,949 | 11,971
Enzyme 3,301 | 4,146
Transcription Factor 1,010 | 1,400
Kinase 537 | 634
Transporter 312 | 473
Epigenetic 214 | 242
Ion Channel 162 | 341
GPCR 154 | 406
Nuclear Receptor 36 | 48
TF/Epigenetic 31 | 38
oGPCR 3 | 421

HPA RNA Tissue

fallopian tube 13,709 | 13,709
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345