Development Level

Tbio 10,187 | 11,445
Tdark 4,080 | 6,588
Tchem 1,451 | 1,598
Tclin 527 | 613

Collection

RFA-RM-18-021 263 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 75 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 946 | 979
preweaning lethality, incomple... 473 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 191 | 207
enlarged heart 188 | 210
decreased vertical activity 175 | 208
abnormal bone structure 166 | 187
increased lean body mass 159 | 172
decreased body weight 150 | 161
abnormal heart morphology 146 | 162
hyperactivity 138 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 123 | 135
increased total body fat amoun... 121 | 134
decreased circulating glucose ... 118 | 126
hypoactivity 117 | 132
decreased bone mineral density 114 | 126
increased circulating alkaline... 110 | 122
male infertility 108 | 123
increased startle reflex 105 | 112
abnormal seminal vesicle morph... 104 | 114
decreased grip strength 103 | 116
embryonic growth retardation 102 | 106
increased bone mineral content 99 | 108
increased or absent threshold ... 94 | 101
short tibia 94 | 97
decreased body length 92 | 101
increased mean corpuscular vol... 90 | 92
cataract 87 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 75 | 82
decreased prepulse inhibition 74 | 82
decreased mean corpuscular vol... 73 | 79
decreased circulating triglyce... 72 | 79
improved glucose tolerance 71 | 79
decreased leukocyte cell numbe... 70 | 73
increased circulating HDL chol... 70 | 80
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
decreased circulating insulin ... 68 | 76
impaired glucose tolerance 67 | 75
increased fasted circulating g... 67 | 76
abnormal eye morphology 66 | 68
abnormal retina morphology 65 | 71
small superior vagus ganglion 65 | 74
decreased circulating HDL chol... 64 | 68
increased circulating sodium l... 64 | 71
abnormal coat-hair pigmentatio... 63 | 64
abnormal gait 63 | 69
abnormal sleep behavior 62 | 70
decreased hemoglobin content 60 | 68
increased monocyte cell number 60 | 63
abnormal behavioral response t... 59 | 66
decreased fasted circulating g... 59 | 65
increased circulating choleste... 59 | 66
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
edema 56 | 59
increased heart weight 56 | 62
abnormal spleen morphology 53 | 55
decreased caudal vertebrae num... 52 | 53
small testis 52 | 58
thrombocytopenia 52 | 56
abnormal skin morphology 49 | 50
female infertility 48 | 60
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
hydrometra 47 | 53
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
decreased circulating alkaline... 44 | 46
increased blood urea nitrogen ... 44 | 48
increased leukocyte cell numbe... 44 | 47
decreased circulating alanine ... 43 | 47
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased hematocrit 42 | 46
increased mean platelet volume 42 | 45
decreased neutrophil cell numb... 41 | 42
enlarged spleen 41 | 41
increased circulating triglyce... 39 | 42
increased hemoglobin content 39 | 45
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
abnormal epididymis morphology 37 | 42
decreased circulating LDL chol... 37 | 38
increased circulating chloride... 37 | 41
limb grasping 37 | 41
decreased circulating creatini... 36 | 39
increased erythrocyte cell num... 36 | 39
increased grip strength 36 | 41
tremors 36 | 39
abnormal cranium morphology 35 | 36

Disease

Carcinoma 9,917 | 11,493
ovarian cancer 8,176 | 8,520
osteosarcoma 7,492 | 7,950
medulloblastoma, large-cell 5,839 | 6,241
psoriasis 5,823 | 6,694
glioblastoma 5,515 | 5,792
atypical teratoid / rhabdoid tumor 4,847 | 5,112
lung cancer 4,486 | 4,740
ependymoma 4,438 | 4,679
group 3 medulloblastoma 3,905 | 4,104
adult high grade glioma 3,549 | 3,801
Breast cancer 3,421 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,200 | 3,291
malignant mesothelioma 3,096 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,906 | 2,989
Astrocytoma, Pilocytic 2,892 | 3,081
invasive ductal carcinoma 2,891 | 2,951
primitive neuroectodermal tumor 2,888 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,874 | 2,955
non-small cell lung cancer 2,806 | 2,890
lung carcinoma 2,708 | 2,843
oligodendroglioma 2,684 | 2,850
lung adenocarcinoma 2,619 | 2,716
astrocytic glioma 2,456 | 2,597
Kidney cancer 2,346 | 2,613
pancreatic cancer 2,295 | 2,398
interstitial cystitis 2,217 | 2,312
Cancer 2,213 | 2,499
subependymal giant cell astrocytoma 2,172 | 2,287
tuberculosis 1,916 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,886 | 1,962
pituitary cancer 1,868 | 1,972
Pick disease 1,823 | 1,894
group 4 medulloblastoma 1,775 | 1,855
ulcerative colitis 1,727 | 1,819
ductal carcinoma in situ 1,704 | 1,745
breast carcinoma 1,597 | 1,638
cystic fibrosis 1,595 | 1,696
colon cancer 1,409 | 1,478
adrenocortical carcinoma 1,396 | 1,428
diabetes mellitus 1,343 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,293 | 1,442
juvenile dermatomyositis 1,156 | 1,187
acute quadriplegic myopathy 1,127 | 1,158
astrocytoma 1,111 | 1,146
Rheumatoid arthritis 1,085 | 1,191
primary pancreatic ductal adenocarcinoma 1,085 | 1,109
spina bifida 1,022 | 1,074
nasopharyngeal carcinoma 1,020 | 1,058
pediatric high grade glioma 1,019 | 1,064
cutaneous lupus erythematosus 1,015 | 1,057
Schizophrenia 1,008 | 1,160
Intellectual disability 956 | 1,016
dermatomyositis 922 | 966
active Crohn's disease 865 | 922
Atopic dermatitis 862 | 952
non primary Sjogren syndrome sicca 817 | 891
gastric carcinoma 774 | 807
acute myeloid leukemia 772 | 783
Waldenstrons macroglobulinemia 753 | 765
Epilepsy 734 | 792
Liver Cirrhosis, Experimental 730 | 769
active ulcerative colitis 718 | 764
esophageal adenocarcinoma 716 | 737
primary Sjogren syndrome 715 | 735
medulloblastoma 679 | 720
aldosterone-producing adenoma 652 | 665
progressive supranuclear palsy 652 | 676
Alzheimer's disease 602 | 658
Dull intelligence 602 | 645
Low intelligence 602 | 645
Mental Retardation 602 | 645
Mental deficiency 602 | 645
Poor school performance 602 | 645
Obesity 599 | 678
Duchenne muscular dystrophy 578 | 601
Bipolar Disorder 575 | 666
Cognitive delay 574 | 608
Global developmental delay 574 | 608
Mental and motor retardation 574 | 608
Melanoma 567 | 711
Seizures 557 | 596
pancreatic carcinoma 549 | 562
fibroadenoma 547 | 559
Muscle hypotonia 538 | 571
hepatocellular carcinoma 534 | 547
Liver cancer 524 | 604
Endometriosis 517 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 500 | 510
chronic rhinosinusitis 499 | 512
Short stature 488 | 531
Down syndrome 470 | 499
Prostatic Neoplasms 462 | 495
mucosa-associated lymphoid tissue lymphoma 459 | 484
Multiple Sclerosis 456 | 540
posterior fossa group A ependymoma 450 | 468
gastric cancer 448 | 459
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 431 | 451

Tissue

Female tissues 16,245 | 17,400
Endocrine System 16,218 | 18,159
Digestive Tract 16,091 | 17,369
Male tissues 16,056 | 17,142
Skin and soft tissues 16,045 | 17,230
Liver and Pancreas 15,908 | 16,750
Blood and immune system 15,885 | 16,909
Urinary Tract 15,867 | 16,678
Respiratory system 15,790 | 16,393
Nervous System 15,784 | 16,725
Cardiovascular System 14,845 | 15,192

Target Family

Non-IDG 9,471 | 12,091
Enzyme 3,732 | 4,145
Transcription Factor 1,165 | 1,400
Kinase 601 | 634
Transporter 397 | 473
GPCR 284 | 408
Ion Channel 264 | 344
Epigenetic 231 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 24 | 421

HPA RNA Tissue

fallopian tube 16,245 | 16,245
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39