Development Level

Tbio 10,280 | 11,651
Tdark 3,878 | 6,593
Tchem 1,237 | 1,388
Tclin 503 | 612

Collection

RFA-RM-18-021 250 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 70 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 950 | 979
preweaning lethality, incomple... 471 | 499
abnormal behavior 276 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 191 | 207
enlarged heart 190 | 210
decreased vertical activity 177 | 208
abnormal bone structure 170 | 187
increased lean body mass 157 | 172
decreased body weight 151 | 161
abnormal heart morphology 148 | 162
decreased bone mineral content 138 | 151
hyperactivity 137 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 126 | 134
hypoactivity 117 | 132
decreased bone mineral density 116 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 111 | 122
male infertility 105 | 123
decreased grip strength 104 | 116
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
abnormal seminal vesicle morph... 98 | 114
increased bone mineral content 98 | 108
decreased body length 96 | 101
short tibia 92 | 97
increased or absent threshold ... 91 | 101
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 89 | 96
cataract 85 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 78 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased circulating triglyce... 75 | 79
decreased prepulse inhibition 74 | 82
decreased leukocyte cell numbe... 72 | 73
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 70 | 75
improved glucose tolerance 70 | 79
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
impaired glucose tolerance 68 | 75
increased bone mineral density 68 | 72
small superior vagus ganglion 68 | 74
abnormal sleep behavior 67 | 70
decreased circulating insulin ... 67 | 76
decreased circulating HDL chol... 66 | 68
abnormal eye morphology 64 | 68
abnormal retina morphology 62 | 71
abnormal gait 61 | 69
increased circulating sodium l... 61 | 71
abnormal behavioral response t... 60 | 66
abnormal coat-hair pigmentatio... 59 | 64
decreased fasted circulating g... 59 | 65
decreased hemoglobin content 59 | 68
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
edema 56 | 59
increased heart weight 56 | 62
small testis 54 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
abnormal spleen morphology 51 | 55
female infertility 51 | 60
hydrometra 50 | 53
abnormal skin morphology 48 | 50
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
increased hematocrit 45 | 46
decreased circulating alkaline... 44 | 46
increased leukocyte cell numbe... 44 | 47
decreased circulating alanine ... 43 | 47
increased blood urea nitrogen ... 43 | 48
decreased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 40 | 43
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
decreased neutrophil cell numb... 39 | 42
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
decreased circulating LDL chol... 36 | 38
increased erythrocyte cell num... 36 | 39
increased grip strength 36 | 41
tremors 36 | 39
abnormal bone mineralization 35 | 38
abnormal cranium morphology 35 | 36
abnormal epididymis morphology 35 | 42
decreased circulating creatini... 35 | 39
increased circulating chloride... 35 | 41

Disease

Carcinoma 9,702 | 11,493
ovarian cancer 8,087 | 8,520
osteosarcoma 7,410 | 7,950
psoriasis 5,769 | 6,694
medulloblastoma, large-cell 5,732 | 6,241
glioblastoma 5,418 | 5,792
atypical teratoid / rhabdoid tumor 4,749 | 5,112
lung cancer 4,466 | 4,740
ependymoma 4,302 | 4,679
group 3 medulloblastoma 3,823 | 4,104
adult high grade glioma 3,465 | 3,801
Breast cancer 3,389 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,176 | 3,291
malignant mesothelioma 3,108 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,891 | 2,989
invasive ductal carcinoma 2,885 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,854 | 2,955
primitive neuroectodermal tumor 2,816 | 3,035
Astrocytoma, Pilocytic 2,812 | 3,081
non-small cell lung cancer 2,801 | 2,890
lung carcinoma 2,635 | 2,843
oligodendroglioma 2,629 | 2,850
lung adenocarcinoma 2,581 | 2,716
astrocytic glioma 2,404 | 2,597
pancreatic cancer 2,277 | 2,398
Kidney cancer 2,272 | 2,613
interstitial cystitis 2,211 | 2,312
Cancer 2,206 | 2,499
subependymal giant cell astrocytoma 2,145 | 2,287
tuberculosis 1,913 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,869 | 1,962
pituitary cancer 1,822 | 1,972
Pick disease 1,798 | 1,894
group 4 medulloblastoma 1,752 | 1,855
ulcerative colitis 1,728 | 1,819
ductal carcinoma in situ 1,702 | 1,745
cystic fibrosis 1,626 | 1,696
breast carcinoma 1,586 | 1,638
colon cancer 1,412 | 1,478
adrenocortical carcinoma 1,386 | 1,428
diabetes mellitus 1,336 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,280 | 1,442
juvenile dermatomyositis 1,166 | 1,187
acute quadriplegic myopathy 1,145 | 1,158
astrocytoma 1,092 | 1,146
Rheumatoid arthritis 1,086 | 1,191
primary pancreatic ductal adenocarcinoma 1,076 | 1,109
spina bifida 1,045 | 1,074
pediatric high grade glioma 1,020 | 1,064
cutaneous lupus erythematosus 1,018 | 1,057
nasopharyngeal carcinoma 994 | 1,058
Schizophrenia 973 | 1,160
Intellectual disability 930 | 1,016
dermatomyositis 921 | 966
Atopic dermatitis 900 | 952
active Crohn's disease 877 | 922
non primary Sjogren syndrome sicca 810 | 891
acute myeloid leukemia 771 | 783
gastric carcinoma 769 | 807
Waldenstrons macroglobulinemia 757 | 765
esophageal adenocarcinoma 724 | 737
active ulcerative colitis 719 | 764
Liver Cirrhosis, Experimental 718 | 769
Epilepsy 717 | 792
primary Sjogren syndrome 714 | 735
medulloblastoma 667 | 720
progressive supranuclear palsy 647 | 676
aldosterone-producing adenoma 641 | 665
Alzheimer's disease 595 | 658
Duchenne muscular dystrophy 590 | 601
Dull intelligence 590 | 645
Low intelligence 590 | 645
Mental Retardation 590 | 645
Mental deficiency 590 | 645
Poor school performance 590 | 645
Obesity 567 | 678
Cognitive delay 565 | 608
Global developmental delay 565 | 608
Mental and motor retardation 565 | 608
Bipolar Disorder 557 | 666
Melanoma 552 | 711
Seizures 547 | 596
pancreatic carcinoma 547 | 562
fibroadenoma 543 | 559
Muscle hypotonia 539 | 571
hepatocellular carcinoma 531 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 504 | 510
Endometriosis 498 | 540
Liver cancer 492 | 604
Short stature 480 | 531
chronic rhinosinusitis 472 | 512
Down syndrome 469 | 499
Prostatic Neoplasms 460 | 495
mucosa-associated lymphoid tissue lymphoma 454 | 484
Multiple Sclerosis 449 | 540
gastric cancer 448 | 459
posterior fossa group A ependymoma 446 | 468
sonic hedgehog group medulloblastoma 434 | 467
Amyotrophic lateral sclerosis 430 | 451

Tissue

Digestive Tract 15,898 | 17,369
Endocrine System 15,836 | 18,159
Skin and soft tissues 15,832 | 17,230
Female tissues 15,803 | 17,400
Male tissues 15,727 | 17,142
Blood and immune system 15,664 | 16,909
Liver and Pancreas 15,613 | 16,750
Urinary Tract 15,592 | 16,678
Respiratory system 15,474 | 16,393
Nervous System 15,454 | 16,725
Cardiovascular System 14,803 | 15,192

Target Family

Non-IDG 9,259 | 12,091
Enzyme 3,687 | 4,145
Transcription Factor 1,161 | 1,400
Kinase 595 | 634
Transporter 382 | 473
GPCR 255 | 408
Ion Channel 243 | 344
Epigenetic 228 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 12 | 421

HPA RNA Tissue

esophagus 15,898 | 15,898
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50