Development Level

Tbio 8,227 | 10,625
Tdark 3,318 | 7,003
Tchem 1,444 | 1,890
Tclin 366 | 602

Collection

Eligible Kinase Proteins 99 | 134
Eligible Ion Channel Proteins 45 | 117
Eligible non-olfactory GPCR Proteins 35 | 143

IMPC Term

preweaning lethality, complete... 582 | 633
preweaning lethality, incomple... 215 | 260
abnormal behavior 188 | 226
embryonic lethality prior to t... 178 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 162 | 186
decreased body weight 150 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 129 | 157
increased circulating alkaline... 104 | 119
increased or absent threshold ... 104 | 128
abnormal bone structure 101 | 131
abnormal embryo size 99 | 112
decreased bone mineral density 99 | 126
decreased circulating glucose ... 97 | 121
decreased body length 95 | 108
decreased grip strength 95 | 123
increased lean body mass 91 | 107
hyperactivity 89 | 108
abnormal retina morphology 87 | 100
enlarged heart 86 | 111
increased mean corpuscular hem... 84 | 93
increased mean corpuscular vol... 83 | 91
increased bone mineral content 80 | 92
decreased circulating choleste... 73 | 85
short tibia 73 | 82
increased grip strength 70 | 83
decreased circulating serum al... 69 | 79
decreased circulating triglyce... 69 | 83
decreased circulating HDL chol... 68 | 77
hypoactivity 68 | 89
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 60 | 64
decreased circulating insulin ... 57 | 75
increased fasted circulating g... 56 | 68
decreased lumbar vertebrae num... 55 | 62
abnormal retinal pigmentation 54 | 61
increased sacral vertebrae num... 54 | 62
increased circulating sodium l... 52 | 71
decreased rib number 49 | 59
abnormal sleep behavior 47 | 63
decreased mean corpuscular vol... 47 | 50
decreased leukocyte cell numbe... 46 | 54
increased circulating HDL chol... 46 | 63
abnormal bone mineralization 45 | 55
increased bone mineral density 44 | 52
increased total body fat amoun... 44 | 57
male infertility 44 | 62
abnormal coat/hair pigmentatio... 43 | 54
decreased hemoglobin content 43 | 53
decreased circulating alanine ... 42 | 53
improved glucose tolerance 42 | 56
increased circulating choleste... 42 | 53
abnormal gait 41 | 51
decreased caudal vertebrae num... 41 | 49
decreased fasted circulating g... 41 | 49
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 40 | 52
increased exploration in new e... 40 | 56
abnormal behavioral response t... 39 | 52
decreased startle reflex 39 | 48
decreased circulating total pr... 38 | 41
increased hemoglobin content 38 | 45
decreased erythrocyte cell num... 37 | 43
increased blood urea nitrogen ... 37 | 44
thrombocytopenia 37 | 46
decreased eosinophil cell numb... 36 | 41
increased rib number 36 | 41
abnormal heart morphology 35 | 51
increased body weight 35 | 42
decreased circulating LDL chol... 34 | 37
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
decreased circulating alkaline... 33 | 41
increased hematocrit 33 | 36
abnormal eye morphology 32 | 38
decreased circulating free fat... 32 | 39
abnormal seminal vesicle morph... 31 | 47
decreased neutrophil cell numb... 31 | 37
decreased circulating fructosa... 30 | 31
decreased mean corpuscular hem... 30 | 34
increased circulating chloride... 30 | 43
increased leukocyte cell numbe... 30 | 37
abnormal spleen morphology 29 | 36
cardiovascular system phenotyp... 29 | 35
increased startle reflex 29 | 38
small testis 29 | 37
abnormal cranium morphology 28 | 32
decreased circulating calcium ... 28 | 33
tremors 28 | 34
decreased T cell number 27 | 31
increased circulating calcium ... 27 | 32
decreased NK T cell number 26 | 28
decreased circulating creatini... 26 | 31
embryonic growth retardation 26 | 28
decreased circulating chloride... 25 | 32
increased circulating potassiu... 25 | 31
increased heart weight 25 | 37
limb grasping 25 | 35
abnormal cornea morphology 24 | 24

Disease

ovarian cancer 7,554 | 8,484
osteosarcoma 6,702 | 7,933
medulloblastoma, large-cell 5,056 | 6,234
psoriasis 4,933 | 6,685
glioblastoma 4,648 | 5,572
lung cancer 4,021 | 4,466
atypical teratoid / rhabdoid tumor 3,569 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,956 | 3,289
malignant mesothelioma 2,799 | 3,162
Breast cancer 2,743 | 3,094
invasive ductal carcinoma 2,687 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,662 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,627 | 2,956
non-small cell lung cancer 2,519 | 2,798
primitive neuroectodermal tumor 2,449 | 3,031
pilocytic astrocytoma 2,379 | 3,086
oligodendroglioma 2,295 | 2,849
lung adenocarcinoma 2,289 | 2,713
lung carcinoma 2,257 | 2,844
pediatric high grade glioma 2,219 | 2,712
ependymoma 2,106 | 2,514
pancreatic cancer 2,033 | 2,300
interstitial cystitis 1,964 | 2,299
subependymal giant cell astrocytoma 1,940 | 2,287
group 3 medulloblastoma 1,885 | 2,254
astrocytic glioma 1,844 | 2,241
Cancer 1,842 | 2,346
ulcerative colitis 1,825 | 2,087
adult high grade glioma 1,664 | 2,148
Pick disease 1,632 | 1,893
group 4 medulloblastoma 1,606 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,606 | 1,795
ductal carcinoma in situ 1,562 | 1,745
pituitary cancer 1,559 | 1,972
Carcinoma 1,478 | 2,147
breast carcinoma 1,458 | 1,614
cystic fibrosis 1,435 | 1,665
tuberculosis 1,364 | 1,557
Multiple myeloma 1,296 | 1,327
adrenocortical carcinoma 1,288 | 1,427
colon cancer 1,286 | 1,475
astrocytoma 1,285 | 1,493
sonic hedgehog group medulloblastoma 1,209 | 1,482
medulloblastoma 1,198 | 1,524
posterior fossa group A ependymoma 1,182 | 1,511
primary pancreatic ductal adenocarcinoma 1,180 | 1,271
juvenile dermatomyositis 1,134 | 1,189
diabetes mellitus 1,127 | 1,663
posterior fossa group B ependymoma 1,118 | 1,530
acute quadriplegic myopathy 1,110 | 1,157
Rheumatoid Arthritis 1,001 | 1,160
spina bifida 987 | 1,064
cutaneous lupus erythematosus 913 | 1,056
dermatomyositis 911 | 933
atypical teratoid/rhabdoid tumor 884 | 1,095
nasopharyngeal carcinoma 878 | 1,056
Atopic dermatitis 796 | 944
active Crohn's disease 785 | 918
gastric carcinoma 742 | 832
Waldenstrons macroglobulinemia 737 | 765
acute myeloid leukemia 729 | 780
primary Sjogren syndrome 722 | 789
non primary Sjogren syndrome sicca 690 | 840
esophageal adenocarcinoma 688 | 737
tuberculosis and treatment for 6 months 647 | 686
progressive supranuclear palsy 608 | 674
aldosterone-producing adenoma 602 | 664
Duchenne muscular dystrophy 575 | 602
pancreatic carcinoma 511 | 567
Alzheimer's disease 498 | 644
hepatocellular carcinoma 485 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 499
Down syndrome 475 | 548
Intellectual disability 466 | 573
fibroadenoma 464 | 557
Endometriosis 434 | 535
Obesity 431 | 616
IGA Glomerulonephritis 428 | 454
Prostatic Neoplasms 394 | 471
mucosa-associated lymphoid tissue lymphoma 394 | 480
chronic rhinosinusitis 391 | 512
gastric cancer 384 | 430
active ulcerative colitis 383 | 477
Amyotrophic Lateral Sclerosis 378 | 431
Mammary Neoplasms 351 | 410
inflammatory breast cancer 340 | 404
Multiple Sclerosis 338 | 498
Neurodegenerative disease 330 | 383
Schizophrenia 325 | 501
hereditary spastic paraplegia 308 | 313
sarcoidosis 304 | 358
non-small cell lung carcinoma 301 | 413
glioblastoma multiforme 292 | 347
tuberculosis and treatment for 3 months 292 | 327
urothelial carcinoma 279 | 318
Polycystic Ovary Syndrome 265 | 332
interstitial lung disease 263 | 291
Kidney disease 258 | 396
Parkinson's disease 255 | 364
nephrosclerosis 244 | 329

Tissue

Digestive Tract 13,355 | 18,473
Skin and soft tissues 13,354 | 18,115
Female tissues 13,353 | 18,647
Endocrine System 13,350 | 18,512
Nervous System 13,349 | 18,561
Urinary Tract 13,349 | 18,444
Liver and Pancreas 13,348 | 18,136
Blood and immune system 13,340 | 17,995
Male tissues 13,337 | 17,969
Cardiovascular System 13,335 | 17,958
Respiratory system 13,329 | 17,484

Target Family

Non-IDG 7,722 | 11,971
Enzyme 3,274 | 4,146
Transcription Factor 969 | 1,400
Kinase 535 | 634
Transporter 299 | 473
Epigenetic 211 | 242
Ion Channel 144 | 341
GPCR 135 | 406
Nuclear Receptor 33 | 48
TF/Epigenetic 32 | 38
oGPCR 1 | 421

HPA RNA Tissue

esophagus 13,355 | 13,355
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108