Development Level

Tbio 10,136 | 11,651
Tdark 4,022 | 6,593
Tchem 1,218 | 1,388
Tclin 487 | 612

Collection

RFA-RM-18-021 239 | 328
Kinase: IDG Consortium (Target... 109 | 125
Ion Channel: IDG Consortium (T... 67 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 274 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
enlarged heart 187 | 210
decreased total body fat amoun... 186 | 207
decreased vertical activity 170 | 208
abnormal bone structure 165 | 187
increased lean body mass 155 | 172
abnormal heart morphology 148 | 162
decreased body weight 147 | 161
decreased bone mineral content 136 | 151
hyperactivity 133 | 148
decreased lean body mass 124 | 135
increased total body fat amoun... 120 | 134
hypoactivity 115 | 132
decreased circulating glucose ... 114 | 126
decreased bone mineral density 113 | 126
increased circulating alkaline... 112 | 122
male infertility 107 | 123
decreased grip strength 105 | 116
increased startle reflex 105 | 112
embryonic growth retardation 100 | 106
abnormal seminal vesicle morph... 99 | 114
increased bone mineral content 98 | 108
increased or absent threshold ... 94 | 101
short tibia 93 | 97
decreased body length 91 | 101
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 88 | 92
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
prenatal lethality prior to he... 82 | 87
decreased lymphocyte cell numb... 80 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 74 | 82
decreased circulating triglyce... 71 | 79
decreased leukocyte cell numbe... 69 | 73
decreased mean corpuscular vol... 69 | 79
increased circulating HDL chol... 69 | 80
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased bone mineral density 68 | 72
decreased circulating insulin ... 67 | 76
impaired glucose tolerance 67 | 75
abnormal retina morphology 66 | 71
decreased startle reflex 66 | 75
decreased circulating HDL chol... 65 | 68
abnormal eye morphology 64 | 68
small superior vagus ganglion 64 | 74
increased circulating sodium l... 63 | 71
abnormal gait 61 | 69
abnormal sleep behavior 61 | 70
decreased fasted circulating g... 61 | 65
abnormal coat-hair pigmentatio... 59 | 64
decreased erythrocyte cell num... 59 | 62
increased circulating choleste... 58 | 66
increased monocyte cell number 58 | 63
abnormal kidney morphology 57 | 65
decreased hemoglobin content 57 | 68
edema 56 | 59
increased heart weight 56 | 62
abnormal behavioral response t... 55 | 66
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
small testis 51 | 58
female infertility 50 | 60
thrombocytopenia 50 | 56
decreased circulating total pr... 49 | 49
decreased blood urea nitrogen ... 48 | 51
abnormal skin morphology 47 | 50
abnormal neural tube closure 46 | 46
increased neutrophil cell numb... 45 | 46
decreased mean corpuscular hem... 44 | 50
hydrometra 44 | 53
decreased circulating alanine ... 43 | 47
decreased circulating alkaline... 43 | 46
increased blood urea nitrogen ... 42 | 48
increased leukocyte cell numbe... 42 | 47
decreased hematocrit 40 | 46
enlarged spleen 40 | 41
increased hematocrit 40 | 46
abnormal testis morphology 39 | 43
increased circulating triglyce... 39 | 42
decreased neutrophil cell numb... 38 | 42
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased circulating chloride... 37 | 41
increased hemoglobin content 37 | 45
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
increased mean platelet volume 36 | 45
limb grasping 36 | 41
tremors 36 | 39
abnormal cranium morphology 35 | 36
decreased circulating creatini... 35 | 39
increased erythrocyte cell num... 35 | 39

Disease

Carcinoma 9,706 | 11,493
ovarian cancer 8,072 | 8,520
osteosarcoma 7,343 | 7,950
medulloblastoma, large-cell 5,738 | 6,241
psoriasis 5,642 | 6,694
glioblastoma 5,411 | 5,792
atypical teratoid / rhabdoid tumor 4,747 | 5,112
lung cancer 4,410 | 4,740
ependymoma 4,332 | 4,679
group 3 medulloblastoma 3,803 | 4,104
adult high grade glioma 3,435 | 3,801
Breast cancer 3,357 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,120 | 3,291
malignant mesothelioma 3,062 | 3,232
invasive ductal carcinoma 2,843 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,839 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,826 | 2,955
primitive neuroectodermal tumor 2,814 | 3,035
Astrocytoma, Pilocytic 2,811 | 3,081
non-small cell lung cancer 2,717 | 2,890
lung carcinoma 2,636 | 2,843
oligodendroglioma 2,632 | 2,850
lung adenocarcinoma 2,519 | 2,716
astrocytic glioma 2,413 | 2,597
Kidney cancer 2,290 | 2,613
pancreatic cancer 2,228 | 2,398
Cancer 2,164 | 2,499
interstitial cystitis 2,156 | 2,312
subependymal giant cell astrocytoma 2,146 | 2,287
tuberculosis 1,880 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,858 | 1,962
pituitary cancer 1,829 | 1,972
Pick disease 1,794 | 1,894
group 4 medulloblastoma 1,756 | 1,855
ulcerative colitis 1,672 | 1,819
ductal carcinoma in situ 1,670 | 1,745
cystic fibrosis 1,570 | 1,696
breast carcinoma 1,546 | 1,638
adrenocortical carcinoma 1,371 | 1,428
colon cancer 1,364 | 1,478
diabetes mellitus 1,309 | 1,728
Multiple myeloma 1,302 | 1,332
Autosomal recessive predisposition 1,281 | 1,442
juvenile dermatomyositis 1,153 | 1,187
acute quadriplegic myopathy 1,119 | 1,158
astrocytoma 1,095 | 1,146
primary pancreatic ductal adenocarcinoma 1,072 | 1,109
Rheumatoid arthritis 1,068 | 1,191
pediatric high grade glioma 1,014 | 1,064
spina bifida 1,008 | 1,074
cutaneous lupus erythematosus 988 | 1,057
Schizophrenia 958 | 1,160
nasopharyngeal carcinoma 958 | 1,058
Intellectual disability 944 | 1,016
dermatomyositis 917 | 966
active Crohn's disease 848 | 922
non primary Sjogren syndrome sicca 818 | 891
Atopic dermatitis 817 | 952
gastric carcinoma 770 | 807
acute myeloid leukemia 768 | 783
Waldenstrons macroglobulinemia 748 | 765
Epilepsy 715 | 792
Liver Cirrhosis, Experimental 715 | 769
primary Sjogren syndrome 702 | 735
active ulcerative colitis 692 | 764
esophageal adenocarcinoma 679 | 737
medulloblastoma 673 | 720
progressive supranuclear palsy 649 | 676
aldosterone-producing adenoma 648 | 665
Dull intelligence 598 | 645
Low intelligence 598 | 645
Mental Retardation 598 | 645
Mental deficiency 598 | 645
Poor school performance 598 | 645
Alzheimer's disease 584 | 658
Duchenne muscular dystrophy 575 | 601
Obesity 575 | 678
Cognitive delay 567 | 608
Global developmental delay 567 | 608
Mental and motor retardation 567 | 608
Melanoma 559 | 711
Bipolar Disorder 551 | 666
Seizures 543 | 596
pancreatic carcinoma 542 | 562
Muscle hypotonia 540 | 571
fibroadenoma 531 | 559
hepatocellular carcinoma 527 | 547
Liver cancer 511 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Short stature 484 | 531
Endometriosis 480 | 540
chronic rhinosinusitis 476 | 512
Down syndrome 464 | 499
Prostatic Neoplasms 458 | 495
gastric cancer 442 | 459
posterior fossa group A ependymoma 442 | 468
Multiple Sclerosis 437 | 540
sonic hedgehog group medulloblastoma 432 | 467
Amyotrophic lateral sclerosis 427 | 451
mucosa-associated lymphoid tissue lymphoma 426 | 484

Tissue

Male tissues 15,863 | 17,142
Endocrine System 15,798 | 18,159
Female tissues 15,691 | 17,400
Digestive Tract 15,627 | 17,369
Skin and soft tissues 15,599 | 17,230
Liver and Pancreas 15,444 | 16,750
Urinary Tract 15,434 | 16,678
Blood and immune system 15,433 | 16,909
Nervous System 15,368 | 16,725
Respiratory system 15,313 | 16,393
Cardiovascular System 14,561 | 15,192

Target Family

Non-IDG 9,250 | 12,091
Enzyme 3,662 | 4,145
Transcription Factor 1,157 | 1,400
Kinase 579 | 634
Transporter 387 | 473
GPCR 250 | 408
Ion Channel 242 | 344
Epigenetic 230 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 36 | 38
oGPCR 29 | 421

HPA RNA Tissue

epididymis 15,863 | 15,863
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50