Development Level

Tbio 10,436 | 11,651
Tdark 4,099 | 6,593
Tchem 1,282 | 1,388
Tclin 532 | 612

Collection

RFA-RM-18-021 263 | 328
Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 76 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 946 | 979
preweaning lethality, incomple... 477 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 190 | 210
decreased vertical activity 175 | 208
abnormal bone structure 169 | 187
increased lean body mass 161 | 172
decreased body weight 151 | 161
abnormal heart morphology 149 | 162
hyperactivity 139 | 148
decreased bone mineral content 138 | 151
decreased lean body mass 126 | 135
increased total body fat amoun... 123 | 134
hypoactivity 121 | 132
decreased circulating glucose ... 115 | 126
decreased bone mineral density 114 | 126
increased circulating alkaline... 113 | 122
male infertility 109 | 123
increased startle reflex 104 | 112
decreased grip strength 102 | 116
embryonic growth retardation 102 | 106
abnormal seminal vesicle morph... 101 | 114
increased bone mineral content 100 | 108
decreased body length 94 | 101
short tibia 94 | 97
increased or absent threshold ... 90 | 101
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 89 | 92
cataract 88 | 92
increased mean corpuscular hem... 88 | 96
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 79 | 83
abnormal lens morphology 77 | 81
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 73 | 79
decreased mean corpuscular vol... 73 | 79
decreased startle reflex 71 | 75
improved glucose tolerance 71 | 79
decreased leukocyte cell numbe... 70 | 73
increased bone mineral density 70 | 72
increased fasted circulating g... 70 | 76
increased circulating HDL chol... 69 | 80
decreased circulating insulin ... 67 | 76
impaired glucose tolerance 67 | 75
decreased circulating HDL chol... 66 | 68
increased circulating sodium l... 66 | 71
abnormal eye morphology 65 | 68
abnormal retina morphology 65 | 71
abnormal sleep behavior 64 | 70
small superior vagus ganglion 64 | 74
abnormal gait 63 | 69
abnormal coat-hair pigmentatio... 61 | 64
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 60 | 68
increased circulating choleste... 60 | 66
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
abnormal kidney morphology 58 | 65
increased heart weight 58 | 62
edema 56 | 59
small testis 53 | 58
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 51 | 56
abnormal spleen morphology 50 | 55
female infertility 49 | 60
abnormal skin morphology 47 | 50
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 45 | 46
increased blood urea nitrogen ... 45 | 48
increased leukocyte cell numbe... 45 | 47
decreased circulating alanine ... 44 | 47
hydrometra 44 | 53
decreased circulating alkaline... 43 | 46
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased hematocrit 42 | 46
increased mean platelet volume 41 | 45
decreased neutrophil cell numb... 40 | 42
increased circulating triglyce... 40 | 42
increased hemoglobin content 40 | 45
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
decreased red blood cell distr... 38 | 41
increased circulating chloride... 38 | 41
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
abnormal bone mineralization 36 | 38
tremors 36 | 39
abnormal cranium morphology 35 | 36
increased grip strength 35 | 41
decreased circulating creatini... 34 | 39

Disease

Carcinoma 9,989 | 11,493
ovarian cancer 8,177 | 8,520
osteosarcoma 7,511 | 7,950
psoriasis 5,868 | 6,694
medulloblastoma, large-cell 5,864 | 6,241
glioblastoma 5,527 | 5,792
atypical teratoid / rhabdoid tumor 4,860 | 5,112
lung cancer 4,512 | 4,740
ependymoma 4,443 | 4,679
group 3 medulloblastoma 3,903 | 4,104
adult high grade glioma 3,560 | 3,801
Breast cancer 3,429 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,212 | 3,291
malignant mesothelioma 3,130 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,929 | 2,989
invasive ductal carcinoma 2,902 | 2,951
Astrocytoma, Pilocytic 2,900 | 3,081
primitive neuroectodermal tumor 2,896 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,893 | 2,955
non-small cell lung cancer 2,796 | 2,890
lung carcinoma 2,700 | 2,843
oligodendroglioma 2,697 | 2,850
lung adenocarcinoma 2,606 | 2,716
astrocytic glioma 2,465 | 2,597
Kidney cancer 2,361 | 2,613
pancreatic cancer 2,311 | 2,398
Cancer 2,249 | 2,499
interstitial cystitis 2,225 | 2,312
subependymal giant cell astrocytoma 2,184 | 2,287
tuberculosis 1,926 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,900 | 1,962
pituitary cancer 1,875 | 1,972
Pick disease 1,832 | 1,894
group 4 medulloblastoma 1,781 | 1,855
ulcerative colitis 1,748 | 1,819
ductal carcinoma in situ 1,712 | 1,745
cystic fibrosis 1,631 | 1,696
breast carcinoma 1,594 | 1,638
colon cancer 1,431 | 1,478
adrenocortical carcinoma 1,403 | 1,428
diabetes mellitus 1,354 | 1,728
Autosomal recessive predisposition 1,309 | 1,442
Multiple myeloma 1,309 | 1,332
juvenile dermatomyositis 1,158 | 1,187
acute quadriplegic myopathy 1,130 | 1,158
astrocytoma 1,110 | 1,146
primary pancreatic ductal adenocarcinoma 1,094 | 1,109
Rheumatoid arthritis 1,087 | 1,191
spina bifida 1,031 | 1,074
nasopharyngeal carcinoma 1,030 | 1,058
pediatric high grade glioma 1,020 | 1,064
Schizophrenia 1,016 | 1,160
cutaneous lupus erythematosus 1,016 | 1,057
Intellectual disability 958 | 1,016
dermatomyositis 918 | 966
active Crohn's disease 886 | 922
Atopic dermatitis 876 | 952
non primary Sjogren syndrome sicca 819 | 891
gastric carcinoma 784 | 807
acute myeloid leukemia 770 | 783
Waldenstrons macroglobulinemia 754 | 765
Epilepsy 732 | 792
active ulcerative colitis 731 | 764
Liver Cirrhosis, Experimental 730 | 769
primary Sjogren syndrome 717 | 735
esophageal adenocarcinoma 707 | 737
medulloblastoma 683 | 720
progressive supranuclear palsy 657 | 676
aldosterone-producing adenoma 651 | 665
Alzheimer's disease 609 | 658
Dull intelligence 609 | 645
Low intelligence 609 | 645
Mental Retardation 609 | 645
Mental deficiency 609 | 645
Poor school performance 609 | 645
Obesity 606 | 678
Bipolar Disorder 582 | 666
Duchenne muscular dystrophy 579 | 601
Melanoma 579 | 711
Cognitive delay 578 | 608
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Seizures 554 | 596
pancreatic carcinoma 547 | 562
fibroadenoma 546 | 559
Muscle hypotonia 544 | 571
hepatocellular carcinoma 538 | 547
Liver cancer 524 | 604
Endometriosis 522 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 510
Short stature 493 | 531
chronic rhinosinusitis 493 | 512
Down syndrome 473 | 499
Prostatic Neoplasms 469 | 495
Multiple Sclerosis 458 | 540
mucosa-associated lymphoid tissue lymphoma 449 | 484
gastric cancer 448 | 459
posterior fossa group A ependymoma 447 | 468
sonic hedgehog group medulloblastoma 439 | 467
Breast Neoplasms 431 | 445

Tissue

Female tissues 16,349 | 17,400
Endocrine System 16,311 | 18,159
Digestive Tract 16,209 | 17,369
Skin and soft tissues 16,194 | 17,230
Male tissues 16,141 | 17,142
Blood and immune system 16,015 | 16,909
Liver and Pancreas 15,989 | 16,750
Urinary Tract 15,956 | 16,678
Nervous System 15,877 | 16,725
Respiratory system 15,847 | 16,393
Cardiovascular System 14,910 | 15,192

Target Family

Non-IDG 9,557 | 12,091
Enzyme 3,738 | 4,145
Transcription Factor 1,183 | 1,400
Kinase 603 | 634
Transporter 394 | 473
GPCR 291 | 408
Ion Channel 263 | 344
Epigenetic 229 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 15 | 421

HPA RNA Tissue

endometrium 16,349 | 16,349
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50