Development Level

Tbio 8,125 | 10,625
Tdark 3,444 | 7,003
Tchem 1,426 | 1,890
Tclin 373 | 602

Collection

Eligible Kinase Proteins 101 | 134
Eligible Ion Channel Proteins 44 | 117
Eligible non-olfactory GPCR Proteins 37 | 143

IMPC Term

preweaning lethality, complete... 582 | 633
preweaning lethality, incomple... 218 | 260
abnormal behavior 194 | 226
embryonic lethality prior to t... 177 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 158 | 186
decreased body weight 150 | 174
embryonic lethality prior to o... 145 | 148
decreased bone mineral content 129 | 157
increased circulating alkaline... 105 | 119
abnormal bone structure 103 | 131
decreased bone mineral density 102 | 126
increased or absent threshold ... 102 | 128
abnormal embryo size 100 | 112
decreased body length 95 | 108
decreased grip strength 95 | 123
decreased circulating glucose ... 92 | 121
hyperactivity 92 | 108
increased lean body mass 91 | 107
abnormal retina morphology 87 | 100
increased mean corpuscular hem... 83 | 93
enlarged heart 82 | 111
increased mean corpuscular vol... 82 | 91
increased bone mineral content 79 | 92
decreased circulating choleste... 73 | 85
short tibia 72 | 82
hypoactivity 71 | 89
decreased circulating HDL chol... 68 | 77
increased grip strength 68 | 83
decreased circulating serum al... 67 | 79
decreased circulating triglyce... 67 | 83
abnormal lens morphology 61 | 73
increased fasted circulating g... 57 | 68
prenatal lethality prior to he... 57 | 64
decreased circulating insulin ... 55 | 75
decreased lumbar vertebrae num... 55 | 62
increased sacral vertebrae num... 54 | 62
abnormal retinal pigmentation 53 | 61
decreased rib number 50 | 59
increased circulating sodium l... 50 | 71
abnormal sleep behavior 48 | 63
increased circulating HDL chol... 47 | 63
male infertility 47 | 62
abnormal bone mineralization 46 | 55
abnormal coat/hair pigmentatio... 46 | 54
decreased mean corpuscular vol... 46 | 50
decreased hemoglobin content 45 | 53
decreased leukocyte cell numbe... 45 | 54
increased bone mineral density 45 | 52
increased total body fat amoun... 45 | 57
abnormal gait 42 | 51
decreased circulating alanine ... 42 | 53
decreased prepulse inhibition 42 | 52
decreased caudal vertebrae num... 41 | 49
impaired glucose tolerance 41 | 52
improved glucose tolerance 41 | 56
increased circulating choleste... 41 | 53
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 39 | 49
increased exploration in new e... 39 | 56
decreased circulating total pr... 38 | 41
decreased startle reflex 37 | 48
increased blood urea nitrogen ... 37 | 44
thrombocytopenia 37 | 46
abnormal behavioral response t... 36 | 52
decreased circulating LDL chol... 36 | 37
increased body weight 36 | 42
increased hemoglobin content 36 | 45
abnormal heart morphology 35 | 51
decreased eosinophil cell numb... 35 | 41
decreased heart weight 35 | 44
increased rib number 35 | 41
decreased circulating free fat... 34 | 39
abnormal neural tube closure 33 | 37
abnormal seminal vesicle morph... 33 | 47
abnormal eye morphology 32 | 38
decreased neutrophil cell numb... 32 | 37
increased startle reflex 32 | 38
decreased circulating alkaline... 31 | 41
decreased circulating calcium ... 31 | 33
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
small testis 30 | 37
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased circulating chloride... 29 | 43
increased leukocyte cell numbe... 29 | 37
abnormal spleen morphology 27 | 36
cardiovascular system phenotyp... 27 | 35
decreased circulating creatini... 27 | 31
increased circulating potassiu... 27 | 31
tremors 27 | 34
decreased T cell number 26 | 31
increased heart weight 26 | 37
abnormal testis morphology 25 | 30
decreased threshold for audito... 25 | 32
embryonic growth retardation 25 | 28
increased circulating calcium ... 25 | 32
limb grasping 25 | 35
decreased circulating aspartat... 24 | 27

Disease

ovarian cancer 7,567 | 8,484
osteosarcoma 6,716 | 7,933
medulloblastoma, large-cell 5,111 | 6,234
psoriasis 4,777 | 6,685
glioblastoma 4,708 | 5,572
lung cancer 3,994 | 4,466
atypical teratoid / rhabdoid tumor 3,622 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,922 | 3,289
malignant mesothelioma 2,798 | 3,162
Breast cancer 2,742 | 3,094
invasive ductal carcinoma 2,687 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 2,655 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,629 | 2,956
primitive neuroectodermal tumor 2,473 | 3,031
pilocytic astrocytoma 2,445 | 3,086
non-small cell lung cancer 2,408 | 2,798
oligodendroglioma 2,331 | 2,849
lung carcinoma 2,294 | 2,844
lung adenocarcinoma 2,248 | 2,713
pediatric high grade glioma 2,236 | 2,712
ependymoma 2,132 | 2,514
pancreatic cancer 1,974 | 2,300
subependymal giant cell astrocytoma 1,953 | 2,287
group 3 medulloblastoma 1,903 | 2,254
interstitial cystitis 1,897 | 2,299
astrocytic glioma 1,878 | 2,241
Cancer 1,841 | 2,346
ulcerative colitis 1,800 | 2,087
adult high grade glioma 1,702 | 2,148
Pick disease 1,670 | 1,893
group 4 medulloblastoma 1,636 | 1,875
pituitary cancer 1,611 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,602 | 1,795
ductal carcinoma in situ 1,544 | 1,745
Carcinoma 1,533 | 2,147
breast carcinoma 1,425 | 1,614
cystic fibrosis 1,391 | 1,665
tuberculosis 1,344 | 1,557
Multiple myeloma 1,299 | 1,327
astrocytoma 1,298 | 1,493
adrenocortical carcinoma 1,281 | 1,427
colon cancer 1,274 | 1,475
medulloblastoma 1,245 | 1,524
posterior fossa group B ependymoma 1,230 | 1,530
sonic hedgehog group medulloblastoma 1,223 | 1,482
posterior fossa group A ependymoma 1,189 | 1,511
primary pancreatic ductal adenocarcinoma 1,185 | 1,271
juvenile dermatomyositis 1,125 | 1,189
diabetes mellitus 1,096 | 1,663
acute quadriplegic myopathy 1,081 | 1,157
Rheumatoid Arthritis 981 | 1,160
spina bifida 905 | 1,064
dermatomyositis 897 | 933
atypical teratoid/rhabdoid tumor 896 | 1,095
nasopharyngeal carcinoma 871 | 1,056
cutaneous lupus erythematosus 867 | 1,056
active Crohn's disease 772 | 918
gastric carcinoma 748 | 832
acute myeloid leukemia 734 | 780
Waldenstrons macroglobulinemia 733 | 765
Atopic dermatitis 731 | 944
primary Sjogren syndrome 703 | 789
non primary Sjogren syndrome sicca 680 | 840
tuberculosis and treatment for 6 months 647 | 686
esophageal adenocarcinoma 617 | 737
progressive supranuclear palsy 615 | 674
aldosterone-producing adenoma 608 | 664
Duchenne muscular dystrophy 555 | 602
Alzheimer's disease 510 | 644
pancreatic carcinoma 499 | 567
Intellectual disability 479 | 573
hepatocellular carcinoma 479 | 532
Down syndrome 477 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 471 | 499
fibroadenoma 468 | 557
Endometriosis 455 | 535
Obesity 438 | 616
chronic rhinosinusitis 431 | 512
IGA Glomerulonephritis 420 | 454
Prostatic Neoplasms 393 | 471
Amyotrophic Lateral Sclerosis 382 | 431
active ulcerative colitis 380 | 477
gastric cancer 378 | 430
mucosa-associated lymphoid tissue lymphoma 378 | 480
Mammary Neoplasms 351 | 410
Schizophrenia 340 | 501
Neurodegenerative disease 335 | 383
Multiple Sclerosis 334 | 498
inflammatory breast cancer 333 | 404
hereditary spastic paraplegia 303 | 313
sarcoidosis 300 | 358
non-small cell lung carcinoma 297 | 413
tuberculosis and treatment for 3 months 297 | 327
glioblastoma multiforme 289 | 347
urothelial carcinoma 271 | 318
Polycystic Ovary Syndrome 267 | 332
Parkinson's disease 266 | 364
interstitial lung disease 265 | 291
Kidney disease 264 | 396
nephrosclerosis 248 | 329

Tissue

Female tissues 13,368 | 18,647
Digestive Tract 13,367 | 18,473
Endocrine System 13,367 | 18,512
Nervous System 13,364 | 18,561
Skin and soft tissues 13,362 | 18,115
Urinary Tract 13,362 | 18,444
Liver and Pancreas 13,360 | 18,136
Male tissues 13,356 | 17,969
Cardiovascular System 13,351 | 17,958
Blood and immune system 13,350 | 17,995
Respiratory system 13,349 | 17,484

Target Family

Non-IDG 7,727 | 11,971
Enzyme 3,257 | 4,146
Transcription Factor 998 | 1,400
Kinase 532 | 634
Transporter 296 | 473
Epigenetic 214 | 242
GPCR 140 | 406
Ion Channel 138 | 341
Nuclear Receptor 34 | 48
TF/Epigenetic 31 | 38
oGPCR 1 | 421

HPA RNA Tissue

endometrium 13,368 | 13,368
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27