Development Level

Tbio 8,137 | 10,625
Tdark 3,299 | 7,003
Tchem 1,483 | 1,890
Tclin 378 | 602

Collection

Eligible Kinase Proteins 99 | 134
Eligible Ion Channel Proteins 43 | 117
Eligible non-olfactory GPCR Proteins 35 | 145

IMPC Term

preweaning lethality, complete... 577 | 633
preweaning lethality, incomple... 215 | 260
abnormal behavior 187 | 226
embryonic lethality prior to t... 177 | 187
decreased lean body mass 163 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 156 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 127 | 157
increased circulating alkaline... 103 | 119
decreased bone mineral density 101 | 126
increased or absent threshold ... 100 | 128
abnormal bone structure 99 | 131
abnormal embryo size 99 | 112
decreased body length 96 | 108
decreased circulating glucose ... 96 | 121
decreased grip strength 94 | 123
abnormal retina morphology 88 | 100
increased lean body mass 88 | 107
hyperactivity 87 | 108
increased mean corpuscular hem... 84 | 93
enlarged heart 83 | 111
increased bone mineral content 82 | 92
decreased circulating choleste... 75 | 85
increased mean corpuscular vol... 75 | 91
short tibia 73 | 82
decreased circulating HDL chol... 70 | 77
decreased circulating serum al... 70 | 79
hypoactivity 70 | 89
decreased circulating triglyce... 68 | 83
increased grip strength 66 | 83
abnormal lens morphology 65 | 73
prenatal lethality prior to he... 58 | 64
decreased circulating insulin ... 55 | 75
increased fasted circulating g... 55 | 68
abnormal retinal pigmentation 53 | 61
increased circulating sodium l... 53 | 71
decreased lumbar vertebrae num... 52 | 62
increased sacral vertebrae num... 52 | 62
decreased rib number 50 | 59
abnormal coat/hair pigmentatio... 48 | 54
abnormal sleep behavior 47 | 63
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
abnormal bone mineralization 45 | 55
increased bone mineral density 45 | 52
increased circulating HDL chol... 45 | 63
male infertility 45 | 62
decreased circulating alanine ... 44 | 53
decreased hemoglobin content 44 | 53
increased circulating choleste... 44 | 53
decreased prepulse inhibition 43 | 52
impaired glucose tolerance 43 | 52
improved glucose tolerance 42 | 56
increased exploration in new e... 42 | 56
decreased startle reflex 41 | 48
decreased caudal vertebrae num... 40 | 49
decreased erythrocyte cell num... 40 | 43
increased total body fat amoun... 40 | 57
abnormal gait 39 | 51
decreased circulating total pr... 39 | 41
thrombocytopenia 39 | 46
increased blood urea nitrogen ... 38 | 44
increased body weight 38 | 42
abnormal behavioral response t... 37 | 52
abnormal heart morphology 37 | 51
decreased fasted circulating g... 37 | 49
decreased circulating LDL chol... 35 | 37
increased hemoglobin content 34 | 45
abnormal neural tube closure 33 | 37
decreased heart weight 33 | 44
increased rib number 33 | 41
abnormal eye morphology 32 | 38
decreased eosinophil cell numb... 32 | 41
decreased neutrophil cell numb... 32 | 37
abnormal seminal vesicle morph... 31 | 47
decreased circulating alkaline... 31 | 41
increased circulating chloride... 31 | 43
increased startle reflex 31 | 38
cardiovascular system phenotyp... 30 | 35
decreased circulating free fat... 30 | 39
decreased mean corpuscular hem... 30 | 34
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
decreased circulating fructosa... 29 | 31
small testis 29 | 37
tremors 29 | 34
abnormal cranium morphology 28 | 32
decreased T cell number 28 | 31
decreased circulating calcium ... 27 | 33
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased circulating creatini... 26 | 31
limb grasping 26 | 35
decreased blood urea nitrogen ... 25 | 31
decreased circulating aspartat... 25 | 27
increased circulating calcium ... 25 | 32
increased circulating potassiu... 25 | 31

Disease

ovarian cancer 7,458 | 8,492
osteosarcoma 6,686 | 7,933
medulloblastoma, large-cell 4,963 | 6,234
psoriasis 4,779 | 6,685
glioblastoma 4,554 | 5,572
lung cancer 3,953 | 4,473
atypical teratoid / rhabdoid tumor 3,473 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,989 | 3,289
malignant mesothelioma 2,740 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 2,695 | 2,988
Breast cancer 2,646 | 3,099
intraductal papillary-mucinous adenoma (IPMA) 2,645 | 2,956
invasive ductal carcinoma 2,596 | 2,950
non-small cell lung cancer 2,375 | 2,798
primitive neuroectodermal tumor 2,371 | 3,031
pilocytic astrocytoma 2,329 | 3,086
lung adenocarcinoma 2,239 | 2,714
oligodendroglioma 2,218 | 2,849
lung carcinoma 2,217 | 2,844
pediatric high grade glioma 2,168 | 2,712
ependymoma 2,037 | 2,514
pancreatic cancer 2,025 | 2,300
interstitial cystitis 1,902 | 2,299
subependymal giant cell astrocytoma 1,891 | 2,287
ulcerative colitis 1,882 | 2,087
Cancer 1,857 | 2,346
group 3 medulloblastoma 1,852 | 2,254
astrocytic glioma 1,770 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,643 | 1,795
adult high grade glioma 1,633 | 2,148
Pick disease 1,607 | 1,893
group 4 medulloblastoma 1,572 | 1,875
pituitary cancer 1,504 | 1,972
ductal carcinoma in situ 1,490 | 1,745
Carcinoma 1,411 | 2,147
breast carcinoma 1,393 | 1,614
tuberculosis 1,361 | 1,563
cystic fibrosis 1,335 | 1,670
Multiple myeloma 1,298 | 1,328
colon cancer 1,295 | 1,475
astrocytoma 1,281 | 1,493
adrenocortical carcinoma 1,253 | 1,427
primary pancreatic ductal adenocarcinoma 1,197 | 1,271
medulloblastoma 1,175 | 1,524
sonic hedgehog group medulloblastoma 1,174 | 1,482
diabetes mellitus 1,147 | 1,663
posterior fossa group A ependymoma 1,143 | 1,511
juvenile dermatomyositis 1,117 | 1,189
posterior fossa group B ependymoma 1,090 | 1,530
acute quadriplegic myopathy 1,061 | 1,157
Rheumatoid Arthritis 993 | 1,171
spina bifida 913 | 1,064
dermatomyositis 893 | 967
cutaneous lupus erythematosus 882 | 1,056
atypical teratoid/rhabdoid tumor 876 | 1,095
active Crohn's disease 819 | 918
nasopharyngeal carcinoma 800 | 1,056
gastric carcinoma 747 | 832
Waldenstrons macroglobulinemia 741 | 765
acute myeloid leukemia 732 | 785
primary Sjogren syndrome 725 | 789
Atopic dermatitis 702 | 944
non primary Sjogren syndrome sicca 679 | 840
tuberculosis and treatment for 6 months 653 | 686
esophageal adenocarcinoma 638 | 737
progressive supranuclear palsy 599 | 674
aldosterone-producing adenoma 595 | 664
Duchenne muscular dystrophy 542 | 602
hepatocellular carcinoma 505 | 550
Alzheimer's disease 499 | 644
pancreatic carcinoma 497 | 567
Down syndrome 470 | 548
Intellectual disability 462 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 455 | 499
fibroadenoma 454 | 557
Obesity 453 | 616
Endometriosis 425 | 535
IGA Glomerulonephritis 423 | 454
Prostatic Neoplasms 401 | 471
active ulcerative colitis 399 | 477
gastric cancer 382 | 436
mucosa-associated lymphoid tissue lymphoma 379 | 480
chronic rhinosinusitis 361 | 512
Amyotrophic Lateral Sclerosis 356 | 432
Mammary Neoplasms 346 | 410
inflammatory breast cancer 336 | 404
Multiple Sclerosis 334 | 498
Schizophrenia 332 | 503
Neurodegenerative disease 322 | 383
sarcoidosis 310 | 368
hereditary spastic paraplegia 302 | 313
tuberculosis and treatment for 3 months 296 | 327
non-small cell lung carcinoma 293 | 413
Polycystic Ovary Syndrome 277 | 335
nephrosclerosis 277 | 329
glioblastoma multiforme 276 | 347
Parkinson's disease 270 | 364
urothelial carcinoma 266 | 318
Kidney disease 264 | 397
interstitial lung disease 248 | 292

Tissue

Digestive Tract 13,297 | 18,473
Endocrine System 13,291 | 18,512
Nervous System 13,289 | 18,561
Female tissues 13,285 | 18,647
Liver and Pancreas 13,285 | 18,136
Urinary Tract 13,285 | 18,444
Skin and soft tissues 13,284 | 18,115
Blood and immune system 13,270 | 17,995
Cardiovascular System 13,255 | 17,958
Male tissues 13,253 | 17,969
Respiratory system 13,250 | 17,484

Target Family

Non-IDG 7,600 | 11,969
Enzyme 3,322 | 4,146
Transcription Factor 955 | 1,400
Kinase 533 | 634
Transporter 318 | 473
Epigenetic 209 | 242
GPCR 148 | 408
Ion Channel 142 | 341
Nuclear Receptor 36 | 48
TF/Epigenetic 32 | 38
oGPCR 2 | 421

HPA RNA Tissue

duodenum 13,297 | 13,297
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.49889 302.1 11