Development Level

Tbio 10,088 | 11,445
Tdark 3,899 | 6,588
Tchem 1,454 | 1,598
Tclin 534 | 613

Collection

RFA-RM-18-021 252 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 76 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 953 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 284 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 190 | 210
decreased vertical activity 173 | 208
abnormal bone structure 169 | 187
increased lean body mass 158 | 172
decreased body weight 153 | 161
abnormal heart morphology 147 | 162
hyperactivity 138 | 148
decreased bone mineral content 137 | 151
decreased lean body mass 123 | 135
increased total body fat amoun... 119 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 113 | 126
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 122
increased startle reflex 104 | 112
decreased grip strength 102 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 101 | 108
male infertility 98 | 123
abnormal seminal vesicle morph... 97 | 114
decreased body length 95 | 101
increased or absent threshold ... 92 | 101
short tibia 92 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
increased mean corpuscular vol... 89 | 92
cataract 87 | 92
prenatal lethality prior to he... 83 | 87
decreased lymphocyte cell numb... 79 | 83
decreased circulating serum al... 78 | 82
abnormal lens morphology 77 | 81
decreased prepulse inhibition 76 | 82
decreased circulating triglyce... 75 | 79
decreased mean corpuscular vol... 73 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 70 | 80
decreased leukocyte cell numbe... 69 | 73
improved glucose tolerance 69 | 79
increased fasted circulating g... 69 | 76
impaired glucose tolerance 68 | 75
small superior vagus ganglion 66 | 74
abnormal gait 65 | 69
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
decreased startle reflex 65 | 75
increased circulating sodium l... 65 | 71
abnormal retina morphology 64 | 71
abnormal eye morphology 63 | 68
abnormal sleep behavior 63 | 70
decreased fasted circulating g... 62 | 65
increased circulating choleste... 61 | 66
abnormal behavioral response t... 60 | 66
abnormal kidney morphology 60 | 65
decreased erythrocyte cell num... 60 | 62
abnormal coat-hair pigmentatio... 59 | 64
decreased hemoglobin content 59 | 68
increased monocyte cell number 58 | 63
edema 56 | 59
increased heart weight 56 | 62
small testis 54 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 53 | 56
abnormal spleen morphology 51 | 55
abnormal skin morphology 48 | 50
decreased circulating total pr... 48 | 49
female infertility 48 | 60
decreased blood urea nitrogen ... 47 | 51
abnormal neural tube closure 45 | 46
hydrometra 45 | 53
decreased circulating alanine ... 44 | 47
decreased mean corpuscular hem... 44 | 50
increased blood urea nitrogen ... 44 | 48
decreased circulating alkaline... 43 | 46
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased leukocyte cell numbe... 42 | 47
decreased neutrophil cell numb... 40 | 42
increased hematocrit 40 | 46
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased mean platelet volume 39 | 45
increased circulating chloride... 38 | 41
increased circulating triglyce... 38 | 42
increased hemoglobin content 38 | 45
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
tremors 36 | 39
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
prolonged QT interval 34 | 38

Disease

Carcinoma 9,730 | 11,493
ovarian cancer 8,112 | 8,520
osteosarcoma 7,442 | 7,950
medulloblastoma, large-cell 5,785 | 6,241
psoriasis 5,699 | 6,694
glioblastoma 5,469 | 5,792
atypical teratoid / rhabdoid tumor 4,799 | 5,112
lung cancer 4,457 | 4,740
ependymoma 4,343 | 4,679
group 3 medulloblastoma 3,850 | 4,104
adult high grade glioma 3,502 | 3,801
Breast cancer 3,365 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,209 | 3,291
malignant mesothelioma 3,094 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,928 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,889 | 2,955
invasive ductal carcinoma 2,865 | 2,951
Astrocytoma, Pilocytic 2,864 | 3,081
primitive neuroectodermal tumor 2,847 | 3,035
non-small cell lung cancer 2,737 | 2,890
oligodendroglioma 2,670 | 2,850
lung carcinoma 2,661 | 2,843
lung adenocarcinoma 2,556 | 2,716
astrocytic glioma 2,445 | 2,597
pancreatic cancer 2,279 | 2,398
Kidney cancer 2,254 | 2,613
Cancer 2,229 | 2,499
interstitial cystitis 2,200 | 2,312
subependymal giant cell astrocytoma 2,167 | 2,287
tuberculosis 1,911 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,896 | 1,962
pituitary cancer 1,838 | 1,972
Pick disease 1,819 | 1,894
group 4 medulloblastoma 1,760 | 1,855
ulcerative colitis 1,755 | 1,819
ductal carcinoma in situ 1,684 | 1,745
cystic fibrosis 1,588 | 1,696
breast carcinoma 1,577 | 1,638
colon cancer 1,432 | 1,478
adrenocortical carcinoma 1,389 | 1,428
diabetes mellitus 1,361 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,291 | 1,442
juvenile dermatomyositis 1,159 | 1,187
acute quadriplegic myopathy 1,121 | 1,158
astrocytoma 1,101 | 1,146
primary pancreatic ductal adenocarcinoma 1,090 | 1,109
Rheumatoid arthritis 1,079 | 1,191
spina bifida 1,019 | 1,074
pediatric high grade glioma 1,018 | 1,064
cutaneous lupus erythematosus 1,003 | 1,057
Schizophrenia 1,000 | 1,160
nasopharyngeal carcinoma 963 | 1,058
Intellectual disability 933 | 1,016
dermatomyositis 913 | 966
active Crohn's disease 899 | 922
Atopic dermatitis 841 | 952
non primary Sjogren syndrome sicca 811 | 891
gastric carcinoma 778 | 807
acute myeloid leukemia 772 | 783
Waldenstrons macroglobulinemia 755 | 765
active ulcerative colitis 733 | 764
Liver Cirrhosis, Experimental 732 | 769
Epilepsy 724 | 792
primary Sjogren syndrome 716 | 735
esophageal adenocarcinoma 691 | 737
medulloblastoma 674 | 720
progressive supranuclear palsy 651 | 676
aldosterone-producing adenoma 646 | 665
Obesity 603 | 678
Alzheimer's disease 599 | 658
Dull intelligence 589 | 645
Low intelligence 589 | 645
Mental Retardation 589 | 645
Mental deficiency 589 | 645
Poor school performance 589 | 645
Cognitive delay 578 | 608
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Bipolar Disorder 574 | 666
Duchenne muscular dystrophy 572 | 601
Melanoma 559 | 711
Seizures 547 | 596
pancreatic carcinoma 542 | 562
fibroadenoma 541 | 559
Muscle hypotonia 539 | 571
hepatocellular carcinoma 533 | 547
Endometriosis 503 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Liver cancer 491 | 604
Short stature 487 | 531
Down syndrome 475 | 499
Prostatic Neoplasms 463 | 495
chronic rhinosinusitis 458 | 512
Multiple Sclerosis 455 | 540
mucosa-associated lymphoid tissue lymphoma 449 | 484
gastric cancer 442 | 459
posterior fossa group A ependymoma 442 | 468
sonic hedgehog group medulloblastoma 439 | 467
Amyotrophic lateral sclerosis 429 | 451

Tissue

Digestive Tract 15,975 | 17,369
Endocrine System 15,909 | 18,159
Female tissues 15,818 | 17,400
Skin and soft tissues 15,775 | 17,230
Male tissues 15,730 | 17,142
Liver and Pancreas 15,709 | 16,750
Blood and immune system 15,668 | 16,909
Urinary Tract 15,622 | 16,678
Nervous System 15,527 | 16,725
Respiratory system 15,483 | 16,393
Cardiovascular System 14,675 | 15,192

Target Family

Non-IDG 9,248 | 12,091
Enzyme 3,720 | 4,145
Transcription Factor 1,163 | 1,400
Kinase 591 | 634
Transporter 395 | 473
GPCR 273 | 408
Ion Channel 270 | 344
Epigenetic 228 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 34 | 38
oGPCR 10 | 421

HPA RNA Tissue

duodenum 15,975 | 15,975
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39