Development Level

Tbio 10,297 | 11,651
Tdark 3,864 | 6,593
Tchem 1,265 | 1,388
Tclin 533 | 612

Collection

Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 71 | 99
GPCR: IDG Consortium (Targets) 68 | 126
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 950 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 281 | 298
embryonic lethality prior to t... 274 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 209 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 188 | 210
decreased vertical activity 173 | 208
abnormal bone structure 167 | 187
increased lean body mass 160 | 172
decreased body weight 152 | 161
abnormal heart morphology 145 | 162
hyperactivity 137 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 125 | 135
increased total body fat amoun... 122 | 134
decreased bone mineral density 116 | 126
hypoactivity 116 | 132
decreased circulating glucose ... 115 | 126
increased circulating alkaline... 111 | 122
decreased grip strength 106 | 116
increased startle reflex 103 | 112
embryonic growth retardation 101 | 106
abnormal seminal vesicle morph... 99 | 114
increased bone mineral content 99 | 108
male infertility 96 | 123
decreased body length 95 | 101
increased or absent threshold ... 94 | 101
short tibia 91 | 97
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 89 | 93
increased mean corpuscular hem... 87 | 96
cataract 85 | 92
prenatal lethality prior to he... 85 | 87
decreased circulating serum al... 79 | 82
decreased lymphocyte cell numb... 79 | 83
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 76 | 79
decreased mean corpuscular vol... 72 | 79
decreased leukocyte cell numbe... 70 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
increased fasted circulating g... 69 | 76
impaired glucose tolerance 68 | 75
small superior vagus ganglion 68 | 74
improved glucose tolerance 67 | 79
abnormal eye morphology 66 | 68
decreased circulating insulin ... 66 | 76
abnormal retina morphology 65 | 71
decreased circulating HDL chol... 65 | 68
abnormal gait 64 | 69
abnormal sleep behavior 64 | 70
increased circulating sodium l... 64 | 71
abnormal behavioral response t... 62 | 66
decreased hemoglobin content 61 | 68
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
increased circulating choleste... 57 | 66
edema 56 | 59
increased heart weight 54 | 62
small testis 54 | 58
thrombocytopenia 54 | 56
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
abnormal skin morphology 48 | 50
decreased circulating total pr... 48 | 49
hydrometra 48 | 53
female infertility 47 | 60
decreased blood urea nitrogen ... 46 | 51
abnormal neural tube closure 45 | 46
decreased mean corpuscular hem... 45 | 50
increased blood urea nitrogen ... 45 | 48
decreased circulating alkaline... 44 | 46
decreased circulating alanine ... 43 | 47
increased neutrophil cell numb... 43 | 46
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
decreased neutrophil cell numb... 40 | 42
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased red blood cell distr... 39 | 41
enlarged spleen 39 | 41
increased hemoglobin content 39 | 45
increased circulating triglyce... 38 | 42
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
increased circulating creatini... 36 | 38
increased erythrocyte cell num... 36 | 39
tremors 36 | 39
increased circulating chloride... 35 | 41
increased grip strength 35 | 41

Disease

Carcinoma 9,742 | 11,493
ovarian cancer 8,133 | 8,520
osteosarcoma 7,472 | 7,950
medulloblastoma, large-cell 5,792 | 6,241
psoriasis 5,755 | 6,694
glioblastoma 5,508 | 5,792
atypical teratoid / rhabdoid tumor 4,822 | 5,112
lung cancer 4,486 | 4,740
ependymoma 4,389 | 4,679
group 3 medulloblastoma 3,880 | 4,104
adult high grade glioma 3,531 | 3,801
Breast cancer 3,391 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,209 | 3,291
malignant mesothelioma 3,116 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,920 | 2,989
invasive ductal carcinoma 2,894 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,889 | 2,955
Astrocytoma, Pilocytic 2,884 | 3,081
primitive neuroectodermal tumor 2,872 | 3,035
non-small cell lung cancer 2,778 | 2,890
oligodendroglioma 2,683 | 2,850
lung carcinoma 2,680 | 2,843
lung adenocarcinoma 2,590 | 2,716
astrocytic glioma 2,460 | 2,597
pancreatic cancer 2,285 | 2,398
Kidney cancer 2,269 | 2,613
Cancer 2,235 | 2,499
interstitial cystitis 2,220 | 2,312
subependymal giant cell astrocytoma 2,181 | 2,287
tuberculosis 1,922 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,889 | 1,962
pituitary cancer 1,850 | 1,972
Pick disease 1,830 | 1,894
ulcerative colitis 1,768 | 1,819
group 4 medulloblastoma 1,767 | 1,855
ductal carcinoma in situ 1,707 | 1,745
cystic fibrosis 1,614 | 1,696
breast carcinoma 1,598 | 1,638
colon cancer 1,442 | 1,478
adrenocortical carcinoma 1,393 | 1,428
diabetes mellitus 1,347 | 1,728
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,292 | 1,442
juvenile dermatomyositis 1,163 | 1,187
acute quadriplegic myopathy 1,130 | 1,158
astrocytoma 1,103 | 1,146
Rheumatoid arthritis 1,088 | 1,191
primary pancreatic ductal adenocarcinoma 1,086 | 1,109
spina bifida 1,029 | 1,074
pediatric high grade glioma 1,025 | 1,064
Schizophrenia 1,012 | 1,160
cutaneous lupus erythematosus 1,012 | 1,057
nasopharyngeal carcinoma 982 | 1,058
Intellectual disability 944 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 903 | 922
Atopic dermatitis 863 | 952
non primary Sjogren syndrome sicca 821 | 891
gastric carcinoma 780 | 807
acute myeloid leukemia 772 | 783
Waldenstrons macroglobulinemia 758 | 765
active ulcerative colitis 743 | 764
Liver Cirrhosis, Experimental 737 | 769
Epilepsy 735 | 792
primary Sjogren syndrome 720 | 735
esophageal adenocarcinoma 700 | 737
medulloblastoma 680 | 720
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 646 | 665
Alzheimer's disease 602 | 658
Dull intelligence 599 | 645
Low intelligence 599 | 645
Mental Retardation 599 | 645
Mental deficiency 599 | 645
Poor school performance 599 | 645
Obesity 589 | 678
Duchenne muscular dystrophy 580 | 601
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Bipolar Disorder 571 | 666
Melanoma 563 | 711
Seizures 556 | 596
fibroadenoma 549 | 559
pancreatic carcinoma 546 | 562
Muscle hypotonia 540 | 571
hepatocellular carcinoma 536 | 547
Endometriosis 504 | 540
Liver cancer 504 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Short stature 487 | 531
Down syndrome 474 | 499
chronic rhinosinusitis 468 | 512
Prostatic Neoplasms 467 | 495
mucosa-associated lymphoid tissue lymphoma 454 | 484
gastric cancer 451 | 459
posterior fossa group A ependymoma 450 | 468
Multiple Sclerosis 449 | 540
sonic hedgehog group medulloblastoma 440 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Digestive Tract 15,959 | 17,369
Endocrine System 15,898 | 18,159
Skin and soft tissues 15,847 | 17,230
Female tissues 15,844 | 17,400
Male tissues 15,791 | 17,142
Liver and Pancreas 15,751 | 16,750
Urinary Tract 15,719 | 16,678
Blood and immune system 15,685 | 16,909
Nervous System 15,562 | 16,725
Respiratory system 15,553 | 16,393
Cardiovascular System 14,766 | 15,192

Target Family

Non-IDG 9,246 | 12,091
Enzyme 3,704 | 4,145
Transcription Factor 1,171 | 1,400
Kinase 597 | 634
Transporter 399 | 473
GPCR 275 | 408
Ion Channel 255 | 344
Epigenetic 228 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 33 | 38
oGPCR 9 | 421

HPA RNA Tissue

colon 15,959 | 15,959
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50