Development Level

Tbio 8,268 | 10,625
Tdark 3,382 | 7,003
Tchem 1,483 | 1,890
Tclin 391 | 602

Collection

Eligible Kinase Proteins 101 | 134
Eligible Ion Channel Proteins 40 | 117
Eligible non-olfactory GPCR Proteins 37 | 143

IMPC Term

preweaning lethality, complete... 582 | 633
preweaning lethality, incomple... 221 | 260
abnormal behavior 191 | 226
embryonic lethality prior to t... 180 | 187
decreased lean body mass 167 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 154 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 128 | 157
increased or absent threshold ... 105 | 128
increased circulating alkaline... 103 | 119
abnormal embryo size 101 | 112
decreased bone mineral density 100 | 126
abnormal bone structure 98 | 131
decreased grip strength 97 | 123
decreased body length 95 | 108
decreased circulating glucose ... 95 | 121
increased lean body mass 93 | 107
abnormal retina morphology 89 | 100
hyperactivity 86 | 108
increased bone mineral content 84 | 92
enlarged heart 83 | 111
increased mean corpuscular hem... 83 | 93
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 74 | 85
short tibia 74 | 82
decreased circulating serum al... 72 | 79
decreased circulating triglyce... 70 | 83
hypoactivity 70 | 89
decreased circulating HDL chol... 68 | 77
increased grip strength 68 | 83
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 60 | 64
increased fasted circulating g... 56 | 68
decreased circulating insulin ... 55 | 75
decreased lumbar vertebrae num... 54 | 62
increased sacral vertebrae num... 53 | 62
abnormal retinal pigmentation 52 | 61
increased circulating sodium l... 52 | 71
decreased rib number 49 | 59
abnormal coat/hair pigmentatio... 48 | 54
decreased mean corpuscular vol... 48 | 50
increased circulating HDL chol... 48 | 63
abnormal sleep behavior 47 | 63
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 46 | 52
male infertility 46 | 62
abnormal bone mineralization 45 | 55
decreased circulating alanine ... 44 | 53
decreased hemoglobin content 44 | 53
increased circulating choleste... 44 | 53
increased total body fat amoun... 44 | 57
decreased prepulse inhibition 43 | 52
improved glucose tolerance 43 | 56
increased exploration in new e... 42 | 56
decreased caudal vertebrae num... 41 | 49
impaired glucose tolerance 41 | 52
abnormal gait 40 | 51
decreased circulating total pr... 39 | 41
decreased erythrocyte cell num... 39 | 43
decreased fasted circulating g... 39 | 49
increased blood urea nitrogen ... 39 | 44
thrombocytopenia 39 | 46
increased body weight 38 | 42
decreased startle reflex 37 | 48
abnormal behavioral response t... 36 | 52
increased hemoglobin content 36 | 45
increased rib number 36 | 41
decreased eosinophil cell numb... 35 | 41
abnormal heart morphology 34 | 51
decreased circulating LDL chol... 34 | 37
decreased heart weight 34 | 44
abnormal neural tube closure 33 | 37
increased startle reflex 33 | 38
abnormal eye morphology 32 | 38
decreased neutrophil cell numb... 32 | 37
abnormal seminal vesicle morph... 31 | 47
decreased circulating alkaline... 31 | 41
small testis 31 | 37
decreased circulating free fat... 30 | 39
decreased circulating fructosa... 30 | 31
increased circulating chloride... 30 | 43
increased hematocrit 30 | 36
increased leukocyte cell numbe... 30 | 37
abnormal cranium morphology 29 | 32
cardiovascular system phenotyp... 29 | 35
decreased mean corpuscular hem... 29 | 34
decreased T cell number 28 | 31
tremors 28 | 34
decreased circulating calcium ... 27 | 33
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased heart weight 27 | 37
abnormal spleen morphology 26 | 36
decreased blood urea nitrogen ... 26 | 31
decreased circulating creatini... 26 | 31
limb grasping 26 | 35
corneal opacity 25 | 25
increased circulating calcium ... 25 | 32
increased circulating potassiu... 25 | 31

Disease

ovarian cancer 7,572 | 8,484
osteosarcoma 6,799 | 7,933
medulloblastoma, large-cell 5,106 | 6,234
psoriasis 4,919 | 6,685
glioblastoma 4,695 | 5,572
lung cancer 4,058 | 4,466
atypical teratoid / rhabdoid tumor 3,599 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,026 | 3,289
malignant mesothelioma 2,828 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 2,743 | 2,988
Breast cancer 2,740 | 3,094
invasive ductal carcinoma 2,705 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,698 | 2,956
primitive neuroectodermal tumor 2,470 | 3,031
non-small cell lung cancer 2,465 | 2,798
pilocytic astrocytoma 2,420 | 3,086
oligodendroglioma 2,318 | 2,849
lung adenocarcinoma 2,313 | 2,713
lung carcinoma 2,299 | 2,844
pediatric high grade glioma 2,246 | 2,712
ependymoma 2,106 | 2,514
pancreatic cancer 2,049 | 2,300
interstitial cystitis 2,005 | 2,299
ulcerative colitis 1,958 | 2,087
subependymal giant cell astrocytoma 1,952 | 2,287
group 3 medulloblastoma 1,901 | 2,254
Cancer 1,882 | 2,346
astrocytic glioma 1,850 | 2,241
adult high grade glioma 1,682 | 2,148
Pick disease 1,662 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,641 | 1,795
group 4 medulloblastoma 1,622 | 1,875
pituitary cancer 1,578 | 1,972
ductal carcinoma in situ 1,569 | 1,745
Carcinoma 1,468 | 2,147
breast carcinoma 1,454 | 1,614
cystic fibrosis 1,419 | 1,665
tuberculosis 1,383 | 1,557
colon cancer 1,375 | 1,475
astrocytoma 1,309 | 1,493
adrenocortical carcinoma 1,299 | 1,427
Multiple myeloma 1,298 | 1,327
medulloblastoma 1,224 | 1,524
sonic hedgehog group medulloblastoma 1,217 | 1,482
primary pancreatic ductal adenocarcinoma 1,197 | 1,271
posterior fossa group A ependymoma 1,184 | 1,511
posterior fossa group B ependymoma 1,152 | 1,530
diabetes mellitus 1,140 | 1,663
juvenile dermatomyositis 1,131 | 1,189
acute quadriplegic myopathy 1,076 | 1,157
Rheumatoid Arthritis 1,004 | 1,160
spina bifida 939 | 1,064
cutaneous lupus erythematosus 913 | 1,056
atypical teratoid/rhabdoid tumor 899 | 1,095
dermatomyositis 894 | 933
active Crohn's disease 864 | 918
nasopharyngeal carcinoma 846 | 1,056
Atopic dermatitis 765 | 944
gastric carcinoma 751 | 832
Waldenstrons macroglobulinemia 745 | 765
primary Sjogren syndrome 743 | 789
acute myeloid leukemia 730 | 780
non primary Sjogren syndrome sicca 685 | 840
tuberculosis and treatment for 6 months 653 | 686
esophageal adenocarcinoma 651 | 737
aldosterone-producing adenoma 610 | 664
progressive supranuclear palsy 610 | 674
Duchenne muscular dystrophy 556 | 602
pancreatic carcinoma 515 | 567
Alzheimer's disease 514 | 644
hepatocellular carcinoma 493 | 532
Down syndrome 485 | 548
fibroadenoma 483 | 557
Intellectual disability 475 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 499
Obesity 450 | 616
Endometriosis 443 | 535
IGA Glomerulonephritis 431 | 454
active ulcerative colitis 425 | 477
Prostatic Neoplasms 405 | 471
gastric cancer 388 | 430
mucosa-associated lymphoid tissue lymphoma 388 | 480
chronic rhinosinusitis 379 | 512
Amyotrophic Lateral Sclerosis 375 | 431
Mammary Neoplasms 356 | 410
inflammatory breast cancer 351 | 404
Schizophrenia 344 | 501
Multiple Sclerosis 343 | 498
Neurodegenerative disease 334 | 383
sarcoidosis 319 | 358
hereditary spastic paraplegia 306 | 313
non-small cell lung carcinoma 304 | 413
tuberculosis and treatment for 3 months 304 | 327
glioblastoma multiforme 287 | 347
urothelial carcinoma 282 | 318
Parkinson's disease 274 | 364
Polycystic Ovary Syndrome 274 | 332
Kidney disease 268 | 396
interstitial lung disease 261 | 291
nephrosclerosis 261 | 329

Tissue

Digestive Tract 13,524 | 18,473
Endocrine System 13,517 | 18,512
Urinary Tract 13,517 | 18,444
Female tissues 13,516 | 18,647
Liver and Pancreas 13,516 | 18,136
Nervous System 13,515 | 18,561
Skin and soft tissues 13,515 | 18,115
Blood and immune system 13,500 | 17,995
Cardiovascular System 13,497 | 17,958
Male tissues 13,496 | 17,969
Respiratory system 13,484 | 17,484

Target Family

Non-IDG 7,760 | 11,971
Enzyme 3,329 | 4,146
Transcription Factor 1,002 | 1,400
Kinase 543 | 634
Transporter 311 | 473
Epigenetic 211 | 242
GPCR 151 | 406
Ion Channel 145 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 32 | 38
oGPCR 3 | 421

HPA RNA Tissue

colon 13,524 | 13,524
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248