Development Level

Tbio 8,174 | 10,625
Tdark 3,574 | 7,003
Tchem 1,415 | 1,890
Tclin 417 | 602

Collection

Eligible Kinase Proteins 110 | 134
Eligible Ion Channel Proteins 67 | 117
Eligible non-olfactory GPCR Proteins 44 | 143

IMPC Term

preweaning lethality, complete... 572 | 633
preweaning lethality, incomple... 228 | 260
abnormal behavior 205 | 226
decreased lean body mass 175 | 195
embryonic lethality prior to t... 173 | 187
decreased total body fat amoun... 162 | 186
decreased body weight 151 | 174
embryonic lethality prior to o... 143 | 148
decreased bone mineral content 136 | 157
abnormal bone structure 109 | 131
decreased bone mineral density 109 | 126
increased circulating alkaline... 106 | 119
decreased grip strength 103 | 123
increased or absent threshold ... 102 | 128
abnormal embryo size 100 | 112
decreased circulating glucose ... 99 | 121
hyperactivity 99 | 108
decreased body length 97 | 108
increased lean body mass 94 | 107
abnormal retina morphology 92 | 100
increased bone mineral content 83 | 92
increased mean corpuscular hem... 82 | 93
increased mean corpuscular vol... 81 | 91
decreased circulating choleste... 79 | 85
enlarged heart 78 | 111
hypoactivity 72 | 89
short tibia 72 | 82
decreased circulating triglyce... 71 | 83
decreased circulating HDL chol... 70 | 77
decreased circulating serum al... 70 | 79
increased grip strength 68 | 83
abnormal lens morphology 60 | 73
increased fasted circulating g... 59 | 68
prenatal lethality prior to he... 59 | 64
increased circulating sodium l... 57 | 71
decreased circulating insulin ... 56 | 75
abnormal retinal pigmentation 55 | 61
abnormal sleep behavior 54 | 63
decreased lumbar vertebrae num... 54 | 62
increased sacral vertebrae num... 54 | 62
increased circulating HDL chol... 50 | 63
decreased leukocyte cell numbe... 49 | 54
decreased rib number 49 | 59
increased total body fat amoun... 48 | 57
male infertility 48 | 62
abnormal bone mineralization 47 | 55
increased bone mineral density 47 | 52
decreased hemoglobin content 46 | 53
abnormal coat/hair pigmentatio... 45 | 54
abnormal gait 45 | 51
decreased mean corpuscular vol... 45 | 50
increased circulating choleste... 45 | 53
decreased prepulse inhibition 44 | 52
improved glucose tolerance 44 | 56
decreased circulating alanine ... 43 | 53
impaired glucose tolerance 43 | 52
abnormal behavioral response t... 42 | 52
decreased fasted circulating g... 42 | 49
increased exploration in new e... 41 | 56
thrombocytopenia 41 | 46
decreased startle reflex 40 | 48
decreased caudal vertebrae num... 39 | 49
decreased erythrocyte cell num... 39 | 43
increased blood urea nitrogen ... 39 | 44
decreased circulating total pr... 38 | 41
increased body weight 38 | 42
increased rib number 36 | 41
increased circulating chloride... 35 | 43
increased startle reflex 35 | 38
decreased circulating LDL chol... 34 | 37
decreased circulating free fat... 34 | 39
decreased heart weight 34 | 44
increased hemoglobin content 34 | 45
abnormal heart morphology 33 | 51
abnormal neural tube closure 33 | 37
decreased eosinophil cell numb... 33 | 41
abnormal eye morphology 32 | 38
abnormal seminal vesicle morph... 32 | 47
decreased circulating alkaline... 32 | 41
decreased neutrophil cell numb... 32 | 37
increased leukocyte cell numbe... 31 | 37
tremors 31 | 34
decreased mean corpuscular hem... 30 | 34
limb grasping 30 | 35
small testis 30 | 37
cardiovascular system phenotyp... 29 | 35
decreased circulating fructosa... 29 | 31
abnormal spleen morphology 28 | 36
decreased circulating calcium ... 28 | 33
abnormal cranium morphology 27 | 32
decreased circulating creatini... 27 | 31
increased heart weight 27 | 37
decreased T cell number 26 | 31
increased circulating calcium ... 26 | 32
increased circulating potassiu... 26 | 31
increased hematocrit 26 | 36
abnormal epididymis morphology 25 | 31
decreased B cell number 25 | 30
embryonic growth retardation 25 | 28
enlarged spleen 25 | 26

Disease

ovarian cancer 7,467 | 8,484
osteosarcoma 6,629 | 7,933
medulloblastoma, large-cell 5,475 | 6,234
glioblastoma 5,091 | 5,572
psoriasis 4,772 | 6,685
atypical teratoid / rhabdoid tumor 3,942 | 4,369
lung cancer 3,857 | 4,466
pilocytic astrocytoma 2,856 | 3,086
primitive neuroectodermal tumor 2,790 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 2,753 | 3,289
oligodendroglioma 2,743 | 2,849
malignant mesothelioma 2,720 | 3,162
Breast cancer 2,631 | 3,094
invasive ductal carcinoma 2,508 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,507 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2,502 | 2,988
pediatric high grade glioma 2,479 | 2,712
ependymoma 2,417 | 2,514
lung carcinoma 2,291 | 2,844
non-small cell lung cancer 2,239 | 2,798
subependymal giant cell astrocytoma 2,180 | 2,287
astrocytic glioma 2,158 | 2,241
lung adenocarcinoma 2,077 | 2,713
group 3 medulloblastoma 2,003 | 2,254
Pick disease 1,857 | 1,893
pancreatic cancer 1,847 | 2,300
adult high grade glioma 1,843 | 2,148
group 4 medulloblastoma 1,754 | 1,875
pituitary cancer 1,714 | 1,972
interstitial cystitis 1,708 | 2,299
Cancer 1,691 | 2,346
ulcerative colitis 1,669 | 2,087
Carcinoma 1,657 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 1,566 | 1,795
astrocytoma 1,447 | 1,493
medulloblastoma 1,425 | 1,524
ductal carcinoma in situ 1,402 | 1,745
cystic fibrosis 1,340 | 1,665
breast carcinoma 1,326 | 1,614
sonic hedgehog group medulloblastoma 1,324 | 1,482
tuberculosis 1,317 | 1,557
posterior fossa group A ependymoma 1,309 | 1,511
posterior fossa group B ependymoma 1,289 | 1,530
Multiple myeloma 1,285 | 1,327
adrenocortical carcinoma 1,243 | 1,427
colon cancer 1,199 | 1,475
primary pancreatic ductal adenocarcinoma 1,142 | 1,271
juvenile dermatomyositis 1,122 | 1,189
diabetes mellitus 1,099 | 1,663
acute quadriplegic myopathy 1,088 | 1,157
atypical teratoid/rhabdoid tumor 997 | 1,095
Rheumatoid Arthritis 961 | 1,160
dermatomyositis 895 | 933
spina bifida 870 | 1,064
cutaneous lupus erythematosus 789 | 1,056
nasopharyngeal carcinoma 741 | 1,056
gastric carcinoma 739 | 832
Waldenstrons macroglobulinemia 725 | 765
active Crohn's disease 717 | 918
acute myeloid leukemia 714 | 780
non primary Sjogren syndrome sicca 684 | 840
progressive supranuclear palsy 656 | 674
tuberculosis and treatment for 6 months 643 | 686
primary Sjogren syndrome 638 | 789
Atopic dermatitis 637 | 944
aldosterone-producing adenoma 604 | 664
Alzheimer's disease 568 | 644
esophageal adenocarcinoma 560 | 737
Duchenne muscular dystrophy 542 | 602
Intellectual disability 519 | 573
Down syndrome 506 | 548
pancreatic carcinoma 489 | 567
hepatocellular carcinoma 478 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 463 | 499
Obesity 456 | 616
fibroadenoma 438 | 557
Schizophrenia 409 | 501
Amyotrophic Lateral Sclerosis 396 | 431
chronic rhinosinusitis 393 | 512
IGA Glomerulonephritis 382 | 454
gastric cancer 375 | 430
Endometriosis 373 | 535
Prostatic Neoplasms 367 | 471
active ulcerative colitis 359 | 477
mucosa-associated lymphoid tissue lymphoma 357 | 480
Neurodegenerative disease 356 | 383
Multiple Sclerosis 331 | 498
glioblastoma multiforme 330 | 347
Mammary Neoplasms 323 | 410
inflammatory breast cancer 316 | 404
hereditary spastic paraplegia 309 | 313
Parkinson's disease 307 | 364
Epilepsy 303 | 346
tuberculosis and treatment for 3 months 288 | 327
sarcoidosis 285 | 358
Polycystic Ovary Syndrome 263 | 332
non-small cell lung carcinoma 257 | 413
urothelial carcinoma 253 | 318
Autistic Disorder 251 | 320
interstitial lung disease 249 | 291

Tissue

Nervous System 13,580 | 18,561
Endocrine System 13,575 | 18,512
Female tissues 13,572 | 18,647
Digestive Tract 13,571 | 18,473
Skin and soft tissues 13,566 | 18,115
Urinary Tract 13,564 | 18,444
Liver and Pancreas 13,558 | 18,136
Cardiovascular System 13,552 | 17,958
Male tissues 13,545 | 17,969
Blood and immune system 13,529 | 17,995
Respiratory system 13,525 | 17,484

Target Family

Non-IDG 7,790 | 11,971
Enzyme 3,265 | 4,146
Transcription Factor 977 | 1,400
Kinase 536 | 634
Transporter 328 | 473
Ion Channel 222 | 341
Epigenetic 219 | 242
GPCR 179 | 406
TF/Epigenetic 31 | 38
Nuclear Receptor 30 | 48
oGPCR 3 | 421

HPA RNA Tissue

cerebral cortex 13,580 | 13,580
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108