Development Level

Tbio 10,330 | 11,651
Tdark 3,984 | 6,593
Tchem 1,242 | 1,388
Tclin 507 | 612

Collection

Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 30 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 947 | 979
preweaning lethality, incomple... 470 | 499
abnormal behavior 274 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 188 | 210
decreased vertical activity 178 | 208
abnormal bone structure 167 | 187
increased lean body mass 157 | 172
decreased body weight 148 | 161
abnormal heart morphology 147 | 162
decreased bone mineral content 135 | 151
hyperactivity 132 | 148
decreased lean body mass 125 | 135
increased total body fat amoun... 122 | 134
hypoactivity 117 | 132
decreased circulating glucose ... 115 | 126
decreased bone mineral density 114 | 126
increased circulating alkaline... 110 | 122
male infertility 107 | 123
embryonic growth retardation 103 | 106
increased startle reflex 102 | 112
decreased grip strength 101 | 116
abnormal seminal vesicle morph... 99 | 114
increased bone mineral content 98 | 108
short tibia 93 | 97
decreased body length 92 | 101
increased or absent threshold ... 91 | 101
increased mean corpuscular vol... 90 | 92
cataract 87 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 78 | 83
abnormal lens morphology 77 | 81
decreased circulating serum al... 77 | 82
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 74 | 79
decreased mean corpuscular vol... 73 | 79
improved glucose tolerance 70 | 79
decreased circulating insulin ... 69 | 76
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
impaired glucose tolerance 68 | 75
abnormal retina morphology 67 | 71
increased fasted circulating g... 67 | 76
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 61 | 68
increased circulating sodium l... 60 | 71
abnormal gait 59 | 69
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
increased circulating choleste... 58 | 66
increased heart weight 58 | 62
increased monocyte cell number 58 | 63
abnormal behavioral response t... 57 | 66
edema 55 | 59
abnormal spleen morphology 53 | 55
small testis 53 | 58
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 51 | 56
abnormal skin morphology 49 | 50
female infertility 49 | 60
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
hydrometra 48 | 53
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 44 | 46
increased blood urea nitrogen ... 44 | 48
increased leukocyte cell numbe... 44 | 47
decreased circulating alkaline... 43 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
enlarged spleen 41 | 41
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
increased hemoglobin content 39 | 45
decreased red blood cell distr... 38 | 41
abnormal epididymis morphology 37 | 42
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
increased circulating chloride... 36 | 41
increased circulating triglyce... 36 | 42
increased erythrocyte cell num... 36 | 39
increased grip strength 36 | 41
tremors 36 | 39
decreased circulating creatini... 35 | 39
limb grasping 35 | 41

Disease

Carcinoma 9,810 | 11,493
ovarian cancer 8,132 | 8,520
osteosarcoma 7,458 | 7,950
psoriasis 5,868 | 6,694
medulloblastoma, large-cell 5,783 | 6,241
glioblastoma 5,452 | 5,792
atypical teratoid / rhabdoid tumor 4,784 | 5,112
lung cancer 4,487 | 4,740
ependymoma 4,356 | 4,679
group 3 medulloblastoma 3,849 | 4,104
adult high grade glioma 3,487 | 3,801
Breast cancer 3,454 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,169 | 3,291
malignant mesothelioma 3,103 | 3,232
invasive ductal carcinoma 2,913 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,879 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,850 | 2,955
primitive neuroectodermal tumor 2,847 | 3,035
Astrocytoma, Pilocytic 2,833 | 3,081
non-small cell lung cancer 2,808 | 2,890
lung carcinoma 2,652 | 2,843
oligodendroglioma 2,643 | 2,850
lung adenocarcinoma 2,592 | 2,716
astrocytic glioma 2,421 | 2,597
Kidney cancer 2,312 | 2,613
pancreatic cancer 2,286 | 2,398
interstitial cystitis 2,219 | 2,312
Cancer 2,201 | 2,499
subependymal giant cell astrocytoma 2,156 | 2,287
tuberculosis 1,913 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,887 | 1,962
pituitary cancer 1,848 | 1,972
Pick disease 1,808 | 1,894
group 4 medulloblastoma 1,766 | 1,855
ulcerative colitis 1,725 | 1,819
ductal carcinoma in situ 1,723 | 1,745
cystic fibrosis 1,615 | 1,696
breast carcinoma 1,607 | 1,638
colon cancer 1,403 | 1,478
adrenocortical carcinoma 1,391 | 1,428
diabetes mellitus 1,339 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,291 | 1,442
juvenile dermatomyositis 1,155 | 1,187
acute quadriplegic myopathy 1,128 | 1,158
astrocytoma 1,101 | 1,146
Rheumatoid arthritis 1,089 | 1,191
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
spina bifida 1,035 | 1,074
cutaneous lupus erythematosus 1,023 | 1,057
pediatric high grade glioma 1,017 | 1,064
nasopharyngeal carcinoma 999 | 1,058
Schizophrenia 980 | 1,160
Intellectual disability 938 | 1,016
dermatomyositis 920 | 966
Atopic dermatitis 902 | 952
active Crohn's disease 868 | 922
non primary Sjogren syndrome sicca 824 | 891
gastric carcinoma 773 | 807
acute myeloid leukemia 769 | 783
Waldenstrons macroglobulinemia 757 | 765
Liver Cirrhosis, Experimental 725 | 769
primary Sjogren syndrome 716 | 735
active ulcerative colitis 713 | 764
esophageal adenocarcinoma 712 | 737
Epilepsy 710 | 792
medulloblastoma 674 | 720
progressive supranuclear palsy 650 | 676
aldosterone-producing adenoma 647 | 665
Dull intelligence 595 | 645
Low intelligence 595 | 645
Mental Retardation 595 | 645
Mental deficiency 595 | 645
Poor school performance 595 | 645
Alzheimer's disease 594 | 658
Melanoma 584 | 711
Obesity 583 | 678
Duchenne muscular dystrophy 581 | 601
Cognitive delay 568 | 608
Global developmental delay 568 | 608
Mental and motor retardation 568 | 608
Bipolar Disorder 559 | 666
fibroadenoma 556 | 559
pancreatic carcinoma 545 | 562
Seizures 539 | 596
Muscle hypotonia 538 | 571
hepatocellular carcinoma 533 | 547
Endometriosis 509 | 540
Liver cancer 507 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Short stature 484 | 531
chronic rhinosinusitis 483 | 512
Down syndrome 470 | 499
Prostatic Neoplasms 465 | 495
Multiple Sclerosis 454 | 540
posterior fossa group A ependymoma 450 | 468
gastric cancer 449 | 459
mucosa-associated lymphoid tissue lymphoma 447 | 484
sonic hedgehog group medulloblastoma 440 | 467
Amyotrophic lateral sclerosis 425 | 451

Tissue

Female tissues 16,063 | 17,400
Endocrine System 15,982 | 18,159
Skin and soft tissues 15,928 | 17,230
Digestive Tract 15,921 | 17,369
Male tissues 15,843 | 17,142
Blood and immune system 15,750 | 16,909
Liver and Pancreas 15,700 | 16,750
Urinary Tract 15,665 | 16,678
Respiratory system 15,556 | 16,393
Nervous System 15,532 | 16,725
Cardiovascular System 14,723 | 15,192

Target Family

Non-IDG 9,357 | 12,091
Enzyme 3,730 | 4,145
Transcription Factor 1,178 | 1,400
Kinase 588 | 634
Transporter 386 | 473
GPCR 255 | 408
Ion Channel 243 | 344
Epigenetic 227 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 34 | 38
oGPCR 21 | 421

HPA RNA Tissue

breast 16,063 | 16,063
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83