Development Level

Tbio 9,413 | 11,651
Tdark 3,576 | 6,593
Tchem 1,161 | 1,388
Tclin 421 | 612

Collection

RFA-RM-18-021 205 | 328
Kinase: IDG Consortium (Target... 97 | 125
Ion Channel: IDG Consortium (T... 57 | 99
GPCR: IDG Consortium (Targets) 54 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 917 | 979
preweaning lethality, incomple... 435 | 499
embryonic lethality prior to t... 265 | 278
abnormal behavior 252 | 298
embryonic lethality prior to o... 235 | 239
abnormal embryo size 204 | 220
enlarged heart 173 | 210
decreased total body fat amoun... 172 | 207
decreased vertical activity 154 | 208
abnormal bone structure 153 | 187
increased lean body mass 144 | 172
decreased body weight 143 | 161
abnormal heart morphology 136 | 162
decreased bone mineral content 123 | 151
hyperactivity 117 | 148
decreased lean body mass 114 | 135
hypoactivity 111 | 132
increased total body fat amoun... 108 | 134
decreased bone mineral density 106 | 126
decreased circulating glucose ... 104 | 126
increased circulating alkaline... 104 | 122
embryonic growth retardation 101 | 106
decreased grip strength 97 | 116
increased startle reflex 97 | 112
increased bone mineral content 94 | 108
male infertility 93 | 123
abnormal seminal vesicle morph... 91 | 114
decreased body length 87 | 101
increased mean corpuscular hem... 87 | 96
increased mean corpuscular vol... 84 | 92
increased or absent threshold ... 84 | 101
short tibia 83 | 97
cataract 81 | 92
prenatal lethality prior to he... 81 | 87
decreased circulating choleste... 79 | 93
abnormal lens morphology 73 | 81
decreased lymphocyte cell numb... 72 | 83
decreased prepulse inhibition 70 | 82
increased bone mineral density 68 | 72
decreased circulating serum al... 67 | 82
decreased circulating triglyce... 66 | 79
increased fasted circulating g... 66 | 76
abnormal retina morphology 65 | 71
decreased mean corpuscular vol... 65 | 79
increased circulating HDL chol... 64 | 80
impaired glucose tolerance 62 | 75
abnormal sleep behavior 61 | 70
decreased leukocyte cell numbe... 61 | 73
abnormal eye morphology 60 | 68
decreased circulating HDL chol... 60 | 68
small superior vagus ganglion 60 | 74
decreased startle reflex 59 | 75
improved glucose tolerance 58 | 79
abnormal behavioral response t... 57 | 66
decreased erythrocyte cell num... 57 | 62
increased circulating sodium l... 57 | 71
decreased hemoglobin content 56 | 68
abnormal coat-hair pigmentatio... 55 | 64
abnormal gait 55 | 69
decreased circulating insulin ... 55 | 76
increased circulating choleste... 53 | 66
increased monocyte cell number 53 | 63
abnormal kidney morphology 51 | 65
decreased fasted circulating g... 51 | 65
edema 50 | 59
increased heart weight 50 | 62
thrombocytopenia 50 | 56
small testis 49 | 58
female infertility 47 | 60
decreased caudal vertebrae num... 46 | 53
abnormal spleen morphology 45 | 55
decreased circulating total pr... 44 | 49
decreased mean corpuscular hem... 44 | 50
decreased circulating alkaline... 43 | 46
abnormal neural tube closure 42 | 46
decreased circulating alanine ... 42 | 47
increased neutrophil cell numb... 42 | 46
abnormal skin morphology 41 | 50
decreased blood urea nitrogen ... 41 | 51
hydrometra 40 | 53
increased blood urea nitrogen ... 40 | 48
decreased hematocrit 39 | 46
increased hematocrit 39 | 46
increased hemoglobin content 39 | 45
decreased neutrophil cell numb... 38 | 42
increased leukocyte cell numbe... 38 | 47
increased mean platelet volume 38 | 45
decreased red blood cell distr... 36 | 41
tremors 36 | 39
abnormal testis morphology 35 | 43
enlarged spleen 35 | 41
increased erythrocyte cell num... 35 | 39
decreased circulating LDL chol... 34 | 38
abnormal bone mineralization 33 | 38
abnormal cranium morphology 33 | 36
enlarged lymph nodes 33 | 37
increased circulating chloride... 33 | 41
increased grip strength 33 | 41
decreased circulating creatini... 32 | 39
increased mean corpuscular hem... 32 | 36

Disease

Carcinoma 8,767 | 11,493
ovarian cancer 7,620 | 8,520
osteosarcoma 7,110 | 7,950
medulloblastoma, large-cell 5,237 | 6,241
psoriasis 5,038 | 6,694
glioblastoma 4,935 | 5,792
atypical teratoid / rhabdoid tumor 4,283 | 5,112
lung cancer 4,124 | 4,740
ependymoma 3,831 | 4,679
group 3 medulloblastoma 3,460 | 4,104
adult high grade glioma 3,060 | 3,801
Breast cancer 3,012 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,875 | 3,291
malignant mesothelioma 2,858 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,595 | 2,989
invasive ductal carcinoma 2,571 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,531 | 2,955
primitive neuroectodermal tumor 2,519 | 3,035
non-small cell lung cancer 2,468 | 2,890
Astrocytoma, Pilocytic 2,462 | 3,081
lung carcinoma 2,297 | 2,843
oligodendroglioma 2,295 | 2,850
lung adenocarcinoma 2,241 | 2,716
astrocytic glioma 2,116 | 2,597
Cancer 2,070 | 2,499
pancreatic cancer 2,064 | 2,398
subependymal giant cell astrocytoma 1,975 | 2,287
Kidney cancer 1,945 | 2,613
interstitial cystitis 1,918 | 2,312
tuberculosis 1,908 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,776 | 1,962
Pick disease 1,651 | 1,894
ulcerative colitis 1,606 | 1,819
group 4 medulloblastoma 1,593 | 1,855
pituitary cancer 1,577 | 1,972
ductal carcinoma in situ 1,479 | 1,745
breast carcinoma 1,384 | 1,638
cystic fibrosis 1,382 | 1,696
Multiple myeloma 1,302 | 1,332
adrenocortical carcinoma 1,265 | 1,428
diabetes mellitus 1,261 | 1,728
colon cancer 1,207 | 1,478
Autosomal recessive predisposition 1,183 | 1,442
juvenile dermatomyositis 1,119 | 1,187
acute quadriplegic myopathy 1,084 | 1,158
astrocytoma 1,047 | 1,146
Rheumatoid arthritis 1,038 | 1,191
primary pancreatic ductal adenocarcinoma 992 | 1,109
spina bifida 952 | 1,074
pediatric high grade glioma 933 | 1,064
dermatomyositis 902 | 966
cutaneous lupus erythematosus 896 | 1,057
nasopharyngeal carcinoma 879 | 1,058
Intellectual disability 864 | 1,016
Schizophrenia 835 | 1,160
active Crohn's disease 789 | 922
acute myeloid leukemia 769 | 783
Waldenstrons macroglobulinemia 760 | 765
non primary Sjogren syndrome sicca 759 | 891
Atopic dermatitis 744 | 952
gastric carcinoma 695 | 807
primary Sjogren syndrome 695 | 735
Liver Cirrhosis, Experimental 682 | 769
Epilepsy 637 | 792
active ulcerative colitis 633 | 764
esophageal adenocarcinoma 623 | 737
progressive supranuclear palsy 615 | 676
medulloblastoma 606 | 720
aldosterone-producing adenoma 587 | 665
pancreatic carcinoma 551 | 562
Dull intelligence 550 | 645
Low intelligence 550 | 645
Mental Retardation 550 | 645
Mental deficiency 550 | 645
Poor school performance 550 | 645
Cognitive delay 541 | 608
Global developmental delay 541 | 608
Mental and motor retardation 541 | 608
Alzheimer's disease 538 | 658
Duchenne muscular dystrophy 532 | 601
hepatocellular carcinoma 529 | 547
Obesity 519 | 678
Muscle hypotonia 509 | 571
Seizures 494 | 596
Bipolar Disorder 465 | 666
mucosa-associated lymphoid tissue lymphoma 464 | 484
autosomal dominant Emery-Dreifuss muscular dystrophy 458 | 510
Short stature 450 | 531
gastric cancer 448 | 459
fibroadenoma 439 | 559
Melanoma 436 | 711
Down syndrome 430 | 499
Endometriosis 426 | 540
Prostatic Neoplasms 419 | 495
tuberculosis and treatment for 6 months 408 | 409
Multiple Sclerosis 407 | 540
chronic rhinosinusitis 401 | 512
posterior fossa group A ependymoma 400 | 468
Breast Neoplasms 390 | 445
Liver cancer 389 | 604

Tissue

Blood and immune system 14,571 | 16,909
Endocrine System 14,531 | 18,159
Digestive Tract 14,474 | 17,369
Female tissues 14,466 | 17,400
Skin and soft tissues 14,443 | 17,230
Male tissues 14,361 | 17,142
Liver and Pancreas 14,356 | 16,750
Respiratory system 14,280 | 16,393
Urinary Tract 14,275 | 16,678
Nervous System 14,246 | 16,725
Cardiovascular System 13,645 | 15,192

Target Family

Non-IDG 8,454 | 12,091
Enzyme 3,463 | 4,145
Transcription Factor 1,053 | 1,400
Kinase 554 | 634
Transporter 338 | 473
Epigenetic 223 | 242
GPCR 215 | 408
Ion Channel 184 | 344
Nuclear Receptor 35 | 48
TF/Epigenetic 33 | 38
oGPCR 19 | 421

HPA RNA Tissue

bone marrow 14,571 | 14,571
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164