Development Level

Tbio 6,930 | 10,625
Tdark 2,814 | 7,003
Tchem 1,232 | 1,890
Tclin 280 | 602

Collection

Eligible Kinase Proteins 88 | 134
Eligible Ion Channel Proteins 25 | 117
Eligible non-olfactory GPCR Proteins 23 | 143

IMPC Term

preweaning lethality, complete... 547 | 633
preweaning lethality, incomple... 176 | 260
embryonic lethality prior to t... 171 | 187
abnormal behavior 157 | 226
embryonic lethality prior to o... 143 | 148
decreased lean body mass 137 | 195
decreased total body fat amoun... 136 | 186
decreased body weight 130 | 174
decreased bone mineral content 110 | 157
abnormal embryo size 93 | 112
abnormal bone structure 87 | 131
increased circulating alkaline... 87 | 119
decreased circulating glucose ... 84 | 121
decreased bone mineral density 83 | 126
increased or absent threshold ... 82 | 128
decreased body length 81 | 108
decreased grip strength 78 | 123
increased mean corpuscular hem... 76 | 93
abnormal retina morphology 71 | 100
increased bone mineral content 71 | 92
increased lean body mass 71 | 107
hyperactivity 70 | 108
increased mean corpuscular vol... 67 | 91
enlarged heart 65 | 111
hypoactivity 59 | 89
increased grip strength 59 | 83
decreased circulating choleste... 58 | 85
decreased circulating serum al... 58 | 79
decreased circulating triglyce... 58 | 83
short tibia 56 | 82
abnormal lens morphology 55 | 73
prenatal lethality prior to he... 55 | 64
decreased circulating HDL chol... 51 | 77
increased circulating sodium l... 48 | 71
increased fasted circulating g... 48 | 68
increased sacral vertebrae num... 48 | 62
decreased lumbar vertebrae num... 46 | 62
abnormal retinal pigmentation 45 | 61
decreased mean corpuscular vol... 43 | 50
increased circulating HDL chol... 43 | 63
increased circulating choleste... 42 | 53
decreased leukocyte cell numbe... 41 | 54
decreased rib number 41 | 59
decreased circulating insulin ... 40 | 75
male infertility 40 | 62
increased bone mineral density 39 | 52
abnormal bone mineralization 38 | 55
increased total body fat amoun... 38 | 57
abnormal coat/hair pigmentatio... 37 | 54
abnormal sleep behavior 37 | 63
decreased circulating alanine ... 37 | 53
decreased hemoglobin content 37 | 53
increased exploration in new e... 37 | 56
decreased caudal vertebrae num... 36 | 49
thrombocytopenia 36 | 46
decreased erythrocyte cell num... 35 | 43
decreased circulating total pr... 34 | 41
impaired glucose tolerance 33 | 52
improved glucose tolerance 33 | 56
increased body weight 33 | 42
abnormal gait 32 | 51
decreased fasted circulating g... 32 | 49
decreased prepulse inhibition 32 | 52
decreased heart weight 31 | 44
decreased circulating LDL chol... 30 | 37
increased hemoglobin content 30 | 45
increased leukocyte cell numbe... 30 | 37
increased rib number 30 | 41
abnormal behavioral response t... 29 | 52
abnormal neural tube closure 29 | 37
decreased eosinophil cell numb... 29 | 41
decreased startle reflex 29 | 48
abnormal eye morphology 27 | 38
abnormal heart morphology 27 | 51
decreased circulating alkaline... 27 | 41
decreased circulating free fat... 27 | 39
decreased mean corpuscular hem... 27 | 34
embryonic growth retardation 27 | 28
decreased neutrophil cell numb... 26 | 37
abnormal cranium morphology 25 | 32
abnormal seminal vesicle morph... 25 | 47
decreased circulating calcium ... 25 | 33
decreased circulating fructosa... 25 | 31
increased blood urea nitrogen ... 25 | 44
increased circulating chloride... 25 | 43
abnormal spleen morphology 24 | 36
decreased NK T cell number 24 | 28
decreased T cell number 23 | 31
decreased blood urea nitrogen ... 23 | 31
decreased circulating chloride... 23 | 32
increased startle reflex 23 | 38
abnormal rib morphology 22 | 28
cardiovascular system phenotyp... 22 | 35
decreased B cell number 22 | 30
decreased circulating creatini... 22 | 31
increased circulating serum al... 22 | 25
increased hematocrit 22 | 36
small testis 22 | 37
tremors 22 | 34
decreased circulating aspartat... 21 | 27

Disease

ovarian cancer 6,495 | 8,484
osteosarcoma 6,026 | 7,933
medulloblastoma, large-cell 4,135 | 6,234
psoriasis 3,876 | 6,685
glioblastoma 3,802 | 5,572
lung cancer 3,326 | 4,466
atypical teratoid / rhabdoid tumor 2,836 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,282 | 3,289
malignant mesothelioma 2,239 | 3,162
Breast cancer 2,059 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 1,991 | 2,988
invasive ductal carcinoma 1,947 | 2,950
primitive neuroectodermal tumor 1,936 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 1,902 | 2,956
non-small cell lung cancer 1,853 | 2,798
pilocytic astrocytoma 1,763 | 3,086
pediatric high grade glioma 1,741 | 2,712
oligodendroglioma 1,725 | 2,849
ependymoma 1,715 | 2,514
lung adenocarcinoma 1,621 | 2,713
group 3 medulloblastoma 1,595 | 2,254
lung carcinoma 1,594 | 2,844
pancreatic cancer 1,561 | 2,300
subependymal giant cell astrocytoma 1,559 | 2,287
Cancer 1,558 | 2,346
ulcerative colitis 1,489 | 2,087
astrocytic glioma 1,418 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 1,413 | 1,795
interstitial cystitis 1,359 | 2,299
Pick disease 1,358 | 1,893
tuberculosis 1,325 | 1,557
adult high grade glioma 1,295 | 2,148
group 4 medulloblastoma 1,288 | 1,875
Multiple myeloma 1,279 | 1,327
astrocytoma 1,094 | 1,493
Carcinoma 1,088 | 2,147
pituitary cancer 1,071 | 1,972
ductal carcinoma in situ 1,006 | 1,745
juvenile dermatomyositis 1,002 | 1,189
adrenocortical carcinoma 988 | 1,427
diabetes mellitus 988 | 1,663
medulloblastoma 974 | 1,524
breast carcinoma 971 | 1,614
acute quadriplegic myopathy 956 | 1,157
cystic fibrosis 947 | 1,665
Rheumatoid Arthritis 941 | 1,160
sonic hedgehog group medulloblastoma 911 | 1,482
primary pancreatic ductal adenocarcinoma 906 | 1,271
colon cancer 904 | 1,475
posterior fossa group A ependymoma 849 | 1,511
dermatomyositis 835 | 933
posterior fossa group B ependymoma 825 | 1,530
Waldenstrons macroglobulinemia 747 | 765
spina bifida 727 | 1,064
cutaneous lupus erythematosus 720 | 1,056
acute myeloid leukemia 676 | 780
atypical teratoid/rhabdoid tumor 676 | 1,095
primary Sjogren syndrome 673 | 789
nasopharyngeal carcinoma 632 | 1,056
tuberculosis and treatment for 6 months 620 | 686
active Crohn's disease 606 | 918
non primary Sjogren syndrome sicca 584 | 840
gastric carcinoma 559 | 832
progressive supranuclear palsy 530 | 674
Atopic dermatitis 498 | 944
pancreatic carcinoma 491 | 567
esophageal adenocarcinoma 483 | 737
aldosterone-producing adenoma 478 | 664
hepatocellular carcinoma 471 | 532
Intellectual disability 409 | 573
Duchenne muscular dystrophy 405 | 602
IGA Glomerulonephritis 405 | 454
Alzheimer's disease 402 | 644
mucosa-associated lymphoid tissue lymphoma 395 | 480
Down syndrome 379 | 548
gastric cancer 362 | 430
autosomal dominant Emery-Dreifuss muscular dystrophy 343 | 499
Obesity 338 | 616
Endometriosis 318 | 535
Prostatic Neoplasms 318 | 471
Amyotrophic Lateral Sclerosis 306 | 431
Multiple Sclerosis 290 | 498
Neurodegenerative disease 285 | 383
tuberculosis and treatment for 3 months 283 | 327
Mammary Neoplasms 279 | 410
chronic rhinosinusitis 277 | 512
inflammatory breast cancer 274 | 404
active ulcerative colitis 271 | 477
hereditary spastic paraplegia 271 | 313
sarcoidosis 271 | 358
fibroadenoma 267 | 557
Schizophrenia 254 | 501
Polycystic Ovary Syndrome 228 | 332
Crohn's disease 225 | 304
Parkinson's disease 213 | 364
Chronic Lymphocytic Leukemia 205 | 242
Kidney disease 200 | 396
Stomach Neoplasms 199 | 282
Peripheral Neuropathy 196 | 303
glioblastoma multiforme 192 | 347

Tissue

Blood and immune system 11,256 | 17,995
Digestive Tract 11,253 | 18,473
Endocrine System 11,253 | 18,512
Liver and Pancreas 11,251 | 18,136
Female tissues 11,250 | 18,647
Nervous System 11,246 | 18,561
Skin and soft tissues 11,246 | 18,115
Urinary Tract 11,243 | 18,444
Respiratory system 11,241 | 17,484
Male tissues 11,239 | 17,969
Cardiovascular System 11,238 | 17,958

Target Family

Non-IDG 6,469 | 11,971
Enzyme 2,862 | 4,146
Transcription Factor 786 | 1,400
Kinase 463 | 634
Transporter 247 | 473
Epigenetic 211 | 242
GPCR 88 | 406
Ion Channel 77 | 341
TF/Epigenetic 29 | 38
Nuclear Receptor 22 | 48
oGPCR 2 | 421

HPA RNA Tissue

bone marrow 11,256 | 11,256
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108