Development Level

Tbio 8,252 | 10,625
Tdark 3,325 | 7,003
Tchem 1,475 | 1,890
Tclin 386 | 602

Collection

Eligible Kinase Proteins 98 | 134
Eligible Ion Channel Proteins 43 | 117
Eligible non-olfactory GPCR Proteins 40 | 143

IMPC Term

preweaning lethality, complete... 584 | 633
preweaning lethality, incomple... 221 | 260
abnormal behavior 189 | 226
embryonic lethality prior to t... 179 | 187
decreased lean body mass 167 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 148 | 174
embryonic lethality prior to o... 146 | 148
decreased bone mineral content 130 | 157
increased circulating alkaline... 105 | 119
increased or absent threshold ... 103 | 128
decreased bone mineral density 101 | 126
decreased circulating glucose ... 101 | 121
abnormal bone structure 100 | 131
abnormal embryo size 99 | 112
decreased grip strength 97 | 123
decreased body length 96 | 108
increased lean body mass 88 | 107
abnormal retina morphology 86 | 100
enlarged heart 85 | 111
increased bone mineral content 84 | 92
increased mean corpuscular hem... 84 | 93
hyperactivity 83 | 108
increased mean corpuscular vol... 80 | 91
decreased circulating choleste... 73 | 85
short tibia 73 | 82
hypoactivity 71 | 89
decreased circulating serum al... 70 | 79
increased grip strength 70 | 83
decreased circulating HDL chol... 68 | 77
decreased circulating triglyce... 68 | 83
abnormal lens morphology 62 | 73
prenatal lethality prior to he... 60 | 64
increased fasted circulating g... 57 | 68
decreased circulating insulin ... 56 | 75
decreased lumbar vertebrae num... 55 | 62
increased sacral vertebrae num... 54 | 62
increased circulating sodium l... 53 | 71
abnormal retinal pigmentation 51 | 61
decreased rib number 50 | 59
increased circulating HDL chol... 49 | 63
increased total body fat amoun... 47 | 57
abnormal coat/hair pigmentatio... 46 | 54
decreased leukocyte cell numbe... 46 | 54
increased bone mineral density 46 | 52
abnormal sleep behavior 45 | 63
decreased hemoglobin content 45 | 53
decreased mean corpuscular vol... 45 | 50
improved glucose tolerance 45 | 56
male infertility 45 | 62
abnormal bone mineralization 44 | 55
increased circulating choleste... 44 | 53
decreased circulating alanine ... 42 | 53
decreased prepulse inhibition 41 | 52
impaired glucose tolerance 41 | 52
decreased erythrocyte cell num... 40 | 43
increased exploration in new e... 40 | 56
abnormal gait 39 | 51
decreased caudal vertebrae num... 39 | 49
thrombocytopenia 39 | 46
decreased circulating total pr... 38 | 41
decreased startle reflex 38 | 48
increased body weight 38 | 42
decreased fasted circulating g... 37 | 49
increased blood urea nitrogen ... 36 | 44
abnormal heart morphology 35 | 51
decreased eosinophil cell numb... 35 | 41
abnormal behavioral response t... 34 | 52
decreased circulating free fat... 34 | 39
decreased heart weight 34 | 44
increased hemoglobin content 34 | 45
decreased circulating LDL chol... 33 | 37
increased rib number 33 | 41
abnormal neural tube closure 32 | 37
abnormal eye morphology 31 | 38
abnormal seminal vesicle morph... 31 | 47
decreased circulating alkaline... 31 | 41
decreased neutrophil cell numb... 31 | 37
increased hematocrit 31 | 36
increased leukocyte cell numbe... 31 | 37
abnormal cranium morphology 30 | 32
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
increased startle reflex 30 | 38
small testis 30 | 37
decreased mean corpuscular hem... 29 | 34
increased circulating chloride... 29 | 43
cardiovascular system phenotyp... 28 | 35
tremors 28 | 34
decreased T cell number 27 | 31
decreased circulating creatini... 27 | 31
embryonic growth retardation 27 | 28
decreased circulating chloride... 26 | 32
increased circulating calcium ... 26 | 32
increased heart weight 26 | 37
abnormal spleen morphology 25 | 36
corneal opacity 25 | 25
increased circulating creatini... 25 | 29
increased circulating potassiu... 25 | 31
limb grasping 25 | 35

Disease

ovarian cancer 7,551 | 8,484
osteosarcoma 6,855 | 7,933
medulloblastoma, large-cell 5,064 | 6,234
psoriasis 4,858 | 6,685
glioblastoma 4,675 | 5,572
lung cancer 4,038 | 4,466
atypical teratoid / rhabdoid tumor 3,559 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,991 | 3,289
malignant mesothelioma 2,828 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 2,714 | 2,988
Breast cancer 2,696 | 3,094
invasive ductal carcinoma 2,690 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,663 | 2,956
non-small cell lung cancer 2,457 | 2,798
primitive neuroectodermal tumor 2,443 | 3,031
pilocytic astrocytoma 2,404 | 3,086
oligodendroglioma 2,285 | 2,849
lung adenocarcinoma 2,277 | 2,713
lung carcinoma 2,273 | 2,844
pediatric high grade glioma 2,236 | 2,712
ependymoma 2,086 | 2,514
pancreatic cancer 2,047 | 2,300
interstitial cystitis 1,987 | 2,299
subependymal giant cell astrocytoma 1,933 | 2,287
ulcerative colitis 1,930 | 2,087
Cancer 1,895 | 2,346
group 3 medulloblastoma 1,891 | 2,254
astrocytic glioma 1,819 | 2,241
adult high grade glioma 1,668 | 2,148
Pick disease 1,658 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,631 | 1,795
group 4 medulloblastoma 1,599 | 1,875
pituitary cancer 1,553 | 1,972
ductal carcinoma in situ 1,548 | 1,745
Carcinoma 1,457 | 2,147
tuberculosis 1,445 | 1,557
breast carcinoma 1,440 | 1,614
cystic fibrosis 1,414 | 1,665
colon cancer 1,326 | 1,475
astrocytoma 1,300 | 1,493
Multiple myeloma 1,297 | 1,327
adrenocortical carcinoma 1,296 | 1,427
sonic hedgehog group medulloblastoma 1,210 | 1,482
medulloblastoma 1,203 | 1,524
primary pancreatic ductal adenocarcinoma 1,189 | 1,271
posterior fossa group A ependymoma 1,182 | 1,511
diabetes mellitus 1,143 | 1,663
juvenile dermatomyositis 1,129 | 1,189
posterior fossa group B ependymoma 1,115 | 1,530
acute quadriplegic myopathy 1,081 | 1,157
Rheumatoid Arthritis 1,018 | 1,160
spina bifida 928 | 1,064
cutaneous lupus erythematosus 911 | 1,056
atypical teratoid/rhabdoid tumor 901 | 1,095
dermatomyositis 901 | 933
nasopharyngeal carcinoma 834 | 1,056
active Crohn's disease 817 | 918
primary Sjogren syndrome 760 | 789
Atopic dermatitis 750 | 944
Waldenstrons macroglobulinemia 749 | 765
gastric carcinoma 747 | 832
acute myeloid leukemia 736 | 780
non primary Sjogren syndrome sicca 689 | 840
tuberculosis and treatment for 6 months 666 | 686
esophageal adenocarcinoma 643 | 737
progressive supranuclear palsy 607 | 674
aldosterone-producing adenoma 605 | 664
Duchenne muscular dystrophy 549 | 602
pancreatic carcinoma 524 | 567
Alzheimer's disease 519 | 644
hepatocellular carcinoma 501 | 532
Down syndrome 482 | 548
fibroadenoma 475 | 557
Intellectual disability 469 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 464 | 499
Obesity 456 | 616
Endometriosis 439 | 535
IGA Glomerulonephritis 433 | 454
mucosa-associated lymphoid tissue lymphoma 415 | 480
gastric cancer 404 | 430
active ulcerative colitis 400 | 477
Prostatic Neoplasms 399 | 471
Amyotrophic Lateral Sclerosis 372 | 431
chronic rhinosinusitis 371 | 512
Multiple Sclerosis 360 | 498
Mammary Neoplasms 359 | 410
inflammatory breast cancer 344 | 404
Schizophrenia 339 | 501
Neurodegenerative disease 329 | 383
sarcoidosis 325 | 358
tuberculosis and treatment for 3 months 316 | 327
hereditary spastic paraplegia 306 | 313
non-small cell lung carcinoma 306 | 413
glioblastoma multiforme 289 | 347
Polycystic Ovary Syndrome 279 | 332
Parkinson's disease 272 | 364
Asthma 270 | 349
Kidney disease 270 | 396
urothelial carcinoma 270 | 318
interstitial lung disease 265 | 291

Tissue

Digestive Tract 13,438 | 18,473
Female tissues 13,433 | 18,647
Endocrine System 13,432 | 18,512
Liver and Pancreas 13,432 | 18,136
Blood and immune system 13,430 | 17,995
Nervous System 13,430 | 18,561
Skin and soft tissues 13,430 | 18,115
Urinary Tract 13,430 | 18,444
Respiratory system 13,418 | 17,484
Male tissues 13,413 | 17,969
Cardiovascular System 13,412 | 17,958

Target Family

Non-IDG 7,756 | 11,971
Enzyme 3,280 | 4,146
Transcription Factor 993 | 1,400
Kinase 532 | 634
Transporter 294 | 473
Epigenetic 211 | 242
GPCR 169 | 406
Ion Channel 135 | 341
Nuclear Receptor 35 | 48
TF/Epigenetic 32 | 38
oGPCR 1 | 421

HPA RNA Tissue

appendix 13,438 | 13,438
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
adipose tissue 12,956 | 12,956
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345