Development Level

Tbio 10,227 | 11,651
Tdark 3,945 | 6,593
Tchem 1,243 | 1,388
Tclin 548 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 81 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 944 | 979
preweaning lethality, incomple... 469 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 197 | 207
enlarged heart 181 | 210
decreased vertical activity 173 | 208
abnormal bone structure 170 | 187
increased lean body mass 161 | 172
decreased body weight 149 | 161
abnormal heart morphology 143 | 162
hyperactivity 138 | 148
decreased bone mineral content 137 | 151
decreased lean body mass 126 | 135
increased total body fat amoun... 121 | 134
hypoactivity 117 | 132
decreased bone mineral density 114 | 126
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 111 | 122
decreased grip strength 104 | 116
increased startle reflex 102 | 112
embryonic growth retardation 101 | 106
male infertility 101 | 123
increased bone mineral content 100 | 108
decreased body length 95 | 101
abnormal seminal vesicle morph... 94 | 114
short tibia 94 | 97
increased or absent threshold ... 93 | 101
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 88 | 93
cataract 87 | 92
increased mean corpuscular hem... 86 | 96
prenatal lethality prior to he... 83 | 87
decreased circulating serum al... 78 | 82
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 72 | 79
decreased mean corpuscular vol... 72 | 79
improved glucose tolerance 71 | 79
decreased startle reflex 70 | 75
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
increased bone mineral density 69 | 72
impaired glucose tolerance 68 | 75
decreased circulating insulin ... 67 | 76
decreased leukocyte cell numbe... 67 | 73
abnormal sleep behavior 66 | 70
abnormal eye morphology 65 | 68
abnormal retina morphology 64 | 71
decreased circulating HDL chol... 64 | 68
increased circulating sodium l... 64 | 71
small superior vagus ganglion 63 | 74
abnormal gait 62 | 69
abnormal behavioral response t... 61 | 66
decreased hemoglobin content 61 | 68
decreased fasted circulating g... 60 | 65
increased circulating choleste... 60 | 66
abnormal coat-hair pigmentatio... 58 | 64
decreased erythrocyte cell num... 58 | 62
abnormal kidney morphology 57 | 65
edema 56 | 59
increased monocyte cell number 56 | 63
increased heart weight 54 | 62
small testis 54 | 58
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 52 | 56
female infertility 51 | 60
abnormal spleen morphology 50 | 55
decreased circulating total pr... 48 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 45 | 46
abnormal skin morphology 45 | 50
decreased blood urea nitrogen ... 45 | 51
decreased circulating alanine ... 45 | 47
decreased circulating alkaline... 44 | 46
hydrometra 44 | 53
decreased hematocrit 43 | 46
increased blood urea nitrogen ... 43 | 48
increased neutrophil cell numb... 43 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 42 | 47
increased circulating triglyce... 40 | 42
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
increased hemoglobin content 39 | 45
decreased circulating LDL chol... 38 | 38
enlarged spleen 38 | 41
increased circulating chloride... 38 | 41
increased mean platelet volume 38 | 45
decreased red blood cell distr... 37 | 41
limb grasping 37 | 41
decreased circulating creatini... 36 | 39
increased erythrocyte cell num... 36 | 39
tremors 36 | 39
abnormal bone mineralization 35 | 38
increased circulating creatini... 35 | 38
increased grip strength 35 | 41

Disease

Carcinoma 9,748 | 11,493
ovarian cancer 8,100 | 8,520
osteosarcoma 7,431 | 7,950
medulloblastoma, large-cell 5,857 | 6,241
psoriasis 5,673 | 6,694
glioblastoma 5,572 | 5,792
atypical teratoid / rhabdoid tumor 4,896 | 5,112
lung cancer 4,477 | 4,740
ependymoma 4,473 | 4,679
group 3 medulloblastoma 3,932 | 4,104
adult high grade glioma 3,583 | 3,801
Breast cancer 3,359 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,127 | 3,291
malignant mesothelioma 3,089 | 3,232
Astrocytoma, Pilocytic 2,966 | 3,081
primitive neuroectodermal tumor 2,923 | 3,035
invasive ductal carcinoma 2,872 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,855 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,822 | 2,955
oligodendroglioma 2,742 | 2,850
non-small cell lung cancer 2,734 | 2,890
lung carcinoma 2,702 | 2,843
lung adenocarcinoma 2,534 | 2,716
astrocytic glioma 2,512 | 2,597
Kidney cancer 2,324 | 2,613
pancreatic cancer 2,240 | 2,398
subependymal giant cell astrocytoma 2,221 | 2,287
Cancer 2,192 | 2,499
interstitial cystitis 2,175 | 2,312
tuberculosis 1,910 | 2,010
pituitary cancer 1,885 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,862 | 1,962
Pick disease 1,857 | 1,894
group 4 medulloblastoma 1,786 | 1,855
ulcerative colitis 1,701 | 1,819
ductal carcinoma in situ 1,690 | 1,745
breast carcinoma 1,581 | 1,638
cystic fibrosis 1,559 | 1,696
adrenocortical carcinoma 1,406 | 1,428
colon cancer 1,395 | 1,478
diabetes mellitus 1,316 | 1,728
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,284 | 1,442
juvenile dermatomyositis 1,152 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
astrocytoma 1,120 | 1,146
Rheumatoid arthritis 1,083 | 1,191
primary pancreatic ductal adenocarcinoma 1,068 | 1,109
pediatric high grade glioma 1,021 | 1,064
Schizophrenia 1,019 | 1,160
spina bifida 1,000 | 1,074
cutaneous lupus erythematosus 988 | 1,057
nasopharyngeal carcinoma 956 | 1,058
Intellectual disability 952 | 1,016
dermatomyositis 921 | 966
active Crohn's disease 857 | 922
Atopic dermatitis 838 | 952
non primary Sjogren syndrome sicca 819 | 891
acute myeloid leukemia 772 | 783
gastric carcinoma 770 | 807
Waldenstrons macroglobulinemia 755 | 765
Epilepsy 741 | 792
Liver Cirrhosis, Experimental 724 | 769
primary Sjogren syndrome 708 | 735
active ulcerative colitis 697 | 764
medulloblastoma 683 | 720
esophageal adenocarcinoma 666 | 737
aldosterone-producing adenoma 662 | 665
progressive supranuclear palsy 659 | 676
Alzheimer's disease 615 | 658
Dull intelligence 601 | 645
Low intelligence 601 | 645
Mental Retardation 601 | 645
Mental deficiency 601 | 645
Poor school performance 601 | 645
Obesity 596 | 678
Bipolar Disorder 589 | 666
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Duchenne muscular dystrophy 578 | 601
Seizures 564 | 596
Melanoma 555 | 711
fibroadenoma 547 | 559
Muscle hypotonia 544 | 571
pancreatic carcinoma 542 | 562
hepatocellular carcinoma 532 | 547
Liver cancer 524 | 604
Endometriosis 500 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Short stature 489 | 531
Down syndrome 478 | 499
chronic rhinosinusitis 469 | 512
Prostatic Neoplasms 461 | 495
Multiple Sclerosis 459 | 540
mucosa-associated lymphoid tissue lymphoma 450 | 484
posterior fossa group A ependymoma 449 | 468
gastric cancer 447 | 459
sonic hedgehog group medulloblastoma 442 | 467
Amyotrophic lateral sclerosis 432 | 451

Tissue

Endocrine System 15,963 | 18,159
Female tissues 15,846 | 17,400
Digestive Tract 15,838 | 17,369
Male tissues 15,783 | 17,142
Skin and soft tissues 15,783 | 17,230
Liver and Pancreas 15,661 | 16,750
Nervous System 15,656 | 16,725
Blood and immune system 15,628 | 16,909
Urinary Tract 15,604 | 16,678
Respiratory system 15,498 | 16,393
Cardiovascular System 14,759 | 15,192

Target Family

Non-IDG 9,275 | 12,091
Enzyme 3,677 | 4,145
Transcription Factor 1,164 | 1,400
Kinase 596 | 634
Transporter 376 | 473
Ion Channel 279 | 344
GPCR 277 | 408
Epigenetic 227 | 242
Nuclear Receptor 46 | 48
TF/Epigenetic 33 | 38
oGPCR 13 | 421

HPA RNA Tissue

adrenal gland 15,963 | 15,963
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
adipose tissue 15,837 | 15,837
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50