Development Level

Tbio 7,930 | 10,625
Tdark 3,241 | 7,003
Tchem 1,411 | 1,890
Tclin 374 | 602

Collection

Eligible Kinase Proteins 92 | 134
Eligible Ion Channel Proteins 38 | 117
Eligible non-olfactory GPCR Proteins 35 | 143

IMPC Term

preweaning lethality, complete... 576 | 633
preweaning lethality, incomple... 210 | 260
abnormal behavior 189 | 226
embryonic lethality prior to t... 174 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 148 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 131 | 157
abnormal bone structure 105 | 131
decreased bone mineral density 102 | 126
increased circulating alkaline... 101 | 119
increased or absent threshold ... 99 | 128
abnormal embryo size 98 | 112
decreased circulating glucose ... 97 | 121
decreased body length 96 | 108
decreased grip strength 91 | 123
increased lean body mass 89 | 107
abnormal retina morphology 87 | 100
hyperactivity 85 | 108
increased mean corpuscular hem... 82 | 93
increased bone mineral content 81 | 92
enlarged heart 78 | 111
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 72 | 85
short tibia 71 | 82
hypoactivity 70 | 89
decreased circulating serum al... 68 | 79
decreased circulating triglyce... 68 | 83
decreased circulating HDL chol... 66 | 77
increased grip strength 66 | 83
abnormal lens morphology 60 | 73
prenatal lethality prior to he... 56 | 64
decreased lumbar vertebrae num... 55 | 62
increased fasted circulating g... 54 | 68
increased sacral vertebrae num... 54 | 62
decreased circulating insulin ... 53 | 75
increased circulating sodium l... 52 | 71
abnormal retinal pigmentation 51 | 61
abnormal sleep behavior 51 | 63
decreased rib number 48 | 59
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
increased bone mineral density 46 | 52
abnormal bone mineralization 44 | 55
abnormal coat/hair pigmentatio... 44 | 54
decreased hemoglobin content 44 | 53
increased total body fat amoun... 44 | 57
improved glucose tolerance 43 | 56
decreased circulating alanine ... 42 | 53
increased circulating HDL chol... 42 | 63
male infertility 42 | 62
decreased prepulse inhibition 41 | 52
increased circulating choleste... 41 | 53
decreased fasted circulating g... 40 | 49
increased exploration in new e... 40 | 56
abnormal gait 39 | 51
decreased caudal vertebrae num... 39 | 49
decreased erythrocyte cell num... 39 | 43
impaired glucose tolerance 39 | 52
abnormal behavioral response t... 38 | 52
decreased circulating total pr... 38 | 41
thrombocytopenia 38 | 46
increased rib number 36 | 41
decreased heart weight 35 | 44
increased body weight 35 | 42
decreased startle reflex 34 | 48
increased blood urea nitrogen ... 34 | 44
increased hemoglobin content 34 | 45
decreased circulating LDL chol... 33 | 37
abnormal eye morphology 32 | 38
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
decreased circulating alkaline... 32 | 41
decreased circulating free fat... 32 | 39
decreased eosinophil cell numb... 32 | 41
abnormal seminal vesicle morph... 31 | 47
increased hematocrit 31 | 36
decreased mean corpuscular hem... 30 | 34
decreased neutrophil cell numb... 30 | 37
increased circulating chloride... 30 | 43
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased leukocyte cell numbe... 29 | 37
increased startle reflex 28 | 38
small testis 28 | 37
tremors 28 | 34
decreased T cell number 27 | 31
decreased circulating calcium ... 27 | 33
abnormal spleen morphology 26 | 36
cardiovascular system phenotyp... 26 | 35
decreased circulating creatini... 26 | 31
embryonic growth retardation 26 | 28
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
increased circulating calcium ... 25 | 32
decreased NK T cell number 24 | 28
decreased circulating aspartat... 24 | 27
enlarged spleen 24 | 26
increased circulating iron lev... 24 | 25

Disease

ovarian cancer 7,373 | 8,484
osteosarcoma 6,613 | 7,933
medulloblastoma, large-cell 4,888 | 6,234
psoriasis 4,640 | 6,685
glioblastoma 4,510 | 5,572
lung cancer 3,902 | 4,466
atypical teratoid / rhabdoid tumor 3,457 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,786 | 3,289
malignant mesothelioma 2,709 | 3,162
invasive ductal carcinoma 2,642 | 2,950
Breast cancer 2,591 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 2,538 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,534 | 2,956
primitive neuroectodermal tumor 2,324 | 3,031
non-small cell lung cancer 2,300 | 2,798
pilocytic astrocytoma 2,300 | 3,086
oligodendroglioma 2,219 | 2,849
lung carcinoma 2,184 | 2,844
lung adenocarcinoma 2,142 | 2,713
pediatric high grade glioma 2,118 | 2,712
ependymoma 2,056 | 2,514
subependymal giant cell astrocytoma 1,897 | 2,287
pancreatic cancer 1,891 | 2,300
group 3 medulloblastoma 1,814 | 2,254
interstitial cystitis 1,811 | 2,299
Cancer 1,792 | 2,346
astrocytic glioma 1,783 | 2,241
ulcerative colitis 1,760 | 2,087
adult high grade glioma 1,610 | 2,148
Pick disease 1,602 | 1,893
group 4 medulloblastoma 1,601 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,593 | 1,795
pituitary cancer 1,503 | 1,972
ductal carcinoma in situ 1,492 | 1,745
Carcinoma 1,448 | 2,147
breast carcinoma 1,414 | 1,614
tuberculosis 1,363 | 1,557
cystic fibrosis 1,339 | 1,665
Multiple myeloma 1,293 | 1,327
astrocytoma 1,272 | 1,493
adrenocortical carcinoma 1,229 | 1,427
colon cancer 1,215 | 1,475
medulloblastoma 1,175 | 1,524
primary pancreatic ductal adenocarcinoma 1,162 | 1,271
sonic hedgehog group medulloblastoma 1,162 | 1,482
juvenile dermatomyositis 1,124 | 1,189
posterior fossa group A ependymoma 1,115 | 1,511
diabetes mellitus 1,106 | 1,663
posterior fossa group B ependymoma 1,100 | 1,530
acute quadriplegic myopathy 1,077 | 1,157
Rheumatoid Arthritis 985 | 1,160
dermatomyositis 895 | 933
cutaneous lupus erythematosus 861 | 1,056
spina bifida 847 | 1,064
atypical teratoid/rhabdoid tumor 844 | 1,095
nasopharyngeal carcinoma 750 | 1,056
Waldenstrons macroglobulinemia 740 | 765
active Crohn's disease 735 | 918
gastric carcinoma 720 | 832
acute myeloid leukemia 717 | 780
Atopic dermatitis 706 | 944
primary Sjogren syndrome 698 | 789
non primary Sjogren syndrome sicca 665 | 840
tuberculosis and treatment for 6 months 658 | 686
aldosterone-producing adenoma 611 | 664
progressive supranuclear palsy 594 | 674
esophageal adenocarcinoma 587 | 737
Duchenne muscular dystrophy 556 | 602
Alzheimer's disease 507 | 644
pancreatic carcinoma 501 | 567
hepatocellular carcinoma 489 | 532
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 499
Down syndrome 474 | 548
fibroadenoma 468 | 557
Obesity 462 | 616
Intellectual disability 458 | 573
mucosa-associated lymphoid tissue lymphoma 405 | 480
IGA Glomerulonephritis 404 | 454
Endometriosis 384 | 535
gastric cancer 384 | 430
Prostatic Neoplasms 382 | 471
Amyotrophic Lateral Sclerosis 371 | 431
chronic rhinosinusitis 370 | 512
active ulcerative colitis 360 | 477
Mammary Neoplasms 340 | 410
Multiple Sclerosis 336 | 498
Schizophrenia 330 | 501
Neurodegenerative disease 325 | 383
inflammatory breast cancer 323 | 404
hereditary spastic paraplegia 301 | 313
tuberculosis and treatment for 3 months 300 | 327
sarcoidosis 297 | 358
non-small cell lung carcinoma 279 | 413
glioblastoma multiforme 277 | 347
Polycystic Ovary Syndrome 270 | 332
Kidney disease 261 | 396
Parkinson's disease 256 | 364
interstitial lung disease 254 | 291
urothelial carcinoma 252 | 318
nephrosclerosis 246 | 329

Tissue

Skin and soft tissues 12,956 | 18,115
Digestive Tract 12,953 | 18,473
Liver and Pancreas 12,952 | 18,136
Endocrine System 12,951 | 18,512
Female tissues 12,951 | 18,647
Urinary Tract 12,951 | 18,444
Blood and immune system 12,949 | 17,995
Male tissues 12,946 | 17,969
Nervous System 12,946 | 18,561
Respiratory system 12,943 | 17,484
Cardiovascular System 12,940 | 17,958

Target Family

Non-IDG 7,468 | 11,971
Enzyme 3,183 | 4,146
Transcription Factor 960 | 1,400
Kinase 505 | 634
Transporter 288 | 473
Epigenetic 209 | 242
GPCR 150 | 406
Ion Channel 127 | 341
Nuclear Receptor 33 | 48
TF/Epigenetic 32 | 38
oGPCR 1 | 421

HPA RNA Tissue

adipose tissue 12,956 | 12,956
testis 14,883 | 14,883
gallbladder 13,734 | 13,734
fallopian tube 13,709 | 13,709
lung 13,654 | 13,654
prostate 13,629 | 13,629
cerebral cortex 13,580 | 13,580
colon 13,524 | 13,524
urinary bladder 13,517 | 13,517
stomach 13,508 | 13,508
small intestine 13,472 | 13,472
appendix 13,438 | 13,438
endometrium 13,368 | 13,368
rectum 13,363 | 13,363
esophagus 13,355 | 13,355
kidney 13,342 | 13,342
adrenal gland 13,297 | 13,297
duodenum 13,297 | 13,297
smooth muscle 13,193 | 13,193
tonsil 13,067 | 13,067
placenta 13,011 | 13,011
spleen 13,000 | 13,000
skin 12,912 | 12,912
salivary gland 12,840 | 12,840
thyroid gland 12,837 | 12,837
lymph node 12,768 | 12,768
heart muscle 12,602 | 12,602
ovary 12,539 | 12,539
liver 12,083 | 12,083
pancreas 11,995 | 11,995
bone marrow 11,256 | 11,256
skeletal muscle 11,030 | 11,030

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
RNA pseudouridylate synthase domain-containing protein 3 RPUSD3 Tdark Enzyme 0.42 34
Dehydrogenase/reductase SDR family member 12 DHRS12 Tdark Enzyme 0.11 0.56 23
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Zinc finger protein 136 ZNF136 Tdark Transcription Factor 0.12 0.68 102
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108