Development Level

Tbio 7,930 | 10,625
Tdark 3,241 | 7,003
Tchem 1,410 | 1,890
Tclin 374 | 602

Collection

Kinase: IDG Consortium (Targets) 86 | 125
Ion Channel: IDG Consortium (Targets) 38 | 102
GPCR: IDG Consortium (Targets) 33 | 127
Kinase: IDG Consortium (Complete/Control) 28 | 37
GPCR: IDG Consortium (Complete/Control) 12 | 26

IMPC Phenotype

preweaning lethality, complete... 576 | 633
preweaning lethality, incomple... 210 | 260
abnormal behavior 189 | 226
embryonic lethality prior to t... 174 | 187
decreased lean body mass 165 | 195
decreased total body fat amoun... 161 | 186
decreased body weight 148 | 174
embryonic lethality prior to o... 144 | 148
decreased bone mineral content 131 | 157
abnormal bone structure 105 | 131
decreased bone mineral density 102 | 126
increased circulating alkaline... 101 | 119
increased or absent threshold ... 99 | 128
abnormal embryo size 98 | 112
decreased circulating glucose ... 97 | 121
decreased body length 96 | 108
decreased grip strength 91 | 123
increased lean body mass 89 | 107
abnormal retina morphology 87 | 100
hyperactivity 85 | 108
increased mean corpuscular hem... 82 | 93
increased bone mineral content 81 | 92
enlarged heart 78 | 111
increased mean corpuscular vol... 78 | 91
decreased circulating choleste... 72 | 85
short tibia 71 | 82
hypoactivity 70 | 89
decreased circulating serum al... 68 | 79
decreased circulating triglyce... 68 | 83
decreased circulating HDL chol... 66 | 77
increased grip strength 66 | 83
abnormal lens morphology 60 | 73
prenatal lethality prior to he... 56 | 64
decreased lumbar vertebrae num... 55 | 62
increased fasted circulating g... 54 | 68
increased sacral vertebrae num... 54 | 62
decreased circulating insulin ... 53 | 75
increased circulating sodium l... 52 | 71
abnormal retinal pigmentation 51 | 61
abnormal sleep behavior 51 | 63
decreased rib number 48 | 59
decreased leukocyte cell numbe... 46 | 54
decreased mean corpuscular vol... 46 | 50
increased bone mineral density 46 | 52
abnormal bone mineralization 44 | 55
abnormal coat-hair pigmentatio... 44 | 54
decreased hemoglobin content 44 | 53
increased total body fat amoun... 44 | 57
improved glucose tolerance 43 | 56
decreased circulating alanine ... 42 | 53
increased circulating HDL chol... 42 | 63
male infertility 42 | 62
decreased prepulse inhibition 41 | 52
increased circulating choleste... 41 | 53
decreased fasted circulating g... 40 | 49
increased exploration in new e... 40 | 56
abnormal gait 39 | 51
decreased caudal vertebrae num... 39 | 49
decreased erythrocyte cell num... 39 | 43
impaired glucose tolerance 39 | 52
abnormal behavioral response t... 38 | 52
decreased circulating total pr... 38 | 41
thrombocytopenia 38 | 46
increased rib number 36 | 41
decreased heart weight 35 | 44
increased body weight 35 | 42
decreased startle reflex 34 | 48
increased blood urea nitrogen ... 34 | 44
increased hemoglobin content 34 | 45
decreased circulating LDL chol... 33 | 37
abnormal eye morphology 32 | 38
abnormal heart morphology 32 | 51
abnormal neural tube closure 32 | 37
decreased circulating alkaline... 32 | 41
decreased circulating free fat... 32 | 39
decreased eosinophil cell numb... 32 | 41
abnormal seminal vesicle morph... 31 | 47
increased hematocrit 31 | 36
decreased mean corpuscular hem... 30 | 34
decreased neutrophil cell numb... 30 | 37
increased circulating chloride... 30 | 43
abnormal cranium morphology 29 | 32
decreased circulating fructosa... 29 | 31
increased leukocyte cell numbe... 29 | 37
increased startle reflex 28 | 38
small testis 28 | 37
tremors 28 | 34
decreased T cell number 27 | 31
decreased circulating calcium ... 27 | 33
abnormal spleen morphology 26 | 36
cardiovascular system phenotyp... 26 | 35
decreased circulating creatini... 26 | 31
embryonic growth retardation 26 | 28
increased circulating potassiu... 26 | 31
increased heart weight 26 | 37
increased circulating calcium ... 25 | 32
decreased NK T cell number 24 | 28
decreased circulating aspartat... 24 | 27
enlarged spleen 24 | 26
increased circulating iron lev... 24 | 25

Disease

ovarian cancer 7,377 | 8,491
osteosarcoma 6,613 | 7,933
medulloblastoma, large-cell 4,888 | 6,234
psoriasis 4,640 | 6,685
glioblastoma 4,510 | 5,572
lung cancer 3,907 | 4,473
atypical teratoid / rhabdoid tumor 3,457 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 2,786 | 3,289
malignant mesothelioma 2,710 | 3,163
invasive ductal carcinoma 2,642 | 2,950
Breast cancer 2,594 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,538 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,534 | 2,956
primitive neuroectodermal tumor 2,324 | 3,031
non-small cell lung cancer 2,300 | 2,798
pilocytic astrocytoma 2,300 | 3,086
oligodendroglioma 2,219 | 2,849
lung carcinoma 2,184 | 2,844
lung adenocarcinoma 2,143 | 2,714
pediatric high grade glioma 2,118 | 2,712
ependymoma 2,056 | 2,514
subependymal giant cell astrocytoma 1,897 | 2,287
pancreatic cancer 1,891 | 2,300
group 3 medulloblastoma 1,814 | 2,254
interstitial cystitis 1,811 | 2,299
Cancer 1,792 | 2,346
astrocytic glioma 1,783 | 2,241
ulcerative colitis 1,760 | 2,087
adult high grade glioma 1,610 | 2,148
Pick disease 1,602 | 1,893
group 4 medulloblastoma 1,601 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,593 | 1,795
pituitary cancer 1,503 | 1,972
ductal carcinoma in situ 1,492 | 1,745
Carcinoma 1,448 | 2,147
breast carcinoma 1,414 | 1,614
tuberculosis 1,368 | 1,563
cystic fibrosis 1,342 | 1,670
Multiple myeloma 1,292 | 1,327
astrocytoma 1,272 | 1,493
adrenocortical carcinoma 1,229 | 1,427
colon cancer 1,215 | 1,475
medulloblastoma 1,175 | 1,524
primary pancreatic ductal adenocarcinoma 1,162 | 1,271
sonic hedgehog group medulloblastoma 1,162 | 1,482
juvenile dermatomyositis 1,124 | 1,189
posterior fossa group A ependymoma 1,115 | 1,511
diabetes mellitus 1,106 | 1,663
posterior fossa group B ependymoma 1,100 | 1,530
acute quadriplegic myopathy 1,077 | 1,157
Rheumatoid Arthritis 985 | 1,170
dermatomyositis 895 | 966
cutaneous lupus erythematosus 861 | 1,056
spina bifida 847 | 1,064
atypical teratoid/rhabdoid tumor 844 | 1,095
nasopharyngeal carcinoma 750 | 1,056
Waldenstrons macroglobulinemia 739 | 764
active Crohn's disease 735 | 918
acute myeloid leukemia 721 | 785
gastric carcinoma 720 | 832
Atopic dermatitis 706 | 944
primary Sjogren syndrome 697 | 788
non primary Sjogren syndrome sicca 665 | 840
tuberculosis and treatment for 6 months 658 | 686
aldosterone-producing adenoma 611 | 664
progressive supranuclear palsy 594 | 674
esophageal adenocarcinoma 587 | 737
Duchenne muscular dystrophy 556 | 602
Alzheimer's disease 507 | 644
hepatocellular carcinoma 506 | 550
pancreatic carcinoma 501 | 567
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 499
Down syndrome 474 | 548
fibroadenoma 468 | 557
Obesity 462 | 616
Intellectual disability 458 | 573
mucosa-associated lymphoid tissue lymphoma 405 | 480
IGA Glomerulonephritis 404 | 454
gastric cancer 390 | 436
Endometriosis 384 | 535
Prostatic Neoplasms 382 | 471
Amyotrophic Lateral Sclerosis 371 | 432
chronic rhinosinusitis 370 | 512
active ulcerative colitis 360 | 477
Mammary Neoplasms 340 | 410
Multiple Sclerosis 336 | 498
Schizophrenia 332 | 503
Neurodegenerative disease 325 | 383
inflammatory breast cancer 323 | 404
hereditary spastic paraplegia 301 | 313
tuberculosis and treatment for 3 months 300 | 327
sarcoidosis 297 | 368
non-small cell lung carcinoma 279 | 413
glioblastoma multiforme 277 | 347
Polycystic Ovary Syndrome 269 | 334
Kidney disease 262 | 397
Parkinson's disease 256 | 364
interstitial lung disease 255 | 292
urothelial carcinoma 252 | 318
nephrosclerosis 246 | 329

Tissue

Skin and soft tissues 12,955 | 18,114
Digestive Tract 12,952 | 18,472
Liver and Pancreas 12,951 | 18,135
Endocrine System 12,950 | 18,511
Female tissues 12,950 | 18,646
Urinary Tract 12,950 | 18,443
Blood and immune system 12,948 | 17,994
Male tissues 12,945 | 17,968
Nervous System 12,945 | 18,560
Respiratory system 12,942 | 17,483
Cardiovascular System 12,939 | 17,957

Target Family

Non-IDG 7,468 | 11,969
Enzyme 3,182 | 4,146
Transcription Factor 960 | 1,400
Kinase 505 | 634
Transporter 288 | 473
Epigenetic 209 | 242
GPCR 150 | 408
Ion Channel 127 | 341
Nuclear Receptor 33 | 48
TF/Epigenetic 32 | 38
oGPCR 1 | 421

HPA RNA Tissue

adipose tissue 12,955 | 12,955
testis 14,882 | 14,882
gallbladder 13,733 | 13,733
fallopian tube 13,708 | 13,708
lung 13,653 | 13,653
prostate 13,628 | 13,628
cerebral cortex 13,579 | 13,579
colon 13,523 | 13,523
urinary bladder 13,516 | 13,516
stomach 13,507 | 13,507
small intestine 13,471 | 13,471
appendix 13,437 | 13,437
endometrium 13,367 | 13,367
rectum 13,362 | 13,362
esophagus 13,354 | 13,354
kidney 13,341 | 13,341
adrenal gland 13,296 | 13,296
duodenum 13,296 | 13,296
smooth muscle 13,192 | 13,192
tonsil 13,066 | 13,066
placenta 13,010 | 13,010
spleen 12,999 | 12,999
skin 12,911 | 12,911
salivary gland 12,839 | 12,839
thyroid gland 12,836 | 12,836
lymph node 12,767 | 12,767
heart muscle 12,601 | 12,601
ovary 12,538 | 12,538
liver 12,082 | 12,082
pancreas 11,994 | 11,994
bone marrow 11,255 | 11,255
skeletal muscle 11,029 | 11,029

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Myeloma-overexpressed gene 2 protein COPS9 Tdark Non-IDG 0.21 0.67 12
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
Phosphoglycerate mutase 2 PGAM2 Tbio Enzyme -1.54638 36.2 160