Development Level

Tbio 10,244 | 11,651
Tdark 3,828 | 6,593
Tchem 1,247 | 1,388
Tclin 518 | 612

Collection

RFA-RM-18-021 250 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 72 | 99
GPCR: IDG Consortium (Targets) 65 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 467 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 235 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 191 | 207
enlarged heart 180 | 210
decreased vertical activity 170 | 208
abnormal bone structure 166 | 187
increased lean body mass 159 | 172
decreased body weight 152 | 161
abnormal heart morphology 142 | 162
decreased bone mineral content 135 | 151
hyperactivity 135 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 122 | 134
hypoactivity 119 | 132
decreased circulating glucose ... 117 | 126
decreased bone mineral density 115 | 126
increased circulating alkaline... 112 | 122
increased startle reflex 105 | 112
decreased grip strength 104 | 116
embryonic growth retardation 103 | 106
male infertility 103 | 123
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 96 | 114
decreased body length 93 | 101
increased or absent threshold ... 93 | 101
short tibia 92 | 97
increased mean corpuscular vol... 90 | 92
decreased circulating choleste... 88 | 93
cataract 86 | 92
increased mean corpuscular hem... 86 | 96
prenatal lethality prior to he... 83 | 87
decreased circulating triglyce... 78 | 79
decreased lymphocyte cell numb... 78 | 83
decreased circulating serum al... 77 | 82
abnormal lens morphology 76 | 81
decreased prepulse inhibition 76 | 82
decreased mean corpuscular vol... 74 | 79
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 70 | 76
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 69 | 75
improved glucose tolerance 69 | 79
increased bone mineral density 69 | 72
abnormal sleep behavior 67 | 70
impaired glucose tolerance 66 | 75
small superior vagus ganglion 66 | 74
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
abnormal eye morphology 64 | 68
abnormal retina morphology 64 | 71
abnormal gait 63 | 69
increased circulating sodium l... 62 | 71
abnormal behavioral response t... 61 | 66
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
abnormal coat-hair pigmentatio... 59 | 64
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 58 | 65
increased monocyte cell number 57 | 63
abnormal kidney morphology 56 | 65
edema 56 | 59
increased heart weight 55 | 62
small testis 54 | 58
thrombocytopenia 53 | 56
decreased caudal vertebrae num... 52 | 53
abnormal spleen morphology 50 | 55
female infertility 48 | 60
decreased circulating total pr... 47 | 49
hydrometra 47 | 53
abnormal skin morphology 46 | 50
abnormal neural tube closure 45 | 46
decreased blood urea nitrogen ... 45 | 51
decreased mean corpuscular hem... 45 | 50
decreased circulating alkaline... 44 | 46
increased blood urea nitrogen ... 44 | 48
increased hematocrit 44 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
decreased hematocrit 42 | 46
increased leukocyte cell numbe... 42 | 47
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
decreased neutrophil cell numb... 37 | 42
decreased red blood cell distr... 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal cranium morphology 36 | 36
decreased circulating LDL chol... 36 | 38
increased circulating chloride... 36 | 41
increased erythrocyte cell num... 36 | 39
increased circulating creatini... 35 | 38
increased grip strength 35 | 41
limb grasping 35 | 41

Disease

Carcinoma 9,681 | 11,493
ovarian cancer 8,091 | 8,520
osteosarcoma 7,447 | 7,950
medulloblastoma, large-cell 5,743 | 6,241
psoriasis 5,666 | 6,694
glioblastoma 5,430 | 5,792
atypical teratoid / rhabdoid tumor 4,769 | 5,112
lung cancer 4,470 | 4,740
ependymoma 4,321 | 4,679
group 3 medulloblastoma 3,843 | 4,104
adult high grade glioma 3,467 | 3,801
Breast cancer 3,377 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,165 | 3,291
malignant mesothelioma 3,099 | 3,232
invasive ductal carcinoma 2,897 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,885 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,849 | 2,955
primitive neuroectodermal tumor 2,842 | 3,035
Astrocytoma, Pilocytic 2,831 | 3,081
non-small cell lung cancer 2,765 | 2,890
oligodendroglioma 2,645 | 2,850
lung carcinoma 2,626 | 2,843
lung adenocarcinoma 2,547 | 2,716
astrocytic glioma 2,415 | 2,597
Kidney cancer 2,278 | 2,613
pancreatic cancer 2,276 | 2,398
Cancer 2,222 | 2,499
interstitial cystitis 2,188 | 2,312
subependymal giant cell astrocytoma 2,156 | 2,287
tuberculosis 1,924 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,885 | 1,962
pituitary cancer 1,823 | 1,972
Pick disease 1,806 | 1,894
group 4 medulloblastoma 1,756 | 1,855
ulcerative colitis 1,729 | 1,819
ductal carcinoma in situ 1,711 | 1,745
cystic fibrosis 1,598 | 1,696
breast carcinoma 1,593 | 1,638
colon cancer 1,411 | 1,478
adrenocortical carcinoma 1,395 | 1,428
diabetes mellitus 1,335 | 1,728
Multiple myeloma 1,304 | 1,332
Autosomal recessive predisposition 1,287 | 1,442
juvenile dermatomyositis 1,159 | 1,187
acute quadriplegic myopathy 1,131 | 1,158
astrocytoma 1,101 | 1,146
primary pancreatic ductal adenocarcinoma 1,082 | 1,109
Rheumatoid arthritis 1,080 | 1,191
spina bifida 1,017 | 1,074
pediatric high grade glioma 1,011 | 1,064
cutaneous lupus erythematosus 1,004 | 1,057
Schizophrenia 995 | 1,160
nasopharyngeal carcinoma 969 | 1,058
Intellectual disability 937 | 1,016
dermatomyositis 922 | 966
active Crohn's disease 870 | 922
Atopic dermatitis 855 | 952
non primary Sjogren syndrome sicca 815 | 891
gastric carcinoma 774 | 807
acute myeloid leukemia 772 | 783
Waldenstrons macroglobulinemia 757 | 765
Liver Cirrhosis, Experimental 728 | 769
Epilepsy 718 | 792
primary Sjogren syndrome 718 | 735
active ulcerative colitis 714 | 764
esophageal adenocarcinoma 695 | 737
medulloblastoma 670 | 720
aldosterone-producing adenoma 651 | 665
progressive supranuclear palsy 650 | 676
Alzheimer's disease 602 | 658
Obesity 599 | 678
Dull intelligence 596 | 645
Low intelligence 596 | 645
Mental Retardation 596 | 645
Mental deficiency 596 | 645
Poor school performance 596 | 645
Duchenne muscular dystrophy 580 | 601
Cognitive delay 578 | 608
Global developmental delay 578 | 608
Mental and motor retardation 578 | 608
Bipolar Disorder 570 | 666
Melanoma 553 | 711
Seizures 550 | 596
pancreatic carcinoma 550 | 562
fibroadenoma 545 | 559
Muscle hypotonia 540 | 571
hepatocellular carcinoma 534 | 547
Endometriosis 500 | 540
Liver cancer 499 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Short stature 489 | 531
Down syndrome 473 | 499
Prostatic Neoplasms 464 | 495
chronic rhinosinusitis 464 | 512
mucosa-associated lymphoid tissue lymphoma 458 | 484
gastric cancer 451 | 459
posterior fossa group A ependymoma 446 | 468
Multiple Sclerosis 443 | 540
sonic hedgehog group medulloblastoma 435 | 467
Amyotrophic lateral sclerosis 434 | 451

Tissue

Skin and soft tissues 15,837 | 17,230
Endocrine System 15,811 | 18,159
Female tissues 15,770 | 17,400
Digestive Tract 15,759 | 17,369
Male tissues 15,685 | 17,142
Liver and Pancreas 15,629 | 16,750
Blood and immune system 15,616 | 16,909
Urinary Tract 15,596 | 16,678
Respiratory system 15,488 | 16,393
Nervous System 15,472 | 16,725
Cardiovascular System 14,767 | 15,192

Target Family

Non-IDG 9,206 | 12,091
Enzyme 3,664 | 4,145
Transcription Factor 1,171 | 1,400
Kinase 591 | 634
Transporter 384 | 473
GPCR 264 | 408
Ion Channel 242 | 344
Epigenetic 227 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 12 | 421

HPA RNA Tissue

adipose tissue 15,837 | 15,837
testis 17,936 | 17,936
cerebral cortex 16,630 | 16,630
prostate 16,460 | 16,460
endometrium 16,349 | 16,349
gallbladder 16,333 | 16,333
lung 16,312 | 16,312
appendix 16,247 | 16,247
fallopian tube 16,245 | 16,245
skin 16,206 | 16,206
small intestine 16,154 | 16,154
stomach 16,099 | 16,099
breast 16,063 | 16,063
duodenum 15,975 | 15,975
spleen 15,972 | 15,972
adrenal gland 15,963 | 15,963
colon 15,959 | 15,959
thyroid gland 15,959 | 15,959
placenta 15,937 | 15,937
seminal vesicle 15,918 | 15,918
kidney 15,917 | 15,917
esophagus 15,898 | 15,898
cervix, uterine 15,871 | 15,871
epididymis 15,863 | 15,863
smooth muscle 15,857 | 15,857
lymph node 15,833 | 15,833
urinary bladder 15,814 | 15,814
rectum 15,705 | 15,705
ovary 15,408 | 15,408
tonsil 15,400 | 15,400
salivary gland 14,981 | 14,981
heart muscle 14,972 | 14,972
parathyroid gland 14,769 | 14,769
liver 14,587 | 14,587
bone marrow 14,571 | 14,571
pancreas 14,070 | 14,070
skeletal muscle 14,011 | 14,011

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50