Development Level

Tbio 10,389 | 11,651
Tdark 4,100 | 6,593
Tchem 1,243 | 1,388
Tclin 521 | 612

Collection

RFA-RM-18-021 269 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 84 | 99
GPCR: IDG Consortium (Targets) 76 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 951 | 979
preweaning lethality, incomple... 471 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 214 | 220
decreased total body fat amoun... 193 | 207
enlarged heart 181 | 210
abnormal bone structure 173 | 187
decreased vertical activity 168 | 208
increased lean body mass 158 | 172
decreased body weight 156 | 161
abnormal heart morphology 141 | 162
hyperactivity 137 | 148
decreased bone mineral content 133 | 151
decreased lean body mass 124 | 135
increased total body fat amoun... 122 | 134
hypoactivity 120 | 132
decreased circulating glucose ... 117 | 126
increased circulating alkaline... 115 | 122
decreased bone mineral density 114 | 126
increased startle reflex 111 | 112
male infertility 109 | 123
decreased grip strength 104 | 116
embryonic growth retardation 102 | 106
abnormal seminal vesicle morph... 98 | 114
increased bone mineral content 98 | 108
short tibia 97 | 97
decreased body length 93 | 101
increased or absent threshold ... 91 | 101
decreased circulating choleste... 90 | 93
cataract 88 | 92
increased mean corpuscular hem... 87 | 96
prenatal lethality prior to he... 85 | 87
increased mean corpuscular vol... 84 | 92
decreased prepulse inhibition 79 | 82
abnormal lens morphology 78 | 81
decreased circulating serum al... 76 | 82
decreased lymphocyte cell numb... 76 | 83
decreased circulating triglyce... 74 | 79
decreased mean corpuscular vol... 74 | 79
decreased startle reflex 71 | 75
increased circulating HDL chol... 70 | 80
increased fasted circulating g... 70 | 76
impaired glucose tolerance 69 | 75
increased bone mineral density 69 | 72
decreased leukocyte cell numbe... 68 | 73
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 65 | 68
decreased circulating insulin ... 65 | 76
improved glucose tolerance 65 | 79
abnormal gait 64 | 69
abnormal sleep behavior 64 | 70
small superior vagus ganglion 64 | 74
increased circulating sodium l... 62 | 71
abnormal coat-hair pigmentatio... 60 | 64
edema 59 | 59
increased circulating choleste... 59 | 66
decreased hemoglobin content 58 | 68
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
decreased erythrocyte cell num... 57 | 62
decreased fasted circulating g... 57 | 65
increased heart weight 56 | 62
increased monocyte cell number 55 | 63
small testis 54 | 58
decreased caudal vertebrae num... 52 | 53
abnormal spleen morphology 50 | 55
female infertility 50 | 60
thrombocytopenia 49 | 56
decreased blood urea nitrogen ... 47 | 51
decreased circulating total pr... 47 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 45 | 47
hydrometra 45 | 53
decreased circulating alkaline... 44 | 46
increased leukocyte cell numbe... 44 | 47
abnormal skin morphology 43 | 50
increased blood urea nitrogen ... 43 | 48
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
decreased hematocrit 41 | 46
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
enlarged spleen 38 | 41
increased circulating chloride... 38 | 41
increased circulating triglyce... 38 | 42
tremors 38 | 39
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
limb grasping 37 | 41
increased grip strength 36 | 41
decreased circulating creatini... 35 | 39
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 9,968 | 11,493
ovarian cancer 8,074 | 8,520
osteosarcoma 7,358 | 7,950
medulloblastoma, large-cell 5,865 | 6,241
psoriasis 5,747 | 6,694
glioblastoma 5,509 | 5,792
atypical teratoid / rhabdoid tumor 4,872 | 5,112
lung cancer 4,437 | 4,740
ependymoma 4,424 | 4,679
group 3 medulloblastoma 3,902 | 4,104
adult high grade glioma 3,542 | 3,801
Breast cancer 3,389 | 3,578
malignant mesothelioma 3,120 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,091 | 3,291
primitive neuroectodermal tumor 2,899 | 3,035
Astrocytoma, Pilocytic 2,888 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,804 | 2,989
invasive ductal carcinoma 2,789 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,759 | 2,955
oligodendroglioma 2,715 | 2,850
non-small cell lung cancer 2,683 | 2,890
lung carcinoma 2,566 | 2,843
lung adenocarcinoma 2,471 | 2,716
astrocytic glioma 2,467 | 2,597
Kidney cancer 2,383 | 2,613
Cancer 2,261 | 2,499
pancreatic cancer 2,228 | 2,398
subependymal giant cell astrocytoma 2,180 | 2,287
interstitial cystitis 2,055 | 2,312
tuberculosis 1,863 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,856 | 1,962
Pick disease 1,841 | 1,894
pituitary cancer 1,834 | 1,972
group 4 medulloblastoma 1,780 | 1,855
ulcerative colitis 1,645 | 1,819
ductal carcinoma in situ 1,639 | 1,745
cystic fibrosis 1,577 | 1,696
breast carcinoma 1,525 | 1,638
diabetes mellitus 1,394 | 1,728
colon cancer 1,353 | 1,478
adrenocortical carcinoma 1,351 | 1,428
Multiple myeloma 1,313 | 1,332
Autosomal recessive predisposition 1,288 | 1,442
juvenile dermatomyositis 1,154 | 1,187
astrocytoma 1,123 | 1,146
acute quadriplegic myopathy 1,117 | 1,158
Rheumatoid arthritis 1,101 | 1,191
primary pancreatic ductal adenocarcinoma 1,061 | 1,109
spina bifida 1,028 | 1,074
pediatric high grade glioma 1,017 | 1,064
Schizophrenia 1,010 | 1,160
Intellectual disability 972 | 1,016
dermatomyositis 946 | 966
nasopharyngeal carcinoma 946 | 1,058
cutaneous lupus erythematosus 924 | 1,057
active Crohn's disease 837 | 922
Atopic dermatitis 823 | 952
non primary Sjogren syndrome sicca 811 | 891
gastric carcinoma 761 | 807
acute myeloid leukemia 757 | 783
Waldenstrons macroglobulinemia 750 | 765
Epilepsy 737 | 792
Liver Cirrhosis, Experimental 698 | 769
active ulcerative colitis 687 | 764
medulloblastoma 683 | 720
primary Sjogren syndrome 673 | 735
esophageal adenocarcinoma 671 | 737
progressive supranuclear palsy 662 | 676
aldosterone-producing adenoma 638 | 665
Dull intelligence 618 | 645
Low intelligence 618 | 645
Mental Retardation 618 | 645
Mental deficiency 618 | 645
Poor school performance 618 | 645
Alzheimer's disease 601 | 658
Melanoma 594 | 711
Obesity 593 | 678
Bipolar Disorder 584 | 666
Cognitive delay 584 | 608
Global developmental delay 584 | 608
Mental and motor retardation 584 | 608
Duchenne muscular dystrophy 573 | 601
Seizures 560 | 596
Muscle hypotonia 553 | 571
Liver cancer 544 | 604
pancreatic carcinoma 535 | 562
hepatocellular carcinoma 516 | 547
fibroadenoma 512 | 559
autosomal dominant Emery-Dreifuss muscular dystrophy 497 | 510
Short stature 496 | 531
Endometriosis 489 | 540
Down syndrome 480 | 499
Multiple Sclerosis 461 | 540
Prostatic Neoplasms 458 | 495
chronic rhinosinusitis 457 | 512
posterior fossa group A ependymoma 443 | 468
sonic hedgehog group medulloblastoma 440 | 467
Amyotrophic lateral sclerosis 430 | 451
gastric cancer 430 | 459
Breast Neoplasms 419 | 445

Tissue

Endocrine System 15,976 | 18,159
Female tissues 15,734 | 17,400
Digestive Tract 15,717 | 17,369
Skin and soft tissues 15,687 | 17,230
Male tissues 15,579 | 17,142
Nervous System 15,509 | 16,725
Blood and immune system 15,487 | 16,909
Liver and Pancreas 15,410 | 16,750
Urinary Tract 15,365 | 16,678
Respiratory system 15,213 | 16,393
Cardiovascular System 14,409 | 15,192

Target Family

Non-IDG 9,425 | 12,091
Enzyme 3,660 | 4,145
Transcription Factor 1,267 | 1,400
Kinase 598 | 634
Transporter 398 | 473
Ion Channel 283 | 344
GPCR 277 | 408
Epigenetic 228 | 242
Nuclear Receptor 46 | 48
oGPCR 36 | 421
TF/Epigenetic 35 | 38

HCA RNA Cell Line

WM-115 16,253 | 16,253
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50