Development Level

Tbio 9,432 | 10,625
Tdark 4,463 | 7,003
Tchem 1,658 | 1,890
Tclin 511 | 602

Collection

Kinase: IDG Consortium (Targets) 115 | 125
Ion Channel: IDG Consortium (Targets) 86 | 102
GPCR: IDG Consortium (Targets) 77 | 128
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 24

IMPC Phenotype

preweaning lethality, complete... 611 | 633
preweaning lethality, incomple... 246 | 260
abnormal behavior 219 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 178 | 186
decreased body weight 168 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 147 | 157
abnormal bone structure 121 | 131
decreased bone mineral density 117 | 126
increased or absent threshold ... 115 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 109 | 123
abnormal embryo size 108 | 112
decreased circulating glucose ... 107 | 121
decreased body length 105 | 108
hyperactivity 103 | 108
enlarged heart 97 | 111
increased lean body mass 97 | 107
abnormal retina morphology 95 | 100
increased bone mineral content 88 | 92
increased mean corpuscular hem... 86 | 93
increased mean corpuscular vol... 84 | 91
decreased circulating choleste... 82 | 85
hypoactivity 82 | 89
short tibia 80 | 82
decreased circulating triglyce... 77 | 83
increased grip strength 75 | 83
decreased circulating serum al... 74 | 79
decreased circulating HDL chol... 72 | 77
abnormal lens morphology 66 | 73
decreased circulating insulin ... 65 | 75
increased circulating sodium l... 63 | 71
prenatal lethality prior to he... 63 | 64
decreased lumbar vertebrae num... 61 | 62
increased fasted circulating g... 61 | 68
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
increased circulating HDL chol... 55 | 63
abnormal bone mineralization 54 | 55
male infertility 54 | 62
increased total body fat amoun... 53 | 57
abnormal coat-hair pigmentatio... 51 | 54
decreased circulating alanine ... 50 | 53
decreased leukocyte cell numbe... 50 | 54
decreased prepulse inhibition 50 | 52
increased bone mineral density 50 | 52
abnormal gait 49 | 51
impaired glucose tolerance 49 | 52
decreased mean corpuscular vol... 48 | 50
increased circulating choleste... 48 | 53
increased exploration in new e... 48 | 56
decreased hemoglobin content 46 | 53
decreased caudal vertebrae num... 45 | 49
decreased startle reflex 45 | 48
abnormal behavioral response t... 44 | 52
decreased fasted circulating g... 44 | 49
improved glucose tolerance 44 | 56
abnormal heart morphology 43 | 51
increased body weight 42 | 42
decreased circulating total pr... 41 | 41
increased blood urea nitrogen ... 41 | 44
thrombocytopenia 41 | 46
decreased erythrocyte cell num... 40 | 43
increased circulating chloride... 40 | 43
abnormal seminal vesicle morph... 39 | 47
decreased circulating alkaline... 39 | 41
decreased eosinophil cell numb... 39 | 41
increased hemoglobin content 39 | 45
decreased heart weight 38 | 44
abnormal eye morphology 37 | 38
decreased circulating free fat... 37 | 39
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased neutrophil cell numb... 36 | 37
increased rib number 36 | 41
increased leukocyte cell numbe... 35 | 37
small testis 35 | 37
tremors 33 | 34
decreased mean corpuscular hem... 32 | 34
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
increased hematocrit 31 | 36
limb grasping 31 | 35
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
abnormal testis morphology 29 | 30
cardiovascular system phenotyp... 29 | 35
decreased T cell number 29 | 31
decreased circulating creatini... 29 | 31
increased heart weight 29 | 37
decreased blood urea nitrogen ... 28 | 31
decreased circulating chloride... 28 | 32
decreased threshold for audito... 28 | 32
female infertility 28 | 34
increased circulating potassiu... 28 | 31

Disease

ovarian cancer 7,961 | 8,491
osteosarcoma 7,272 | 7,933
medulloblastoma, large-cell 5,808 | 6,234
psoriasis 5,695 | 6,685
glioblastoma 5,254 | 5,572
lung cancer 4,207 | 4,473
atypical teratoid / rhabdoid tumor 4,128 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,061 | 3,289
malignant mesothelioma 3,036 | 3,163
Breast cancer 2,930 | 3,098
primitive neuroectodermal tumor 2,863 | 3,031
pilocytic astrocytoma 2,859 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,780 | 2,988
invasive ductal carcinoma 2,760 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,741 | 2,956
oligodendroglioma 2,689 | 2,849
non-small cell lung cancer 2,583 | 2,798
pediatric high grade glioma 2,567 | 2,712
lung carcinoma 2,551 | 2,844
lung adenocarcinoma 2,449 | 2,714
ependymoma 2,388 | 2,514
subependymal giant cell astrocytoma 2,160 | 2,287
pancreatic cancer 2,121 | 2,300
astrocytic glioma 2,112 | 2,241
Cancer 2,111 | 2,346
group 3 medulloblastoma 2,108 | 2,254
interstitial cystitis 2,036 | 2,299
adult high grade glioma 1,944 | 2,148
Carcinoma 1,928 | 2,147
ulcerative colitis 1,885 | 2,087
Pick disease 1,827 | 1,893
pituitary cancer 1,821 | 1,972
group 4 medulloblastoma 1,791 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,676 | 1,795
ductal carcinoma in situ 1,624 | 1,745
cystic fibrosis 1,542 | 1,670
breast carcinoma 1,489 | 1,614
astrocytoma 1,444 | 1,493
tuberculosis 1,432 | 1,563
medulloblastoma 1,426 | 1,524
posterior fossa group A ependymoma 1,410 | 1,511
sonic hedgehog group medulloblastoma 1,401 | 1,482
posterior fossa group B ependymoma 1,394 | 1,530
colon cancer 1,340 | 1,475
adrenocortical carcinoma 1,332 | 1,427
diabetes mellitus 1,330 | 1,663
Multiple myeloma 1,297 | 1,327
primary pancreatic ductal adenocarcinoma 1,210 | 1,271
juvenile dermatomyositis 1,146 | 1,189
acute quadriplegic myopathy 1,108 | 1,157
Rheumatoid Arthritis 1,074 | 1,170
atypical teratoid/rhabdoid tumor 1,024 | 1,095
spina bifida 1,009 | 1,064
dermatomyositis 941 | 966
nasopharyngeal carcinoma 939 | 1,056
cutaneous lupus erythematosus 915 | 1,056
active Crohn's disease 827 | 918
Atopic dermatitis 807 | 944
gastric carcinoma 779 | 832
non primary Sjogren syndrome sicca 754 | 840
acute myeloid leukemia 746 | 785
Waldenstrons macroglobulinemia 743 | 764
primary Sjogren syndrome 716 | 788
esophageal adenocarcinoma 668 | 737
tuberculosis and treatment for 6 months 661 | 686
progressive supranuclear palsy 656 | 674
aldosterone-producing adenoma 633 | 664
Alzheimer's disease 586 | 644
Duchenne muscular dystrophy 567 | 602
Intellectual disability 548 | 573
Obesity 539 | 616
pancreatic carcinoma 536 | 567
Down syndrome 525 | 548
hepatocellular carcinoma 516 | 550
fibroadenoma 508 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 486 | 499
Endometriosis 478 | 535
chronic rhinosinusitis 454 | 512
Prostatic Neoplasms 433 | 471
IGA Glomerulonephritis 430 | 454
Schizophrenia 426 | 503
Multiple Sclerosis 423 | 498
active ulcerative colitis 418 | 477
Amyotrophic Lateral Sclerosis 408 | 432
mucosa-associated lymphoid tissue lymphoma 408 | 480
gastric cancer 404 | 436
Mammary Neoplasms 384 | 410
inflammatory breast cancer 366 | 404
Neurodegenerative disease 365 | 383
non-small cell lung carcinoma 365 | 413
glioblastoma multiforme 330 | 347
Parkinson's disease 326 | 364
sarcoidosis 326 | 368
Kidney disease 321 | 397
Epilepsy 309 | 346
hereditary spastic paraplegia 306 | 313
Polycystic Ovary Syndrome 303 | 334
tuberculosis and treatment for 3 months 299 | 327
urothelial carcinoma 293 | 318
Asthma 278 | 349

Tissue

Nervous System 15,850 | 18,560
Female tissues 15,831 | 18,646
Digestive Tract 15,825 | 18,472
Endocrine System 15,811 | 18,511
Urinary Tract 15,764 | 18,443
Liver and Pancreas 15,724 | 18,135
Male tissues 15,716 | 17,968
Cardiovascular System 15,694 | 17,957
Blood and immune system 15,685 | 17,994
Skin and soft tissues 15,652 | 18,114
Respiratory system 15,511 | 17,483

Target Family

Non-IDG 9,286 | 11,969
Enzyme 3,632 | 4,146
Transcription Factor 1,263 | 1,400
Kinase 591 | 634
Transporter 398 | 473
Ion Channel 279 | 341
GPCR 277 | 408
Epigenetic 222 | 242
Nuclear Receptor 46 | 48
oGPCR 36 | 421
TF/Epigenetic 34 | 38

HCA RNA Cell Line

WM-115 16,064 | 16,064
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50