Development Level

Tbio 9,429 | 10,625
Tdark 4,370 | 7,003
Tchem 1,692 | 1,890
Tclin 496 | 602

Collection

Kinase: IDG Consortium (Targets) 109 | 125
GPCR: IDG Consortium (Targets) 72 | 127
Ion Channel: IDG Consortium (Targets) 72 | 102
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 26

IMPC Phenotype

preweaning lethality, complete... 608 | 633
preweaning lethality, incomple... 241 | 260
abnormal behavior 214 | 226
embryonic lethality prior to t... 185 | 187
decreased lean body mass 181 | 195
decreased total body fat amoun... 173 | 186
decreased body weight 161 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 141 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 117 | 128
decreased bone mineral density 112 | 126
increased circulating alkaline... 112 | 119
decreased grip strength 111 | 123
abnormal embryo size 108 | 112
decreased circulating glucose ... 105 | 121
decreased body length 102 | 108
enlarged heart 99 | 111
hyperactivity 99 | 108
increased lean body mass 97 | 107
abnormal retina morphology 96 | 100
increased mean corpuscular hem... 90 | 93
increased bone mineral content 88 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 81 | 85
hypoactivity 81 | 89
short tibia 78 | 82
decreased circulating triglyce... 74 | 83
decreased circulating HDL chol... 73 | 77
increased grip strength 72 | 83
decreased circulating serum al... 71 | 79
abnormal lens morphology 68 | 73
prenatal lethality prior to he... 64 | 64
decreased circulating insulin ... 63 | 75
decreased lumbar vertebrae num... 60 | 62
increased fasted circulating g... 60 | 68
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 58 | 61
increased circulating sodium l... 58 | 71
decreased rib number 57 | 59
increased circulating HDL chol... 55 | 63
abnormal bone mineralization 54 | 55
abnormal sleep behavior 53 | 63
abnormal coat-hair pigmentatio... 52 | 54
male infertility 52 | 62
decreased prepulse inhibition 51 | 52
increased total body fat amoun... 51 | 57
decreased hemoglobin content 50 | 53
decreased leukocyte cell numbe... 50 | 54
improved glucose tolerance 50 | 56
decreased mean corpuscular vol... 49 | 50
increased bone mineral density 49 | 52
increased circulating choleste... 48 | 53
decreased circulating alanine ... 47 | 53
impaired glucose tolerance 47 | 52
increased exploration in new e... 47 | 56
abnormal gait 46 | 51
decreased startle reflex 46 | 48
abnormal behavioral response t... 45 | 52
decreased fasted circulating g... 45 | 49
decreased caudal vertebrae num... 44 | 49
abnormal heart morphology 43 | 51
decreased erythrocyte cell num... 43 | 43
increased hemoglobin content 43 | 45
thrombocytopenia 43 | 46
decreased circulating alkaline... 40 | 41
increased blood urea nitrogen ... 40 | 44
abnormal seminal vesicle morph... 39 | 47
decreased heart weight 39 | 44
increased body weight 39 | 42
decreased circulating total pr... 38 | 41
decreased eosinophil cell numb... 38 | 41
increased rib number 38 | 41
increased circulating chloride... 37 | 43
abnormal eye morphology 36 | 38
decreased neutrophil cell numb... 36 | 37
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
decreased circulating free fat... 35 | 39
small testis 35 | 37
increased startle reflex 34 | 38
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
tremors 33 | 34
abnormal cranium morphology 32 | 32
cardiovascular system phenotyp... 32 | 35
increased heart weight 32 | 37
increased hematocrit 32 | 36
increased circulating calcium ... 31 | 32
abnormal spleen morphology 30 | 36
decreased circulating chloride... 30 | 32
decreased circulating fructosa... 30 | 31
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
limb grasping 29 | 35
abnormal testis morphology 28 | 30
decreased B cell number 28 | 30
decreased circulating creatini... 28 | 31
increased circulating potassiu... 28 | 31
decreased NK T cell number 27 | 28

Disease

ovarian cancer 7,909 | 8,491
osteosarcoma 7,343 | 7,933
psoriasis 5,637 | 6,685
medulloblastoma, large-cell 5,636 | 6,234
glioblastoma 5,121 | 5,572
lung cancer 4,222 | 4,473
atypical teratoid / rhabdoid tumor 3,978 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,068 | 3,289
malignant mesothelioma 2,991 | 3,163
Breast cancer 2,860 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,773 | 2,988
invasive ductal carcinoma 2,749 | 2,950
pilocytic astrocytoma 2,744 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 2,737 | 2,956
primitive neuroectodermal tumor 2,733 | 3,031
non-small cell lung cancer 2,589 | 2,798
oligodendroglioma 2,558 | 2,849
lung carcinoma 2,526 | 2,844
pediatric high grade glioma 2,467 | 2,712
lung adenocarcinoma 2,445 | 2,714
ependymoma 2,306 | 2,514
pancreatic cancer 2,144 | 2,300
Cancer 2,137 | 2,346
subependymal giant cell astrocytoma 2,104 | 2,287
interstitial cystitis 2,084 | 2,299
group 3 medulloblastoma 2,060 | 2,254
astrocytic glioma 2,022 | 2,241
ulcerative colitis 1,951 | 2,087
adult high grade glioma 1,910 | 2,148
Carcinoma 1,810 | 2,147
Pick disease 1,763 | 1,893
pituitary cancer 1,748 | 1,972
group 4 medulloblastoma 1,733 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,727 | 1,795
ductal carcinoma in situ 1,610 | 1,745
cystic fibrosis 1,522 | 1,670
tuberculosis 1,482 | 1,563
breast carcinoma 1,478 | 1,614
astrocytoma 1,407 | 1,493
medulloblastoma 1,365 | 1,524
diabetes mellitus 1,364 | 1,663
colon cancer 1,345 | 1,475
sonic hedgehog group medulloblastoma 1,344 | 1,482
posterior fossa group B ependymoma 1,338 | 1,530
adrenocortical carcinoma 1,336 | 1,427
posterior fossa group A ependymoma 1,329 | 1,511
Multiple myeloma 1,297 | 1,327
primary pancreatic ductal adenocarcinoma 1,206 | 1,271
juvenile dermatomyositis 1,154 | 1,189
acute quadriplegic myopathy 1,114 | 1,157
Rheumatoid Arthritis 1,098 | 1,170
spina bifida 1,006 | 1,064
atypical teratoid/rhabdoid tumor 983 | 1,095
cutaneous lupus erythematosus 970 | 1,056
dermatomyositis 946 | 966
nasopharyngeal carcinoma 946 | 1,056
active Crohn's disease 841 | 918
Atopic dermatitis 808 | 944
gastric carcinoma 770 | 832
primary Sjogren syndrome 755 | 788
non primary Sjogren syndrome sicca 752 | 840
Waldenstrons macroglobulinemia 751 | 764
acute myeloid leukemia 748 | 785
esophageal adenocarcinoma 692 | 737
tuberculosis and treatment for 6 months 669 | 686
progressive supranuclear palsy 634 | 674
aldosterone-producing adenoma 622 | 664
Alzheimer's disease 570 | 644
Duchenne muscular dystrophy 567 | 602
Obesity 542 | 616
pancreatic carcinoma 541 | 567
hepatocellular carcinoma 531 | 550
Intellectual disability 527 | 573
Down syndrome 509 | 548
fibroadenoma 502 | 557
Endometriosis 480 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 480 | 499
mucosa-associated lymphoid tissue lymphoma 445 | 480
Prostatic Neoplasms 443 | 471
chronic rhinosinusitis 441 | 512
IGA Glomerulonephritis 438 | 454
active ulcerative colitis 429 | 477
Multiple Sclerosis 421 | 498
gastric cancer 418 | 436
Schizophrenia 412 | 503
Amyotrophic Lateral Sclerosis 408 | 432
Mammary Neoplasms 384 | 410
inflammatory breast cancer 360 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 354 | 413
Kidney disease 350 | 397
sarcoidosis 342 | 368
tuberculosis and treatment for 3 months 313 | 327
Parkinson's disease 311 | 364
Polycystic Ovary Syndrome 307 | 334
glioblastoma multiforme 306 | 347
hereditary spastic paraplegia 304 | 313
Asthma 297 | 349
nephrosclerosis 297 | 329
urothelial carcinoma 288 | 318

Tissue

Nervous System 15,767 | 18,560
Female tissues 15,740 | 18,646
Digestive Tract 15,738 | 18,472
Endocrine System 15,734 | 18,511
Urinary Tract 15,682 | 18,443
Liver and Pancreas 15,651 | 18,135
Blood and immune system 15,642 | 17,994
Male tissues 15,625 | 17,968
Cardiovascular System 15,602 | 17,957
Skin and soft tissues 15,564 | 18,114
Respiratory system 15,445 | 17,483

Target Family

Non-IDG 9,274 | 11,969
Enzyme 3,677 | 4,146
Transcription Factor 1,207 | 1,400
Kinase 581 | 634
Transporter 398 | 473
GPCR 274 | 408
Ion Channel 244 | 341
Epigenetic 219 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 36 | 38
oGPCR 32 | 421

HCA RNA Cell Line

U-937 15,987 | 15,987
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66