Development Level

Tbio 9,435 | 10,625
Tdark 4,510 | 7,003
Tchem 1,661 | 1,890
Tclin 499 | 602

Collection

Kinase: IDG Consortium (Targets) 113 | 125
Ion Channel: IDG Consortium (Targets) 82 | 102
GPCR: IDG Consortium (Targets) 69 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 26

IMPC Phenotype

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 243 | 260
abnormal behavior 220 | 226
embryonic lethality prior to t... 186 | 187
decreased lean body mass 185 | 195
decreased total body fat amoun... 179 | 186
decreased body weight 167 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 147 | 157
abnormal bone structure 123 | 131
increased or absent threshold ... 120 | 128
decreased bone mineral density 117 | 126
increased circulating alkaline... 116 | 119
decreased grip strength 111 | 123
decreased circulating glucose ... 110 | 121
abnormal embryo size 106 | 112
decreased body length 104 | 108
hyperactivity 103 | 108
increased lean body mass 99 | 107
abnormal retina morphology 97 | 100
enlarged heart 93 | 111
increased mean corpuscular hem... 90 | 93
increased mean corpuscular vol... 87 | 91
increased bone mineral content 86 | 92
hypoactivity 82 | 89
decreased circulating choleste... 81 | 85
short tibia 79 | 82
decreased circulating triglyce... 75 | 83
decreased circulating HDL chol... 74 | 77
abnormal lens morphology 71 | 73
decreased circulating serum al... 71 | 79
increased grip strength 71 | 83
decreased circulating insulin ... 67 | 75
increased fasted circulating g... 66 | 68
increased circulating sodium l... 64 | 71
prenatal lethality prior to he... 63 | 64
decreased lumbar vertebrae num... 59 | 62
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 58 | 61
abnormal sleep behavior 58 | 63
decreased rib number 54 | 59
male infertility 54 | 62
abnormal bone mineralization 53 | 55
increased circulating HDL chol... 53 | 63
decreased circulating alanine ... 50 | 53
decreased hemoglobin content 50 | 53
increased total body fat amoun... 50 | 57
abnormal coat-hair pigmentatio... 49 | 54
decreased prepulse inhibition 49 | 52
increased bone mineral density 49 | 52
increased circulating choleste... 49 | 53
increased exploration in new e... 49 | 56
abnormal gait 48 | 51
decreased leukocyte cell numbe... 48 | 54
decreased mean corpuscular vol... 48 | 50
impaired glucose tolerance 48 | 52
decreased startle reflex 45 | 48
improved glucose tolerance 45 | 56
decreased fasted circulating g... 44 | 49
abnormal behavioral response t... 43 | 52
thrombocytopenia 43 | 46
decreased caudal vertebrae num... 42 | 49
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased hemoglobin content 42 | 45
abnormal heart morphology 41 | 51
decreased circulating total pr... 40 | 41
increased body weight 40 | 42
increased circulating chloride... 40 | 43
decreased circulating alkaline... 38 | 41
decreased eosinophil cell numb... 38 | 41
increased rib number 38 | 41
decreased neutrophil cell numb... 37 | 37
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased circulating free fat... 36 | 39
decreased heart weight 36 | 44
abnormal eye morphology 35 | 38
abnormal seminal vesicle morph... 35 | 47
increased leukocyte cell numbe... 35 | 37
small testis 34 | 37
decreased mean corpuscular hem... 33 | 34
increased heart weight 33 | 37
tremors 33 | 34
abnormal spleen morphology 32 | 36
increased hematocrit 32 | 36
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
cardiovascular system phenotyp... 31 | 35
decreased T cell number 31 | 31
decreased circulating calcium ... 30 | 33
decreased circulating chloride... 29 | 32
decreased circulating fructosa... 29 | 31
female infertility 29 | 34
increased circulating calcium ... 29 | 32
increased circulating potassiu... 29 | 31
decreased blood urea nitrogen ... 28 | 31
decreased circulating creatini... 28 | 31
decreased threshold for audito... 28 | 32

Disease

ovarian cancer 7,995 | 8,491
osteosarcoma 7,312 | 7,933
medulloblastoma, large-cell 5,847 | 6,234
psoriasis 5,709 | 6,685
glioblastoma 5,305 | 5,572
lung cancer 4,220 | 4,473
atypical teratoid / rhabdoid tumor 4,144 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,061 | 3,289
malignant mesothelioma 3,037 | 3,163
Breast cancer 2,913 | 3,098
pilocytic astrocytoma 2,904 | 3,086
primitive neuroectodermal tumor 2,892 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,770 | 2,988
invasive ductal carcinoma 2,749 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,744 | 2,956
oligodendroglioma 2,721 | 2,849
pediatric high grade glioma 2,594 | 2,712
non-small cell lung cancer 2,588 | 2,798
lung carcinoma 2,557 | 2,844
lung adenocarcinoma 2,436 | 2,714
ependymoma 2,412 | 2,514
subependymal giant cell astrocytoma 2,193 | 2,287
astrocytic glioma 2,137 | 2,241
pancreatic cancer 2,131 | 2,300
group 3 medulloblastoma 2,119 | 2,254
Cancer 2,084 | 2,346
interstitial cystitis 2,046 | 2,299
adult high grade glioma 1,960 | 2,148
Carcinoma 1,929 | 2,147
ulcerative colitis 1,917 | 2,087
Pick disease 1,835 | 1,893
pituitary cancer 1,826 | 1,972
group 4 medulloblastoma 1,793 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,686 | 1,795
ductal carcinoma in situ 1,616 | 1,745
cystic fibrosis 1,550 | 1,670
breast carcinoma 1,485 | 1,614
astrocytoma 1,461 | 1,493
tuberculosis 1,453 | 1,563
medulloblastoma 1,439 | 1,524
posterior fossa group A ependymoma 1,416 | 1,511
sonic hedgehog group medulloblastoma 1,408 | 1,482
posterior fossa group B ependymoma 1,403 | 1,530
colon cancer 1,349 | 1,475
adrenocortical carcinoma 1,344 | 1,427
diabetes mellitus 1,320 | 1,663
Multiple myeloma 1,296 | 1,327
primary pancreatic ductal adenocarcinoma 1,221 | 1,271
juvenile dermatomyositis 1,149 | 1,189
acute quadriplegic myopathy 1,117 | 1,157
Rheumatoid Arthritis 1,088 | 1,170
atypical teratoid/rhabdoid tumor 1,045 | 1,095
spina bifida 1,012 | 1,064
nasopharyngeal carcinoma 950 | 1,056
dermatomyositis 947 | 966
cutaneous lupus erythematosus 920 | 1,056
active Crohn's disease 842 | 918
Atopic dermatitis 812 | 944
gastric carcinoma 792 | 832
non primary Sjogren syndrome sicca 757 | 840
acute myeloid leukemia 747 | 785
Waldenstrons macroglobulinemia 742 | 764
primary Sjogren syndrome 725 | 788
esophageal adenocarcinoma 673 | 737
tuberculosis and treatment for 6 months 667 | 686
progressive supranuclear palsy 652 | 674
aldosterone-producing adenoma 624 | 664
Alzheimer's disease 587 | 644
Duchenne muscular dystrophy 570 | 602
Intellectual disability 542 | 573
Obesity 537 | 616
pancreatic carcinoma 535 | 567
Down syndrome 527 | 548
hepatocellular carcinoma 521 | 550
fibroadenoma 508 | 557
Endometriosis 486 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 482 | 499
chronic rhinosinusitis 457 | 512
IGA Glomerulonephritis 435 | 454
Schizophrenia 434 | 503
Prostatic Neoplasms 432 | 471
Multiple Sclerosis 427 | 498
active ulcerative colitis 426 | 477
gastric cancer 414 | 436
mucosa-associated lymphoid tissue lymphoma 409 | 480
Amyotrophic Lateral Sclerosis 408 | 432
Mammary Neoplasms 382 | 410
inflammatory breast cancer 365 | 404
Neurodegenerative disease 363 | 383
non-small cell lung carcinoma 359 | 413
glioblastoma multiforme 334 | 347
Parkinson's disease 328 | 364
sarcoidosis 328 | 368
Kidney disease 322 | 397
Epilepsy 315 | 346
tuberculosis and treatment for 3 months 307 | 327
hereditary spastic paraplegia 304 | 313
Polycystic Ovary Syndrome 300 | 334
urothelial carcinoma 293 | 318
nephrosclerosis 288 | 329

Tissue

Nervous System 15,881 | 18,560
Female tissues 15,866 | 18,646
Digestive Tract 15,856 | 18,472
Endocrine System 15,842 | 18,511
Urinary Tract 15,802 | 18,443
Liver and Pancreas 15,755 | 18,135
Male tissues 15,738 | 17,968
Cardiovascular System 15,731 | 17,957
Blood and immune system 15,717 | 17,994
Skin and soft tissues 15,689 | 18,114
Respiratory system 15,547 | 17,483

Target Family

Non-IDG 9,373 | 11,969
Enzyme 3,662 | 4,146
Transcription Factor 1,217 | 1,400
Kinase 584 | 634
Transporter 387 | 473
GPCR 280 | 408
Ion Channel 276 | 341
Epigenetic 224 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 25 | 421

HCA RNA Cell Line

U-87 MG 16,105 | 16,105
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66