Development Level

Tbio 10,399 | 11,651
Tdark 4,134 | 6,593
Tchem 1,244 | 1,388
Tclin 508 | 612

Collection

Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 69 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 951 | 979
preweaning lethality, incomple... 468 | 499
abnormal behavior 281 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 214 | 220
decreased total body fat amoun... 196 | 207
enlarged heart 181 | 210
abnormal bone structure 172 | 187
decreased vertical activity 170 | 208
increased lean body mass 164 | 172
decreased body weight 153 | 161
abnormal heart morphology 141 | 162
hyperactivity 137 | 148
decreased bone mineral content 134 | 151
decreased lean body mass 127 | 135
increased total body fat amoun... 124 | 134
hypoactivity 121 | 132
decreased circulating glucose ... 117 | 126
increased circulating alkaline... 114 | 122
decreased bone mineral density 113 | 126
increased startle reflex 110 | 112
decreased grip strength 105 | 116
male infertility 105 | 123
embryonic growth retardation 103 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 94 | 114
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
short tibia 93 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
cataract 87 | 92
increased mean corpuscular vol... 87 | 92
prenatal lethality prior to he... 85 | 87
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 73 | 82
decreased circulating triglyce... 72 | 79
increased fasted circulating g... 72 | 76
decreased mean corpuscular vol... 71 | 79
decreased circulating insulin ... 69 | 76
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
impaired glucose tolerance 68 | 75
improved glucose tolerance 68 | 79
increased circulating HDL chol... 68 | 80
abnormal retina morphology 67 | 71
decreased circulating HDL chol... 67 | 68
decreased leukocyte cell numbe... 67 | 73
abnormal sleep behavior 65 | 70
abnormal gait 64 | 69
increased circulating sodium l... 64 | 71
small superior vagus ganglion 64 | 74
abnormal eye morphology 63 | 68
decreased hemoglobin content 61 | 68
increased circulating choleste... 60 | 66
decreased erythrocyte cell num... 59 | 62
increased heart weight 59 | 62
abnormal coat-hair pigmentatio... 58 | 64
decreased fasted circulating g... 58 | 65
abnormal behavioral response t... 57 | 66
edema 57 | 59
increased monocyte cell number 55 | 63
small testis 54 | 58
abnormal kidney morphology 53 | 65
decreased caudal vertebrae num... 51 | 53
female infertility 51 | 60
thrombocytopenia 51 | 56
abnormal spleen morphology 49 | 55
decreased mean corpuscular hem... 48 | 50
decreased circulating total pr... 47 | 49
abnormal neural tube closure 46 | 46
decreased blood urea nitrogen ... 46 | 51
decreased circulating alanine ... 46 | 47
hydrometra 45 | 53
increased leukocyte cell numbe... 45 | 47
abnormal skin morphology 44 | 50
decreased circulating alkaline... 44 | 46
increased blood urea nitrogen ... 44 | 48
decreased hematocrit 43 | 46
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
increased circulating triglyce... 41 | 42
increased neutrophil cell numb... 41 | 46
increased mean platelet volume 40 | 45
abnormal testis morphology 39 | 43
decreased red blood cell distr... 39 | 41
enlarged spleen 39 | 41
increased circulating chloride... 38 | 41
tremors 38 | 39
decreased circulating LDL chol... 37 | 38
limb grasping 37 | 41
abnormal bone mineralization 36 | 38
increased erythrocyte cell num... 36 | 39
abnormal epididymis morphology 35 | 42
decreased neutrophil cell numb... 35 | 42
increased grip strength 35 | 41
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 9,974 | 11,493
ovarian cancer 8,109 | 8,520
osteosarcoma 7,398 | 7,950
medulloblastoma, large-cell 5,905 | 6,241
psoriasis 5,759 | 6,694
glioblastoma 5,563 | 5,792
atypical teratoid / rhabdoid tumor 4,903 | 5,112
ependymoma 4,472 | 4,679
lung cancer 4,446 | 4,740
group 3 medulloblastoma 3,920 | 4,104
adult high grade glioma 3,577 | 3,801
Breast cancer 3,372 | 3,578
malignant mesothelioma 3,122 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,090 | 3,291
Astrocytoma, Pilocytic 2,935 | 3,081
primitive neuroectodermal tumor 2,927 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,794 | 2,989
invasive ductal carcinoma 2,779 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,761 | 2,955
oligodendroglioma 2,747 | 2,850
non-small cell lung cancer 2,691 | 2,890
lung carcinoma 2,572 | 2,843
astrocytic glioma 2,506 | 2,597
lung adenocarcinoma 2,458 | 2,716
Kidney cancer 2,380 | 2,613
pancreatic cancer 2,240 | 2,398
Cancer 2,234 | 2,499
subependymal giant cell astrocytoma 2,212 | 2,287
interstitial cystitis 2,066 | 2,312
tuberculosis 1,888 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,868 | 1,962
Pick disease 1,850 | 1,894
pituitary cancer 1,840 | 1,972
group 4 medulloblastoma 1,788 | 1,855
ulcerative colitis 1,670 | 1,819
ductal carcinoma in situ 1,632 | 1,745
cystic fibrosis 1,586 | 1,696
breast carcinoma 1,521 | 1,638
diabetes mellitus 1,385 | 1,728
adrenocortical carcinoma 1,363 | 1,428
colon cancer 1,363 | 1,478
Multiple myeloma 1,310 | 1,332
Autosomal recessive predisposition 1,286 | 1,442
juvenile dermatomyositis 1,157 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
astrocytoma 1,126 | 1,146
Rheumatoid arthritis 1,119 | 1,191
primary pancreatic ductal adenocarcinoma 1,070 | 1,109
spina bifida 1,031 | 1,074
pediatric high grade glioma 1,024 | 1,064
Schizophrenia 1,012 | 1,160
Intellectual disability 968 | 1,016
nasopharyngeal carcinoma 957 | 1,058
dermatomyositis 952 | 966
cutaneous lupus erythematosus 929 | 1,057
active Crohn's disease 852 | 922
Atopic dermatitis 826 | 952
non primary Sjogren syndrome sicca 810 | 891
gastric carcinoma 774 | 807
acute myeloid leukemia 758 | 783
Waldenstrons macroglobulinemia 749 | 765
Epilepsy 742 | 792
Liver Cirrhosis, Experimental 712 | 769
active ulcerative colitis 699 | 764
medulloblastoma 692 | 720
primary Sjogren syndrome 685 | 735
esophageal adenocarcinoma 676 | 737
progressive supranuclear palsy 658 | 676
aldosterone-producing adenoma 629 | 665
Dull intelligence 616 | 645
Low intelligence 616 | 645
Mental Retardation 616 | 645
Mental deficiency 616 | 645
Poor school performance 616 | 645
Alzheimer's disease 601 | 658
Melanoma 596 | 711
Obesity 594 | 678
Bipolar Disorder 588 | 666
Cognitive delay 582 | 608
Global developmental delay 582 | 608
Mental and motor retardation 582 | 608
Duchenne muscular dystrophy 576 | 601
Seizures 559 | 596
Liver cancer 551 | 604
Muscle hypotonia 550 | 571
pancreatic carcinoma 534 | 562
hepatocellular carcinoma 520 | 547
fibroadenoma 512 | 559
Endometriosis 497 | 540
Short stature 497 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Down syndrome 481 | 499
Multiple Sclerosis 466 | 540
chronic rhinosinusitis 460 | 512
Prostatic Neoplasms 457 | 495
posterior fossa group A ependymoma 445 | 468
gastric cancer 440 | 459
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 429 | 451
Breast Neoplasms 417 | 445

Tissue

Endocrine System 15,998 | 18,159
Female tissues 15,773 | 17,400
Digestive Tract 15,740 | 17,369
Skin and soft tissues 15,700 | 17,230
Male tissues 15,621 | 17,142
Nervous System 15,525 | 16,725
Blood and immune system 15,515 | 16,909
Liver and Pancreas 15,432 | 16,750
Urinary Tract 15,405 | 16,678
Respiratory system 15,250 | 16,393
Cardiovascular System 14,420 | 15,192

Target Family

Non-IDG 9,507 | 12,091
Enzyme 3,688 | 4,145
Transcription Factor 1,220 | 1,400
Kinase 591 | 634
Transporter 387 | 473
GPCR 280 | 408
Ion Channel 279 | 344
Epigenetic 230 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 36 | 38
oGPCR 25 | 421

HCA RNA Cell Line

U-87 MG 16,285 | 16,285
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50