Development Level

Tbio 9,478 | 10,625
Tdark 4,431 | 7,003
Tchem 1,693 | 1,890
Tclin 490 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 82 | 102
GPCR: IDG Consortium (Targets) 74 | 127
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 18 | 26

IMPC Phenotype

preweaning lethality, complete... 612 | 633
preweaning lethality, incomple... 240 | 260
abnormal behavior 211 | 226
decreased lean body mass 184 | 195
embryonic lethality prior to t... 184 | 187
decreased total body fat amoun... 173 | 186
decreased body weight 166 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 123 | 131
increased or absent threshold ... 120 | 128
decreased bone mineral density 117 | 126
increased circulating alkaline... 114 | 119
decreased grip strength 110 | 123
decreased circulating glucose ... 108 | 121
abnormal embryo size 107 | 112
decreased body length 103 | 108
hyperactivity 101 | 108
enlarged heart 100 | 111
abnormal retina morphology 96 | 100
increased lean body mass 94 | 107
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 88 | 91
increased bone mineral content 85 | 92
decreased circulating choleste... 82 | 85
hypoactivity 79 | 89
increased grip strength 78 | 83
short tibia 76 | 82
decreased circulating HDL chol... 74 | 77
decreased circulating serum al... 73 | 79
decreased circulating triglyce... 73 | 83
abnormal lens morphology 69 | 73
prenatal lethality prior to he... 64 | 64
decreased circulating insulin ... 63 | 75
increased circulating sodium l... 62 | 71
increased fasted circulating g... 62 | 68
abnormal retinal pigmentation 58 | 61
decreased lumbar vertebrae num... 58 | 62
decreased rib number 58 | 59
increased sacral vertebrae num... 57 | 62
abnormal sleep behavior 56 | 63
increased circulating HDL chol... 55 | 63
abnormal bone mineralization 54 | 55
male infertility 53 | 62
abnormal coat-hair pigmentatio... 52 | 54
decreased prepulse inhibition 52 | 52
increased total body fat amoun... 52 | 57
decreased leukocyte cell numbe... 50 | 54
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
increased circulating choleste... 49 | 53
increased exploration in new e... 49 | 56
decreased circulating alanine ... 48 | 53
decreased hemoglobin content 48 | 53
decreased mean corpuscular vol... 48 | 50
improved glucose tolerance 47 | 56
abnormal behavioral response t... 46 | 52
decreased fasted circulating g... 46 | 49
abnormal gait 45 | 51
decreased startle reflex 45 | 48
thrombocytopenia 44 | 46
abnormal heart morphology 43 | 51
decreased caudal vertebrae num... 43 | 49
decreased erythrocyte cell num... 43 | 43
increased blood urea nitrogen ... 42 | 44
increased hemoglobin content 42 | 45
decreased circulating alkaline... 41 | 41
decreased circulating total pr... 41 | 41
abnormal seminal vesicle morph... 40 | 47
increased body weight 40 | 42
decreased heart weight 39 | 44
increased rib number 38 | 41
abnormal eye morphology 37 | 38
increased circulating chloride... 37 | 43
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased eosinophil cell numb... 36 | 41
decreased neutrophil cell numb... 35 | 37
increased leukocyte cell numbe... 35 | 37
increased startle reflex 34 | 38
tremors 34 | 34
decreased circulating free fat... 33 | 39
decreased mean corpuscular hem... 33 | 34
increased heart weight 33 | 37
abnormal cranium morphology 32 | 32
increased hematocrit 32 | 36
small testis 32 | 37
cardiovascular system phenotyp... 31 | 35
decreased circulating chloride... 31 | 32
increased circulating calcium ... 31 | 32
abnormal spleen morphology 30 | 36
decreased T cell number 30 | 31
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 29 | 31
female infertility 29 | 34
limb grasping 29 | 35
decreased circulating creatini... 28 | 31
decreased threshold for audito... 28 | 32
increased circulating potassiu... 28 | 31

Disease

ovarian cancer 7,962 | 8,491
osteosarcoma 7,341 | 7,933
psoriasis 5,687 | 6,685
medulloblastoma, large-cell 5,642 | 6,234
glioblastoma 5,128 | 5,572
lung cancer 4,196 | 4,473
atypical teratoid / rhabdoid tumor 3,993 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,087 | 3,289
malignant mesothelioma 3,006 | 3,163
Breast cancer 2,879 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,793 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,776 | 2,956
pilocytic astrocytoma 2,751 | 3,086
invasive ductal carcinoma 2,748 | 2,950
primitive neuroectodermal tumor 2,736 | 3,031
non-small cell lung cancer 2,611 | 2,798
oligodendroglioma 2,569 | 2,849
lung carcinoma 2,525 | 2,844
pediatric high grade glioma 2,472 | 2,712
lung adenocarcinoma 2,466 | 2,714
ependymoma 2,309 | 2,514
pancreatic cancer 2,166 | 2,300
Cancer 2,144 | 2,346
subependymal giant cell astrocytoma 2,106 | 2,287
interstitial cystitis 2,088 | 2,299
group 3 medulloblastoma 2,075 | 2,254
astrocytic glioma 2,014 | 2,241
ulcerative colitis 1,943 | 2,087
adult high grade glioma 1,905 | 2,148
Carcinoma 1,791 | 2,147
pituitary cancer 1,764 | 1,972
Pick disease 1,741 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,727 | 1,795
group 4 medulloblastoma 1,725 | 1,875
ductal carcinoma in situ 1,617 | 1,745
cystic fibrosis 1,524 | 1,670
breast carcinoma 1,490 | 1,614
tuberculosis 1,465 | 1,563
astrocytoma 1,412 | 1,493
diabetes mellitus 1,377 | 1,663
medulloblastoma 1,377 | 1,524
colon cancer 1,356 | 1,475
sonic hedgehog group medulloblastoma 1,348 | 1,482
posterior fossa group A ependymoma 1,345 | 1,511
adrenocortical carcinoma 1,344 | 1,427
posterior fossa group B ependymoma 1,339 | 1,530
Multiple myeloma 1,299 | 1,327
primary pancreatic ductal adenocarcinoma 1,223 | 1,271
juvenile dermatomyositis 1,149 | 1,189
acute quadriplegic myopathy 1,114 | 1,157
Rheumatoid Arthritis 1,100 | 1,170
spina bifida 1,011 | 1,064
atypical teratoid/rhabdoid tumor 1,010 | 1,095
nasopharyngeal carcinoma 959 | 1,056
cutaneous lupus erythematosus 958 | 1,056
dermatomyositis 943 | 966
active Crohn's disease 849 | 918
Atopic dermatitis 808 | 944
gastric carcinoma 779 | 832
non primary Sjogren syndrome sicca 764 | 840
acute myeloid leukemia 757 | 785
Waldenstrons macroglobulinemia 750 | 764
primary Sjogren syndrome 734 | 788
esophageal adenocarcinoma 695 | 737
tuberculosis and treatment for 6 months 662 | 686
aldosterone-producing adenoma 631 | 664
progressive supranuclear palsy 630 | 674
Duchenne muscular dystrophy 566 | 602
Alzheimer's disease 561 | 644
pancreatic carcinoma 546 | 567
Obesity 543 | 616
Intellectual disability 537 | 573
hepatocellular carcinoma 533 | 550
Down syndrome 510 | 548
fibroadenoma 509 | 557
Endometriosis 482 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 480 | 499
chronic rhinosinusitis 453 | 512
active ulcerative colitis 437 | 477
Prostatic Neoplasms 436 | 471
IGA Glomerulonephritis 435 | 454
mucosa-associated lymphoid tissue lymphoma 434 | 480
Multiple Sclerosis 427 | 498
gastric cancer 417 | 436
Schizophrenia 407 | 503
Amyotrophic Lateral Sclerosis 401 | 432
Mammary Neoplasms 385 | 410
inflammatory breast cancer 366 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 352 | 413
Kidney disease 341 | 397
sarcoidosis 338 | 368
glioblastoma multiforme 314 | 347
Parkinson's disease 309 | 364
Polycystic Ovary Syndrome 309 | 334
tuberculosis and treatment for 3 months 309 | 327
hereditary spastic paraplegia 303 | 313
nephrosclerosis 301 | 329
urothelial carcinoma 294 | 318
Asthma 291 | 349

Tissue

Nervous System 15,854 | 18,560
Female tissues 15,826 | 18,646
Endocrine System 15,819 | 18,511
Digestive Tract 15,814 | 18,472
Urinary Tract 15,760 | 18,443
Liver and Pancreas 15,738 | 18,135
Male tissues 15,709 | 17,968
Blood and immune system 15,704 | 17,994
Cardiovascular System 15,673 | 17,957
Skin and soft tissues 15,638 | 18,114
Respiratory system 15,487 | 17,483

Target Family

Non-IDG 9,389 | 11,969
Enzyme 3,675 | 4,146
Transcription Factor 1,213 | 1,400
Kinase 583 | 634
Transporter 400 | 473
GPCR 267 | 408
Ion Channel 243 | 341
Epigenetic 224 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 34 | 38
oGPCR 22 | 421

HCA RNA Cell Line

U-698 16,092 | 16,092
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66