Development Level

Tbio 10,448 | 11,651
Tdark 4,069 | 6,593
Tchem 1,263 | 1,388
Tclin 499 | 612

Collection

RFA-RM-18-021 259 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 80 | 99
GPCR: IDG Consortium (Targets) 74 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 468 | 499
abnormal behavior 277 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 189 | 207
enlarged heart 189 | 210
decreased vertical activity 173 | 208
abnormal bone structure 171 | 187
increased lean body mass 158 | 172
decreased body weight 155 | 161
abnormal heart morphology 146 | 162
hyperactivity 137 | 148
decreased bone mineral content 136 | 151
decreased lean body mass 126 | 135
increased total body fat amoun... 121 | 134
hypoactivity 119 | 132
decreased bone mineral density 115 | 126
decreased circulating glucose ... 115 | 126
increased circulating alkaline... 115 | 122
male infertility 107 | 123
increased startle reflex 105 | 112
decreased grip strength 104 | 116
embryonic growth retardation 101 | 106
abnormal seminal vesicle morph... 100 | 114
increased bone mineral content 98 | 108
increased or absent threshold ... 97 | 101
decreased body length 93 | 101
decreased circulating choleste... 91 | 93
increased mean corpuscular hem... 91 | 96
short tibia 90 | 97
cataract 89 | 92
increased mean corpuscular vol... 88 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 79 | 83
decreased prepulse inhibition 79 | 82
abnormal lens morphology 77 | 81
decreased circulating serum al... 76 | 82
decreased mean corpuscular vol... 74 | 79
increased circulating HDL chol... 73 | 80
decreased circulating triglyce... 72 | 79
decreased startle reflex 70 | 75
decreased leukocyte cell numbe... 69 | 73
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
increased fasted circulating g... 69 | 76
small superior vagus ganglion 69 | 74
decreased circulating HDL chol... 68 | 68
increased bone mineral density 68 | 72
abnormal retina morphology 66 | 71
abnormal eye morphology 65 | 68
decreased circulating insulin ... 65 | 76
abnormal sleep behavior 63 | 70
abnormal coat-hair pigmentatio... 61 | 64
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
increased circulating sodium l... 61 | 71
abnormal gait 60 | 69
increased heart weight 60 | 62
decreased erythrocyte cell num... 59 | 62
decreased fasted circulating g... 59 | 65
abnormal kidney morphology 58 | 65
abnormal behavioral response t... 57 | 66
edema 57 | 59
increased monocyte cell number 57 | 63
thrombocytopenia 54 | 56
small testis 53 | 58
female infertility 52 | 60
decreased caudal vertebrae num... 51 | 53
decreased blood urea nitrogen ... 49 | 51
hydrometra 49 | 53
abnormal spleen morphology 48 | 55
decreased mean corpuscular hem... 48 | 50
decreased circulating total pr... 47 | 49
increased blood urea nitrogen ... 47 | 48
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased circulating alanine ... 45 | 47
increased leukocyte cell numbe... 45 | 47
abnormal skin morphology 44 | 50
decreased hematocrit 44 | 46
increased neutrophil cell numb... 44 | 46
increased hematocrit 42 | 46
increased hemoglobin content 41 | 45
decreased red blood cell distr... 40 | 41
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
tremors 39 | 39
increased grip strength 38 | 41
increased mean platelet volume 38 | 45
abnormal bone mineralization 37 | 38
decreased circulating LDL chol... 37 | 38
enlarged spleen 37 | 41
increased circulating triglyce... 37 | 42
increased erythrocyte cell num... 37 | 39
abnormal epididymis morphology 36 | 42
increased circulating chloride... 36 | 41
increased mean corpuscular hem... 36 | 36
decreased circulating creatini... 35 | 39

Disease

Carcinoma 9,836 | 11,493
ovarian cancer 8,073 | 8,520
osteosarcoma 7,428 | 7,950
psoriasis 5,742 | 6,694
medulloblastoma, large-cell 5,701 | 6,241
glioblastoma 5,375 | 5,792
atypical teratoid / rhabdoid tumor 4,721 | 5,112
lung cancer 4,405 | 4,740
ependymoma 4,251 | 4,679
group 3 medulloblastoma 3,775 | 4,104
adult high grade glioma 3,429 | 3,801
Breast cancer 3,313 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,117 | 3,291
malignant mesothelioma 3,097 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,816 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,792 | 2,955
Astrocytoma, Pilocytic 2,777 | 3,081
invasive ductal carcinoma 2,777 | 2,951
primitive neuroectodermal tumor 2,771 | 3,035
non-small cell lung cancer 2,710 | 2,890
oligodendroglioma 2,595 | 2,850
lung carcinoma 2,540 | 2,843
lung adenocarcinoma 2,488 | 2,716
astrocytic glioma 2,354 | 2,597
Cancer 2,292 | 2,499
pancreatic cancer 2,259 | 2,398
Kidney cancer 2,248 | 2,613
subependymal giant cell astrocytoma 2,126 | 2,287
interstitial cystitis 2,105 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,909 | 1,962
tuberculosis 1,903 | 2,010
pituitary cancer 1,777 | 1,972
Pick disease 1,756 | 1,894
group 4 medulloblastoma 1,731 | 1,855
ulcerative colitis 1,696 | 1,819
ductal carcinoma in situ 1,633 | 1,745
cystic fibrosis 1,561 | 1,696
breast carcinoma 1,526 | 1,638
diabetes mellitus 1,447 | 1,728
colon cancer 1,369 | 1,478
adrenocortical carcinoma 1,361 | 1,428
Multiple myeloma 1,315 | 1,332
Autosomal recessive predisposition 1,311 | 1,442
juvenile dermatomyositis 1,157 | 1,187
Rheumatoid arthritis 1,129 | 1,191
acute quadriplegic myopathy 1,123 | 1,158
astrocytoma 1,106 | 1,146
primary pancreatic ductal adenocarcinoma 1,072 | 1,109
spina bifida 1,032 | 1,074
pediatric high grade glioma 996 | 1,064
Schizophrenia 985 | 1,160
cutaneous lupus erythematosus 967 | 1,057
nasopharyngeal carcinoma 966 | 1,058
Intellectual disability 951 | 1,016
dermatomyositis 948 | 966
active Crohn's disease 859 | 922
Atopic dermatitis 823 | 952
non primary Sjogren syndrome sicca 820 | 891
acute myeloid leukemia 768 | 783
gastric carcinoma 760 | 807
Waldenstrons macroglobulinemia 757 | 765
Liver Cirrhosis, Experimental 729 | 769
Epilepsy 726 | 792
active ulcerative colitis 715 | 764
esophageal adenocarcinoma 698 | 737
primary Sjogren syndrome 691 | 735
medulloblastoma 665 | 720
progressive supranuclear palsy 637 | 676
aldosterone-producing adenoma 636 | 665
Dull intelligence 606 | 645
Low intelligence 606 | 645
Mental Retardation 606 | 645
Mental deficiency 606 | 645
Poor school performance 606 | 645
Obesity 596 | 678
Cognitive delay 589 | 608
Global developmental delay 589 | 608
Mental and motor retardation 589 | 608
Alzheimer's disease 580 | 658
Duchenne muscular dystrophy 572 | 601
Bipolar Disorder 565 | 666
Melanoma 558 | 711
Seizures 550 | 596
Muscle hypotonia 546 | 571
pancreatic carcinoma 546 | 562
hepatocellular carcinoma 533 | 547
fibroadenoma 513 | 559
Short stature 503 | 531
Endometriosis 493 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 510
Liver cancer 491 | 604
Down syndrome 469 | 499
Multiple Sclerosis 467 | 540
Prostatic Neoplasms 461 | 495
chronic rhinosinusitis 456 | 512
gastric cancer 444 | 459
mucosa-associated lymphoid tissue lymphoma 437 | 484
posterior fossa group A ependymoma 434 | 468
sonic hedgehog group medulloblastoma 433 | 467
Amyotrophic lateral sclerosis 420 | 451

Tissue

Endocrine System 15,976 | 18,159
Digestive Tract 15,747 | 17,369
Female tissues 15,705 | 17,400
Skin and soft tissues 15,676 | 17,230
Male tissues 15,588 | 17,142
Blood and immune system 15,554 | 16,909
Liver and Pancreas 15,454 | 16,750
Urinary Tract 15,399 | 16,678
Nervous System 15,393 | 16,725
Respiratory system 15,219 | 16,393
Cardiovascular System 14,359 | 15,192

Target Family

Non-IDG 9,524 | 12,091
Enzyme 3,705 | 4,145
Transcription Factor 1,216 | 1,400
Kinase 591 | 634
Transporter 400 | 473
GPCR 268 | 408
Ion Channel 246 | 344
Epigenetic 230 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 35 | 38
oGPCR 22 | 421

HCA RNA Cell Line

U-698 16,279 | 16,279
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50