Development Level

Tbio 9,474 | 10,625
Tdark 4,606 | 7,003
Tchem 1,679 | 1,890
Tclin 497 | 602

Collection

Kinase: IDG Consortium (Targets) 114 | 125
Ion Channel: IDG Consortium (Targets) 79 | 102
GPCR: IDG Consortium (Targets) 73 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 26

IMPC Phenotype

preweaning lethality, complete... 607 | 633
preweaning lethality, incomple... 245 | 260
abnormal behavior 212 | 226
decreased lean body mass 184 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 175 | 186
decreased body weight 164 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 144 | 157
abnormal bone structure 122 | 131
increased or absent threshold ... 121 | 128
decreased bone mineral density 117 | 126
increased circulating alkaline... 116 | 119
decreased grip strength 112 | 123
abnormal embryo size 106 | 112
decreased circulating glucose ... 106 | 121
decreased body length 102 | 108
enlarged heart 100 | 111
hyperactivity 98 | 108
increased lean body mass 96 | 107
abnormal retina morphology 94 | 100
increased mean corpuscular hem... 91 | 93
increased mean corpuscular vol... 87 | 91
increased bone mineral content 85 | 92
decreased circulating choleste... 81 | 85
hypoactivity 78 | 89
short tibia 77 | 82
increased grip strength 76 | 83
decreased circulating serum al... 75 | 79
decreased circulating HDL chol... 74 | 77
decreased circulating triglyce... 74 | 83
abnormal lens morphology 68 | 73
increased circulating sodium l... 64 | 71
increased fasted circulating g... 64 | 68
prenatal lethality prior to he... 63 | 64
decreased circulating insulin ... 61 | 75
abnormal retinal pigmentation 59 | 61
decreased lumbar vertebrae num... 59 | 62
increased circulating HDL chol... 59 | 63
increased sacral vertebrae num... 58 | 62
decreased rib number 57 | 59
abnormal sleep behavior 56 | 63
abnormal bone mineralization 54 | 55
abnormal coat-hair pigmentatio... 53 | 54
male infertility 53 | 62
increased circulating choleste... 52 | 53
increased total body fat amoun... 52 | 57
decreased prepulse inhibition 50 | 52
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
increased exploration in new e... 50 | 56
decreased hemoglobin content 49 | 53
decreased mean corpuscular vol... 48 | 50
abnormal behavioral response t... 47 | 52
decreased leukocyte cell numbe... 47 | 54
improved glucose tolerance 47 | 56
abnormal heart morphology 46 | 51
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
decreased circulating alanine ... 45 | 53
decreased startle reflex 44 | 48
decreased fasted circulating g... 43 | 49
thrombocytopenia 43 | 46
decreased erythrocyte cell num... 42 | 43
increased hemoglobin content 41 | 45
increased blood urea nitrogen ... 40 | 44
increased body weight 40 | 42
decreased circulating alkaline... 39 | 41
decreased circulating total pr... 39 | 41
decreased heart weight 38 | 44
increased rib number 38 | 41
abnormal seminal vesicle morph... 37 | 47
decreased eosinophil cell numb... 37 | 41
increased circulating chloride... 37 | 43
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
decreased circulating free fat... 36 | 39
decreased neutrophil cell numb... 36 | 37
decreased circulating LDL chol... 34 | 37
small testis 34 | 37
tremors 34 | 34
increased leukocyte cell numbe... 33 | 37
abnormal cranium morphology 31 | 32
decreased circulating fructosa... 31 | 31
decreased mean corpuscular hem... 31 | 34
increased heart weight 31 | 37
increased hematocrit 31 | 36
abnormal spleen morphology 30 | 36
decreased blood urea nitrogen ... 30 | 31
decreased circulating chloride... 30 | 32
female infertility 30 | 34
increased startle reflex 30 | 38
limb grasping 30 | 35
decreased T cell number 29 | 31
decreased circulating calcium ... 29 | 33
decreased threshold for audito... 29 | 32
cardiovascular system phenotyp... 28 | 35
increased circulating calcium ... 28 | 32
embryonic growth retardation 27 | 28
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,940 | 8,491
osteosarcoma 7,312 | 7,933
psoriasis 5,691 | 6,685
medulloblastoma, large-cell 5,658 | 6,234
glioblastoma 5,120 | 5,572
lung cancer 4,158 | 4,473
atypical teratoid / rhabdoid tumor 3,978 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,078 | 3,289
malignant mesothelioma 2,993 | 3,163
Breast cancer 2,867 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,770 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,745 | 2,956
pilocytic astrocytoma 2,735 | 3,086
invasive ductal carcinoma 2,729 | 2,950
primitive neuroectodermal tumor 2,727 | 3,031
non-small cell lung cancer 2,566 | 2,798
oligodendroglioma 2,565 | 2,849
lung carcinoma 2,495 | 2,844
pediatric high grade glioma 2,474 | 2,712
lung adenocarcinoma 2,414 | 2,714
ependymoma 2,314 | 2,514
pancreatic cancer 2,138 | 2,300
Cancer 2,126 | 2,346
subependymal giant cell astrocytoma 2,121 | 2,287
group 3 medulloblastoma 2,095 | 2,254
interstitial cystitis 2,052 | 2,299
astrocytic glioma 2,028 | 2,241
ulcerative colitis 1,896 | 2,087
adult high grade glioma 1,889 | 2,148
Carcinoma 1,806 | 2,147
Pick disease 1,757 | 1,893
pituitary cancer 1,746 | 1,972
group 4 medulloblastoma 1,726 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,694 | 1,795
ductal carcinoma in situ 1,610 | 1,745
cystic fibrosis 1,517 | 1,670
breast carcinoma 1,491 | 1,614
tuberculosis 1,445 | 1,563
astrocytoma 1,397 | 1,493
medulloblastoma 1,367 | 1,524
diabetes mellitus 1,357 | 1,663
posterior fossa group B ependymoma 1,354 | 1,530
sonic hedgehog group medulloblastoma 1,349 | 1,482
posterior fossa group A ependymoma 1,343 | 1,511
colon cancer 1,340 | 1,475
adrenocortical carcinoma 1,318 | 1,427
Multiple myeloma 1,295 | 1,327
primary pancreatic ductal adenocarcinoma 1,215 | 1,271
juvenile dermatomyositis 1,144 | 1,189
acute quadriplegic myopathy 1,117 | 1,157
Rheumatoid Arthritis 1,088 | 1,170
spina bifida 1,008 | 1,064
atypical teratoid/rhabdoid tumor 1,004 | 1,095
cutaneous lupus erythematosus 945 | 1,056
dermatomyositis 942 | 966
nasopharyngeal carcinoma 940 | 1,056
active Crohn's disease 827 | 918
Atopic dermatitis 795 | 944
gastric carcinoma 781 | 832
non primary Sjogren syndrome sicca 756 | 840
acute myeloid leukemia 749 | 785
Waldenstrons macroglobulinemia 746 | 764
primary Sjogren syndrome 732 | 788
esophageal adenocarcinoma 690 | 737
tuberculosis and treatment for 6 months 664 | 686
progressive supranuclear palsy 639 | 674
aldosterone-producing adenoma 625 | 664
Alzheimer's disease 568 | 644
Duchenne muscular dystrophy 560 | 602
Obesity 541 | 616
Intellectual disability 536 | 573
pancreatic carcinoma 531 | 567
hepatocellular carcinoma 526 | 550
Down syndrome 513 | 548
fibroadenoma 494 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 481 | 499
Endometriosis 476 | 535
chronic rhinosinusitis 450 | 512
Prostatic Neoplasms 435 | 471
IGA Glomerulonephritis 431 | 454
active ulcerative colitis 426 | 477
Multiple Sclerosis 421 | 498
gastric cancer 414 | 436
mucosa-associated lymphoid tissue lymphoma 413 | 480
Schizophrenia 409 | 503
Amyotrophic Lateral Sclerosis 401 | 432
Mammary Neoplasms 374 | 410
inflammatory breast cancer 365 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 343 | 413
sarcoidosis 329 | 368
Kidney disease 328 | 397
Parkinson's disease 315 | 364
glioblastoma multiforme 314 | 347
tuberculosis and treatment for 3 months 309 | 327
Polycystic Ovary Syndrome 306 | 334
hereditary spastic paraplegia 303 | 313
nephrosclerosis 296 | 329
Asthma 291 | 349
urothelial carcinoma 286 | 318

Tissue

Nervous System 15,992 | 18,560
Female tissues 15,982 | 18,646
Endocrine System 15,973 | 18,511
Digestive Tract 15,949 | 18,472
Urinary Tract 15,894 | 18,443
Liver and Pancreas 15,865 | 18,135
Male tissues 15,822 | 17,968
Blood and immune system 15,803 | 17,994
Skin and soft tissues 15,774 | 18,114
Cardiovascular System 15,773 | 17,957
Respiratory system 15,597 | 17,483

Target Family

Non-IDG 9,459 | 11,969
Enzyme 3,673 | 4,146
Transcription Factor 1,242 | 1,400
Kinase 590 | 634
Transporter 408 | 473
GPCR 270 | 408
Ion Channel 260 | 341
Epigenetic 227 | 242
oGPCR 48 | 421
Nuclear Receptor 46 | 48
TF/Epigenetic 33 | 38

HCA RNA Cell Line

U-266/84 16,256 | 16,256
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66