Development Level

Tbio 10,433 | 11,651
Tdark 4,241 | 6,593
Tchem 1,260 | 1,388
Tclin 506 | 612

Collection

Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 76 | 99
GPCR: IDG Consortium (Targets) 72 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 466 | 499
abnormal behavior 274 | 298
embryonic lethality prior to t... 269 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 189 | 207
enlarged heart 183 | 210
abnormal bone structure 172 | 187
decreased vertical activity 169 | 208
increased lean body mass 160 | 172
decreased body weight 152 | 161
abnormal heart morphology 142 | 162
decreased bone mineral content 136 | 151
hyperactivity 133 | 148
decreased lean body mass 126 | 135
increased total body fat amoun... 121 | 134
hypoactivity 116 | 132
decreased bone mineral density 115 | 126
increased circulating alkaline... 115 | 122
decreased circulating glucose ... 114 | 126
decreased grip strength 109 | 116
male infertility 109 | 123
embryonic growth retardation 103 | 106
increased startle reflex 101 | 112
increased bone mineral content 100 | 108
increased or absent threshold ... 96 | 101
abnormal seminal vesicle morph... 95 | 114
decreased body length 92 | 101
increased mean corpuscular hem... 92 | 96
short tibia 92 | 97
decreased circulating choleste... 89 | 93
increased mean corpuscular vol... 89 | 92
cataract 85 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 80 | 83
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 75 | 82
increased circulating HDL chol... 75 | 80
decreased mean corpuscular vol... 74 | 79
decreased circulating triglyce... 72 | 79
impaired glucose tolerance 71 | 75
improved glucose tolerance 70 | 79
increased fasted circulating g... 70 | 76
increased bone mineral density 68 | 72
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 66 | 68
decreased leukocyte cell numbe... 66 | 73
decreased startle reflex 66 | 75
small superior vagus ganglion 66 | 74
abnormal sleep behavior 64 | 70
increased circulating sodium l... 64 | 71
abnormal eye morphology 63 | 68
decreased circulating insulin ... 63 | 76
increased circulating choleste... 63 | 66
abnormal coat-hair pigmentatio... 62 | 64
decreased hemoglobin content 62 | 68
decreased erythrocyte cell num... 61 | 62
abnormal gait 60 | 69
abnormal behavioral response t... 59 | 66
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
increased heart weight 58 | 62
edema 57 | 59
increased monocyte cell number 56 | 63
small testis 54 | 58
thrombocytopenia 54 | 56
female infertility 53 | 60
decreased caudal vertebrae num... 52 | 53
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 49 | 51
hydrometra 48 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased circulating alkaline... 45 | 46
abnormal skin morphology 44 | 50
increased blood urea nitrogen ... 44 | 48
increased neutrophil cell numb... 44 | 46
decreased circulating alanine ... 43 | 47
decreased hematocrit 43 | 46
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
increased leukocyte cell numbe... 42 | 47
increased mean platelet volume 42 | 45
increased circulating triglyce... 40 | 42
abnormal testis morphology 39 | 43
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
enlarged spleen 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
increased circulating chloride... 37 | 41
limb grasping 37 | 41
increased grip strength 36 | 41
abnormal epididymis morphology 35 | 42
decreased circulating LDL chol... 35 | 38
enlarged lymph nodes 35 | 37
increased erythrocyte cell num... 35 | 39

Disease

Carcinoma 9,884 | 11,493
ovarian cancer 8,050 | 8,520
osteosarcoma 7,399 | 7,950
psoriasis 5,743 | 6,694
medulloblastoma, large-cell 5,715 | 6,241
glioblastoma 5,362 | 5,792
atypical teratoid / rhabdoid tumor 4,704 | 5,112
lung cancer 4,370 | 4,740
ependymoma 4,263 | 4,679
group 3 medulloblastoma 3,798 | 4,104
adult high grade glioma 3,418 | 3,801
Breast cancer 3,312 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,108 | 3,291
malignant mesothelioma 3,076 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,794 | 2,989
Astrocytoma, Pilocytic 2,763 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,763 | 2,955
primitive neuroectodermal tumor 2,762 | 3,035
invasive ductal carcinoma 2,759 | 2,951
non-small cell lung cancer 2,663 | 2,890
oligodendroglioma 2,591 | 2,850
lung carcinoma 2,511 | 2,843
lung adenocarcinoma 2,436 | 2,716
astrocytic glioma 2,367 | 2,597
Cancer 2,275 | 2,499
Kidney cancer 2,255 | 2,613
pancreatic cancer 2,229 | 2,398
subependymal giant cell astrocytoma 2,140 | 2,287
interstitial cystitis 2,072 | 2,312
tuberculosis 1,881 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,877 | 1,962
Pick disease 1,772 | 1,894
pituitary cancer 1,759 | 1,972
group 4 medulloblastoma 1,726 | 1,855
ulcerative colitis 1,657 | 1,819
ductal carcinoma in situ 1,626 | 1,745
cystic fibrosis 1,551 | 1,696
breast carcinoma 1,526 | 1,638
diabetes mellitus 1,423 | 1,728
colon cancer 1,354 | 1,478
adrenocortical carcinoma 1,336 | 1,428
Autosomal recessive predisposition 1,314 | 1,442
Multiple myeloma 1,310 | 1,332
juvenile dermatomyositis 1,152 | 1,187
acute quadriplegic myopathy 1,126 | 1,158
Rheumatoid arthritis 1,117 | 1,191
astrocytoma 1,091 | 1,146
primary pancreatic ductal adenocarcinoma 1,063 | 1,109
spina bifida 1,027 | 1,074
pediatric high grade glioma 993 | 1,064
Schizophrenia 980 | 1,160
Intellectual disability 959 | 1,016
cutaneous lupus erythematosus 954 | 1,057
dermatomyositis 947 | 966
nasopharyngeal carcinoma 947 | 1,058
active Crohn's disease 837 | 922
non primary Sjogren syndrome sicca 815 | 891
Atopic dermatitis 810 | 952
gastric carcinoma 762 | 807
acute myeloid leukemia 761 | 783
Waldenstrons macroglobulinemia 753 | 765
Liver Cirrhosis, Experimental 722 | 769
Epilepsy 712 | 792
active ulcerative colitis 695 | 764
esophageal adenocarcinoma 693 | 737
primary Sjogren syndrome 687 | 735
medulloblastoma 662 | 720
progressive supranuclear palsy 646 | 676
aldosterone-producing adenoma 630 | 665
Dull intelligence 614 | 645
Low intelligence 614 | 645
Mental Retardation 614 | 645
Mental deficiency 614 | 645
Poor school performance 614 | 645
Obesity 605 | 678
Cognitive delay 586 | 608
Global developmental delay 586 | 608
Mental and motor retardation 586 | 608
Alzheimer's disease 585 | 658
Duchenne muscular dystrophy 566 | 601
Bipolar Disorder 560 | 666
Muscle hypotonia 552 | 571
Seizures 552 | 596
Melanoma 543 | 711
pancreatic carcinoma 530 | 562
hepatocellular carcinoma 525 | 547
Short stature 498 | 531
fibroadenoma 498 | 559
Liver cancer 496 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 492 | 510
Endometriosis 487 | 540
Down syndrome 471 | 499
Prostatic Neoplasms 461 | 495
Multiple Sclerosis 460 | 540
chronic rhinosinusitis 453 | 512
gastric cancer 441 | 459
posterior fossa group A ependymoma 433 | 468
sonic hedgehog group medulloblastoma 429 | 467
Amyotrophic lateral sclerosis 419 | 451
mucosa-associated lymphoid tissue lymphoma 416 | 484

Tissue

Endocrine System 16,140 | 18,159
Digestive Tract 15,793 | 17,369
Female tissues 15,789 | 17,400
Skin and soft tissues 15,726 | 17,230
Male tissues 15,659 | 17,142
Blood and immune system 15,603 | 16,909
Liver and Pancreas 15,471 | 16,750
Nervous System 15,462 | 16,725
Urinary Tract 15,406 | 16,678
Respiratory system 15,249 | 16,393
Cardiovascular System 14,374 | 15,192

Target Family

Non-IDG 9,595 | 12,091
Enzyme 3,699 | 4,145
Transcription Factor 1,246 | 1,400
Kinase 596 | 634
Transporter 408 | 473
GPCR 271 | 408
Ion Channel 264 | 344
Epigenetic 233 | 242
oGPCR 48 | 421
Nuclear Receptor 46 | 48
TF/Epigenetic 34 | 38

HCA RNA Cell Line

U-266/84 16,440 | 16,440
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50