Development Level

Tbio 9,670 | 10,625
Tdark 4,658 | 7,003
Tchem 1,711 | 1,890
Tclin 516 | 602

Collection

Kinase: IDG Consortium (Targets) 117 | 125
Ion Channel: IDG Consortium (Targets) 87 | 102
GPCR: IDG Consortium (Targets) 77 | 127
Kinase: IDG Consortium (Complete/Control) 34 | 37
GPCR: IDG Consortium (Complete/Control) 22 | 26

IMPC Phenotype

preweaning lethality, complete... 623 | 633
preweaning lethality, incomple... 248 | 260
abnormal behavior 214 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 180 | 186
decreased body weight 166 | 174
decreased bone mineral content 149 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 123 | 131
increased or absent threshold ... 123 | 128
decreased bone mineral density 116 | 126
decreased grip strength 115 | 123
increased circulating alkaline... 115 | 119
decreased circulating glucose ... 112 | 121
abnormal embryo size 110 | 112
decreased body length 105 | 108
enlarged heart 103 | 111
hyperactivity 103 | 108
increased lean body mass 100 | 107
abnormal retina morphology 96 | 100
increased mean corpuscular hem... 90 | 93
increased bone mineral content 89 | 92
increased mean corpuscular vol... 86 | 91
decreased circulating choleste... 83 | 85
hypoactivity 81 | 89
short tibia 80 | 82
increased grip strength 79 | 83
decreased circulating HDL chol... 76 | 77
decreased circulating triglyce... 74 | 83
decreased circulating serum al... 73 | 79
abnormal lens morphology 69 | 73
increased fasted circulating g... 66 | 68
decreased circulating insulin ... 65 | 75
increased circulating sodium l... 65 | 71
prenatal lethality prior to he... 64 | 64
abnormal retinal pigmentation 60 | 61
decreased lumbar vertebrae num... 59 | 62
abnormal sleep behavior 58 | 63
decreased rib number 58 | 59
increased circulating HDL chol... 58 | 63
increased sacral vertebrae num... 58 | 62
abnormal coat-hair pigmentatio... 54 | 54
abnormal bone mineralization 53 | 55
increased total body fat amoun... 53 | 57
male infertility 53 | 62
decreased circulating alanine ... 52 | 53
decreased leukocyte cell numbe... 52 | 54
increased bone mineral density 51 | 52
decreased prepulse inhibition 50 | 52
impaired glucose tolerance 50 | 52
increased circulating choleste... 50 | 53
increased exploration in new e... 50 | 56
decreased hemoglobin content 49 | 53
improved glucose tolerance 49 | 56
decreased fasted circulating g... 48 | 49
decreased mean corpuscular vol... 48 | 50
abnormal gait 47 | 51
decreased startle reflex 47 | 48
abnormal behavioral response t... 46 | 52
abnormal heart morphology 45 | 51
decreased caudal vertebrae num... 44 | 49
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
abnormal seminal vesicle morph... 41 | 47
decreased circulating total pr... 41 | 41
thrombocytopenia 41 | 46
decreased circulating alkaline... 40 | 41
increased body weight 40 | 42
increased rib number 40 | 41
increased circulating chloride... 39 | 43
abnormal eye morphology 38 | 38
decreased eosinophil cell numb... 38 | 41
decreased heart weight 38 | 44
abnormal neural tube closure 37 | 37
decreased circulating LDL chol... 37 | 37
decreased circulating free fat... 37 | 39
decreased neutrophil cell numb... 37 | 37
increased leukocyte cell numbe... 36 | 37
increased startle reflex 36 | 38
small testis 34 | 37
limb grasping 33 | 35
tremors 33 | 34
abnormal cranium morphology 32 | 32
cardiovascular system phenotyp... 32 | 35
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
increased hematocrit 32 | 36
abnormal spleen morphology 31 | 36
decreased T cell number 30 | 31
decreased circulating creatini... 30 | 31
increased circulating calcium ... 30 | 32
decreased circulating calcium ... 29 | 33
decreased circulating chloride... 29 | 32
decreased circulating fructosa... 29 | 31
decreased NK T cell number 28 | 28
decreased blood urea nitrogen ... 28 | 31
embryonic growth retardation 28 | 28
increased circulating potassiu... 28 | 31

Disease

ovarian cancer 8,037 | 8,491
osteosarcoma 7,441 | 7,933
psoriasis 5,818 | 6,685
medulloblastoma, large-cell 5,797 | 6,234
glioblastoma 5,240 | 5,572
lung cancer 4,255 | 4,473
atypical teratoid / rhabdoid tumor 4,096 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,106 | 3,289
malignant mesothelioma 3,028 | 3,163
Breast cancer 2,918 | 3,098
pilocytic astrocytoma 2,855 | 3,086
primitive neuroectodermal tumor 2,827 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,811 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,788 | 2,956
invasive ductal carcinoma 2,786 | 2,950
oligodendroglioma 2,650 | 2,849
non-small cell lung cancer 2,625 | 2,798
lung carcinoma 2,614 | 2,844
pediatric high grade glioma 2,558 | 2,712
lung adenocarcinoma 2,522 | 2,714
ependymoma 2,368 | 2,514
pancreatic cancer 2,168 | 2,300
Cancer 2,156 | 2,346
subependymal giant cell astrocytoma 2,146 | 2,287
group 3 medulloblastoma 2,116 | 2,254
interstitial cystitis 2,113 | 2,299
astrocytic glioma 2,082 | 2,241
ulcerative colitis 1,945 | 2,087
adult high grade glioma 1,942 | 2,148
Carcinoma 1,932 | 2,147
pituitary cancer 1,825 | 1,972
Pick disease 1,790 | 1,893
group 4 medulloblastoma 1,760 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,729 | 1,795
ductal carcinoma in situ 1,633 | 1,745
cystic fibrosis 1,529 | 1,670
breast carcinoma 1,512 | 1,614
tuberculosis 1,475 | 1,563
medulloblastoma 1,427 | 1,524
astrocytoma 1,424 | 1,493
sonic hedgehog group medulloblastoma 1,394 | 1,482
posterior fossa group B ependymoma 1,390 | 1,530
posterior fossa group A ependymoma 1,387 | 1,511
diabetes mellitus 1,372 | 1,663
colon cancer 1,371 | 1,475
adrenocortical carcinoma 1,349 | 1,427
Multiple myeloma 1,293 | 1,327
primary pancreatic ductal adenocarcinoma 1,233 | 1,271
juvenile dermatomyositis 1,156 | 1,189
acute quadriplegic myopathy 1,117 | 1,157
Rheumatoid Arthritis 1,104 | 1,170
atypical teratoid/rhabdoid tumor 1,024 | 1,095
spina bifida 1,012 | 1,064
nasopharyngeal carcinoma 972 | 1,056
cutaneous lupus erythematosus 967 | 1,056
dermatomyositis 944 | 966
active Crohn's disease 847 | 918
Atopic dermatitis 818 | 944
gastric carcinoma 793 | 832
non primary Sjogren syndrome sicca 770 | 840
primary Sjogren syndrome 760 | 788
acute myeloid leukemia 758 | 785
Waldenstrons macroglobulinemia 745 | 764
esophageal adenocarcinoma 690 | 737
tuberculosis and treatment for 6 months 667 | 686
progressive supranuclear palsy 642 | 674
aldosterone-producing adenoma 630 | 664
Alzheimer's disease 586 | 644
Duchenne muscular dystrophy 573 | 602
pancreatic carcinoma 549 | 567
Intellectual disability 548 | 573
Obesity 543 | 616
hepatocellular carcinoma 538 | 550
Down syndrome 520 | 548
fibroadenoma 515 | 557
Endometriosis 486 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 482 | 499
chronic rhinosinusitis 467 | 512
IGA Glomerulonephritis 442 | 454
Prostatic Neoplasms 439 | 471
mucosa-associated lymphoid tissue lymphoma 439 | 480
active ulcerative colitis 438 | 477
Multiple Sclerosis 435 | 498
Schizophrenia 427 | 503
gastric cancer 419 | 436
Amyotrophic Lateral Sclerosis 406 | 432
Mammary Neoplasms 381 | 410
non-small cell lung carcinoma 376 | 413
inflammatory breast cancer 370 | 404
Neurodegenerative disease 358 | 383
Kidney disease 351 | 397
sarcoidosis 343 | 368
glioblastoma multiforme 321 | 347
Parkinson's disease 319 | 364
tuberculosis and treatment for 3 months 313 | 327
Polycystic Ovary Syndrome 309 | 334
nephrosclerosis 307 | 329
hereditary spastic paraplegia 305 | 313
urothelial carcinoma 298 | 318
Asthma 297 | 349

Tissue

Nervous System 16,296 | 18,560
Female tissues 16,285 | 18,646
Endocrine System 16,273 | 18,511
Digestive Tract 16,260 | 18,472
Urinary Tract 16,211 | 18,443
Liver and Pancreas 16,155 | 18,135
Male tissues 16,122 | 17,968
Blood and immune system 16,104 | 17,994
Cardiovascular System 16,089 | 17,957
Skin and soft tissues 16,064 | 18,114
Respiratory system 15,896 | 17,483

Target Family

Non-IDG 9,651 | 11,969
Enzyme 3,721 | 4,146
Transcription Factor 1,231 | 1,400
Kinase 599 | 634
Transporter 408 | 473
Ion Channel 294 | 341
GPCR 289 | 408
Epigenetic 228 | 242
oGPCR 54 | 421
Nuclear Receptor 44 | 48
TF/Epigenetic 36 | 38

HCA RNA Cell Line

U-266/70 16,555 | 16,555
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Interleukin-9 IL9 Tbio Non-IDG -2.46520 301.6 339
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131