Development Level

Tbio 10,642 | 11,651
Tdark 4,298 | 6,593
Tchem 1,280 | 1,388
Tclin 525 | 612

Collection

RFA-RM-18-021 272 | 328
Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 85 | 99
GPCR: IDG Consortium (Targets) 76 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 959 | 979
preweaning lethality, incomple... 470 | 499
abnormal behavior 282 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 218 | 220
enlarged heart 196 | 210
decreased total body fat amoun... 189 | 207
decreased vertical activity 179 | 208
abnormal bone structure 173 | 187
increased lean body mass 160 | 172
abnormal heart morphology 152 | 162
decreased body weight 151 | 161
hyperactivity 139 | 148
decreased bone mineral content 138 | 151
decreased lean body mass 128 | 135
increased total body fat amoun... 123 | 134
hypoactivity 121 | 132
decreased circulating glucose ... 118 | 126
increased circulating alkaline... 115 | 122
decreased bone mineral density 112 | 126
male infertility 111 | 123
decreased grip strength 110 | 116
increased startle reflex 110 | 112
embryonic growth retardation 105 | 106
abnormal seminal vesicle morph... 104 | 114
increased bone mineral content 99 | 108
increased or absent threshold ... 97 | 101
decreased body length 96 | 101
short tibia 94 | 97
decreased circulating choleste... 91 | 93
increased mean corpuscular hem... 90 | 96
increased mean corpuscular vol... 86 | 92
prenatal lethality prior to he... 86 | 87
cataract 83 | 92
decreased lymphocyte cell numb... 82 | 83
decreased prepulse inhibition 78 | 82
abnormal lens morphology 76 | 81
decreased circulating serum al... 76 | 82
decreased mean corpuscular vol... 74 | 79
increased circulating HDL chol... 74 | 80
decreased circulating triglyce... 71 | 79
decreased leukocyte cell numbe... 71 | 73
increased fasted circulating g... 71 | 76
decreased startle reflex 69 | 75
impaired glucose tolerance 69 | 75
improved glucose tolerance 69 | 79
increased bone mineral density 69 | 72
small superior vagus ganglion 69 | 74
abnormal eye morphology 68 | 68
abnormal retina morphology 67 | 71
decreased circulating HDL chol... 67 | 68
abnormal sleep behavior 65 | 70
decreased circulating insulin ... 64 | 76
increased circulating sodium l... 64 | 71
abnormal coat-hair pigmentatio... 63 | 64
decreased fasted circulating g... 62 | 65
decreased hemoglobin content 62 | 68
increased monocyte cell number 62 | 63
abnormal gait 61 | 69
increased circulating choleste... 61 | 66
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
edema 58 | 59
increased heart weight 57 | 62
abnormal kidney morphology 56 | 65
decreased caudal vertebrae num... 53 | 53
small testis 53 | 58
thrombocytopenia 52 | 56
hydrometra 51 | 53
abnormal spleen morphology 50 | 55
female infertility 49 | 60
decreased circulating total pr... 48 | 49
decreased circulating alanine ... 47 | 47
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
abnormal skin morphology 46 | 50
decreased blood urea nitrogen ... 46 | 51
decreased circulating alkaline... 46 | 46
increased blood urea nitrogen ... 45 | 48
increased neutrophil cell numb... 45 | 46
decreased hematocrit 44 | 46
increased hematocrit 43 | 46
increased hemoglobin content 43 | 45
increased leukocyte cell numbe... 43 | 47
increased mean platelet volume 42 | 45
decreased red blood cell distr... 41 | 41
increased circulating triglyce... 41 | 42
increased grip strength 40 | 41
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
limb grasping 39 | 41
tremors 39 | 39
decreased circulating LDL chol... 38 | 38
decreased neutrophil cell numb... 38 | 42
increased erythrocyte cell num... 38 | 39
decreased circulating creatini... 37 | 39
increased circulating chloride... 37 | 41
abnormal bone mineralization 36 | 38
increased mean corpuscular hem... 36 | 36

Disease

Carcinoma 10,180 | 11,493
ovarian cancer 8,149 | 8,520
osteosarcoma 7,529 | 7,950
psoriasis 5,870 | 6,694
medulloblastoma, large-cell 5,855 | 6,241
glioblastoma 5,488 | 5,792
atypical teratoid / rhabdoid tumor 4,841 | 5,112
lung cancer 4,490 | 4,740
ependymoma 4,395 | 4,679
group 3 medulloblastoma 3,889 | 4,104
adult high grade glioma 3,526 | 3,801
Breast cancer 3,380 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,136 | 3,291
malignant mesothelioma 3,116 | 3,232
Astrocytoma, Pilocytic 2,882 | 3,081
primitive neuroectodermal tumor 2,862 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,835 | 2,989
invasive ductal carcinoma 2,815 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,806 | 2,955
non-small cell lung cancer 2,729 | 2,890
oligodendroglioma 2,675 | 2,850
lung carcinoma 2,631 | 2,843
lung adenocarcinoma 2,544 | 2,716
astrocytic glioma 2,433 | 2,597
Kidney cancer 2,382 | 2,613
Cancer 2,311 | 2,499
pancreatic cancer 2,269 | 2,398
subependymal giant cell astrocytoma 2,165 | 2,287
interstitial cystitis 2,132 | 2,312
tuberculosis 1,921 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,912 | 1,962
pituitary cancer 1,838 | 1,972
Pick disease 1,804 | 1,894
group 4 medulloblastoma 1,759 | 1,855
ulcerative colitis 1,701 | 1,819
ductal carcinoma in situ 1,648 | 1,745
cystic fibrosis 1,561 | 1,696
breast carcinoma 1,547 | 1,638
diabetes mellitus 1,439 | 1,728
colon cancer 1,384 | 1,478
adrenocortical carcinoma 1,367 | 1,428
Autosomal recessive predisposition 1,345 | 1,442
Multiple myeloma 1,308 | 1,332
juvenile dermatomyositis 1,164 | 1,187
Rheumatoid arthritis 1,133 | 1,191
acute quadriplegic myopathy 1,125 | 1,158
astrocytoma 1,107 | 1,146
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
spina bifida 1,031 | 1,074
pediatric high grade glioma 1,021 | 1,064
Schizophrenia 1,019 | 1,160
nasopharyngeal carcinoma 979 | 1,058
cutaneous lupus erythematosus 976 | 1,057
Intellectual disability 973 | 1,016
dermatomyositis 949 | 966
active Crohn's disease 857 | 922
Atopic dermatitis 831 | 952
non primary Sjogren syndrome sicca 831 | 891
gastric carcinoma 774 | 807
acute myeloid leukemia 769 | 783
Waldenstrons macroglobulinemia 752 | 765
Liver Cirrhosis, Experimental 732 | 769
Epilepsy 730 | 792
primary Sjogren syndrome 712 | 735
active ulcerative colitis 711 | 764
esophageal adenocarcinoma 693 | 737
medulloblastoma 684 | 720
progressive supranuclear palsy 648 | 676
aldosterone-producing adenoma 635 | 665
Dull intelligence 619 | 645
Low intelligence 619 | 645
Mental Retardation 619 | 645
Mental deficiency 619 | 645
Poor school performance 619 | 645
Obesity 607 | 678
Alzheimer's disease 606 | 658
Melanoma 592 | 711
Cognitive delay 587 | 608
Global developmental delay 587 | 608
Mental and motor retardation 587 | 608
Bipolar Disorder 583 | 666
Duchenne muscular dystrophy 579 | 601
Muscle hypotonia 557 | 571
Seizures 551 | 596
pancreatic carcinoma 548 | 562
hepatocellular carcinoma 537 | 547
Liver cancer 535 | 604
fibroadenoma 519 | 559
Short stature 503 | 531
Endometriosis 497 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 510
Multiple Sclerosis 477 | 540
Down syndrome 476 | 499
chronic rhinosinusitis 470 | 512
Prostatic Neoplasms 464 | 495
gastric cancer 446 | 459
sonic hedgehog group medulloblastoma 443 | 467
mucosa-associated lymphoid tissue lymphoma 442 | 484
posterior fossa group A ependymoma 432 | 468
Amyotrophic lateral sclerosis 424 | 451

Tissue

Endocrine System 16,416 | 18,159
Female tissues 16,056 | 17,400
Digestive Tract 16,054 | 17,369
Skin and soft tissues 15,982 | 17,230
Male tissues 15,920 | 17,142
Blood and immune system 15,838 | 16,909
Nervous System 15,739 | 16,725
Liver and Pancreas 15,701 | 16,750
Urinary Tract 15,669 | 16,678
Respiratory system 15,490 | 16,393
Cardiovascular System 14,557 | 15,192

Target Family

Non-IDG 9,792 | 12,091
Enzyme 3,748 | 4,145
Transcription Factor 1,235 | 1,400
Kinase 607 | 634
Transporter 408 | 473
Ion Channel 297 | 344
GPCR 289 | 408
Epigenetic 234 | 242
oGPCR 54 | 421
Nuclear Receptor 44 | 48
TF/Epigenetic 37 | 38

HCA RNA Cell Line

U-266/70 16,745 | 16,745
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115