Development Level

Tbio 10,302 | 11,445
Tdark 4,112 | 6,588
Tchem 1,440 | 1,598
Tclin 511 | 613

Collection

RFA-RM-18-021 257 | 328
Kinase: IDG Consortium (Target... 118 | 125
Ion Channel: IDG Consortium (T... 79 | 99
GPCR: IDG Consortium (Targets) 72 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 950 | 979
preweaning lethality, incomple... 469 | 499
abnormal behavior 279 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 190 | 207
enlarged heart 187 | 210
decreased vertical activity 176 | 208
abnormal bone structure 169 | 187
increased lean body mass 162 | 172
decreased body weight 155 | 161
abnormal heart morphology 143 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 123 | 135
increased total body fat amoun... 123 | 134
hypoactivity 118 | 132
decreased circulating glucose ... 116 | 126
decreased bone mineral density 113 | 126
increased circulating alkaline... 113 | 122
decreased grip strength 109 | 116
increased startle reflex 104 | 112
male infertility 104 | 123
abnormal seminal vesicle morph... 102 | 114
embryonic growth retardation 102 | 106
increased bone mineral content 98 | 108
decreased body length 95 | 101
increased or absent threshold ... 94 | 101
decreased circulating choleste... 91 | 93
increased mean corpuscular hem... 90 | 96
short tibia 90 | 97
cataract 88 | 92
increased mean corpuscular vol... 87 | 92
prenatal lethality prior to he... 85 | 87
decreased lymphocyte cell numb... 78 | 83
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased mean corpuscular vol... 75 | 79
decreased circulating serum al... 74 | 82
decreased circulating triglyce... 73 | 79
increased circulating HDL chol... 72 | 80
improved glucose tolerance 71 | 79
increased bone mineral density 70 | 72
decreased circulating insulin ... 68 | 76
decreased leukocyte cell numbe... 68 | 73
decreased startle reflex 68 | 75
abnormal eye morphology 67 | 68
impaired glucose tolerance 67 | 75
increased fasted circulating g... 67 | 76
abnormal retina morphology 66 | 71
decreased circulating HDL chol... 65 | 68
small superior vagus ganglion 65 | 74
abnormal gait 64 | 69
abnormal sleep behavior 63 | 70
increased circulating sodium l... 62 | 71
abnormal coat-hair pigmentatio... 61 | 64
decreased fasted circulating g... 61 | 65
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
abnormal kidney morphology 58 | 65
decreased erythrocyte cell num... 58 | 62
edema 58 | 59
increased monocyte cell number 57 | 63
abnormal behavioral response t... 56 | 66
increased heart weight 56 | 62
small testis 55 | 58
decreased caudal vertebrae num... 53 | 53
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
decreased circulating total pr... 48 | 49
female infertility 48 | 60
abnormal skin morphology 47 | 50
decreased blood urea nitrogen ... 47 | 51
hydrometra 47 | 53
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
decreased circulating alkaline... 45 | 46
decreased circulating alanine ... 44 | 47
decreased hematocrit 43 | 46
increased leukocyte cell numbe... 43 | 47
increased blood urea nitrogen ... 42 | 48
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 40 | 43
enlarged spleen 40 | 41
decreased red blood cell distr... 39 | 41
increased hemoglobin content 39 | 45
increased mean platelet volume 39 | 45
abnormal bone mineralization 38 | 38
decreased neutrophil cell numb... 38 | 42
increased circulating chloride... 38 | 41
increased circulating triglyce... 38 | 42
limb grasping 38 | 41
tremors 38 | 39
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased grip strength 36 | 41
increased mean corpuscular hem... 36 | 36
abnormal cranium morphology 35 | 36

Disease

Carcinoma 9,949 | 11,493
ovarian cancer 8,120 | 8,520
osteosarcoma 7,429 | 7,950
medulloblastoma, large-cell 5,799 | 6,241
psoriasis 5,780 | 6,694
glioblastoma 5,469 | 5,792
atypical teratoid / rhabdoid tumor 4,788 | 5,112
lung cancer 4,464 | 4,740
ependymoma 4,342 | 4,679
group 3 medulloblastoma 3,845 | 4,104
adult high grade glioma 3,501 | 3,801
Breast cancer 3,378 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,148 | 3,291
malignant mesothelioma 3,138 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,858 | 2,989
Astrocytoma, Pilocytic 2,843 | 3,081
primitive neuroectodermal tumor 2,843 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,812 | 2,955
invasive ductal carcinoma 2,805 | 2,951
non-small cell lung cancer 2,721 | 2,890
oligodendroglioma 2,660 | 2,850
lung carcinoma 2,595 | 2,843
lung adenocarcinoma 2,515 | 2,716
astrocytic glioma 2,423 | 2,597
Kidney cancer 2,302 | 2,613
Cancer 2,283 | 2,499
pancreatic cancer 2,274 | 2,398
subependymal giant cell astrocytoma 2,160 | 2,287
interstitial cystitis 2,121 | 2,312
tuberculosis 1,897 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,881 | 1,962
pituitary cancer 1,815 | 1,972
Pick disease 1,799 | 1,894
group 4 medulloblastoma 1,751 | 1,855
ulcerative colitis 1,700 | 1,819
ductal carcinoma in situ 1,651 | 1,745
cystic fibrosis 1,613 | 1,696
breast carcinoma 1,538 | 1,638
diabetes mellitus 1,415 | 1,728
colon cancer 1,393 | 1,478
adrenocortical carcinoma 1,373 | 1,428
Multiple myeloma 1,311 | 1,332
Autosomal recessive predisposition 1,309 | 1,442
juvenile dermatomyositis 1,159 | 1,187
acute quadriplegic myopathy 1,130 | 1,158
Rheumatoid arthritis 1,125 | 1,191
astrocytoma 1,108 | 1,146
primary pancreatic ductal adenocarcinoma 1,078 | 1,109
spina bifida 1,032 | 1,074
pediatric high grade glioma 1,009 | 1,064
Schizophrenia 998 | 1,160
nasopharyngeal carcinoma 969 | 1,058
cutaneous lupus erythematosus 966 | 1,057
Intellectual disability 961 | 1,016
dermatomyositis 955 | 966
active Crohn's disease 868 | 922
Atopic dermatitis 840 | 952
non primary Sjogren syndrome sicca 817 | 891
acute myeloid leukemia 770 | 783
gastric carcinoma 767 | 807
Waldenstrons macroglobulinemia 758 | 765
Epilepsy 725 | 792
Liver Cirrhosis, Experimental 719 | 769
active ulcerative colitis 719 | 764
primary Sjogren syndrome 698 | 735
esophageal adenocarcinoma 695 | 737
medulloblastoma 683 | 720
progressive supranuclear palsy 648 | 676
aldosterone-producing adenoma 641 | 665
Dull intelligence 609 | 645
Low intelligence 609 | 645
Mental Retardation 609 | 645
Mental deficiency 609 | 645
Poor school performance 609 | 645
Alzheimer's disease 601 | 658
Obesity 598 | 678
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Duchenne muscular dystrophy 578 | 601
Melanoma 574 | 711
Bipolar Disorder 572 | 666
Seizures 551 | 596
Muscle hypotonia 544 | 571
pancreatic carcinoma 536 | 562
hepatocellular carcinoma 529 | 547
Liver cancer 527 | 604
fibroadenoma 516 | 559
Endometriosis 507 | 540
Short stature 498 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 493 | 510
Down syndrome 472 | 499
Prostatic Neoplasms 472 | 495
Multiple Sclerosis 465 | 540
chronic rhinosinusitis 461 | 512
posterior fossa group A ependymoma 444 | 468
sonic hedgehog group medulloblastoma 444 | 467
gastric cancer 443 | 459
mucosa-associated lymphoid tissue lymphoma 429 | 484
Amyotrophic lateral sclerosis 426 | 451

Tissue

Endocrine System 16,086 | 18,159
Female tissues 15,835 | 17,400
Digestive Tract 15,823 | 17,369
Skin and soft tissues 15,785 | 17,230
Male tissues 15,683 | 17,142
Blood and immune system 15,597 | 16,909
Nervous System 15,553 | 16,725
Liver and Pancreas 15,527 | 16,750
Urinary Tract 15,471 | 16,678
Respiratory system 15,334 | 16,393
Cardiovascular System 14,494 | 15,192

Target Family

Non-IDG 9,554 | 12,091
Enzyme 3,692 | 4,145
Transcription Factor 1,250 | 1,400
Kinase 599 | 634
Transporter 394 | 473
GPCR 272 | 408
Ion Channel 270 | 344
Epigenetic 227 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 37 | 38
oGPCR 26 | 421

HCA RNA Cell Line

U-251 MG 16,365 | 16,365
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39