Development Level

Tbio 10,511 | 11,651
Tdark 4,184 | 6,593
Tchem 1,268 | 1,388
Tclin 520 | 612

Collection

RFA-RM-18-021 255 | 328
Kinase: IDG Consortium (Target... 117 | 125
Ion Channel: IDG Consortium (T... 77 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 956 | 979
preweaning lethality, incomple... 473 | 499
abnormal behavior 283 | 298
embryonic lethality prior to t... 272 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 194 | 207
enlarged heart 188 | 210
abnormal bone structure 176 | 187
decreased vertical activity 174 | 208
increased lean body mass 158 | 172
decreased body weight 153 | 161
abnormal heart morphology 144 | 162
decreased bone mineral content 141 | 151
hyperactivity 138 | 148
decreased lean body mass 128 | 135
increased total body fat amoun... 123 | 134
hypoactivity 121 | 132
decreased bone mineral density 118 | 126
increased circulating alkaline... 117 | 122
decreased circulating glucose ... 113 | 126
male infertility 112 | 123
increased startle reflex 108 | 112
decreased grip strength 104 | 116
embryonic growth retardation 103 | 106
increased bone mineral content 102 | 108
abnormal seminal vesicle morph... 97 | 114
decreased body length 96 | 101
increased or absent threshold ... 94 | 101
short tibia 91 | 97
decreased circulating choleste... 90 | 93
cataract 88 | 92
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 87 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 80 | 83
decreased prepulse inhibition 79 | 82
abnormal lens morphology 77 | 81
decreased circulating serum al... 75 | 82
decreased mean corpuscular vol... 74 | 79
decreased circulating triglyce... 73 | 79
increased circulating HDL chol... 73 | 80
small superior vagus ganglion 71 | 74
decreased startle reflex 70 | 75
increased fasted circulating g... 70 | 76
decreased circulating insulin ... 69 | 76
increased bone mineral density 69 | 72
impaired glucose tolerance 68 | 75
improved glucose tolerance 68 | 79
decreased circulating HDL chol... 67 | 68
decreased leukocyte cell numbe... 67 | 73
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
abnormal sleep behavior 65 | 70
increased circulating sodium l... 63 | 71
abnormal gait 61 | 69
increased circulating choleste... 61 | 66
abnormal behavioral response t... 60 | 66
abnormal coat-hair pigmentatio... 60 | 64
decreased hemoglobin content 60 | 68
abnormal kidney morphology 59 | 65
decreased fasted circulating g... 59 | 65
increased monocyte cell number 59 | 63
decreased erythrocyte cell num... 58 | 62
edema 57 | 59
increased heart weight 56 | 62
small testis 56 | 58
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 52 | 56
female infertility 51 | 60
abnormal spleen morphology 50 | 55
hydrometra 50 | 53
decreased circulating total pr... 48 | 49
decreased mean corpuscular hem... 48 | 50
abnormal skin morphology 47 | 50
decreased blood urea nitrogen ... 47 | 51
abnormal neural tube closure 45 | 46
increased blood urea nitrogen ... 45 | 48
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased hematocrit 44 | 46
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased hemoglobin content 42 | 45
increased mean platelet volume 42 | 45
abnormal testis morphology 41 | 43
increased leukocyte cell numbe... 41 | 47
enlarged spleen 40 | 41
tremors 39 | 39
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
abnormal bone mineralization 37 | 38
increased erythrocyte cell num... 37 | 39
limb grasping 37 | 41
abnormal epididymis morphology 36 | 42
decreased circulating LDL chol... 36 | 38
increased circulating chloride... 36 | 41
increased grip strength 36 | 41
abnormal cranium morphology 35 | 36

Disease

Carcinoma 10,032 | 11,493
ovarian cancer 8,158 | 8,520
osteosarcoma 7,450 | 7,950
medulloblastoma, large-cell 5,837 | 6,241
psoriasis 5,822 | 6,694
glioblastoma 5,475 | 5,792
atypical teratoid / rhabdoid tumor 4,818 | 5,112
lung cancer 4,494 | 4,740
ependymoma 4,366 | 4,679
group 3 medulloblastoma 3,868 | 4,104
adult high grade glioma 3,514 | 3,801
Breast cancer 3,398 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,160 | 3,291
malignant mesothelioma 3,138 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,870 | 2,989
Astrocytoma, Pilocytic 2,862 | 3,081
invasive ductal carcinoma 2,850 | 2,951
primitive neuroectodermal tumor 2,849 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 2,830 | 2,955
non-small cell lung cancer 2,752 | 2,890
oligodendroglioma 2,665 | 2,850
lung carcinoma 2,614 | 2,843
lung adenocarcinoma 2,541 | 2,716
astrocytic glioma 2,445 | 2,597
Kidney cancer 2,358 | 2,613
Cancer 2,292 | 2,499
pancreatic cancer 2,269 | 2,398
subependymal giant cell astrocytoma 2,172 | 2,287
interstitial cystitis 2,142 | 2,312
tuberculosis 1,913 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,889 | 1,962
pituitary cancer 1,823 | 1,972
Pick disease 1,801 | 1,894
group 4 medulloblastoma 1,756 | 1,855
ulcerative colitis 1,716 | 1,819
ductal carcinoma in situ 1,673 | 1,745
cystic fibrosis 1,613 | 1,696
breast carcinoma 1,559 | 1,638
diabetes mellitus 1,415 | 1,728
colon cancer 1,406 | 1,478
adrenocortical carcinoma 1,381 | 1,428
Autosomal recessive predisposition 1,307 | 1,442
Multiple myeloma 1,307 | 1,332
juvenile dermatomyositis 1,167 | 1,187
Rheumatoid arthritis 1,130 | 1,191
acute quadriplegic myopathy 1,130 | 1,158
astrocytoma 1,110 | 1,146
primary pancreatic ductal adenocarcinoma 1,077 | 1,109
spina bifida 1,026 | 1,074
pediatric high grade glioma 1,007 | 1,064
Schizophrenia 996 | 1,160
cutaneous lupus erythematosus 970 | 1,057
nasopharyngeal carcinoma 967 | 1,058
Intellectual disability 965 | 1,016
dermatomyositis 956 | 966
active Crohn's disease 882 | 922
Atopic dermatitis 854 | 952
non primary Sjogren syndrome sicca 824 | 891
gastric carcinoma 771 | 807
acute myeloid leukemia 764 | 783
Waldenstrons macroglobulinemia 751 | 765
Epilepsy 723 | 792
Liver Cirrhosis, Experimental 718 | 769
active ulcerative colitis 718 | 764
primary Sjogren syndrome 699 | 735
esophageal adenocarcinoma 694 | 737
medulloblastoma 686 | 720
progressive supranuclear palsy 652 | 676
aldosterone-producing adenoma 645 | 665
Dull intelligence 609 | 645
Low intelligence 609 | 645
Mental Retardation 609 | 645
Mental deficiency 609 | 645
Poor school performance 609 | 645
Obesity 602 | 678
Alzheimer's disease 594 | 658
Cognitive delay 584 | 608
Global developmental delay 584 | 608
Mental and motor retardation 584 | 608
Duchenne muscular dystrophy 583 | 601
Melanoma 583 | 711
Bipolar Disorder 577 | 666
Muscle hypotonia 552 | 571
Seizures 551 | 596
pancreatic carcinoma 537 | 562
fibroadenoma 529 | 559
hepatocellular carcinoma 529 | 547
Liver cancer 528 | 604
Endometriosis 505 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 498 | 510
Short stature 496 | 531
Down syndrome 473 | 499
Prostatic Neoplasms 466 | 495
Multiple Sclerosis 464 | 540
chronic rhinosinusitis 459 | 512
gastric cancer 445 | 459
posterior fossa group A ependymoma 443 | 468
sonic hedgehog group medulloblastoma 441 | 467
Amyotrophic lateral sclerosis 430 | 451
mucosa-associated lymphoid tissue lymphoma 429 | 484

Tissue

Endocrine System 16,187 | 18,159
Female tissues 15,921 | 17,400
Digestive Tract 15,904 | 17,369
Skin and soft tissues 15,855 | 17,230
Male tissues 15,788 | 17,142
Blood and immune system 15,687 | 16,909
Liver and Pancreas 15,597 | 16,750
Nervous System 15,584 | 16,725
Urinary Tract 15,532 | 16,678
Respiratory system 15,383 | 16,393
Cardiovascular System 14,516 | 15,192

Target Family

Non-IDG 9,624 | 12,091
Enzyme 3,710 | 4,145
Transcription Factor 1,262 | 1,400
Kinase 604 | 634
Transporter 407 | 473
GPCR 267 | 408
Ion Channel 266 | 344
Epigenetic 234 | 242
Nuclear Receptor 44 | 48
TF/Epigenetic 37 | 38
oGPCR 28 | 421

HCA RNA Cell Line

U-2197 16,483 | 16,483
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50