Development Level

Tbio 9,985 | 10,625
Tdark 5,016 | 7,003
Tchem 1,793 | 1,890
Tclin 571 | 602

Collection

Kinase: IDG Consortium (Targets) 121 | 125
Ion Channel: IDG Consortium (Targets) 98 | 102
GPCR: IDG Consortium (Targets) 92 | 127
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 21 | 26

IMPC Phenotype

preweaning lethality, complete... 625 | 633
preweaning lethality, incomple... 251 | 260
abnormal behavior 226 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 186 | 187
decreased total body fat amoun... 183 | 186
decreased body weight 172 | 174
decreased bone mineral content 153 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 128 | 131
increased or absent threshold ... 126 | 128
decreased bone mineral density 122 | 126
decreased grip strength 120 | 123
increased circulating alkaline... 117 | 119
decreased circulating glucose ... 115 | 121
abnormal embryo size 108 | 112
decreased body length 107 | 108
enlarged heart 106 | 111
hyperactivity 103 | 108
increased lean body mass 103 | 107
abnormal retina morphology 98 | 100
increased mean corpuscular hem... 92 | 93
increased bone mineral content 90 | 92
increased mean corpuscular vol... 90 | 91
hypoactivity 88 | 89
decreased circulating choleste... 84 | 85
decreased circulating triglyce... 81 | 83
increased grip strength 80 | 83
short tibia 80 | 82
decreased circulating HDL chol... 76 | 77
decreased circulating insulin ... 75 | 75
decreased circulating serum al... 75 | 79
abnormal lens morphology 72 | 73
increased circulating sodium l... 70 | 71
increased fasted circulating g... 67 | 68
prenatal lethality prior to he... 64 | 64
abnormal sleep behavior 61 | 63
decreased lumbar vertebrae num... 61 | 62
increased circulating HDL chol... 60 | 63
increased sacral vertebrae num... 60 | 62
male infertility 60 | 62
abnormal retinal pigmentation 59 | 61
decreased rib number 56 | 59
abnormal bone mineralization 55 | 55
increased total body fat amoun... 55 | 57
abnormal coat-hair pigmentatio... 53 | 54
decreased leukocyte cell numbe... 52 | 54
increased circulating choleste... 52 | 53
increased exploration in new e... 52 | 56
decreased prepulse inhibition 51 | 52
impaired glucose tolerance 51 | 52
improved glucose tolerance 51 | 56
increased bone mineral density 51 | 52
abnormal behavioral response t... 50 | 52
decreased circulating alanine ... 50 | 53
decreased hemoglobin content 50 | 53
decreased mean corpuscular vol... 50 | 50
abnormal gait 49 | 51
abnormal heart morphology 48 | 51
decreased caudal vertebrae num... 48 | 49
decreased fasted circulating g... 48 | 49
decreased startle reflex 48 | 48
increased hemoglobin content 45 | 45
abnormal seminal vesicle morph... 44 | 47
thrombocytopenia 44 | 46
decreased erythrocyte cell num... 43 | 43
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
increased circulating chloride... 41 | 43
decreased circulating alkaline... 40 | 41
decreased circulating total pr... 40 | 41
decreased heart weight 40 | 44
abnormal eye morphology 38 | 38
decreased eosinophil cell numb... 38 | 41
increased rib number 38 | 41
decreased circulating free fat... 37 | 39
increased startle reflex 37 | 38
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased neutrophil cell numb... 36 | 37
increased leukocyte cell numbe... 36 | 37
small testis 36 | 37
increased heart weight 35 | 37
limb grasping 35 | 35
increased hematocrit 34 | 36
tremors 34 | 34
abnormal spleen morphology 33 | 36
cardiovascular system phenotyp... 33 | 35
decreased mean corpuscular hem... 33 | 34
abnormal cranium morphology 32 | 32
decreased T cell number 31 | 31
increased circulating calcium ... 31 | 32
abnormal testis morphology 30 | 30
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased threshold for audito... 30 | 32
female infertility 30 | 34
increased circulating potassiu... 30 | 31
abnormal epididymis morphology 29 | 31
decreased circulating chloride... 29 | 32

Disease

ovarian cancer 8,206 | 8,491
osteosarcoma 7,569 | 7,933
psoriasis 6,169 | 6,685
medulloblastoma, large-cell 5,987 | 6,234
glioblastoma 5,412 | 5,572
lung cancer 4,337 | 4,473
atypical teratoid / rhabdoid tumor 4,236 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,199 | 3,289
malignant mesothelioma 3,099 | 3,163
Breast cancer 3,006 | 3,098
pilocytic astrocytoma 2,979 | 3,086
primitive neuroectodermal tumor 2,938 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,916 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,893 | 2,956
invasive ductal carcinoma 2,865 | 2,950
oligodendroglioma 2,761 | 2,849
non-small cell lung cancer 2,717 | 2,798
lung carcinoma 2,713 | 2,844
pediatric high grade glioma 2,642 | 2,712
lung adenocarcinoma 2,601 | 2,714
ependymoma 2,441 | 2,514
pancreatic cancer 2,236 | 2,300
Cancer 2,231 | 2,346
subependymal giant cell astrocytoma 2,220 | 2,287
interstitial cystitis 2,191 | 2,299
group 3 medulloblastoma 2,179 | 2,254
astrocytic glioma 2,170 | 2,241
adult high grade glioma 2,041 | 2,148
Carcinoma 2,039 | 2,147
ulcerative colitis 2,006 | 2,087
pituitary cancer 1,899 | 1,972
Pick disease 1,848 | 1,893
group 4 medulloblastoma 1,827 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,744 | 1,795
ductal carcinoma in situ 1,696 | 1,745
cystic fibrosis 1,617 | 1,670
breast carcinoma 1,560 | 1,614
tuberculosis 1,492 | 1,563
medulloblastoma 1,475 | 1,524
astrocytoma 1,467 | 1,493
posterior fossa group B ependymoma 1,459 | 1,530
posterior fossa group A ependymoma 1,457 | 1,511
diabetes mellitus 1,442 | 1,663
sonic hedgehog group medulloblastoma 1,435 | 1,482
colon cancer 1,422 | 1,475
adrenocortical carcinoma 1,390 | 1,427
Multiple myeloma 1,300 | 1,327
primary pancreatic ductal adenocarcinoma 1,249 | 1,271
juvenile dermatomyositis 1,170 | 1,189
acute quadriplegic myopathy 1,139 | 1,157
Rheumatoid Arthritis 1,126 | 1,170
atypical teratoid/rhabdoid tumor 1,061 | 1,095
spina bifida 1,040 | 1,064
nasopharyngeal carcinoma 1,011 | 1,056
cutaneous lupus erythematosus 996 | 1,056
dermatomyositis 956 | 966
active Crohn's disease 883 | 918
Atopic dermatitis 875 | 944
gastric carcinoma 809 | 832
non primary Sjogren syndrome sicca 793 | 840
acute myeloid leukemia 762 | 785
primary Sjogren syndrome 760 | 788
Waldenstrons macroglobulinemia 755 | 764
esophageal adenocarcinoma 717 | 737
tuberculosis and treatment for 6 months 671 | 686
progressive supranuclear palsy 656 | 674
aldosterone-producing adenoma 653 | 664
Alzheimer's disease 616 | 644
Duchenne muscular dystrophy 585 | 602
Obesity 580 | 616
Intellectual disability 561 | 573
pancreatic carcinoma 550 | 567
fibroadenoma 545 | 557
hepatocellular carcinoma 537 | 550
Down syndrome 532 | 548
Endometriosis 511 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 494 | 499
chronic rhinosinusitis 489 | 512
Schizophrenia 466 | 503
Multiple Sclerosis 454 | 498
Prostatic Neoplasms 453 | 471
active ulcerative colitis 452 | 477
IGA Glomerulonephritis 442 | 454
mucosa-associated lymphoid tissue lymphoma 439 | 480
Amyotrophic Lateral Sclerosis 424 | 432
gastric cancer 422 | 436
Mammary Neoplasms 402 | 410
non-small cell lung carcinoma 383 | 413
inflammatory breast cancer 382 | 404
Neurodegenerative disease 374 | 383
Kidney disease 371 | 397
sarcoidosis 353 | 368
Parkinson's disease 346 | 364
glioblastoma multiforme 336 | 347
Epilepsy 328 | 346
Polycystic Ovary Syndrome 322 | 334
Asthma 319 | 349
nephrosclerosis 315 | 329
tuberculosis and treatment for 3 months 313 | 327
hereditary spastic paraplegia 308 | 313

Tissue

Nervous System 17,054 | 18,560
Female tissues 17,038 | 18,646
Endocrine System 17,032 | 18,511
Digestive Tract 17,005 | 18,472
Urinary Tract 16,938 | 18,443
Liver and Pancreas 16,841 | 18,135
Skin and soft tissues 16,799 | 18,114
Male tissues 16,798 | 17,968
Cardiovascular System 16,773 | 17,957
Blood and immune system 16,761 | 17,994
Respiratory system 16,492 | 17,483

Target Family

Non-IDG 10,100 | 11,969
Enzyme 3,853 | 4,146
Transcription Factor 1,324 | 1,400
Kinase 615 | 634
Transporter 424 | 473
GPCR 330 | 408
Ion Channel 312 | 341
Epigenetic 232 | 242
oGPCR 91 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 36 | 38

HCA RNA Cell Line

U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66