Development Level

Tbio 11,010 | 11,651
Tdark 4,628 | 6,593
Tchem 1,341 | 1,388
Tclin 580 | 612

Collection

Kinase: IDG Consortium (Target... 124 | 125
Ion Channel: IDG Consortium (T... 95 | 99
GPCR: IDG Consortium (Targets) 91 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 21 | 25

IMPC Phenotype

preweaning lethality, complete... 972 | 979
preweaning lethality, incomple... 483 | 499
abnormal behavior 293 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 216 | 220
decreased total body fat amoun... 202 | 207
enlarged heart 197 | 210
decreased vertical activity 189 | 208
abnormal bone structure 180 | 187
increased lean body mass 167 | 172
decreased body weight 159 | 161
abnormal heart morphology 150 | 162
decreased bone mineral content 144 | 151
hyperactivity 140 | 148
decreased lean body mass 132 | 135
increased total body fat amoun... 131 | 134
hypoactivity 128 | 132
decreased bone mineral density 122 | 126
decreased circulating glucose ... 121 | 126
increased circulating alkaline... 119 | 122
male infertility 114 | 123
decreased grip strength 111 | 116
increased startle reflex 111 | 112
abnormal seminal vesicle morph... 106 | 114
embryonic growth retardation 103 | 106
increased bone mineral content 102 | 108
increased or absent threshold ... 99 | 101
decreased body length 98 | 101
increased mean corpuscular hem... 94 | 96
short tibia 94 | 97
decreased circulating choleste... 92 | 93
increased mean corpuscular vol... 91 | 92
cataract 88 | 92
prenatal lethality prior to he... 87 | 87
decreased prepulse inhibition 81 | 82
decreased lymphocyte cell numb... 79 | 83
decreased circulating serum al... 78 | 82
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 77 | 79
decreased circulating insulin ... 76 | 76
decreased circulating triglyce... 76 | 79
increased circulating HDL chol... 76 | 80
decreased startle reflex 74 | 75
increased fasted circulating g... 74 | 76
improved glucose tolerance 73 | 79
small superior vagus ganglion 73 | 74
decreased leukocyte cell numbe... 72 | 73
increased bone mineral density 72 | 72
impaired glucose tolerance 71 | 75
increased circulating sodium l... 70 | 71
abnormal eye morphology 68 | 68
abnormal retina morphology 68 | 71
abnormal sleep behavior 68 | 70
decreased circulating HDL chol... 68 | 68
abnormal gait 67 | 69
decreased hemoglobin content 65 | 68
increased circulating choleste... 65 | 66
decreased fasted circulating g... 63 | 65
abnormal behavioral response t... 62 | 66
abnormal coat-hair pigmentatio... 62 | 64
decreased erythrocyte cell num... 61 | 62
abnormal kidney morphology 60 | 65
increased heart weight 60 | 62
increased monocyte cell number 58 | 63
small testis 58 | 58
edema 57 | 59
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 52 | 53
abnormal spleen morphology 51 | 55
female infertility 51 | 60
hydrometra 50 | 53
abnormal skin morphology 48 | 50
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
decreased mean corpuscular hem... 47 | 50
abnormal neural tube closure 46 | 46
decreased circulating alanine ... 46 | 47
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased blood urea nitrogen ... 45 | 48
increased leukocyte cell numbe... 45 | 47
increased neutrophil cell numb... 44 | 46
abnormal testis morphology 43 | 43
increased hematocrit 43 | 46
increased hemoglobin content 43 | 45
increased circulating triglyce... 41 | 42
increased mean platelet volume 41 | 45
limb grasping 41 | 41
decreased neutrophil cell numb... 40 | 42
decreased red blood cell distr... 40 | 41
abnormal epididymis morphology 39 | 42
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
increased grip strength 38 | 41
decreased circulating LDL chol... 37 | 38
increased erythrocyte cell num... 37 | 39
increased mean corpuscular hem... 36 | 36

Disease

Carcinoma 10,624 | 11,493
ovarian cancer 8,324 | 8,520
osteosarcoma 7,657 | 7,950
psoriasis 6,223 | 6,694
medulloblastoma, large-cell 6,045 | 6,241
glioblastoma 5,672 | 5,792
atypical teratoid / rhabdoid tumor 4,996 | 5,112
lung cancer 4,588 | 4,740
ependymoma 4,558 | 4,679
group 3 medulloblastoma 4,014 | 4,104
adult high grade glioma 3,687 | 3,801
Breast cancer 3,500 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,230 | 3,291
malignant mesothelioma 3,191 | 3,232
Astrocytoma, Pilocytic 3,007 | 3,081
primitive neuroectodermal tumor 2,972 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,941 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,911 | 2,955
invasive ductal carcinoma 2,896 | 2,951
non-small cell lung cancer 2,823 | 2,890
oligodendroglioma 2,787 | 2,850
lung carcinoma 2,730 | 2,843
lung adenocarcinoma 2,624 | 2,716
astrocytic glioma 2,535 | 2,597
Kidney cancer 2,516 | 2,613
Cancer 2,390 | 2,499
pancreatic cancer 2,346 | 2,398
subependymal giant cell astrocytoma 2,239 | 2,287
interstitial cystitis 2,210 | 2,312
tuberculosis 1,935 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,928 | 1,962
pituitary cancer 1,913 | 1,972
Pick disease 1,863 | 1,894
group 4 medulloblastoma 1,817 | 1,855
ulcerative colitis 1,752 | 1,819
ductal carcinoma in situ 1,712 | 1,745
cystic fibrosis 1,656 | 1,696
breast carcinoma 1,597 | 1,638
diabetes mellitus 1,515 | 1,728
colon cancer 1,437 | 1,478
adrenocortical carcinoma 1,408 | 1,428
Autosomal recessive predisposition 1,387 | 1,442
Multiple myeloma 1,315 | 1,332
juvenile dermatomyositis 1,178 | 1,187
Rheumatoid arthritis 1,154 | 1,191
acute quadriplegic myopathy 1,148 | 1,158
astrocytoma 1,136 | 1,146
primary pancreatic ductal adenocarcinoma 1,096 | 1,109
Schizophrenia 1,090 | 1,160
spina bifida 1,061 | 1,074
pediatric high grade glioma 1,044 | 1,064
nasopharyngeal carcinoma 1,018 | 1,058
cutaneous lupus erythematosus 1,006 | 1,057
Intellectual disability 998 | 1,016
dermatomyositis 961 | 966
active Crohn's disease 893 | 922
Atopic dermatitis 891 | 952
non primary Sjogren syndrome sicca 853 | 891
gastric carcinoma 790 | 807
acute myeloid leukemia 773 | 783
Epilepsy 771 | 792
Waldenstrons macroglobulinemia 762 | 765
Liver Cirrhosis, Experimental 744 | 769
active ulcerative colitis 737 | 764
esophageal adenocarcinoma 720 | 737
primary Sjogren syndrome 714 | 735
medulloblastoma 707 | 720
progressive supranuclear palsy 663 | 676
Melanoma 662 | 711
aldosterone-producing adenoma 658 | 665
Obesity 642 | 678
Dull intelligence 635 | 645
Low intelligence 635 | 645
Mental Retardation 635 | 645
Mental deficiency 635 | 645
Poor school performance 635 | 645
Bipolar Disorder 633 | 666
Alzheimer's disease 629 | 658
Cognitive delay 601 | 608
Global developmental delay 601 | 608
Mental and motor retardation 601 | 608
Duchenne muscular dystrophy 591 | 601
Seizures 584 | 596
Liver cancer 580 | 604
Muscle hypotonia 566 | 571
pancreatic carcinoma 550 | 562
fibroadenoma 549 | 559
hepatocellular carcinoma 537 | 547
Endometriosis 522 | 540
Short stature 518 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 506 | 510
Multiple Sclerosis 498 | 540
chronic rhinosinusitis 492 | 512
Down syndrome 488 | 499
Prostatic Neoplasms 480 | 495
posterior fossa group A ependymoma 460 | 468
sonic hedgehog group medulloblastoma 455 | 467
gastric cancer 450 | 459
Amyotrophic lateral sclerosis 445 | 451
mucosa-associated lymphoid tissue lymphoma 441 | 484

Tissue

Endocrine System 17,139 | 18,159
Female tissues 16,702 | 17,400
Digestive Tract 16,701 | 17,369
Skin and soft tissues 16,601 | 17,230
Male tissues 16,516 | 17,142
Blood and immune system 16,327 | 16,909
Nervous System 16,271 | 16,725
Liver and Pancreas 16,248 | 16,750
Urinary Tract 16,186 | 16,678
Respiratory system 15,961 | 16,393
Cardiovascular System 14,929 | 15,192

Target Family

Non-IDG 10,242 | 12,091
Enzyme 3,884 | 4,145
Transcription Factor 1,328 | 1,400
Kinase 622 | 634
Transporter 424 | 473
GPCR 330 | 408
Ion Channel 315 | 344
Epigenetic 238 | 242
oGPCR 91 | 421
Nuclear Receptor 48 | 48
TF/Epigenetic 37 | 38

HCA RNA Cell Line

U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50