Development Level

Tbio 9,989 | 11,445
Tdark 4,061 | 6,588
Tchem 1,391 | 1,598
Tclin 473 | 613

Collection

RFA-RM-18-021 246 | 328
Kinase: IDG Consortium (Target... 113 | 125
Ion Channel: IDG Consortium (T... 74 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 951 | 979
preweaning lethality, incomple... 462 | 499
embryonic lethality prior to t... 272 | 278
abnormal behavior 267 | 298
embryonic lethality prior to o... 237 | 239
abnormal embryo size 214 | 220
decreased total body fat amoun... 189 | 207
enlarged heart 177 | 210
abnormal bone structure 169 | 187
decreased vertical activity 161 | 208
decreased body weight 156 | 161
increased lean body mass 156 | 172
abnormal heart morphology 138 | 162
decreased bone mineral content 133 | 151
hyperactivity 129 | 148
decreased lean body mass 124 | 135
increased total body fat amoun... 121 | 134
hypoactivity 116 | 132
increased circulating alkaline... 114 | 122
decreased bone mineral density 113 | 126
decreased circulating glucose ... 109 | 126
increased startle reflex 108 | 112
decreased grip strength 104 | 116
embryonic growth retardation 102 | 106
male infertility 100 | 123
increased bone mineral content 97 | 108
decreased body length 95 | 101
increased or absent threshold ... 94 | 101
abnormal seminal vesicle morph... 91 | 114
increased mean corpuscular hem... 88 | 96
decreased circulating choleste... 87 | 93
short tibia 87 | 97
prenatal lethality prior to he... 85 | 87
cataract 84 | 92
increased mean corpuscular vol... 84 | 92
decreased prepulse inhibition 77 | 82
abnormal lens morphology 76 | 81
decreased circulating triglyce... 74 | 79
decreased circulating serum al... 72 | 82
decreased mean corpuscular vol... 72 | 79
decreased lymphocyte cell numb... 71 | 83
decreased startle reflex 71 | 75
increased fasted circulating g... 71 | 76
increased bone mineral density 68 | 72
abnormal retina morphology 67 | 71
decreased circulating insulin ... 66 | 76
decreased leukocyte cell numbe... 66 | 73
increased circulating HDL chol... 66 | 80
impaired glucose tolerance 64 | 75
small superior vagus ganglion 64 | 74
abnormal sleep behavior 63 | 70
decreased circulating HDL chol... 63 | 68
abnormal eye morphology 62 | 68
improved glucose tolerance 62 | 79
increased circulating sodium l... 61 | 71
abnormal behavioral response t... 59 | 66
abnormal gait 59 | 69
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased hemoglobin content 57 | 68
decreased erythrocyte cell num... 56 | 62
edema 56 | 59
increased circulating choleste... 56 | 66
increased heart weight 54 | 62
increased monocyte cell number 54 | 63
decreased fasted circulating g... 53 | 65
small testis 53 | 58
decreased caudal vertebrae num... 51 | 53
abnormal spleen morphology 49 | 55
thrombocytopenia 48 | 56
female infertility 47 | 60
hydrometra 47 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating alanine ... 46 | 47
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
increased blood urea nitrogen ... 45 | 48
increased hematocrit 43 | 46
abnormal skin morphology 41 | 50
enlarged spleen 41 | 41
increased hemoglobin content 41 | 45
increased leukocyte cell numbe... 41 | 47
decreased circulating alkaline... 40 | 46
increased neutrophil cell numb... 40 | 46
decreased hematocrit 38 | 46
decreased neutrophil cell numb... 38 | 42
decreased red blood cell distr... 38 | 41
increased circulating triglyce... 38 | 42
increased mean platelet volume 38 | 45
abnormal bone mineralization 37 | 38
abnormal testis morphology 37 | 43
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
limb grasping 37 | 41
tremors 37 | 39
increased erythrocyte cell num... 36 | 39
abnormal epididymis morphology 35 | 42
enlarged lymph nodes 35 | 37
increased circulating chloride... 35 | 41

Disease

Carcinoma 9,736 | 11,493
ovarian cancer 7,999 | 8,520
osteosarcoma 7,249 | 7,950
medulloblastoma, large-cell 5,694 | 6,241
psoriasis 5,580 | 6,694
glioblastoma 5,372 | 5,792
atypical teratoid / rhabdoid tumor 4,726 | 5,112
lung cancer 4,334 | 4,740
ependymoma 4,297 | 4,679
group 3 medulloblastoma 3,773 | 4,104
adult high grade glioma 3,428 | 3,801
Breast cancer 3,306 | 3,578
malignant mesothelioma 3,094 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,022 | 3,291
primitive neuroectodermal tumor 2,798 | 3,035
Astrocytoma, Pilocytic 2,756 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,732 | 2,989
invasive ductal carcinoma 2,727 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,699 | 2,955
oligodendroglioma 2,605 | 2,850
non-small cell lung cancer 2,589 | 2,890
lung carcinoma 2,467 | 2,843
lung adenocarcinoma 2,399 | 2,716
astrocytic glioma 2,375 | 2,597
Kidney cancer 2,317 | 2,613
Cancer 2,205 | 2,499
pancreatic cancer 2,185 | 2,398
subependymal giant cell astrocytoma 2,108 | 2,287
interstitial cystitis 1,976 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,832 | 1,962
tuberculosis 1,818 | 2,010
Pick disease 1,786 | 1,894
pituitary cancer 1,765 | 1,972
group 4 medulloblastoma 1,740 | 1,855
ductal carcinoma in situ 1,605 | 1,745
ulcerative colitis 1,600 | 1,819
cystic fibrosis 1,540 | 1,696
breast carcinoma 1,484 | 1,638
diabetes mellitus 1,365 | 1,728
adrenocortical carcinoma 1,326 | 1,428
colon cancer 1,323 | 1,478
Multiple myeloma 1,303 | 1,332
Autosomal recessive predisposition 1,264 | 1,442
juvenile dermatomyositis 1,139 | 1,187
acute quadriplegic myopathy 1,107 | 1,158
Rheumatoid arthritis 1,098 | 1,191
astrocytoma 1,091 | 1,146
primary pancreatic ductal adenocarcinoma 1,046 | 1,109
spina bifida 1,014 | 1,074
pediatric high grade glioma 1,004 | 1,064
Schizophrenia 971 | 1,160
Intellectual disability 953 | 1,016
dermatomyositis 941 | 966
nasopharyngeal carcinoma 928 | 1,058
cutaneous lupus erythematosus 879 | 1,057
active Crohn's disease 814 | 922
Atopic dermatitis 804 | 952
non primary Sjogren syndrome sicca 800 | 891
acute myeloid leukemia 746 | 783
gastric carcinoma 743 | 807
Waldenstrons macroglobulinemia 732 | 765
Epilepsy 708 | 792
Liver Cirrhosis, Experimental 685 | 769
active ulcerative colitis 672 | 764
medulloblastoma 662 | 720
primary Sjogren syndrome 650 | 735
progressive supranuclear palsy 649 | 676
esophageal adenocarcinoma 642 | 737
aldosterone-producing adenoma 619 | 665
Dull intelligence 604 | 645
Low intelligence 604 | 645
Mental Retardation 604 | 645
Mental deficiency 604 | 645
Poor school performance 604 | 645
Alzheimer's disease 593 | 658
Cognitive delay 577 | 608
Global developmental delay 577 | 608
Mental and motor retardation 577 | 608
Melanoma 576 | 711
Obesity 576 | 678
Duchenne muscular dystrophy 566 | 601
Muscle hypotonia 547 | 571
Bipolar Disorder 546 | 666
Seizures 534 | 596
Liver cancer 527 | 604
pancreatic carcinoma 517 | 562
hepatocellular carcinoma 511 | 547
Short stature 494 | 531
fibroadenoma 492 | 559
Endometriosis 490 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 510
Down syndrome 463 | 499
Prostatic Neoplasms 454 | 495
chronic rhinosinusitis 449 | 512
sonic hedgehog group medulloblastoma 436 | 467
Multiple Sclerosis 433 | 540
posterior fossa group A ependymoma 427 | 468
gastric cancer 425 | 459
Amyotrophic lateral sclerosis 424 | 451
Breast Neoplasms 411 | 445

Tissue

Endocrine System 15,637 | 18,159
Female tissues 15,409 | 17,400
Digestive Tract 15,377 | 17,369
Skin and soft tissues 15,352 | 17,230
Male tissues 15,289 | 17,142
Blood and immune system 15,178 | 16,909
Nervous System 15,178 | 16,725
Liver and Pancreas 15,111 | 16,750
Urinary Tract 15,074 | 16,678
Respiratory system 14,933 | 16,393
Cardiovascular System 14,170 | 15,192

Target Family

Non-IDG 9,284 | 12,091
Enzyme 3,603 | 4,145
Transcription Factor 1,223 | 1,400
Kinase 585 | 634
Transporter 381 | 473
GPCR 259 | 408
Ion Channel 249 | 344
Epigenetic 231 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 37 | 38
oGPCR 20 | 421

HCA RNA Cell Line

U-138 MG 15,914 | 15,914
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.39614 24.1 46