Development Level

Tbio 9,216 | 10,625
Tdark 4,422 | 7,003
Tchem 1,633 | 1,890
Tclin 462 | 602

Collection

Kinase: IDG Consortium (Targets) 111 | 125
Ion Channel: IDG Consortium (Targets) 77 | 102
GPCR: IDG Consortium (Targets) 68 | 127
Kinase: IDG Consortium (Complete/Control) 32 | 37
GPCR: IDG Consortium (Complete/Control) 23 | 26

IMPC Phenotype

preweaning lethality, complete... 612 | 633
preweaning lethality, incomple... 239 | 260
abnormal behavior 211 | 226
decreased lean body mass 188 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 179 | 186
decreased body weight 168 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 121 | 131
decreased bone mineral density 118 | 126
increased or absent threshold ... 116 | 128
increased circulating alkaline... 114 | 119
decreased grip strength 108 | 123
abnormal embryo size 106 | 112
decreased body length 104 | 108
decreased circulating glucose ... 102 | 121
hyperactivity 100 | 108
increased lean body mass 95 | 107
enlarged heart 93 | 111
abnormal retina morphology 91 | 100
increased mean corpuscular hem... 87 | 93
increased bone mineral content 83 | 92
increased mean corpuscular vol... 83 | 91
hypoactivity 80 | 89
decreased circulating choleste... 79 | 85
decreased circulating triglyce... 77 | 83
short tibia 75 | 82
increased grip strength 72 | 83
decreased circulating HDL chol... 71 | 77
decreased circulating serum al... 71 | 79
abnormal lens morphology 68 | 73
decreased circulating insulin ... 65 | 75
prenatal lethality prior to he... 63 | 64
increased fasted circulating g... 62 | 68
increased circulating sodium l... 61 | 71
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 59 | 62
abnormal retinal pigmentation 55 | 61
abnormal sleep behavior 55 | 63
abnormal bone mineralization 54 | 55
decreased rib number 53 | 59
increased total body fat amoun... 53 | 57
increased circulating HDL chol... 51 | 63
male infertility 50 | 62
abnormal coat-hair pigmentatio... 49 | 54
decreased circulating alanine ... 49 | 53
decreased prepulse inhibition 49 | 52
decreased leukocyte cell numbe... 48 | 54
decreased mean corpuscular vol... 48 | 50
impaired glucose tolerance 48 | 52
abnormal behavioral response t... 47 | 52
decreased startle reflex 47 | 48
increased bone mineral density 47 | 52
increased exploration in new e... 47 | 56
decreased hemoglobin content 46 | 53
increased circulating choleste... 46 | 53
abnormal gait 45 | 51
improved glucose tolerance 45 | 56
decreased caudal vertebrae num... 42 | 49
abnormal heart morphology 41 | 51
decreased circulating total pr... 41 | 41
increased blood urea nitrogen ... 41 | 44
increased hemoglobin content 41 | 45
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 40 | 49
increased body weight 40 | 42
thrombocytopenia 40 | 46
increased circulating chloride... 39 | 43
decreased eosinophil cell numb... 37 | 41
decreased heart weight 37 | 44
increased rib number 37 | 41
decreased circulating LDL chol... 36 | 37
decreased circulating alkaline... 36 | 41
increased startle reflex 36 | 38
abnormal eye morphology 35 | 38
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
abnormal seminal vesicle morph... 34 | 47
increased hematocrit 34 | 36
increased leukocyte cell numbe... 34 | 37
decreased neutrophil cell numb... 33 | 37
small testis 33 | 37
decreased mean corpuscular hem... 32 | 34
tremors 32 | 34
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
limb grasping 31 | 35
decreased T cell number 30 | 31
increased circulating calcium ... 30 | 32
increased heart weight 30 | 37
cardiovascular system phenotyp... 29 | 35
decreased circulating fructosa... 29 | 31
decreased circulating calcium ... 28 | 33
decreased circulating creatini... 28 | 31
increased circulating potassiu... 28 | 31
decreased blood urea nitrogen ... 27 | 31
decreased circulating chloride... 27 | 32
embryonic growth retardation 27 | 28
increased monocyte cell number 27 | 27

Disease

ovarian cancer 7,889 | 8,491
osteosarcoma 7,166 | 7,933
medulloblastoma, large-cell 5,639 | 6,234
psoriasis 5,532 | 6,685
glioblastoma 5,129 | 5,572
lung cancer 4,109 | 4,473
atypical teratoid / rhabdoid tumor 4,022 | 4,369
malignant mesothelioma 3,011 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,995 | 3,289
Breast cancer 2,871 | 3,098
primitive neuroectodermal tumor 2,766 | 3,031
pilocytic astrocytoma 2,727 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,710 | 2,988
invasive ductal carcinoma 2,699 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,685 | 2,956
oligodendroglioma 2,581 | 2,849
pediatric high grade glioma 2,494 | 2,712
non-small cell lung cancer 2,488 | 2,798
lung carcinoma 2,455 | 2,844
lung adenocarcinoma 2,381 | 2,714
ependymoma 2,322 | 2,514
subependymal giant cell astrocytoma 2,090 | 2,287
pancreatic cancer 2,079 | 2,300
Cancer 2,058 | 2,346
group 3 medulloblastoma 2,047 | 2,254
astrocytic glioma 2,038 | 2,241
interstitial cystitis 1,959 | 2,299
adult high grade glioma 1,894 | 2,148
Carcinoma 1,881 | 2,147
ulcerative colitis 1,836 | 2,087
Pick disease 1,772 | 1,893
pituitary cancer 1,753 | 1,972
group 4 medulloblastoma 1,751 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,652 | 1,795
ductal carcinoma in situ 1,591 | 1,745
cystic fibrosis 1,506 | 1,670
breast carcinoma 1,450 | 1,614
astrocytoma 1,396 | 1,493
tuberculosis 1,393 | 1,563
medulloblastoma 1,388 | 1,524
posterior fossa group B ependymoma 1,360 | 1,530
posterior fossa group A ependymoma 1,357 | 1,511
sonic hedgehog group medulloblastoma 1,351 | 1,482
colon cancer 1,311 | 1,475
adrenocortical carcinoma 1,308 | 1,427
diabetes mellitus 1,304 | 1,663
Multiple myeloma 1,288 | 1,327
primary pancreatic ductal adenocarcinoma 1,195 | 1,271
juvenile dermatomyositis 1,131 | 1,189
acute quadriplegic myopathy 1,098 | 1,157
Rheumatoid Arthritis 1,071 | 1,170
spina bifida 996 | 1,064
atypical teratoid/rhabdoid tumor 986 | 1,095
dermatomyositis 936 | 966
nasopharyngeal carcinoma 922 | 1,056
cutaneous lupus erythematosus 871 | 1,056
active Crohn's disease 804 | 918
Atopic dermatitis 791 | 944
gastric carcinoma 763 | 832
non primary Sjogren syndrome sicca 746 | 840
acute myeloid leukemia 736 | 785
Waldenstrons macroglobulinemia 725 | 764
primary Sjogren syndrome 691 | 788
tuberculosis and treatment for 6 months 655 | 686
progressive supranuclear palsy 643 | 674
esophageal adenocarcinoma 639 | 737
aldosterone-producing adenoma 614 | 664
Alzheimer's disease 581 | 644
Duchenne muscular dystrophy 559 | 602
Intellectual disability 536 | 573
pancreatic carcinoma 518 | 567
Obesity 517 | 616
hepatocellular carcinoma 511 | 550
Down syndrome 505 | 548
fibroadenoma 488 | 557
Endometriosis 480 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 477 | 499
chronic rhinosinusitis 446 | 512
Prostatic Neoplasms 428 | 471
IGA Glomerulonephritis 421 | 454
active ulcerative colitis 410 | 477
Schizophrenia 405 | 503
Amyotrophic Lateral Sclerosis 403 | 432
gastric cancer 399 | 436
Multiple Sclerosis 394 | 498
mucosa-associated lymphoid tissue lymphoma 387 | 480
Mammary Neoplasms 378 | 410
Neurodegenerative disease 358 | 383
inflammatory breast cancer 358 | 404
non-small cell lung carcinoma 349 | 413
glioblastoma multiforme 320 | 347
sarcoidosis 316 | 368
Parkinson's disease 315 | 364
Kidney disease 312 | 397
Polycystic Ovary Syndrome 306 | 334
hereditary spastic paraplegia 304 | 313
tuberculosis and treatment for 3 months 297 | 327
Epilepsy 289 | 346
urothelial carcinoma 281 | 318
interstitial lung disease 269 | 292

Tissue

Nervous System 15,509 | 18,560
Female tissues 15,498 | 18,646
Endocrine System 15,485 | 18,511
Digestive Tract 15,479 | 18,472
Urinary Tract 15,431 | 18,443
Liver and Pancreas 15,393 | 18,135
Male tissues 15,369 | 17,968
Cardiovascular System 15,355 | 17,957
Blood and immune system 15,339 | 17,994
Skin and soft tissues 15,315 | 18,114
Respiratory system 15,171 | 17,483

Target Family

Non-IDG 9,157 | 11,969
Enzyme 3,571 | 4,146
Transcription Factor 1,219 | 1,400
Kinase 578 | 634
Transporter 381 | 473
GPCR 259 | 408
Ion Channel 246 | 341
Epigenetic 225 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 36 | 38
oGPCR 19 | 421

HCA RNA Cell Line

U-138 MG 15,733 | 15,733
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.29669 19.6 50