Development Level

Tbio 9,239 | 11,445
Tdark 3,540 | 6,588
Tchem 1,271 | 1,598
Tclin 411 | 613

Collection

RFA-RM-18-021 206 | 328
Kinase: IDG Consortium (Target... 102 | 125
Ion Channel: IDG Consortium (T... 58 | 99
GPCR: IDG Consortium (Targets) 54 | 126
Kinase: IDG Consortium (Comple... 31 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 920 | 979
preweaning lethality, incomple... 425 | 499
embryonic lethality prior to t... 263 | 278
abnormal behavior 254 | 298
embryonic lethality prior to o... 234 | 239
abnormal embryo size 205 | 220
decreased total body fat amoun... 170 | 207
enlarged heart 164 | 210
abnormal bone structure 158 | 187
decreased body weight 148 | 161
increased lean body mass 145 | 172
decreased vertical activity 140 | 208
abnormal heart morphology 131 | 162
hyperactivity 125 | 148
decreased bone mineral content 119 | 151
decreased lean body mass 112 | 135
increased total body fat amoun... 109 | 134
increased circulating alkaline... 104 | 122
hypoactivity 103 | 132
decreased bone mineral density 102 | 126
increased startle reflex 101 | 112
decreased circulating glucose ... 99 | 126
embryonic growth retardation 98 | 106
male infertility 93 | 123
decreased body length 89 | 101
increased bone mineral content 89 | 108
decreased grip strength 88 | 116
increased mean corpuscular hem... 86 | 96
increased mean corpuscular vol... 84 | 92
abnormal seminal vesicle morph... 83 | 114
cataract 83 | 92
decreased circulating choleste... 82 | 93
short tibia 82 | 97
increased or absent threshold ... 80 | 101
prenatal lethality prior to he... 79 | 87
abnormal lens morphology 74 | 81
decreased prepulse inhibition 69 | 82
increased bone mineral density 68 | 72
decreased circulating serum al... 67 | 82
decreased circulating triglyce... 67 | 79
decreased lymphocyte cell numb... 67 | 83
decreased mean corpuscular vol... 66 | 79
increased fasted circulating g... 66 | 76
abnormal eye morphology 63 | 68
abnormal retina morphology 63 | 71
decreased circulating HDL chol... 62 | 68
decreased leukocyte cell numbe... 62 | 73
increased circulating HDL chol... 62 | 80
impaired glucose tolerance 60 | 75
small superior vagus ganglion 60 | 74
improved glucose tolerance 59 | 79
abnormal sleep behavior 58 | 70
increased circulating sodium l... 58 | 71
abnormal gait 57 | 69
abnormal behavioral response t... 56 | 66
abnormal coat-hair pigmentatio... 56 | 64
decreased erythrocyte cell num... 56 | 62
decreased hemoglobin content 56 | 68
decreased startle reflex 56 | 75
edema 55 | 59
decreased circulating insulin ... 54 | 76
increased circulating choleste... 53 | 66
abnormal kidney morphology 52 | 65
increased heart weight 52 | 62
increased monocyte cell number 50 | 63
decreased caudal vertebrae num... 49 | 53
decreased fasted circulating g... 48 | 65
small testis 48 | 58
thrombocytopenia 47 | 56
abnormal spleen morphology 46 | 55
decreased circulating total pr... 45 | 49
decreased mean corpuscular hem... 45 | 50
abnormal neural tube closure 43 | 46
abnormal skin morphology 43 | 50
hydrometra 43 | 53
decreased circulating alanine ... 42 | 47
decreased blood urea nitrogen ... 41 | 51
female infertility 41 | 60
decreased hematocrit 40 | 46
increased blood urea nitrogen ... 40 | 48
decreased circulating alkaline... 38 | 46
decreased neutrophil cell numb... 37 | 42
increased hematocrit 37 | 46
increased hemoglobin content 37 | 45
increased neutrophil cell numb... 37 | 46
abnormal bone mineralization 36 | 38
abnormal testis morphology 36 | 43
enlarged spleen 36 | 41
increased leukocyte cell numbe... 36 | 47
increased mean platelet volume 36 | 45
decreased circulating LDL chol... 35 | 38
increased circulating triglyce... 34 | 42
increased grip strength 34 | 41
increased mean corpuscular hem... 34 | 36
tremors 34 | 39
abnormal cranium morphology 33 | 36
decreased red blood cell distr... 33 | 41
enlarged lymph nodes 33 | 37
increased erythrocyte cell num... 32 | 39
pallor 32 | 34

Disease

Carcinoma 8,823 | 11,493
ovarian cancer 7,648 | 8,520
osteosarcoma 6,926 | 7,950
medulloblastoma, large-cell 5,283 | 6,241
psoriasis 5,004 | 6,694
glioblastoma 4,969 | 5,792
atypical teratoid / rhabdoid tumor 4,351 | 5,112
lung cancer 4,116 | 4,740
ependymoma 3,892 | 4,679
group 3 medulloblastoma 3,464 | 4,104
adult high grade glioma 3,090 | 3,801
Breast cancer 3,063 | 3,578
malignant mesothelioma 2,909 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,856 | 3,291
primitive neuroectodermal tumor 2,560 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,559 | 2,989
invasive ductal carcinoma 2,539 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,503 | 2,955
Astrocytoma, Pilocytic 2,455 | 3,081
non-small cell lung cancer 2,412 | 2,890
oligodendroglioma 2,361 | 2,850
lung carcinoma 2,229 | 2,843
lung adenocarcinoma 2,204 | 2,716
astrocytic glioma 2,160 | 2,597
Cancer 2,079 | 2,499
pancreatic cancer 2,061 | 2,398
Kidney cancer 2,055 | 2,613
subependymal giant cell astrocytoma 1,965 | 2,287
interstitial cystitis 1,805 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,788 | 1,962
tuberculosis 1,763 | 2,010
Pick disease 1,657 | 1,894
group 4 medulloblastoma 1,615 | 1,855
pituitary cancer 1,574 | 1,972
ulcerative colitis 1,526 | 1,819
ductal carcinoma in situ 1,472 | 1,745
cystic fibrosis 1,412 | 1,696
breast carcinoma 1,378 | 1,638
Multiple myeloma 1,300 | 1,332
diabetes mellitus 1,269 | 1,728
adrenocortical carcinoma 1,249 | 1,428
colon cancer 1,215 | 1,478
Autosomal recessive predisposition 1,162 | 1,442
juvenile dermatomyositis 1,114 | 1,187
acute quadriplegic myopathy 1,089 | 1,158
Rheumatoid arthritis 1,045 | 1,191
astrocytoma 1,037 | 1,146
primary pancreatic ductal adenocarcinoma 995 | 1,109
spina bifida 964 | 1,074
pediatric high grade glioma 935 | 1,064
dermatomyositis 930 | 966
Intellectual disability 888 | 1,016
Schizophrenia 860 | 1,160
nasopharyngeal carcinoma 852 | 1,058
cutaneous lupus erythematosus 810 | 1,057
active Crohn's disease 758 | 922
non primary Sjogren syndrome sicca 753 | 891
Waldenstrons macroglobulinemia 735 | 765
acute myeloid leukemia 733 | 783
Atopic dermatitis 708 | 952
gastric carcinoma 698 | 807
Liver Cirrhosis, Experimental 650 | 769
Epilepsy 642 | 792
primary Sjogren syndrome 630 | 735
esophageal adenocarcinoma 626 | 737
medulloblastoma 625 | 720
active ulcerative colitis 618 | 764
progressive supranuclear palsy 617 | 676
aldosterone-producing adenoma 590 | 665
Dull intelligence 560 | 645
Low intelligence 560 | 645
Mental Retardation 560 | 645
Mental deficiency 560 | 645
Poor school performance 560 | 645
Cognitive delay 552 | 608
Global developmental delay 552 | 608
Mental and motor retardation 552 | 608
Alzheimer's disease 532 | 658
Duchenne muscular dystrophy 530 | 601
Muscle hypotonia 513 | 571
pancreatic carcinoma 511 | 562
Obesity 502 | 678
hepatocellular carcinoma 501 | 547
Seizures 492 | 596
Bipolar Disorder 478 | 666
Melanoma 464 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 464 | 510
Short stature 458 | 531
Liver cancer 455 | 604
fibroadenoma 437 | 559
Down syndrome 436 | 499
Endometriosis 436 | 540
Prostatic Neoplasms 427 | 495
gastric cancer 420 | 459
chronic rhinosinusitis 407 | 512
Amyotrophic lateral sclerosis 404 | 451
sonic hedgehog group medulloblastoma 401 | 467
posterior fossa group A ependymoma 398 | 468
tuberculosis and treatment for 6 months 397 | 409
Multiple Sclerosis 390 | 540

Tissue

Endocrine System 14,240 | 18,159
Female tissues 14,154 | 17,400
Digestive Tract 14,137 | 17,369
Skin and soft tissues 14,135 | 17,230
Male tissues 14,082 | 17,142
Blood and immune system 14,074 | 16,909
Liver and Pancreas 14,024 | 16,750
Nervous System 13,999 | 16,725
Urinary Tract 13,988 | 16,678
Respiratory system 13,910 | 16,393
Cardiovascular System 13,399 | 15,192

Target Family

Non-IDG 8,438 | 12,091
Enzyme 3,379 | 4,145
Transcription Factor 1,066 | 1,400
Kinase 555 | 634
Transporter 332 | 473
Epigenetic 223 | 242
GPCR 193 | 408
Ion Channel 193 | 344
Nuclear Receptor 36 | 48
TF/Epigenetic 35 | 38
oGPCR 11 | 421

HCA RNA Cell Line

TIME 14,461 | 14,461
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29