Development Level

Tbio 9,763 | 11,178
Tdark 3,951 | 6,569
Tchem 1,635 | 1,885
Tclin 484 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 456 | 499
abnormal behavior 276 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 178 | 210
abnormal bone structure 167 | 187
decreased vertical activity 163 | 208
increased lean body mass 154 | 172
decreased body weight 151 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 133 | 151
hyperactivity 133 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 120 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 112 | 122
decreased bone mineral density 108 | 126
increased startle reflex 105 | 112
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
male infertility 99 | 123
increased bone mineral content 94 | 108
abnormal seminal vesicle morph... 92 | 114
decreased body length 92 | 101
increased or absent threshold ... 90 | 101
cataract 88 | 92
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 86 | 96
short tibia 86 | 97
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased circulating serum al... 74 | 82
decreased lymphocyte cell numb... 72 | 83
decreased mean corpuscular vol... 72 | 79
decreased circulating triglyce... 71 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 68 | 80
increased fasted circulating g... 68 | 76
abnormal eye morphology 66 | 68
decreased circulating insulin ... 66 | 76
decreased leukocyte cell numbe... 66 | 73
decreased startle reflex 66 | 75
improved glucose tolerance 65 | 79
small superior vagus ganglion 65 | 74
abnormal retina morphology 64 | 71
abnormal sleep behavior 64 | 70
impaired glucose tolerance 63 | 75
abnormal gait 62 | 69
increased circulating sodium l... 62 | 71
decreased circulating HDL chol... 61 | 68
decreased hemoglobin content 61 | 68
abnormal coat-hair pigmentatio... 59 | 64
increased heart weight 59 | 62
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
increased circulating choleste... 57 | 66
decreased erythrocyte cell num... 56 | 62
edema 56 | 59
small testis 55 | 58
thrombocytopenia 53 | 56
increased monocyte cell number 52 | 63
decreased caudal vertebrae num... 51 | 53
decreased fasted circulating g... 51 | 65
female infertility 51 | 60
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 47 | 50
decreased circulating total pr... 45 | 49
hydrometra 45 | 53
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
abnormal skin morphology 43 | 50
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 42 | 48
increased leukocyte cell numbe... 42 | 47
abnormal testis morphology 41 | 43
increased hemoglobin content 41 | 45
increased hematocrit 40 | 46
decreased red blood cell distr... 39 | 41
decreased neutrophil cell numb... 38 | 42
enlarged spleen 38 | 41
increased mean platelet volume 38 | 45
abnormal epididymis morphology 37 | 42
abnormal bone mineralization 36 | 38
increased circulating chloride... 36 | 41
limb grasping 36 | 41
tremors 36 | 39
increased circulating triglyce... 35 | 42
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
decreased circulating LDL chol... 34 | 38
enlarged lymph nodes 34 | 37

Disease

Carcinoma 9,379 | 11,192
ovarian cancer 7,740 | 8,297
osteosarcoma 7,177 | 7,766
medulloblastoma, large-cell 5,495 | 6,086
psoriasis 5,386 | 6,514
glioblastoma 5,181 | 5,635
atypical teratoid / rhabdoid tumor 4,531 | 4,971
lung cancer 4,233 | 4,607
ependymoma 4,080 | 4,559
group 3 medulloblastoma 3,662 | 4,002
adult high grade glioma 3,273 | 3,701
Breast cancer 3,129 | 3,469
malignant mesothelioma 2,969 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,937 | 3,204
primitive neuroectodermal tumor 2,693 | 2,957
Astrocytoma, Pilocytic 2,668 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,642 | 2,902
invasive ductal carcinoma 2,632 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,605 | 2,872
non-small cell lung cancer 2,533 | 2,799
oligodendroglioma 2,486 | 2,768
lung carcinoma 2,394 | 2,755
lung adenocarcinoma 2,305 | 2,627
astrocytic glioma 2,278 | 2,530
Kidney cancer 2,178 | 2,548
Cancer 2,129 | 2,388
pancreatic cancer 2,106 | 2,322
subependymal giant cell astrocytoma 2,068 | 2,230
interstitial cystitis 1,985 | 2,237
tuberculosis 1,851 | 1,963
pancreatic ductal adenocarcinoma liver metastasis 1,786 | 1,911
Pick disease 1,729 | 1,856
pituitary cancer 1,689 | 1,915
group 4 medulloblastoma 1,680 | 1,806
ulcerative colitis 1,605 | 1,765
ductal carcinoma in situ 1,524 | 1,686
cystic fibrosis 1,455 | 1,629
breast carcinoma 1,418 | 1,589
diabetes mellitus 1,328 | 1,683
adrenocortical carcinoma 1,284 | 1,385
Multiple myeloma 1,273 | 1,296
colon cancer 1,268 | 1,428
Autosomal recessive predisposition 1,231 | 1,407
juvenile dermatomyositis 1,101 | 1,147
acute quadriplegic myopathy 1,087 | 1,133
Rheumatoid arthritis 1,075 | 1,156
astrocytoma 1,063 | 1,113
primary pancreatic ductal adenocarcinoma 1,002 | 1,071
spina bifida 996 | 1,053
pediatric high grade glioma 970 | 1,035
Schizophrenia 944 | 1,136
dermatomyositis 924 | 941
Intellectual disability 917 | 998
cutaneous lupus erythematosus 905 | 1,016
nasopharyngeal carcinoma 877 | 1,024
active Crohn's disease 810 | 882
non primary Sjogren syndrome sicca 776 | 861
Atopic dermatitis 747 | 915
acute myeloid leukemia 737 | 760
Waldenstrons macroglobulinemia 732 | 742
gastric carcinoma 721 | 781
Epilepsy 689 | 775
active ulcerative colitis 667 | 736
primary Sjogren syndrome 666 | 710
Liver Cirrhosis, Experimental 661 | 733
medulloblastoma 640 | 702
esophageal adenocarcinoma 625 | 696
progressive supranuclear palsy 619 | 656
aldosterone-producing adenoma 598 | 646
Dull intelligence 583 | 634
Low intelligence 583 | 634
Mental Retardation 583 | 634
Mental deficiency 583 | 634
Poor school performance 583 | 634
Alzheimer's disease 561 | 640
Cognitive delay 561 | 596
Global developmental delay 561 | 596
Mental and motor retardation 561 | 596
Obesity 553 | 655
Seizures 536 | 584
Duchenne muscular dystrophy 535 | 587
Muscle hypotonia 532 | 562
Bipolar Disorder 530 | 646
Melanoma 521 | 689
pancreatic carcinoma 521 | 555
hepatocellular carcinoma 514 | 536
Short stature 480 | 514
Liver cancer 478 | 589
fibroadenoma 469 | 538
Endometriosis 458 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 456 | 492
Down syndrome 441 | 480
chronic rhinosinusitis 437 | 505
Multiple Sclerosis 435 | 527
gastric cancer 426 | 445
Prostatic Neoplasms 424 | 472
sonic hedgehog group medulloblastoma 422 | 459
mucosa-associated lymphoid tissue lymphoma 419 | 473
posterior fossa group A ependymoma 419 | 456
Amyotrophic lateral sclerosis 403 | 437

Tissue

Endocrine System 15,565 | 18,159
Female tissues 15,366 | 17,400
Digestive Tract 15,361 | 17,369
Skin and soft tissues 15,328 | 17,230
Male tissues 15,247 | 17,142
Blood and immune system 15,224 | 16,909
Nervous System 15,117 | 16,725
Liver and Pancreas 15,108 | 16,750
Urinary Tract 15,064 | 16,678
Respiratory system 14,944 | 16,393
Cardiovascular System 14,186 | 15,192

Target Family

Non-IDG 9,196 | 12,091
Enzyme 3,601 | 4,145
Transcription Factor 1,244 | 1,400
Kinase 592 | 634
Transporter 382 | 473
GPCR 255 | 408
Ion Channel 238 | 344
Epigenetic 228 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 35 | 38
oGPCR 21 | 421

HCA RNA Cell Line

THP-1 15,833 | 15,833
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101