Development Level

Tbio 9,987 | 11,445
Tdark 3,959 | 6,588
Tchem 1,402 | 1,598
Tclin 485 | 613

Collection

RFA-RM-18-021 239 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 69 | 99
GPCR: IDG Consortium (Targets) 63 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 942 | 979
preweaning lethality, incomple... 456 | 499
abnormal behavior 276 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 181 | 207
enlarged heart 178 | 210
abnormal bone structure 167 | 187
decreased vertical activity 163 | 208
increased lean body mass 154 | 172
decreased body weight 151 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 133 | 151
hyperactivity 133 | 148
decreased lean body mass 122 | 135
increased total body fat amoun... 120 | 134
hypoactivity 116 | 132
decreased circulating glucose ... 113 | 126
increased circulating alkaline... 112 | 122
decreased bone mineral density 108 | 126
increased startle reflex 105 | 112
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
male infertility 99 | 123
increased bone mineral content 94 | 108
abnormal seminal vesicle morph... 92 | 114
decreased body length 92 | 101
increased or absent threshold ... 90 | 101
cataract 88 | 92
increased mean corpuscular vol... 87 | 92
decreased circulating choleste... 86 | 93
increased mean corpuscular hem... 86 | 96
short tibia 86 | 97
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 77 | 81
decreased prepulse inhibition 77 | 82
decreased circulating serum al... 74 | 82
decreased lymphocyte cell numb... 72 | 83
decreased mean corpuscular vol... 72 | 79
decreased circulating triglyce... 71 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 68 | 80
increased fasted circulating g... 68 | 76
abnormal eye morphology 66 | 68
decreased circulating insulin ... 66 | 76
decreased leukocyte cell numbe... 66 | 73
decreased startle reflex 66 | 75
improved glucose tolerance 65 | 79
small superior vagus ganglion 65 | 74
abnormal retina morphology 64 | 71
abnormal sleep behavior 64 | 70
impaired glucose tolerance 63 | 75
abnormal gait 62 | 69
increased circulating sodium l... 62 | 71
decreased circulating HDL chol... 61 | 68
decreased hemoglobin content 61 | 68
abnormal coat-hair pigmentatio... 59 | 64
increased heart weight 59 | 62
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
increased circulating choleste... 57 | 66
decreased erythrocyte cell num... 56 | 62
edema 56 | 59
small testis 55 | 58
thrombocytopenia 53 | 56
increased monocyte cell number 52 | 63
decreased caudal vertebrae num... 51 | 53
decreased fasted circulating g... 51 | 65
female infertility 51 | 60
abnormal spleen morphology 49 | 55
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 47 | 50
decreased circulating total pr... 45 | 49
hydrometra 45 | 53
abnormal neural tube closure 44 | 46
decreased circulating alkaline... 44 | 46
abnormal skin morphology 43 | 50
decreased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
decreased circulating alanine ... 42 | 47
increased blood urea nitrogen ... 42 | 48
increased leukocyte cell numbe... 42 | 47
abnormal testis morphology 41 | 43
increased hemoglobin content 41 | 45
increased hematocrit 40 | 46
decreased red blood cell distr... 39 | 41
decreased neutrophil cell numb... 38 | 42
enlarged spleen 38 | 41
increased mean platelet volume 38 | 45
abnormal epididymis morphology 37 | 42
abnormal bone mineralization 36 | 38
increased circulating chloride... 36 | 41
limb grasping 36 | 41
tremors 36 | 39
increased circulating triglyce... 35 | 42
increased erythrocyte cell num... 35 | 39
increased grip strength 35 | 41
decreased circulating LDL chol... 34 | 38
enlarged lymph nodes 34 | 37

Disease

Carcinoma 9,616 | 11,493
ovarian cancer 7,945 | 8,520
osteosarcoma 7,341 | 7,950
medulloblastoma, large-cell 5,634 | 6,241
psoriasis 5,532 | 6,694
glioblastoma 5,325 | 5,792
atypical teratoid / rhabdoid tumor 4,664 | 5,112
lung cancer 4,348 | 4,740
ependymoma 4,187 | 4,679
group 3 medulloblastoma 3,751 | 4,104
adult high grade glioma 3,364 | 3,801
Breast cancer 3,223 | 3,578
malignant mesothelioma 3,060 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,014 | 3,291
primitive neuroectodermal tumor 2,764 | 3,035
Astrocytoma, Pilocytic 2,738 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,720 | 2,989
invasive ductal carcinoma 2,707 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,678 | 2,955
non-small cell lung cancer 2,612 | 2,890
oligodendroglioma 2,561 | 2,850
lung carcinoma 2,470 | 2,843
lung adenocarcinoma 2,384 | 2,716
astrocytic glioma 2,338 | 2,597
Kidney cancer 2,230 | 2,613
Cancer 2,226 | 2,499
pancreatic cancer 2,168 | 2,398
subependymal giant cell astrocytoma 2,118 | 2,287
interstitial cystitis 2,051 | 2,312
tuberculosis 1,897 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,832 | 1,962
Pick disease 1,762 | 1,894
pituitary cancer 1,739 | 1,972
group 4 medulloblastoma 1,724 | 1,855
ulcerative colitis 1,648 | 1,819
ductal carcinoma in situ 1,577 | 1,745
cystic fibrosis 1,511 | 1,696
breast carcinoma 1,461 | 1,638
diabetes mellitus 1,367 | 1,728
adrenocortical carcinoma 1,325 | 1,428
colon cancer 1,310 | 1,478
Multiple myeloma 1,309 | 1,332
Autosomal recessive predisposition 1,260 | 1,442
juvenile dermatomyositis 1,139 | 1,187
acute quadriplegic myopathy 1,110 | 1,158
Rheumatoid arthritis 1,108 | 1,191
astrocytoma 1,095 | 1,146
primary pancreatic ductal adenocarcinoma 1,035 | 1,109
spina bifida 1,014 | 1,074
pediatric high grade glioma 995 | 1,064
Schizophrenia 963 | 1,160
dermatomyositis 949 | 966
cutaneous lupus erythematosus 940 | 1,057
Intellectual disability 934 | 1,016
nasopharyngeal carcinoma 906 | 1,058
active Crohn's disease 841 | 922
non primary Sjogren syndrome sicca 801 | 891
Atopic dermatitis 779 | 952
acute myeloid leukemia 760 | 783
Waldenstrons macroglobulinemia 755 | 765
gastric carcinoma 742 | 807
Epilepsy 703 | 792
Liver Cirrhosis, Experimental 694 | 769
active ulcerative colitis 692 | 764
primary Sjogren syndrome 690 | 735
esophageal adenocarcinoma 661 | 737
medulloblastoma 657 | 720
progressive supranuclear palsy 636 | 676
aldosterone-producing adenoma 616 | 665
Dull intelligence 594 | 645
Low intelligence 594 | 645
Mental Retardation 594 | 645
Mental deficiency 594 | 645
Poor school performance 594 | 645
Alzheimer's disease 577 | 658
Cognitive delay 571 | 608
Global developmental delay 571 | 608
Mental and motor retardation 571 | 608
Obesity 570 | 678
Bipolar Disorder 548 | 666
Duchenne muscular dystrophy 548 | 601
Seizures 546 | 596
Muscle hypotonia 540 | 571
Melanoma 537 | 711
pancreatic carcinoma 527 | 562
hepatocellular carcinoma 525 | 547
Short stature 493 | 531
Liver cancer 490 | 604
fibroadenoma 485 | 559
Endometriosis 475 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 510
Down syndrome 457 | 499
Multiple Sclerosis 447 | 540
Prostatic Neoplasms 442 | 495
chronic rhinosinusitis 442 | 512
gastric cancer 440 | 459
posterior fossa group A ependymoma 431 | 468
sonic hedgehog group medulloblastoma 430 | 467
mucosa-associated lymphoid tissue lymphoma 429 | 484
Amyotrophic lateral sclerosis 415 | 451

Tissue

Endocrine System 15,565 | 18,159
Female tissues 15,366 | 17,400
Digestive Tract 15,361 | 17,369
Skin and soft tissues 15,328 | 17,230
Male tissues 15,247 | 17,142
Blood and immune system 15,224 | 16,909
Nervous System 15,117 | 16,725
Liver and Pancreas 15,108 | 16,750
Urinary Tract 15,064 | 16,678
Respiratory system 14,944 | 16,393
Cardiovascular System 14,186 | 15,192

Target Family

Non-IDG 9,196 | 12,091
Enzyme 3,601 | 4,145
Transcription Factor 1,244 | 1,400
Kinase 592 | 634
Transporter 382 | 473
GPCR 255 | 408
Ion Channel 238 | 344
Epigenetic 228 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 35 | 38
oGPCR 21 | 421

HCA RNA Cell Line

THP-1 15,833 | 15,833
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endosomal/lysosomal potassium channel TMEM175 TMEM175 Tbio Non-IDG -0.65375 3.76 42
WASH complex subunit 2C WASHC2C Tbio Non-IDG -0.83634 0.00000 45
Transmembrane protein 170A TMEM170A Tdark Non-IDG 0.00000 1.18 3
Protein AF-9 MLLT3 Tbio Non-IDG -1.99555 93.8 210
Scm-like with four MBT domains protein 1 SFMBT1 Tbio Epigenetic -2.06810 112.0 113
Guanine deaminase GDA Tbio Enzyme -1.48687 32.3 196
ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 Tbio Transporter -0.85002 7.18 96
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 Tbio Enzyme -1.24396 15.5 189
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Solute carrier organic anion transporter family member 3A1 SLCO3A1 Tbio Transporter -1.39614 24.1 46