Development Level

Tbio 10,324 | 11,651
Tdark 4,160 | 6,593
Tchem 1,233 | 1,388
Tclin 496 | 612

Collection

RFA-RM-18-021 253 | 328
Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 269 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 177 | 210
abnormal bone structure 171 | 187
decreased vertical activity 170 | 208
increased lean body mass 159 | 172
decreased body weight 155 | 161
abnormal heart morphology 140 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
hypoactivity 119 | 132
increased total body fat amoun... 117 | 134
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 114 | 122
decreased bone mineral density 108 | 126
male infertility 107 | 123
decreased grip strength 104 | 116
increased startle reflex 104 | 112
embryonic growth retardation 103 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 95 | 114
increased or absent threshold ... 93 | 101
decreased body length 92 | 101
short tibia 92 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 86 | 92
cataract 85 | 92
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 74 | 79
decreased circulating serum al... 73 | 82
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 71 | 75
increased fasted circulating g... 71 | 76
increased bone mineral density 70 | 72
decreased circulating insulin ... 69 | 76
impaired glucose tolerance 69 | 75
decreased leukocyte cell numbe... 68 | 73
decreased circulating HDL chol... 67 | 68
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
abnormal retina morphology 65 | 71
increased circulating HDL chol... 65 | 80
improved glucose tolerance 64 | 79
increased circulating sodium l... 64 | 71
abnormal sleep behavior 62 | 70
increased heart weight 60 | 62
abnormal gait 59 | 69
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
decreased fasted circulating g... 58 | 65
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 56 | 65
edema 56 | 59
increased circulating choleste... 56 | 66
decreased erythrocyte cell num... 55 | 62
increased monocyte cell number 55 | 63
small testis 54 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 50 | 56
decreased mean corpuscular hem... 48 | 50
female infertility 48 | 60
hydrometra 48 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
abnormal skin morphology 45 | 50
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 45 | 48
decreased circulating alanine ... 44 | 47
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
decreased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased circulating triglyce... 40 | 42
increased leukocyte cell numbe... 40 | 47
enlarged spleen 39 | 41
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
decreased red blood cell distr... 38 | 41
limb grasping 38 | 41
tremors 38 | 39
decreased circulating LDL chol... 37 | 38
decreased neutrophil cell numb... 37 | 42
increased circulating chloride... 37 | 41
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 34 | 36
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,815 | 11,493
ovarian cancer 8,032 | 8,520
osteosarcoma 7,327 | 7,950
medulloblastoma, large-cell 5,758 | 6,241
psoriasis 5,724 | 6,694
glioblastoma 5,417 | 5,792
atypical teratoid / rhabdoid tumor 4,790 | 5,112
lung cancer 4,361 | 4,740
ependymoma 4,344 | 4,679
group 3 medulloblastoma 3,830 | 4,104
adult high grade glioma 3,469 | 3,801
Breast cancer 3,351 | 3,578
malignant mesothelioma 3,092 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,080 | 3,291
primitive neuroectodermal tumor 2,836 | 3,035
Astrocytoma, Pilocytic 2,812 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,768 | 2,989
invasive ductal carcinoma 2,741 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,733 | 2,955
oligodendroglioma 2,645 | 2,850
non-small cell lung cancer 2,629 | 2,890
lung carcinoma 2,500 | 2,843
lung adenocarcinoma 2,433 | 2,716
astrocytic glioma 2,406 | 2,597
Kidney cancer 2,298 | 2,613
Cancer 2,231 | 2,499
pancreatic cancer 2,217 | 2,398
subependymal giant cell astrocytoma 2,139 | 2,287
interstitial cystitis 2,030 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,863 | 1,962
tuberculosis 1,839 | 2,010
pituitary cancer 1,785 | 1,972
Pick disease 1,784 | 1,894
group 4 medulloblastoma 1,744 | 1,855
ductal carcinoma in situ 1,624 | 1,745
ulcerative colitis 1,620 | 1,819
cystic fibrosis 1,547 | 1,696
breast carcinoma 1,523 | 1,638
diabetes mellitus 1,363 | 1,728
colon cancer 1,339 | 1,478
adrenocortical carcinoma 1,334 | 1,428
Multiple myeloma 1,305 | 1,332
Autosomal recessive predisposition 1,279 | 1,442
juvenile dermatomyositis 1,140 | 1,187
acute quadriplegic myopathy 1,111 | 1,158
astrocytoma 1,100 | 1,146
Rheumatoid arthritis 1,098 | 1,191
primary pancreatic ductal adenocarcinoma 1,062 | 1,109
spina bifida 1,023 | 1,074
pediatric high grade glioma 1,014 | 1,064
Schizophrenia 989 | 1,160
nasopharyngeal carcinoma 956 | 1,058
Intellectual disability 953 | 1,016
dermatomyositis 937 | 966
cutaneous lupus erythematosus 905 | 1,057
active Crohn's disease 838 | 922
Atopic dermatitis 815 | 952
non primary Sjogren syndrome sicca 809 | 891
gastric carcinoma 760 | 807
acute myeloid leukemia 752 | 783
Waldenstrons macroglobulinemia 741 | 765
Epilepsy 729 | 792
active ulcerative colitis 688 | 764
Liver Cirrhosis, Experimental 686 | 769
esophageal adenocarcinoma 675 | 737
medulloblastoma 674 | 720
primary Sjogren syndrome 665 | 735
progressive supranuclear palsy 649 | 676
aldosterone-producing adenoma 628 | 665
Dull intelligence 606 | 645
Low intelligence 606 | 645
Mental Retardation 606 | 645
Mental deficiency 606 | 645
Poor school performance 606 | 645
Alzheimer's disease 580 | 658
Cognitive delay 580 | 608
Global developmental delay 580 | 608
Mental and motor retardation 580 | 608
Obesity 578 | 678
Bipolar Disorder 562 | 666
Melanoma 561 | 711
Duchenne muscular dystrophy 557 | 601
Seizures 549 | 596
Muscle hypotonia 548 | 571
Liver cancer 525 | 604
pancreatic carcinoma 523 | 562
hepatocellular carcinoma 522 | 547
fibroadenoma 514 | 559
Short stature 497 | 531
Endometriosis 494 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 510
Down syndrome 472 | 499
chronic rhinosinusitis 465 | 512
Prostatic Neoplasms 456 | 495
Multiple Sclerosis 445 | 540
sonic hedgehog group medulloblastoma 434 | 467
gastric cancer 433 | 459
posterior fossa group A ependymoma 430 | 468
Amyotrophic lateral sclerosis 423 | 451
Breast Neoplasms 414 | 445

Tissue

Endocrine System 15,922 | 18,159
Female tissues 15,692 | 17,400
Digestive Tract 15,682 | 17,369
Skin and soft tissues 15,633 | 17,230
Male tissues 15,553 | 17,142
Blood and immune system 15,445 | 16,909
Nervous System 15,399 | 16,725
Liver and Pancreas 15,352 | 16,750
Urinary Tract 15,309 | 16,678
Respiratory system 15,186 | 16,393
Cardiovascular System 14,317 | 15,192

Target Family

Non-IDG 9,455 | 12,091
Enzyme 3,663 | 4,145
Transcription Factor 1,245 | 1,400
Kinase 592 | 634
Transporter 397 | 473
Ion Channel 275 | 344
GPCR 258 | 408
Epigenetic 231 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38
oGPCR 21 | 421

HCA RNA Cell Line

T-47d 16,213 | 16,213
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298