Development Level

Tbio 9,371 | 10,625
Tdark 4,527 | 7,003
Tchem 1,653 | 1,890
Tclin 486 | 602

Collection

Eligible Kinase Proteins 120 | 134
Eligible Ion Channel Proteins 88 | 117
Eligible non-olfactory GPCR Proteins 73 | 145

IMPC Term

preweaning lethality, complete... 608 | 633
preweaning lethality, incomple... 241 | 260
abnormal behavior 215 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 177 | 186
decreased body weight 169 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 115 | 128
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 119
decreased circulating glucose ... 109 | 121
decreased grip strength 109 | 123
abnormal embryo size 103 | 112
decreased body length 103 | 108
hyperactivity 101 | 108
increased lean body mass 96 | 107
abnormal retina morphology 94 | 100
enlarged heart 92 | 111
increased mean corpuscular hem... 89 | 93
increased bone mineral content 85 | 92
increased mean corpuscular vol... 85 | 91
decreased circulating choleste... 83 | 85
hypoactivity 80 | 89
short tibia 80 | 82
decreased circulating triglyce... 77 | 83
decreased circulating HDL chol... 75 | 77
decreased circulating serum al... 72 | 79
increased grip strength 72 | 83
abnormal lens morphology 68 | 73
decreased circulating insulin ... 66 | 75
increased fasted circulating g... 65 | 68
increased circulating sodium l... 64 | 71
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 56 | 61
abnormal sleep behavior 55 | 63
decreased rib number 55 | 59
male infertility 55 | 62
abnormal bone mineralization 52 | 55
increased circulating HDL chol... 52 | 63
increased total body fat amoun... 51 | 57
decreased leukocyte cell numbe... 50 | 54
impaired glucose tolerance 50 | 52
abnormal coat/hair pigmentatio... 48 | 54
decreased mean corpuscular vol... 48 | 50
decreased prepulse inhibition 48 | 52
increased circulating choleste... 48 | 53
decreased circulating alanine ... 47 | 53
increased bone mineral density 47 | 52
increased exploration in new e... 47 | 56
decreased hemoglobin content 46 | 53
decreased startle reflex 46 | 48
abnormal gait 45 | 51
decreased caudal vertebrae num... 45 | 49
improved glucose tolerance 45 | 56
abnormal behavioral response t... 44 | 52
abnormal heart morphology 42 | 51
decreased fasted circulating g... 42 | 49
increased blood urea nitrogen ... 42 | 44
increased body weight 42 | 42
thrombocytopenia 42 | 46
increased hemoglobin content 41 | 45
decreased circulating total pr... 40 | 41
decreased erythrocyte cell num... 40 | 43
increased circulating chloride... 39 | 43
abnormal eye morphology 38 | 38
decreased circulating alkaline... 38 | 41
increased rib number 38 | 41
abnormal seminal vesicle morph... 37 | 47
decreased eosinophil cell numb... 37 | 41
decreased heart weight 37 | 44
decreased neutrophil cell numb... 37 | 37
decreased circulating LDL chol... 36 | 37
abnormal neural tube closure 35 | 37
decreased circulating free fat... 35 | 39
increased heart weight 34 | 37
small testis 34 | 37
abnormal spleen morphology 33 | 36
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
tremors 33 | 34
increased startle reflex 32 | 38
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
increased hematocrit 31 | 36
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
abnormal testis morphology 29 | 30
decreased T cell number 29 | 31
decreased blood urea nitrogen ... 29 | 31
abnormal epididymis morphology 28 | 31
cardiovascular system phenotyp... 28 | 35
decreased B cell number 28 | 30
decreased circulating chloride... 28 | 32
decreased NK T cell number 27 | 28
increased circulating calcium ... 27 | 32

Disease

ovarian cancer 7,921 | 8,492
osteosarcoma 7,242 | 7,933
medulloblastoma, large-cell 5,702 | 6,234
psoriasis 5,676 | 6,685
glioblastoma 5,169 | 5,572
lung cancer 4,142 | 4,473
atypical teratoid / rhabdoid tumor 4,054 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,052 | 3,289
malignant mesothelioma 3,014 | 3,163
Breast cancer 2,907 | 3,099
primitive neuroectodermal tumor 2,802 | 3,031
pilocytic astrocytoma 2,785 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,745 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,718 | 2,956
invasive ductal carcinoma 2,713 | 2,950
oligodendroglioma 2,621 | 2,849
non-small cell lung cancer 2,533 | 2,798
pediatric high grade glioma 2,512 | 2,712
lung carcinoma 2,487 | 2,844
lung adenocarcinoma 2,414 | 2,714
ependymoma 2,350 | 2,514
subependymal giant cell astrocytoma 2,121 | 2,287
pancreatic cancer 2,113 | 2,300
Cancer 2,081 | 2,346
group 3 medulloblastoma 2,078 | 2,254
astrocytic glioma 2,070 | 2,241
interstitial cystitis 2,013 | 2,299
adult high grade glioma 1,925 | 2,148
ulcerative colitis 1,858 | 2,087
Carcinoma 1,850 | 2,147
pituitary cancer 1,774 | 1,972
Pick disease 1,771 | 1,893
group 4 medulloblastoma 1,754 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,681 | 1,795
ductal carcinoma in situ 1,611 | 1,745
cystic fibrosis 1,514 | 1,670
breast carcinoma 1,489 | 1,614
tuberculosis 1,411 | 1,563
astrocytoma 1,404 | 1,493
medulloblastoma 1,402 | 1,524
posterior fossa group B ependymoma 1,394 | 1,530
sonic hedgehog group medulloblastoma 1,373 | 1,482
posterior fossa group A ependymoma 1,355 | 1,511
colon cancer 1,327 | 1,475
adrenocortical carcinoma 1,315 | 1,427
diabetes mellitus 1,302 | 1,663
Multiple myeloma 1,291 | 1,328
primary pancreatic ductal adenocarcinoma 1,213 | 1,271
juvenile dermatomyositis 1,132 | 1,189
acute quadriplegic myopathy 1,102 | 1,157
Rheumatoid Arthritis 1,068 | 1,171
atypical teratoid/rhabdoid tumor 1,015 | 1,095
spina bifida 1,006 | 1,064
nasopharyngeal carcinoma 950 | 1,056
dermatomyositis 933 | 967
cutaneous lupus erythematosus 896 | 1,056
active Crohn's disease 828 | 918
Atopic dermatitis 802 | 944
gastric carcinoma 779 | 832
non primary Sjogren syndrome sicca 754 | 840
acute myeloid leukemia 740 | 785
Waldenstrons macroglobulinemia 735 | 765
primary Sjogren syndrome 707 | 789
esophageal adenocarcinoma 672 | 737
tuberculosis and treatment for 6 months 657 | 686
progressive supranuclear palsy 642 | 674
aldosterone-producing adenoma 623 | 664
Alzheimer's disease 564 | 644
Duchenne muscular dystrophy 551 | 602
Intellectual disability 538 | 573
pancreatic carcinoma 524 | 567
hepatocellular carcinoma 523 | 550
Obesity 519 | 616
Down syndrome 517 | 548
fibroadenoma 510 | 557
Endometriosis 484 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 478 | 499
chronic rhinosinusitis 462 | 512
Prostatic Neoplasms 430 | 471
IGA Glomerulonephritis 423 | 454
active ulcerative colitis 423 | 477
Schizophrenia 422 | 503
gastric cancer 407 | 436
Multiple Sclerosis 404 | 498
Amyotrophic Lateral Sclerosis 402 | 432
mucosa-associated lymphoid tissue lymphoma 398 | 480
Mammary Neoplasms 381 | 410
inflammatory breast cancer 362 | 404
Neurodegenerative disease 356 | 383
non-small cell lung carcinoma 347 | 413
sarcoidosis 327 | 368
Kidney disease 325 | 397
glioblastoma multiforme 319 | 347
Parkinson's disease 316 | 364
Polycystic Ovary Syndrome 303 | 335
tuberculosis and treatment for 3 months 303 | 327
hereditary spastic paraplegia 302 | 313
Epilepsy 300 | 346
urothelial carcinoma 294 | 318
nephrosclerosis 273 | 329

Tissue

Nervous System 15,803 | 18,561
Female tissues 15,782 | 18,647
Digestive Tract 15,774 | 18,473
Endocrine System 15,769 | 18,512
Urinary Tract 15,710 | 18,444
Liver and Pancreas 15,682 | 18,136
Male tissues 15,665 | 17,969
Cardiovascular System 15,628 | 17,958
Blood and immune system 15,621 | 17,995
Skin and soft tissues 15,598 | 18,115
Respiratory system 15,452 | 17,484

Target Family

Non-IDG 9,326 | 11,969
Enzyme 3,637 | 4,146
Transcription Factor 1,241 | 1,400
Kinase 586 | 634
Transporter 397 | 473
Ion Channel 272 | 341
GPCR 258 | 408
Epigenetic 225 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 35 | 38
oGPCR 20 | 421

HCA RNA Cell Line

T-47d 16,037 | 16,037
U-2 OS 17,366 | 17,366
EFO-21 17,117 | 17,117
SCLC-21H 16,946 | 16,946
NTERA-2 16,846 | 16,846
U-266/70 16,556 | 16,556
BEWO 16,541 | 16,541
SH-SY5Y 16,521 | 16,521
HMC-1 16,394 | 16,394
NB-4 16,360 | 16,360
HaCaT 16,331 | 16,331
U-2197 16,301 | 16,301
U-266/84 16,257 | 16,257
U-251 MG 16,195 | 16,195
U-87 MG 16,106 | 16,106
Karpas-707 16,094 | 16,094
U-698 16,093 | 16,093
WM-115 16,065 | 16,065
K-562 16,049 | 16,049
U-937 15,988 | 15,988
AF22 15,979 | 15,979
SK-MEL-30 15,962 | 15,962
A-431 15,947 | 15,947
CAPAN-2 15,918 | 15,918
RPMI-8226 15,832 | 15,832
SK-BR-3 15,827 | 15,827
REH 15,783 | 15,783
U-138 MG 15,734 | 15,734
HEK 293 15,668 | 15,668
THP-1 15,652 | 15,652
MOLT-4 15,626 | 15,626
HDLM-2 15,579 | 15,579
Daudi 15,575 | 15,575
RH-30 15,520 | 15,520
HeLa 15,516 | 15,516
RT4 15,502 | 15,502
AN3-CA 15,463 | 15,463
BJ hTERT+ SV40 Large T+ 15,430 | 15,430
BJ hTERT+ SV40 Large T+ RasG12... 15,312 | 15,312
BJ 15,277 | 15,277
HTCEpi 15,272 | 15,272
CACO-2 15,255 | 15,255
PC-3 15,204 | 15,204
BJ hTERT+ 15,182 | 15,182
HEL 15,175 | 15,175
SiHa 15,107 | 15,107
RPTEC TERT1 15,102 | 15,102
MCF7 15,049 | 15,049
HBF TERT88 15,033 | 15,033
Hep G2 15,000 | 15,000
A549 14,995 | 14,995
HL-60 14,864 | 14,864
LHCN-M2 14,817 | 14,817
ASC TERT1 14,671 | 14,671
HUVEC TERT2 14,544 | 14,544
TIME 14,297 | 14,297

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.25741 172.1 240