Development Level

Tbio 9,912 | 11,178
Tdark 4,147 | 6,569
Tchem 1,658 | 1,885
Tclin 496 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 948 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 280 | 298
embryonic lethality prior to t... 269 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 195 | 207
enlarged heart 177 | 210
abnormal bone structure 171 | 187
decreased vertical activity 170 | 208
increased lean body mass 159 | 172
decreased body weight 155 | 161
abnormal heart morphology 140 | 162
hyperactivity 137 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 122 | 135
hypoactivity 119 | 132
increased total body fat amoun... 117 | 134
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 114 | 122
decreased bone mineral density 108 | 126
male infertility 107 | 123
decreased grip strength 104 | 116
increased startle reflex 104 | 112
embryonic growth retardation 103 | 106
increased bone mineral content 99 | 108
abnormal seminal vesicle morph... 95 | 114
increased or absent threshold ... 93 | 101
decreased body length 92 | 101
short tibia 92 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 88 | 96
increased mean corpuscular vol... 86 | 92
cataract 85 | 92
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 76 | 81
decreased lymphocyte cell numb... 76 | 83
decreased prepulse inhibition 75 | 82
decreased circulating triglyce... 74 | 79
decreased circulating serum al... 73 | 82
decreased mean corpuscular vol... 71 | 79
decreased startle reflex 71 | 75
increased fasted circulating g... 71 | 76
increased bone mineral density 70 | 72
decreased circulating insulin ... 69 | 76
impaired glucose tolerance 69 | 75
decreased leukocyte cell numbe... 68 | 73
decreased circulating HDL chol... 67 | 68
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
abnormal retina morphology 65 | 71
increased circulating HDL chol... 65 | 80
improved glucose tolerance 64 | 79
increased circulating sodium l... 64 | 71
abnormal sleep behavior 62 | 70
increased heart weight 60 | 62
abnormal gait 59 | 69
decreased hemoglobin content 59 | 68
abnormal coat-hair pigmentatio... 58 | 64
decreased fasted circulating g... 58 | 65
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 56 | 65
edema 56 | 59
increased circulating choleste... 56 | 66
decreased erythrocyte cell num... 55 | 62
increased monocyte cell number 55 | 63
small testis 54 | 58
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 51 | 53
thrombocytopenia 50 | 56
decreased mean corpuscular hem... 48 | 50
female infertility 48 | 60
hydrometra 48 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
abnormal skin morphology 45 | 50
decreased circulating alkaline... 45 | 46
increased blood urea nitrogen ... 45 | 48
decreased circulating alanine ... 44 | 47
increased hematocrit 42 | 46
increased neutrophil cell numb... 42 | 46
abnormal testis morphology 41 | 43
decreased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased circulating triglyce... 40 | 42
increased leukocyte cell numbe... 40 | 47
enlarged spleen 39 | 41
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
decreased red blood cell distr... 38 | 41
limb grasping 38 | 41
tremors 38 | 39
decreased circulating LDL chol... 37 | 38
decreased neutrophil cell numb... 37 | 42
increased circulating chloride... 37 | 41
abnormal bone mineralization 36 | 38
increased grip strength 36 | 41
abnormal cranium morphology 34 | 36
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,571 | 11,192
ovarian cancer 7,827 | 8,297
osteosarcoma 7,160 | 7,766
medulloblastoma, large-cell 5,620 | 6,086
psoriasis 5,577 | 6,514
glioblastoma 5,277 | 5,635
atypical teratoid / rhabdoid tumor 4,661 | 4,971
lung cancer 4,247 | 4,607
ependymoma 4,235 | 4,559
group 3 medulloblastoma 3,741 | 4,002
adult high grade glioma 3,385 | 3,701
Breast cancer 3,254 | 3,469
intraductal papillary-mucinous neoplasm (IPMN) 3,003 | 3,204
malignant mesothelioma 3,003 | 3,135
primitive neuroectodermal tumor 2,767 | 2,957
Astrocytoma, Pilocytic 2,745 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,692 | 2,902
invasive ductal carcinoma 2,665 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,658 | 2,872
oligodendroglioma 2,570 | 2,768
non-small cell lung cancer 2,549 | 2,799
lung carcinoma 2,422 | 2,755
lung adenocarcinoma 2,358 | 2,627
astrocytic glioma 2,345 | 2,530
Kidney cancer 2,250 | 2,548
pancreatic cancer 2,148 | 2,322
Cancer 2,131 | 2,388
subependymal giant cell astrocytoma 2,089 | 2,230
interstitial cystitis 1,965 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,814 | 1,911
tuberculosis 1,799 | 1,963
Pick disease 1,751 | 1,856
pituitary cancer 1,733 | 1,915
group 4 medulloblastoma 1,702 | 1,806
ulcerative colitis 1,575 | 1,765
ductal carcinoma in situ 1,570 | 1,686
cystic fibrosis 1,489 | 1,629
breast carcinoma 1,477 | 1,589
diabetes mellitus 1,321 | 1,683
colon cancer 1,296 | 1,428
adrenocortical carcinoma 1,293 | 1,385
Multiple myeloma 1,269 | 1,296
Autosomal recessive predisposition 1,248 | 1,407
juvenile dermatomyositis 1,102 | 1,147
acute quadriplegic myopathy 1,087 | 1,133
astrocytoma 1,069 | 1,113
Rheumatoid arthritis 1,064 | 1,156
primary pancreatic ductal adenocarcinoma 1,025 | 1,071
spina bifida 1,004 | 1,053
pediatric high grade glioma 985 | 1,035
Schizophrenia 969 | 1,136
Intellectual disability 936 | 998
nasopharyngeal carcinoma 927 | 1,024
dermatomyositis 912 | 941
cutaneous lupus erythematosus 875 | 1,016
active Crohn's disease 803 | 882
non primary Sjogren syndrome sicca 784 | 861
Atopic dermatitis 782 | 915
gastric carcinoma 737 | 781
acute myeloid leukemia 729 | 760
Waldenstrons macroglobulinemia 718 | 742
Epilepsy 712 | 775
active ulcerative colitis 663 | 736
medulloblastoma 657 | 702
Liver Cirrhosis, Experimental 652 | 733
primary Sjogren syndrome 642 | 710
esophageal adenocarcinoma 638 | 696
progressive supranuclear palsy 632 | 656
aldosterone-producing adenoma 612 | 646
Dull intelligence 596 | 634
Low intelligence 596 | 634
Mental Retardation 596 | 634
Mental deficiency 596 | 634
Poor school performance 596 | 634
Cognitive delay 569 | 596
Global developmental delay 569 | 596
Mental and motor retardation 569 | 596
Alzheimer's disease 562 | 640
Obesity 558 | 655
Melanoma 548 | 689
Duchenne muscular dystrophy 544 | 587
Bipolar Disorder 543 | 646
Muscle hypotonia 540 | 562
Seizures 537 | 584
pancreatic carcinoma 517 | 555
Liver cancer 515 | 589
hepatocellular carcinoma 511 | 536
fibroadenoma 495 | 538
Short stature 482 | 514
Endometriosis 476 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 472 | 492
chronic rhinosinusitis 458 | 505
Down syndrome 455 | 480
Multiple Sclerosis 435 | 527
Prostatic Neoplasms 434 | 472
sonic hedgehog group medulloblastoma 426 | 459
gastric cancer 419 | 445
posterior fossa group A ependymoma 419 | 456
Amyotrophic lateral sclerosis 410 | 437
mucosa-associated lymphoid tissue lymphoma 393 | 473

Tissue

Endocrine System 15,922 | 18,159
Female tissues 15,692 | 17,400
Digestive Tract 15,682 | 17,369
Skin and soft tissues 15,633 | 17,230
Male tissues 15,553 | 17,142
Blood and immune system 15,445 | 16,909
Nervous System 15,399 | 16,725
Liver and Pancreas 15,352 | 16,750
Urinary Tract 15,309 | 16,678
Respiratory system 15,186 | 16,393
Cardiovascular System 14,317 | 15,192

Target Family

Non-IDG 9,455 | 12,091
Enzyme 3,663 | 4,145
Transcription Factor 1,245 | 1,400
Kinase 592 | 634
Transporter 397 | 473
Ion Channel 275 | 344
GPCR 258 | 408
Epigenetic 231 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 36 | 38
oGPCR 21 | 421

HCA RNA Cell Line

T-47d 16,213 | 16,213
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
Melanoma-associated antigen B1 MAGEB1 Tbio Non-IDG -0.95979 9.05 218
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153
Neutral alpha-glucosidase C GANC Tchem Enzyme -1.74673 51.7 93