Development Level

Tbio 8,952 | 10,625
Tdark 4,114 | 7,003
Tchem 1,588 | 1,890
Tclin 452 | 602

Collection

Kinase: IDG Consortium (Targets) 106 | 125
Ion Channel: IDG Consortium (Targets) 67 | 102
GPCR: IDG Consortium (Targets) 62 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 19 | 26

IMPC Phenotype

preweaning lethality, complete... 599 | 633
preweaning lethality, incomple... 235 | 260
abnormal behavior 206 | 226
embryonic lethality prior to t... 181 | 187
decreased lean body mass 178 | 195
decreased total body fat amoun... 170 | 186
decreased body weight 163 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 145 | 157
abnormal bone structure 118 | 131
decreased bone mineral density 112 | 126
increased circulating alkaline... 112 | 119
increased or absent threshold ... 111 | 128
abnormal embryo size 103 | 112
decreased circulating glucose ... 103 | 121
decreased body length 101 | 108
decreased grip strength 101 | 123
hyperactivity 98 | 108
enlarged heart 92 | 111
increased lean body mass 92 | 107
abnormal retina morphology 90 | 100
increased mean corpuscular hem... 87 | 93
increased mean corpuscular vol... 86 | 91
increased bone mineral content 82 | 92
decreased circulating choleste... 78 | 85
hypoactivity 77 | 89
decreased circulating serum al... 73 | 79
decreased circulating triglyce... 73 | 83
short tibia 73 | 82
decreased circulating HDL chol... 71 | 77
increased grip strength 70 | 83
abnormal lens morphology 65 | 73
prenatal lethality prior to he... 62 | 64
increased fasted circulating g... 61 | 68
decreased circulating insulin ... 60 | 75
decreased lumbar vertebrae num... 59 | 62
increased circulating sodium l... 58 | 71
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 57 | 61
increased circulating HDL chol... 54 | 63
abnormal bone mineralization 53 | 55
abnormal sleep behavior 53 | 63
decreased rib number 52 | 59
decreased prepulse inhibition 49 | 52
increased total body fat amoun... 49 | 57
male infertility 49 | 62
decreased mean corpuscular vol... 48 | 50
increased exploration in new e... 48 | 56
abnormal coat-hair pigmentatio... 47 | 54
increased bone mineral density 47 | 52
increased circulating choleste... 47 | 53
decreased circulating alanine ... 46 | 53
decreased hemoglobin content 46 | 53
decreased startle reflex 45 | 48
impaired glucose tolerance 45 | 52
abnormal behavioral response t... 44 | 52
decreased caudal vertebrae num... 44 | 49
decreased leukocyte cell numbe... 44 | 54
abnormal gait 43 | 51
improved glucose tolerance 43 | 56
thrombocytopenia 43 | 46
decreased circulating total pr... 40 | 41
decreased erythrocyte cell num... 40 | 43
decreased fasted circulating g... 40 | 49
increased body weight 40 | 42
increased hemoglobin content 40 | 45
abnormal heart morphology 39 | 51
increased blood urea nitrogen ... 39 | 44
decreased heart weight 38 | 44
abnormal seminal vesicle morph... 35 | 47
decreased circulating LDL chol... 35 | 37
increased rib number 35 | 41
abnormal eye morphology 34 | 38
abnormal neural tube closure 34 | 37
decreased circulating alkaline... 34 | 41
decreased circulating free fat... 34 | 39
decreased neutrophil cell numb... 34 | 37
decreased eosinophil cell numb... 33 | 41
increased circulating chloride... 33 | 43
decreased mean corpuscular hem... 32 | 34
increased hematocrit 32 | 36
increased leukocyte cell numbe... 32 | 37
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
increased startle reflex 31 | 38
small testis 31 | 37
decreased threshold for audito... 30 | 32
tremors 30 | 34
decreased circulating calcium ... 29 | 33
decreased circulating fructosa... 29 | 31
increased heart weight 29 | 37
cardiovascular system phenotyp... 28 | 35
decreased T cell number 28 | 31
decreased circulating creatini... 28 | 31
increased circulating calcium ... 28 | 32
limb grasping 28 | 35
abnormal kidney morphology 27 | 30
decreased NK T cell number 27 | 28
female infertility 27 | 34
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,712 | 8,491
osteosarcoma 7,053 | 7,933
medulloblastoma, large-cell 5,451 | 6,234
psoriasis 5,304 | 6,685
glioblastoma 4,930 | 5,572
lung cancer 4,042 | 4,473
atypical teratoid / rhabdoid tumor 3,846 | 4,369
malignant mesothelioma 2,922 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 2,918 | 3,289
Breast cancer 2,779 | 3,098
primitive neuroectodermal tumor 2,663 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,609 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,594 | 2,956
pilocytic astrocytoma 2,592 | 3,086
invasive ductal carcinoma 2,582 | 2,950
oligodendroglioma 2,452 | 2,849
non-small cell lung cancer 2,450 | 2,798
pediatric high grade glioma 2,375 | 2,712
lung carcinoma 2,322 | 2,844
lung adenocarcinoma 2,295 | 2,714
ependymoma 2,227 | 2,514
pancreatic cancer 2,034 | 2,300
Cancer 2,031 | 2,346
subependymal giant cell astrocytoma 2,018 | 2,287
group 3 medulloblastoma 1,987 | 2,254
astrocytic glioma 1,950 | 2,241
interstitial cystitis 1,879 | 2,299
ulcerative colitis 1,819 | 2,087
adult high grade glioma 1,805 | 2,148
Pick disease 1,699 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 1,689 | 1,795
Carcinoma 1,683 | 2,147
group 4 medulloblastoma 1,678 | 1,875
pituitary cancer 1,662 | 1,972
ductal carcinoma in situ 1,523 | 1,745
cystic fibrosis 1,458 | 1,670
breast carcinoma 1,413 | 1,614
tuberculosis 1,389 | 1,563
astrocytoma 1,353 | 1,493
medulloblastoma 1,324 | 1,524
sonic hedgehog group medulloblastoma 1,309 | 1,482
posterior fossa group B ependymoma 1,291 | 1,530
Multiple myeloma 1,283 | 1,327
adrenocortical carcinoma 1,273 | 1,427
posterior fossa group A ependymoma 1,270 | 1,511
diabetes mellitus 1,265 | 1,663
colon cancer 1,264 | 1,475
primary pancreatic ductal adenocarcinoma 1,165 | 1,271
juvenile dermatomyositis 1,117 | 1,189
acute quadriplegic myopathy 1,089 | 1,157
Rheumatoid Arthritis 1,043 | 1,170
spina bifida 978 | 1,064
atypical teratoid/rhabdoid tumor 960 | 1,095
dermatomyositis 927 | 966
nasopharyngeal carcinoma 893 | 1,056
cutaneous lupus erythematosus 858 | 1,056
active Crohn's disease 800 | 918
Atopic dermatitis 755 | 944
Waldenstrons macroglobulinemia 740 | 764
gastric carcinoma 739 | 832
acute myeloid leukemia 734 | 785
non primary Sjogren syndrome sicca 716 | 840
primary Sjogren syndrome 681 | 788
esophageal adenocarcinoma 664 | 737
tuberculosis and treatment for 6 months 648 | 686
progressive supranuclear palsy 625 | 674
aldosterone-producing adenoma 601 | 664
Alzheimer's disease 542 | 644
Duchenne muscular dystrophy 532 | 602
pancreatic carcinoma 512 | 567
Intellectual disability 511 | 573
hepatocellular carcinoma 507 | 550
Obesity 497 | 616
Down syndrome 486 | 548
fibroadenoma 476 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 461 | 499
Endometriosis 460 | 535
Prostatic Neoplasms 427 | 471
chronic rhinosinusitis 425 | 512
IGA Glomerulonephritis 412 | 454
active ulcerative colitis 396 | 477
gastric cancer 396 | 436
Multiple Sclerosis 394 | 498
Amyotrophic Lateral Sclerosis 390 | 432
mucosa-associated lymphoid tissue lymphoma 382 | 480
Schizophrenia 377 | 503
Mammary Neoplasms 375 | 410
inflammatory breast cancer 347 | 404
Neurodegenerative disease 342 | 383
Kidney disease 322 | 397
sarcoidosis 322 | 368
non-small cell lung carcinoma 313 | 413
Polycystic Ovary Syndrome 303 | 334
Parkinson's disease 299 | 364
hereditary spastic paraplegia 299 | 313
glioblastoma multiforme 295 | 347
tuberculosis and treatment for 3 months 290 | 327
nephrosclerosis 273 | 329
urothelial carcinoma 268 | 318
Epilepsy 263 | 346

Tissue

Nervous System 14,915 | 18,560
Female tissues 14,897 | 18,646
Digestive Tract 14,890 | 18,472
Endocrine System 14,879 | 18,511
Urinary Tract 14,846 | 18,443
Liver and Pancreas 14,840 | 18,135
Male tissues 14,813 | 17,968
Cardiovascular System 14,804 | 17,957
Blood and immune system 14,802 | 17,994
Skin and soft tissues 14,741 | 18,114
Respiratory system 14,660 | 17,483

Target Family

Non-IDG 8,714 | 11,969
Enzyme 3,508 | 4,146
Transcription Factor 1,182 | 1,400
Kinase 568 | 634
Transporter 372 | 473
GPCR 230 | 408
Ion Channel 223 | 341
Epigenetic 222 | 242
Nuclear Receptor 40 | 48
TF/Epigenetic 33 | 38
oGPCR 14 | 421

HCA RNA Cell Line

SiHa 15,106 | 15,106
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66