Development Level

Tbio 9,858 | 11,651
Tdark 3,767 | 6,593
Tchem 1,201 | 1,388
Tclin 460 | 612

Collection

Kinase: IDG Consortium (Target... 108 | 125
Ion Channel: IDG Consortium (T... 65 | 99
GPCR: IDG Consortium (Targets) 62 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 932 | 979
preweaning lethality, incomple... 455 | 499
embryonic lethality prior to t... 267 | 278
abnormal behavior 264 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 207 | 220
decreased total body fat amoun... 184 | 207
enlarged heart 176 | 210
abnormal bone structure 163 | 187
decreased vertical activity 159 | 208
decreased body weight 153 | 161
increased lean body mass 151 | 172
abnormal heart morphology 136 | 162
decreased bone mineral content 130 | 151
hyperactivity 130 | 148
decreased lean body mass 117 | 135
increased total body fat amoun... 113 | 134
decreased circulating glucose ... 112 | 126
hypoactivity 112 | 132
increased circulating alkaline... 112 | 122
decreased bone mineral density 108 | 126
increased startle reflex 104 | 112
embryonic growth retardation 101 | 106
male infertility 100 | 123
increased bone mineral content 94 | 108
decreased grip strength 93 | 116
abnormal seminal vesicle morph... 92 | 114
decreased body length 89 | 101
increased mean corpuscular hem... 86 | 96
increased mean corpuscular vol... 86 | 92
short tibia 86 | 97
cataract 85 | 92
increased or absent threshold ... 85 | 101
decreased circulating choleste... 84 | 93
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 77 | 81
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 74 | 82
decreased mean corpuscular vol... 73 | 79
decreased circulating triglyce... 71 | 79
decreased lymphocyte cell numb... 70 | 83
increased bone mineral density 69 | 72
increased circulating HDL chol... 69 | 80
decreased startle reflex 68 | 75
increased fasted circulating g... 68 | 76
impaired glucose tolerance 65 | 75
abnormal retina morphology 64 | 71
decreased circulating HDL chol... 64 | 68
small superior vagus ganglion 64 | 74
abnormal sleep behavior 62 | 70
decreased circulating insulin ... 62 | 76
decreased leukocyte cell numbe... 62 | 73
abnormal eye morphology 60 | 68
decreased hemoglobin content 60 | 68
improved glucose tolerance 60 | 79
increased circulating choleste... 58 | 66
increased circulating sodium l... 58 | 71
abnormal behavioral response t... 56 | 66
abnormal coat-hair pigmentatio... 56 | 64
abnormal kidney morphology 56 | 65
decreased erythrocyte cell num... 56 | 62
increased heart weight 56 | 62
edema 55 | 59
abnormal gait 54 | 69
decreased fasted circulating g... 53 | 65
increased monocyte cell number 52 | 63
small testis 52 | 58
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
abnormal spleen morphology 50 | 55
decreased blood urea nitrogen ... 47 | 51
female infertility 47 | 60
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
hydrometra 46 | 53
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 44 | 47
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased blood urea nitrogen ... 41 | 48
increased leukocyte cell numbe... 41 | 47
abnormal skin morphology 40 | 50
decreased circulating alkaline... 40 | 46
increased hemoglobin content 40 | 45
increased neutrophil cell numb... 40 | 46
abnormal testis morphology 39 | 43
enlarged spleen 39 | 41
decreased red blood cell distr... 38 | 41
increased mean platelet volume 38 | 45
increased circulating triglyce... 37 | 42
abnormal bone mineralization 36 | 38
decreased circulating LDL chol... 36 | 38
decreased neutrophil cell numb... 36 | 42
tremors 36 | 39
increased erythrocyte cell num... 35 | 39
abnormal cranium morphology 34 | 36
increased grip strength 34 | 41
limb grasping 34 | 41
decreased circulating aspartat... 33 | 34
decreased circulating creatini... 33 | 39

Disease

Carcinoma 9,279 | 11,493
ovarian cancer 7,825 | 8,520
osteosarcoma 7,137 | 7,950
medulloblastoma, large-cell 5,509 | 6,241
psoriasis 5,352 | 6,694
glioblastoma 5,164 | 5,792
atypical teratoid / rhabdoid tumor 4,547 | 5,112
lung cancer 4,242 | 4,740
ependymoma 4,059 | 4,679
group 3 medulloblastoma 3,638 | 4,104
adult high grade glioma 3,266 | 3,801
Breast cancer 3,185 | 3,578
malignant mesothelioma 3,005 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,947 | 3,291
primitive neuroectodermal tumor 2,698 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,634 | 2,989
Astrocytoma, Pilocytic 2,618 | 3,081
invasive ductal carcinoma 2,611 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,610 | 2,955
non-small cell lung cancer 2,540 | 2,890
oligodendroglioma 2,476 | 2,850
lung carcinoma 2,337 | 2,843
lung adenocarcinoma 2,315 | 2,716
astrocytic glioma 2,270 | 2,597
Cancer 2,176 | 2,499
Kidney cancer 2,130 | 2,613
pancreatic cancer 2,120 | 2,398
subependymal giant cell astrocytoma 2,037 | 2,287
interstitial cystitis 1,898 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,866 | 1,962
tuberculosis 1,803 | 2,010
Pick disease 1,712 | 1,894
pituitary cancer 1,674 | 1,972
group 4 medulloblastoma 1,670 | 1,855
ulcerative colitis 1,582 | 1,819
ductal carcinoma in situ 1,538 | 1,745
cystic fibrosis 1,491 | 1,696
breast carcinoma 1,448 | 1,638
diabetes mellitus 1,330 | 1,728
Multiple myeloma 1,300 | 1,332
adrenocortical carcinoma 1,291 | 1,428
colon cancer 1,277 | 1,478
Autosomal recessive predisposition 1,250 | 1,442
juvenile dermatomyositis 1,125 | 1,187
acute quadriplegic myopathy 1,098 | 1,158
Rheumatoid arthritis 1,070 | 1,191
astrocytoma 1,066 | 1,146
primary pancreatic ductal adenocarcinoma 1,019 | 1,109
spina bifida 997 | 1,074
pediatric high grade glioma 961 | 1,064
dermatomyositis 932 | 966
Schizophrenia 924 | 1,160
Intellectual disability 921 | 1,016
nasopharyngeal carcinoma 899 | 1,058
cutaneous lupus erythematosus 867 | 1,057
active Crohn's disease 810 | 922
Atopic dermatitis 770 | 952
non primary Sjogren syndrome sicca 767 | 891
Waldenstrons macroglobulinemia 747 | 765
acute myeloid leukemia 745 | 783
gastric carcinoma 719 | 807
Epilepsy 680 | 792
Liver Cirrhosis, Experimental 674 | 769
esophageal adenocarcinoma 667 | 737
active ulcerative colitis 658 | 764
medulloblastoma 649 | 720
primary Sjogren syndrome 643 | 735
progressive supranuclear palsy 630 | 676
aldosterone-producing adenoma 606 | 665
Dull intelligence 594 | 645
Low intelligence 594 | 645
Mental Retardation 594 | 645
Mental deficiency 594 | 645
Poor school performance 594 | 645
Cognitive delay 573 | 608
Global developmental delay 573 | 608
Mental and motor retardation 573 | 608
Obesity 558 | 678
Alzheimer's disease 552 | 658
Duchenne muscular dystrophy 539 | 601
Muscle hypotonia 531 | 571
Seizures 528 | 596
Bipolar Disorder 517 | 666
pancreatic carcinoma 512 | 562
hepatocellular carcinoma 506 | 547
Melanoma 500 | 711
fibroadenoma 480 | 559
Short stature 478 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 473 | 510
Endometriosis 470 | 540
Liver cancer 459 | 604
Prostatic Neoplasms 451 | 495
Down syndrome 450 | 499
Multiple Sclerosis 432 | 540
chronic rhinosinusitis 428 | 512
gastric cancer 423 | 459
posterior fossa group A ependymoma 419 | 468
sonic hedgehog group medulloblastoma 419 | 467
Amyotrophic lateral sclerosis 412 | 451
Breast Neoplasms 410 | 445

Tissue

Endocrine System 15,030 | 18,159
Digestive Tract 14,907 | 17,369
Female tissues 14,890 | 17,400
Skin and soft tissues 14,855 | 17,230
Male tissues 14,782 | 17,142
Blood and immune system 14,728 | 16,909
Liver and Pancreas 14,700 | 16,750
Nervous System 14,666 | 16,725
Urinary Tract 14,666 | 16,678
Respiratory system 14,506 | 16,393
Cardiovascular System 13,830 | 15,192

Target Family

Non-IDG 8,847 | 12,091
Enzyme 3,535 | 4,145
Transcription Factor 1,185 | 1,400
Kinase 574 | 634
Transporter 372 | 473
GPCR 230 | 408
Epigenetic 228 | 242
Ion Channel 227 | 344
Nuclear Receptor 40 | 48
TF/Epigenetic 34 | 38
oGPCR 14 | 421

HCA RNA Cell Line

SiHa 15,286 | 15,286
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50