Development Level

Tbio 10,306 | 11,651
Tdark 4,114 | 6,593
Tchem 1,233 | 1,388
Tclin 489 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 66 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 18 | 25

IMPC Phenotype

preweaning lethality, complete... 943 | 979
preweaning lethality, incomple... 463 | 499
abnormal behavior 272 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 212 | 220
decreased total body fat amoun... 191 | 207
enlarged heart 179 | 210
decreased vertical activity 168 | 208
abnormal bone structure 166 | 187
increased lean body mass 156 | 172
decreased body weight 151 | 161
abnormal heart morphology 140 | 162
decreased bone mineral content 133 | 151
hyperactivity 132 | 148
decreased lean body mass 123 | 135
hypoactivity 119 | 132
increased total body fat amoun... 118 | 134
decreased bone mineral density 116 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 114 | 122
male infertility 106 | 123
increased startle reflex 102 | 112
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 96 | 114
decreased body length 95 | 101
increased or absent threshold ... 94 | 101
short tibia 90 | 97
decreased circulating choleste... 88 | 93
increased mean corpuscular hem... 88 | 96
cataract 86 | 92
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 84 | 87
decreased prepulse inhibition 79 | 82
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 75 | 79
decreased circulating serum al... 73 | 82
decreased lymphocyte cell numb... 72 | 83
increased circulating HDL chol... 72 | 80
increased fasted circulating g... 72 | 76
decreased circulating triglyce... 71 | 79
decreased startle reflex 71 | 75
increased bone mineral density 71 | 72
abnormal retina morphology 68 | 71
decreased leukocyte cell numbe... 66 | 73
abnormal eye morphology 65 | 68
impaired glucose tolerance 65 | 75
improved glucose tolerance 65 | 79
abnormal sleep behavior 64 | 70
decreased circulating HDL chol... 64 | 68
decreased circulating insulin ... 62 | 76
increased circulating choleste... 62 | 66
small superior vagus ganglion 62 | 74
decreased fasted circulating g... 60 | 65
decreased hemoglobin content 60 | 68
abnormal coat-hair pigmentatio... 59 | 64
abnormal gait 59 | 69
increased circulating sodium l... 59 | 71
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 57 | 65
decreased erythrocyte cell num... 57 | 62
edema 57 | 59
increased heart weight 57 | 62
increased monocyte cell number 54 | 63
small testis 53 | 58
decreased caudal vertebrae num... 52 | 53
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
female infertility 50 | 60
decreased blood urea nitrogen ... 49 | 51
decreased mean corpuscular hem... 48 | 50
decreased circulating total pr... 46 | 49
abnormal neural tube closure 45 | 46
hydrometra 45 | 53
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
increased leukocyte cell numbe... 44 | 47
increased blood urea nitrogen ... 43 | 48
increased hematocrit 43 | 46
decreased circulating alkaline... 41 | 46
decreased hematocrit 41 | 46
increased hemoglobin content 41 | 45
increased neutrophil cell numb... 41 | 46
enlarged spleen 40 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
decreased red blood cell distr... 38 | 41
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
decreased neutrophil cell numb... 37 | 42
increased grip strength 37 | 41
decreased circulating LDL chol... 36 | 38
increased circulating triglyce... 36 | 42
increased erythrocyte cell num... 36 | 39
limb grasping 36 | 41
tremors 36 | 39
decreased circulating creatini... 35 | 39
enlarged lymph nodes 35 | 37

Disease

Carcinoma 9,731 | 11,493
ovarian cancer 7,970 | 8,520
osteosarcoma 7,345 | 7,950
medulloblastoma, large-cell 5,693 | 6,241
psoriasis 5,687 | 6,694
glioblastoma 5,364 | 5,792
atypical teratoid / rhabdoid tumor 4,710 | 5,112
lung cancer 4,366 | 4,740
ependymoma 4,254 | 4,679
group 3 medulloblastoma 3,770 | 4,104
adult high grade glioma 3,414 | 3,801
Breast cancer 3,275 | 3,578
malignant mesothelioma 3,092 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,046 | 3,291
primitive neuroectodermal tumor 2,768 | 3,035
Astrocytoma, Pilocytic 2,765 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,753 | 2,989
invasive ductal carcinoma 2,721 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,708 | 2,955
non-small cell lung cancer 2,631 | 2,890
oligodendroglioma 2,577 | 2,850
lung carcinoma 2,482 | 2,843
lung adenocarcinoma 2,418 | 2,716
astrocytic glioma 2,348 | 2,597
Kidney cancer 2,250 | 2,613
Cancer 2,236 | 2,499
pancreatic cancer 2,199 | 2,398
subependymal giant cell astrocytoma 2,119 | 2,287
interstitial cystitis 2,031 | 2,312
tuberculosis 1,878 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,843 | 1,962
Pick disease 1,766 | 1,894
pituitary cancer 1,745 | 1,972
group 4 medulloblastoma 1,733 | 1,855
ulcerative colitis 1,637 | 1,819
ductal carcinoma in situ 1,583 | 1,745
cystic fibrosis 1,533 | 1,696
breast carcinoma 1,481 | 1,638
diabetes mellitus 1,373 | 1,728
adrenocortical carcinoma 1,340 | 1,428
colon cancer 1,318 | 1,478
Multiple myeloma 1,312 | 1,332
Autosomal recessive predisposition 1,291 | 1,442
juvenile dermatomyositis 1,141 | 1,187
acute quadriplegic myopathy 1,117 | 1,158
Rheumatoid arthritis 1,110 | 1,191
astrocytoma 1,092 | 1,146
primary pancreatic ductal adenocarcinoma 1,051 | 1,109
spina bifida 1,016 | 1,074
pediatric high grade glioma 996 | 1,064
Schizophrenia 961 | 1,160
cutaneous lupus erythematosus 943 | 1,057
dermatomyositis 943 | 966
Intellectual disability 940 | 1,016
nasopharyngeal carcinoma 939 | 1,058
active Crohn's disease 840 | 922
non primary Sjogren syndrome sicca 807 | 891
Atopic dermatitis 798 | 952
gastric carcinoma 755 | 807
acute myeloid leukemia 753 | 783
Waldenstrons macroglobulinemia 752 | 765
Epilepsy 698 | 792
Liver Cirrhosis, Experimental 689 | 769
active ulcerative colitis 688 | 764
primary Sjogren syndrome 677 | 735
medulloblastoma 667 | 720
esophageal adenocarcinoma 664 | 737
progressive supranuclear palsy 644 | 676
aldosterone-producing adenoma 620 | 665
Dull intelligence 600 | 645
Low intelligence 600 | 645
Mental Retardation 600 | 645
Mental deficiency 600 | 645
Poor school performance 600 | 645
Obesity 577 | 678
Alzheimer's disease 572 | 658
Cognitive delay 570 | 608
Global developmental delay 570 | 608
Mental and motor retardation 570 | 608
Duchenne muscular dystrophy 552 | 601
Bipolar Disorder 546 | 666
Seizures 542 | 596
Muscle hypotonia 539 | 571
Melanoma 534 | 711
pancreatic carcinoma 525 | 562
hepatocellular carcinoma 518 | 547
Liver cancer 505 | 604
fibroadenoma 497 | 559
Short stature 489 | 531
Endometriosis 484 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 475 | 510
Down syndrome 464 | 499
Prostatic Neoplasms 453 | 495
Multiple Sclerosis 450 | 540
chronic rhinosinusitis 450 | 512
gastric cancer 436 | 459
posterior fossa group A ependymoma 435 | 468
sonic hedgehog group medulloblastoma 422 | 467
Amyotrophic lateral sclerosis 421 | 451
mucosa-associated lymphoid tissue lymphoma 412 | 484

Tissue

Endocrine System 15,872 | 18,159
Female tissues 15,622 | 17,400
Digestive Tract 15,604 | 17,369
Skin and soft tissues 15,577 | 17,230
Male tissues 15,486 | 17,142
Blood and immune system 15,395 | 16,909
Nervous System 15,347 | 16,725
Liver and Pancreas 15,326 | 16,750
Urinary Tract 15,259 | 16,678
Respiratory system 15,138 | 16,393
Cardiovascular System 14,308 | 15,192

Target Family

Non-IDG 9,435 | 12,091
Enzyme 3,675 | 4,145
Transcription Factor 1,221 | 1,400
Kinase 591 | 634
Transporter 394 | 473
Ion Channel 248 | 344
GPCR 245 | 408
Epigenetic 230 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 37 | 38
oGPCR 25 | 421

HCA RNA Cell Line

SK-MEL-30 16,142 | 16,142
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50