Development Level

Tbio 9,806 | 11,178
Tdark 4,068 | 6,569
Tchem 1,649 | 1,885
Tclin 485 | 612

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 59 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 946 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 178 | 210
abnormal bone structure 174 | 187
decreased vertical activity 164 | 208
increased lean body mass 154 | 172
decreased body weight 148 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 137 | 151
hyperactivity 131 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 121 | 134
hypoactivity 119 | 132
decreased bone mineral density 117 | 126
increased circulating alkaline... 111 | 122
decreased circulating glucose ... 110 | 126
male infertility 105 | 123
increased startle reflex 104 | 112
embryonic growth retardation 101 | 106
decreased grip strength 99 | 116
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 96 | 114
decreased body length 94 | 101
short tibia 93 | 97
increased or absent threshold ... 91 | 101
cataract 87 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 76 | 81
decreased circulating serum al... 74 | 82
decreased prepulse inhibition 74 | 82
decreased lymphocyte cell numb... 73 | 83
decreased circulating triglyce... 71 | 79
decreased mean corpuscular vol... 71 | 79
decreased circulating insulin ... 70 | 76
impaired glucose tolerance 70 | 75
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased circulating HDL chol... 67 | 80
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
decreased circulating HDL chol... 65 | 68
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 63 | 73
abnormal sleep behavior 62 | 70
increased circulating sodium l... 62 | 71
abnormal gait 59 | 69
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
decreased hemoglobin content 58 | 68
abnormal coat-hair pigmentatio... 57 | 64
decreased erythrocyte cell num... 57 | 62
increased heart weight 57 | 62
edema 56 | 59
increased circulating choleste... 56 | 66
increased monocyte cell number 55 | 63
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
abnormal spleen morphology 49 | 55
thrombocytopenia 49 | 56
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
hydrometra 47 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating alkaline... 45 | 46
decreased circulating total pr... 45 | 49
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 43 | 47
abnormal skin morphology 42 | 50
increased neutrophil cell numb... 42 | 46
decreased hematocrit 41 | 46
increased blood urea nitrogen ... 41 | 48
increased hematocrit 41 | 46
abnormal testis morphology 40 | 43
increased leukocyte cell numbe... 40 | 47
increased circulating triglyce... 39 | 42
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
abnormal bone mineralization 36 | 38
decreased neutrophil cell numb... 36 | 42
increased circulating chloride... 36 | 41
tremors 36 | 39
abnormal cranium morphology 34 | 36
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,519 | 11,192
ovarian cancer 7,801 | 8,297
osteosarcoma 7,117 | 7,766
medulloblastoma, large-cell 5,559 | 6,086
psoriasis 5,533 | 6,514
glioblastoma 5,223 | 5,635
atypical teratoid / rhabdoid tumor 4,604 | 4,971
lung cancer 4,248 | 4,607
ependymoma 4,173 | 4,559
group 3 medulloblastoma 3,700 | 4,002
adult high grade glioma 3,333 | 3,701
Breast cancer 3,232 | 3,469
malignant mesothelioma 2,987 | 3,135
intraductal papillary-mucinous neoplasm (IPMN) 2,976 | 3,204
primitive neuroectodermal tumor 2,747 | 2,957
Astrocytoma, Pilocytic 2,706 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 2,685 | 2,902
invasive ductal carcinoma 2,649 | 2,867
intraductal papillary-mucinous adenoma (IPMA) 2,643 | 2,872
non-small cell lung cancer 2,541 | 2,799
oligodendroglioma 2,540 | 2,768
lung carcinoma 2,414 | 2,755
lung adenocarcinoma 2,336 | 2,627
astrocytic glioma 2,329 | 2,530
Kidney cancer 2,224 | 2,548
pancreatic cancer 2,129 | 2,322
Cancer 2,119 | 2,388
subependymal giant cell astrocytoma 2,072 | 2,230
interstitial cystitis 1,969 | 2,237
pancreatic ductal adenocarcinoma liver metastasis 1,805 | 1,911
tuberculosis 1,802 | 1,963
Pick disease 1,745 | 1,856
pituitary cancer 1,727 | 1,915
group 4 medulloblastoma 1,689 | 1,806
ulcerative colitis 1,570 | 1,765
ductal carcinoma in situ 1,553 | 1,686
cystic fibrosis 1,503 | 1,629
breast carcinoma 1,457 | 1,589
diabetes mellitus 1,321 | 1,683
adrenocortical carcinoma 1,291 | 1,385
colon cancer 1,287 | 1,428
Multiple myeloma 1,271 | 1,296
Autosomal recessive predisposition 1,245 | 1,407
juvenile dermatomyositis 1,102 | 1,147
acute quadriplegic myopathy 1,085 | 1,133
astrocytoma 1,065 | 1,113
Rheumatoid arthritis 1,058 | 1,156
spina bifida 1,006 | 1,053
primary pancreatic ductal adenocarcinoma 1,004 | 1,071
pediatric high grade glioma 977 | 1,035
Schizophrenia 952 | 1,136
Intellectual disability 925 | 998
nasopharyngeal carcinoma 923 | 1,024
dermatomyositis 916 | 941
cutaneous lupus erythematosus 891 | 1,016
active Crohn's disease 817 | 882
non primary Sjogren syndrome sicca 778 | 861
Atopic dermatitis 759 | 915
acute myeloid leukemia 727 | 760
gastric carcinoma 719 | 781
Waldenstrons macroglobulinemia 718 | 742
Epilepsy 690 | 775
active ulcerative colitis 677 | 736
Liver Cirrhosis, Experimental 653 | 733
medulloblastoma 652 | 702
esophageal adenocarcinoma 651 | 696
primary Sjogren syndrome 640 | 710
progressive supranuclear palsy 630 | 656
aldosterone-producing adenoma 610 | 646
Dull intelligence 584 | 634
Low intelligence 584 | 634
Mental Retardation 584 | 634
Mental deficiency 584 | 634
Poor school performance 584 | 634
Cognitive delay 567 | 596
Global developmental delay 567 | 596
Mental and motor retardation 567 | 596
Alzheimer's disease 554 | 640
Obesity 548 | 655
Bipolar Disorder 545 | 646
Melanoma 543 | 689
Duchenne muscular dystrophy 537 | 587
Muscle hypotonia 533 | 562
Seizures 527 | 584
pancreatic carcinoma 514 | 555
Liver cancer 507 | 589
hepatocellular carcinoma 503 | 536
fibroadenoma 483 | 538
Short stature 475 | 514
Endometriosis 468 | 521
autosomal dominant Emery-Dreifuss muscular dystrophy 458 | 492
Down syndrome 445 | 480
chronic rhinosinusitis 445 | 505
Prostatic Neoplasms 431 | 472
Multiple Sclerosis 426 | 527
posterior fossa group A ependymoma 425 | 456
sonic hedgehog group medulloblastoma 417 | 459
gastric cancer 415 | 445
Amyotrophic lateral sclerosis 414 | 437
tuberculosis and treatment for 6 months 395 | 399

Tissue

Endocrine System 15,725 | 18,159
Female tissues 15,513 | 17,400
Digestive Tract 15,499 | 17,369
Skin and soft tissues 15,437 | 17,230
Male tissues 15,386 | 17,142
Blood and immune system 15,310 | 16,909
Nervous System 15,210 | 16,725
Liver and Pancreas 15,209 | 16,750
Urinary Tract 15,164 | 16,678
Respiratory system 15,052 | 16,393
Cardiovascular System 14,211 | 15,192

Target Family

Non-IDG 9,325 | 12,091
Enzyme 3,651 | 4,145
Transcription Factor 1,206 | 1,400
Kinase 587 | 634
Transporter 390 | 473
Ion Channel 265 | 344
GPCR 246 | 408
Epigenetic 229 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 34 | 38
oGPCR 34 | 421

HCA RNA Cell Line

SK-BR-3 16,008 | 16,008
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Potassium voltage-gated channel subfamily H member 1 KCNH1 Tclin Ion Channel -2.86111 714.2 150
Appetite-regulating hormone GHRL Tchem Non-IDG -3.63688 5052.5 631
Transmembrane protein 256 TMEM256 Tdark Non-IDG 0.15 0.62 15
DENN domain-containing protein 1A DENND1A Tbio Non-IDG -1.14835 13.7 90
Beta-1,4-galactosyltransferase 7 B4GALT7 Tbio Enzyme -1.56894 38.8 65
Melanoma-associated antigen 9 MAGEA9B Tbio Non-IDG -1.32496 23.3 213
Melanoma-associated antigen 11 MAGEA11 Tbio Non-IDG -1.28291 22.2 180
Melanoma-associated antigen 12 MAGEA12 Tbio Non-IDG -1.35716 21.7 116
General transcription factor IIE subunit 1 GTF2E1 Tbio Non-IDG 0.16 0.68 153