Development Level

Tbio 10,210 | 11,651
Tdark 4,081 | 6,593
Tchem 1,232 | 1,388
Tclin 485 | 612

Collection

RFA-RM-18-021 248 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 78 | 99
GPCR: IDG Consortium (Targets) 59 | 126
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 946 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 273 | 298
embryonic lethality prior to t... 270 | 278
embryonic lethality prior to o... 236 | 239
abnormal embryo size 211 | 220
decreased total body fat amoun... 187 | 207
enlarged heart 178 | 210
abnormal bone structure 174 | 187
decreased vertical activity 164 | 208
increased lean body mass 154 | 172
decreased body weight 148 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 137 | 151
hyperactivity 131 | 148
decreased lean body mass 127 | 135
increased total body fat amoun... 121 | 134
hypoactivity 119 | 132
decreased bone mineral density 117 | 126
increased circulating alkaline... 111 | 122
decreased circulating glucose ... 110 | 126
male infertility 105 | 123
increased startle reflex 104 | 112
embryonic growth retardation 101 | 106
decreased grip strength 99 | 116
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 96 | 114
decreased body length 94 | 101
short tibia 93 | 97
increased or absent threshold ... 91 | 101
cataract 87 | 92
decreased circulating choleste... 87 | 93
increased mean corpuscular hem... 87 | 96
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 84 | 87
abnormal lens morphology 76 | 81
decreased circulating serum al... 74 | 82
decreased prepulse inhibition 74 | 82
decreased lymphocyte cell numb... 73 | 83
decreased circulating triglyce... 71 | 79
decreased mean corpuscular vol... 71 | 79
decreased circulating insulin ... 70 | 76
impaired glucose tolerance 70 | 75
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
increased fasted circulating g... 69 | 76
improved glucose tolerance 68 | 79
increased circulating HDL chol... 67 | 80
small superior vagus ganglion 67 | 74
abnormal eye morphology 66 | 68
decreased circulating HDL chol... 65 | 68
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 63 | 73
abnormal sleep behavior 62 | 70
increased circulating sodium l... 62 | 71
abnormal gait 59 | 69
abnormal behavioral response t... 58 | 66
abnormal kidney morphology 58 | 65
decreased fasted circulating g... 58 | 65
decreased hemoglobin content 58 | 68
abnormal coat-hair pigmentatio... 57 | 64
decreased erythrocyte cell num... 57 | 62
increased heart weight 57 | 62
edema 56 | 59
increased circulating choleste... 56 | 66
increased monocyte cell number 55 | 63
small testis 53 | 58
decreased caudal vertebrae num... 50 | 53
abnormal spleen morphology 49 | 55
thrombocytopenia 49 | 56
decreased mean corpuscular hem... 47 | 50
female infertility 47 | 60
hydrometra 47 | 53
decreased blood urea nitrogen ... 46 | 51
decreased circulating alkaline... 45 | 46
decreased circulating total pr... 45 | 49
abnormal neural tube closure 44 | 46
decreased circulating alanine ... 43 | 47
abnormal skin morphology 42 | 50
increased neutrophil cell numb... 42 | 46
decreased hematocrit 41 | 46
increased blood urea nitrogen ... 41 | 48
increased hematocrit 41 | 46
abnormal testis morphology 40 | 43
increased leukocyte cell numbe... 40 | 47
increased circulating triglyce... 39 | 42
increased mean platelet volume 39 | 45
abnormal epididymis morphology 38 | 42
enlarged spleen 38 | 41
increased hemoglobin content 38 | 45
limb grasping 38 | 41
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
abnormal bone mineralization 36 | 38
decreased neutrophil cell numb... 36 | 42
increased circulating chloride... 36 | 41
tremors 36 | 39
abnormal cranium morphology 34 | 36
increased mean corpuscular hem... 34 | 36

Disease

Carcinoma 9,756 | 11,493
ovarian cancer 8,006 | 8,520
osteosarcoma 7,282 | 7,950
medulloblastoma, large-cell 5,697 | 6,241
psoriasis 5,679 | 6,694
glioblastoma 5,362 | 5,792
atypical teratoid / rhabdoid tumor 4,732 | 5,112
lung cancer 4,366 | 4,740
ependymoma 4,279 | 4,679
group 3 medulloblastoma 3,790 | 4,104
adult high grade glioma 3,418 | 3,801
Breast cancer 3,329 | 3,578
malignant mesothelioma 3,079 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,053 | 3,291
primitive neuroectodermal tumor 2,814 | 3,035
Astrocytoma, Pilocytic 2,775 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,760 | 2,989
invasive ductal carcinoma 2,725 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,720 | 2,955
non-small cell lung cancer 2,621 | 2,890
oligodendroglioma 2,613 | 2,850
lung carcinoma 2,491 | 2,843
lung adenocarcinoma 2,414 | 2,716
astrocytic glioma 2,387 | 2,597
Kidney cancer 2,275 | 2,613
Cancer 2,214 | 2,499
pancreatic cancer 2,197 | 2,398
subependymal giant cell astrocytoma 2,122 | 2,287
interstitial cystitis 2,032 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,852 | 1,962
tuberculosis 1,845 | 2,010
Pick disease 1,779 | 1,894
pituitary cancer 1,778 | 1,972
group 4 medulloblastoma 1,735 | 1,855
ulcerative colitis 1,614 | 1,819
ductal carcinoma in situ 1,607 | 1,745
cystic fibrosis 1,557 | 1,696
breast carcinoma 1,500 | 1,638
diabetes mellitus 1,362 | 1,728
adrenocortical carcinoma 1,332 | 1,428
colon cancer 1,328 | 1,478
Multiple myeloma 1,307 | 1,332
Autosomal recessive predisposition 1,272 | 1,442
juvenile dermatomyositis 1,140 | 1,187
acute quadriplegic myopathy 1,109 | 1,158
astrocytoma 1,095 | 1,146
Rheumatoid arthritis 1,093 | 1,191
primary pancreatic ductal adenocarcinoma 1,038 | 1,109
spina bifida 1,025 | 1,074
pediatric high grade glioma 1,001 | 1,064
Schizophrenia 969 | 1,160
nasopharyngeal carcinoma 953 | 1,058
Intellectual disability 942 | 1,016
dermatomyositis 941 | 966
cutaneous lupus erythematosus 923 | 1,057
active Crohn's disease 851 | 922
non primary Sjogren syndrome sicca 801 | 891
Atopic dermatitis 791 | 952
acute myeloid leukemia 750 | 783
gastric carcinoma 743 | 807
Waldenstrons macroglobulinemia 741 | 765
Epilepsy 704 | 792
active ulcerative colitis 700 | 764
Liver Cirrhosis, Experimental 687 | 769
esophageal adenocarcinoma 685 | 737
medulloblastoma 668 | 720
primary Sjogren syndrome 662 | 735
progressive supranuclear palsy 647 | 676
aldosterone-producing adenoma 628 | 665
Dull intelligence 595 | 645
Low intelligence 595 | 645
Mental Retardation 595 | 645
Mental deficiency 595 | 645
Poor school performance 595 | 645
Cognitive delay 576 | 608
Global developmental delay 576 | 608
Mental and motor retardation 576 | 608
Alzheimer's disease 571 | 658
Obesity 568 | 678
Bipolar Disorder 562 | 666
Melanoma 558 | 711
Duchenne muscular dystrophy 551 | 601
Muscle hypotonia 540 | 571
Seizures 536 | 596
pancreatic carcinoma 520 | 562
Liver cancer 518 | 604
hepatocellular carcinoma 514 | 547
fibroadenoma 500 | 559
Short stature 487 | 531
Endometriosis 485 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 476 | 510
Down syndrome 462 | 499
Prostatic Neoplasms 451 | 495
chronic rhinosinusitis 451 | 512
Multiple Sclerosis 438 | 540
posterior fossa group A ependymoma 437 | 468
gastric cancer 429 | 459
Amyotrophic lateral sclerosis 427 | 451
sonic hedgehog group medulloblastoma 425 | 467
Breast Neoplasms 410 | 445

Tissue

Endocrine System 15,725 | 18,159
Female tissues 15,513 | 17,400
Digestive Tract 15,499 | 17,369
Skin and soft tissues 15,437 | 17,230
Male tissues 15,386 | 17,142
Blood and immune system 15,310 | 16,909
Nervous System 15,210 | 16,725
Liver and Pancreas 15,209 | 16,750
Urinary Tract 15,164 | 16,678
Respiratory system 15,052 | 16,393
Cardiovascular System 14,211 | 15,192

Target Family

Non-IDG 9,325 | 12,091
Enzyme 3,651 | 4,145
Transcription Factor 1,206 | 1,400
Kinase 587 | 634
Transporter 390 | 473
Ion Channel 265 | 344
GPCR 246 | 408
Epigenetic 229 | 242
Nuclear Receptor 41 | 48
TF/Epigenetic 34 | 38
oGPCR 34 | 421

HCA RNA Cell Line

SK-BR-3 16,008 | 16,008
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164