Development Level

Tbio 9,271 | 10,625
Tdark 4,439 | 7,003
Tchem 1,640 | 1,890
Tclin 477 | 602

Collection

Eligible Kinase Proteins 120 | 134
Eligible Ion Channel Proteins 87 | 117
Eligible non-olfactory GPCR Proteins 63 | 145

IMPC Term

preweaning lethality, complete... 610 | 633
preweaning lethality, incomple... 242 | 260
abnormal behavior 212 | 226
decreased lean body mass 183 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 172 | 186
decreased body weight 163 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 124 | 131
decreased bone mineral density 115 | 126
increased or absent threshold ... 112 | 128
decreased grip strength 111 | 123
increased circulating alkaline... 110 | 119
abnormal embryo size 105 | 112
decreased circulating glucose ... 104 | 121
decreased body length 103 | 108
hyperactivity 98 | 108
increased lean body mass 96 | 107
enlarged heart 94 | 111
abnormal retina morphology 91 | 100
increased mean corpuscular hem... 86 | 93
increased bone mineral content 84 | 92
increased mean corpuscular vol... 83 | 91
decreased circulating choleste... 82 | 85
hypoactivity 80 | 89
short tibia 76 | 82
decreased circulating HDL chol... 74 | 77
decreased circulating triglyce... 74 | 83
decreased circulating serum al... 73 | 79
increased grip strength 72 | 83
abnormal lens morphology 68 | 73
decreased circulating insulin ... 64 | 75
increased circulating sodium l... 62 | 71
increased fasted circulating g... 62 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 61 | 62
decreased rib number 57 | 59
abnormal retinal pigmentation 55 | 61
male infertility 55 | 62
abnormal sleep behavior 54 | 63
increased total body fat amoun... 54 | 57
abnormal bone mineralization 53 | 55
increased circulating HDL chol... 53 | 63
impaired glucose tolerance 51 | 52
improved glucose tolerance 49 | 56
increased bone mineral density 49 | 52
abnormal coat/hair pigmentatio... 48 | 54
decreased mean corpuscular vol... 47 | 50
decreased prepulse inhibition 47 | 52
increased circulating choleste... 47 | 53
abnormal behavioral response t... 46 | 52
decreased circulating alanine ... 46 | 53
decreased hemoglobin content 46 | 53
decreased leukocyte cell numbe... 46 | 54
increased exploration in new e... 46 | 56
decreased startle reflex 45 | 48
abnormal gait 44 | 51
decreased caudal vertebrae num... 44 | 49
decreased fasted circulating g... 42 | 49
thrombocytopenia 41 | 46
abnormal heart morphology 40 | 51
decreased erythrocyte cell num... 40 | 43
decreased heart weight 40 | 44
abnormal seminal vesicle morph... 39 | 47
decreased circulating alkaline... 39 | 41
decreased circulating total pr... 39 | 41
increased blood urea nitrogen ... 39 | 44
increased body weight 39 | 42
increased hemoglobin content 39 | 45
abnormal eye morphology 38 | 38
increased circulating chloride... 38 | 43
decreased eosinophil cell numb... 37 | 41
decreased neutrophil cell numb... 37 | 37
increased rib number 37 | 41
decreased circulating LDL chol... 36 | 37
decreased circulating free fat... 36 | 39
abnormal neural tube closure 34 | 37
increased startle reflex 34 | 38
small testis 34 | 37
decreased mean corpuscular hem... 33 | 34
increased leukocyte cell numbe... 33 | 37
increased heart weight 32 | 37
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
increased hematocrit 31 | 36
tremors 31 | 34
abnormal spleen morphology 30 | 36
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased T cell number 29 | 31
decreased blood urea nitrogen ... 29 | 31
abnormal testis morphology 28 | 30
decreased circulating creatini... 28 | 31
cardiovascular system phenotyp... 27 | 35
decreased NK T cell number 27 | 28
embryonic growth retardation 27 | 28
increased circulating calcium ... 27 | 32
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,897 | 8,492
osteosarcoma 7,197 | 7,933
medulloblastoma, large-cell 5,641 | 6,234
psoriasis 5,633 | 6,685
glioblastoma 5,115 | 5,572
lung cancer 4,145 | 4,473
atypical teratoid / rhabdoid tumor 4,010 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,024 | 3,289
malignant mesothelioma 3,001 | 3,163
Breast cancer 2,886 | 3,099
primitive neuroectodermal tumor 2,781 | 3,031
pilocytic astrocytoma 2,750 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,734 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,701 | 2,956
invasive ductal carcinoma 2,694 | 2,950
oligodendroglioma 2,588 | 2,849
non-small cell lung cancer 2,525 | 2,798
pediatric high grade glioma 2,491 | 2,712
lung carcinoma 2,477 | 2,844
lung adenocarcinoma 2,393 | 2,714
ependymoma 2,329 | 2,514
subependymal giant cell astrocytoma 2,105 | 2,287
pancreatic cancer 2,102 | 2,300
Cancer 2,069 | 2,346
group 3 medulloblastoma 2,062 | 2,254
astrocytic glioma 2,041 | 2,241
interstitial cystitis 2,014 | 2,299
adult high grade glioma 1,883 | 2,148
ulcerative colitis 1,860 | 2,087
Carcinoma 1,828 | 2,147
Pick disease 1,765 | 1,893
pituitary cancer 1,763 | 1,972
group 4 medulloblastoma 1,735 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,670 | 1,795
ductal carcinoma in situ 1,592 | 1,745
cystic fibrosis 1,525 | 1,670
breast carcinoma 1,465 | 1,614
tuberculosis 1,417 | 1,563
astrocytoma 1,408 | 1,493
medulloblastoma 1,381 | 1,524
posterior fossa group B ependymoma 1,365 | 1,530
sonic hedgehog group medulloblastoma 1,362 | 1,482
posterior fossa group A ependymoma 1,334 | 1,511
colon cancer 1,316 | 1,475
adrenocortical carcinoma 1,312 | 1,427
diabetes mellitus 1,299 | 1,663
Multiple myeloma 1,293 | 1,328
primary pancreatic ductal adenocarcinoma 1,190 | 1,271
juvenile dermatomyositis 1,132 | 1,189
acute quadriplegic myopathy 1,100 | 1,157
Rheumatoid Arthritis 1,062 | 1,171
spina bifida 1,006 | 1,064
atypical teratoid/rhabdoid tumor 995 | 1,095
nasopharyngeal carcinoma 947 | 1,056
dermatomyositis 933 | 967
cutaneous lupus erythematosus 916 | 1,056
active Crohn's disease 842 | 918
Atopic dermatitis 776 | 944
gastric carcinoma 763 | 832
non primary Sjogren syndrome sicca 745 | 840
acute myeloid leukemia 738 | 785
Waldenstrons macroglobulinemia 734 | 765
primary Sjogren syndrome 705 | 789
esophageal adenocarcinoma 682 | 737
tuberculosis and treatment for 6 months 657 | 686
progressive supranuclear palsy 640 | 674
aldosterone-producing adenoma 623 | 664
Alzheimer's disease 556 | 644
Duchenne muscular dystrophy 545 | 602
Intellectual disability 532 | 573
pancreatic carcinoma 521 | 567
hepatocellular carcinoma 513 | 550
Obesity 511 | 616
Down syndrome 504 | 548
fibroadenoma 496 | 557
Endometriosis 476 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 465 | 499
chronic rhinosinusitis 448 | 512
Prostatic Neoplasms 427 | 471
active ulcerative colitis 427 | 477
IGA Glomerulonephritis 422 | 454
Schizophrenia 415 | 503
Amyotrophic Lateral Sclerosis 406 | 432
gastric cancer 402 | 436
mucosa-associated lymphoid tissue lymphoma 399 | 480
Multiple Sclerosis 397 | 498
Mammary Neoplasms 375 | 410
inflammatory breast cancer 373 | 404
Neurodegenerative disease 359 | 383
non-small cell lung carcinoma 332 | 413
Kidney disease 323 | 397
glioblastoma multiforme 318 | 347
Parkinson's disease 317 | 364
sarcoidosis 315 | 368
Polycystic Ovary Syndrome 304 | 335
tuberculosis and treatment for 3 months 302 | 327
hereditary spastic paraplegia 301 | 313
urothelial carcinoma 288 | 318
Epilepsy 285 | 346
nephrosclerosis 275 | 329

Tissue

Nervous System 15,619 | 18,561
Female tissues 15,607 | 18,647
Endocrine System 15,595 | 18,512
Digestive Tract 15,590 | 18,473
Urinary Tract 15,537 | 18,444
Liver and Pancreas 15,515 | 18,136
Male tissues 15,478 | 17,969
Blood and immune system 15,452 | 17,995
Cardiovascular System 15,447 | 17,958
Skin and soft tissues 15,419 | 18,115
Respiratory system 15,289 | 17,484

Target Family

Non-IDG 9,192 | 11,969
Enzyme 3,625 | 4,146
Transcription Factor 1,201 | 1,400
Kinase 581 | 634
Transporter 390 | 473
Ion Channel 261 | 341
GPCR 246 | 408
Epigenetic 223 | 242
Nuclear Receptor 41 | 48
oGPCR 34 | 421
TF/Epigenetic 33 | 38

HCA RNA Cell Line

SK-BR-3 15,827 | 15,827
U-2 OS 17,366 | 17,366
EFO-21 17,117 | 17,117
SCLC-21H 16,946 | 16,946
NTERA-2 16,846 | 16,846
U-266/70 16,556 | 16,556
BEWO 16,541 | 16,541
SH-SY5Y 16,521 | 16,521
HMC-1 16,394 | 16,394
NB-4 16,360 | 16,360
HaCaT 16,331 | 16,331
U-2197 16,301 | 16,301
U-266/84 16,257 | 16,257
U-251 MG 16,195 | 16,195
U-87 MG 16,106 | 16,106
Karpas-707 16,094 | 16,094
U-698 16,093 | 16,093
WM-115 16,065 | 16,065
K-562 16,049 | 16,049
T-47d 16,037 | 16,037
U-937 15,988 | 15,988
AF22 15,979 | 15,979
SK-MEL-30 15,962 | 15,962
A-431 15,947 | 15,947
CAPAN-2 15,918 | 15,918
RPMI-8226 15,832 | 15,832
REH 15,783 | 15,783
U-138 MG 15,734 | 15,734
HEK 293 15,668 | 15,668
THP-1 15,652 | 15,652
MOLT-4 15,626 | 15,626
HDLM-2 15,579 | 15,579
Daudi 15,575 | 15,575
RH-30 15,520 | 15,520
HeLa 15,516 | 15,516
RT4 15,502 | 15,502
AN3-CA 15,463 | 15,463
BJ hTERT+ SV40 Large T+ 15,430 | 15,430
BJ hTERT+ SV40 Large T+ RasG12... 15,312 | 15,312
BJ 15,277 | 15,277
HTCEpi 15,272 | 15,272
CACO-2 15,255 | 15,255
PC-3 15,204 | 15,204
BJ hTERT+ 15,182 | 15,182
HEL 15,175 | 15,175
SiHa 15,107 | 15,107
RPTEC TERT1 15,102 | 15,102
MCF7 15,049 | 15,049
HBF TERT88 15,033 | 15,033
Hep G2 15,000 | 15,000
A549 14,995 | 14,995
HL-60 14,864 | 14,864
LHCN-M2 14,817 | 14,817
ASC TERT1 14,671 | 14,671
HUVEC TERT2 14,544 | 14,544
TIME 14,297 | 14,297

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.02098 96.6 198
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.43448 279.3 62
HLA class I histocompatibility antigen, alpha chain G HLA-G Tbio Non-IDG -3.07995 1275.9 729
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Absent in melanoma 1 protein AIM1 Tbio Non-IDG -1.08081 11.8 9
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.17984 142.0 237
Thioredoxin domain-containing protein 2 TXNDC2 Tbio Non-IDG -0.71996 6.88 13
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.17375 14.4 26
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.38872 3.06 24