Development Level

Tbio 10,637 | 11,651
Tdark 4,242 | 6,593
Tchem 1,288 | 1,388
Tclin 540 | 612

Collection

Kinase: IDG Consortium (Target... 120 | 125
Ion Channel: IDG Consortium (T... 83 | 99
GPCR: IDG Consortium (Targets) 82 | 126
Kinase: IDG Consortium (Comple... 36 | 37
GPCR: IDG Consortium (Complete... 22 | 25

IMPC Phenotype

preweaning lethality, complete... 957 | 979
preweaning lethality, incomple... 474 | 499
abnormal behavior 285 | 298
embryonic lethality prior to t... 275 | 278
embryonic lethality prior to o... 238 | 239
abnormal embryo size 213 | 220
decreased total body fat amoun... 197 | 207
enlarged heart 183 | 210
decreased vertical activity 178 | 208
abnormal bone structure 177 | 187
increased lean body mass 163 | 172
decreased body weight 157 | 161
abnormal heart morphology 143 | 162
decreased bone mineral content 140 | 151
hyperactivity 140 | 148
decreased lean body mass 131 | 135
increased total body fat amoun... 129 | 134
hypoactivity 124 | 132
decreased bone mineral density 117 | 126
increased circulating alkaline... 115 | 122
decreased circulating glucose ... 113 | 126
increased startle reflex 110 | 112
male infertility 109 | 123
decreased grip strength 106 | 116
embryonic growth retardation 103 | 106
increased bone mineral content 102 | 108
abnormal seminal vesicle morph... 100 | 114
decreased body length 95 | 101
increased or absent threshold ... 94 | 101
short tibia 94 | 97
decreased circulating choleste... 90 | 93
increased mean corpuscular hem... 90 | 96
increased mean corpuscular vol... 88 | 92
cataract 87 | 92
prenatal lethality prior to he... 84 | 87
decreased lymphocyte cell numb... 80 | 83
decreased prepulse inhibition 79 | 82
abnormal lens morphology 78 | 81
decreased circulating serum al... 74 | 82
decreased circulating triglyce... 74 | 79
decreased mean corpuscular vol... 73 | 79
impaired glucose tolerance 71 | 75
increased circulating HDL chol... 71 | 80
increased fasted circulating g... 71 | 76
improved glucose tolerance 70 | 79
decreased circulating insulin ... 69 | 76
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 69 | 75
increased bone mineral density 69 | 72
abnormal retina morphology 68 | 71
decreased circulating HDL chol... 68 | 68
small superior vagus ganglion 68 | 74
abnormal sleep behavior 67 | 70
abnormal eye morphology 66 | 68
increased circulating sodium l... 66 | 71
abnormal gait 64 | 69
abnormal kidney morphology 62 | 65
abnormal coat-hair pigmentatio... 61 | 64
decreased hemoglobin content 61 | 68
increased circulating choleste... 61 | 66
decreased fasted circulating g... 60 | 65
abnormal behavioral response t... 59 | 66
decreased erythrocyte cell num... 59 | 62
increased heart weight 59 | 62
increased monocyte cell number 58 | 63
edema 57 | 59
small testis 53 | 58
abnormal spleen morphology 52 | 55
thrombocytopenia 52 | 56
decreased caudal vertebrae num... 51 | 53
female infertility 49 | 60
decreased blood urea nitrogen ... 47 | 51
hydrometra 47 | 53
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal neural tube closure 45 | 46
increased blood urea nitrogen ... 45 | 48
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
decreased circulating alkaline... 44 | 46
increased neutrophil cell numb... 44 | 46
decreased hematocrit 42 | 46
increased hemoglobin content 42 | 45
increased circulating triglyce... 41 | 42
increased leukocyte cell numbe... 41 | 47
increased mean platelet volume 41 | 45
abnormal testis morphology 40 | 43
increased hematocrit 40 | 46
decreased neutrophil cell numb... 39 | 42
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
decreased red blood cell distr... 38 | 41
increased erythrocyte cell num... 38 | 39
limb grasping 38 | 41
tremors 38 | 39
abnormal bone mineralization 37 | 38
abnormal epididymis morphology 37 | 42
decreased circulating creatini... 37 | 39
increased grip strength 37 | 41
decreased circulating LDL chol... 36 | 38

Disease

Carcinoma 10,164 | 11,493
ovarian cancer 8,186 | 8,520
osteosarcoma 7,484 | 7,950
medulloblastoma, large-cell 5,934 | 6,241
psoriasis 5,897 | 6,694
glioblastoma 5,586 | 5,792
atypical teratoid / rhabdoid tumor 4,924 | 5,112
lung cancer 4,516 | 4,740
ependymoma 4,484 | 4,679
group 3 medulloblastoma 3,954 | 4,104
adult high grade glioma 3,613 | 3,801
Breast cancer 3,416 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,170 | 3,291
malignant mesothelioma 3,120 | 3,232
Astrocytoma, Pilocytic 2,950 | 3,081
primitive neuroectodermal tumor 2,913 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,884 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,853 | 2,955
invasive ductal carcinoma 2,852 | 2,951
non-small cell lung cancer 2,737 | 2,890
oligodendroglioma 2,734 | 2,850
lung carcinoma 2,649 | 2,843
lung adenocarcinoma 2,545 | 2,716
astrocytic glioma 2,497 | 2,597
Kidney cancer 2,411 | 2,613
Cancer 2,308 | 2,499
pancreatic cancer 2,278 | 2,398
subependymal giant cell astrocytoma 2,212 | 2,287
interstitial cystitis 2,141 | 2,312
tuberculosis 1,907 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,893 | 1,962
pituitary cancer 1,887 | 1,972
Pick disease 1,847 | 1,894
group 4 medulloblastoma 1,791 | 1,855
ulcerative colitis 1,710 | 1,819
ductal carcinoma in situ 1,667 | 1,745
cystic fibrosis 1,592 | 1,696
breast carcinoma 1,577 | 1,638
diabetes mellitus 1,440 | 1,728
colon cancer 1,418 | 1,478
adrenocortical carcinoma 1,391 | 1,428
Autosomal recessive predisposition 1,340 | 1,442
Multiple myeloma 1,306 | 1,332
juvenile dermatomyositis 1,164 | 1,187
acute quadriplegic myopathy 1,138 | 1,158
Rheumatoid arthritis 1,130 | 1,191
astrocytoma 1,123 | 1,146
primary pancreatic ductal adenocarcinoma 1,075 | 1,109
Schizophrenia 1,038 | 1,160
pediatric high grade glioma 1,028 | 1,064
spina bifida 1,026 | 1,074
Intellectual disability 984 | 1,016
cutaneous lupus erythematosus 965 | 1,057
nasopharyngeal carcinoma 964 | 1,058
dermatomyositis 952 | 966
active Crohn's disease 882 | 922
Atopic dermatitis 830 | 952
non primary Sjogren syndrome sicca 823 | 891
gastric carcinoma 775 | 807
acute myeloid leukemia 763 | 783
Waldenstrons macroglobulinemia 754 | 765
Epilepsy 751 | 792
Liver Cirrhosis, Experimental 724 | 769
active ulcerative colitis 719 | 764
medulloblastoma 697 | 720
primary Sjogren syndrome 693 | 735
esophageal adenocarcinoma 684 | 737
progressive supranuclear palsy 657 | 676
aldosterone-producing adenoma 653 | 665
Dull intelligence 623 | 645
Low intelligence 623 | 645
Mental Retardation 623 | 645
Mental deficiency 623 | 645
Poor school performance 623 | 645
Obesity 618 | 678
Melanoma 613 | 711
Alzheimer's disease 608 | 658
Bipolar Disorder 599 | 666
Cognitive delay 592 | 608
Global developmental delay 592 | 608
Mental and motor retardation 592 | 608
Duchenne muscular dystrophy 585 | 601
Seizures 571 | 596
Muscle hypotonia 557 | 571
pancreatic carcinoma 544 | 562
Liver cancer 543 | 604
hepatocellular carcinoma 534 | 547
fibroadenoma 530 | 559
Short stature 505 | 531
Endometriosis 502 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 499 | 510
Down syndrome 479 | 499
Prostatic Neoplasms 477 | 495
Multiple Sclerosis 470 | 540
chronic rhinosinusitis 467 | 512
posterior fossa group A ependymoma 447 | 468
sonic hedgehog group medulloblastoma 446 | 467
gastric cancer 441 | 459
Amyotrophic lateral sclerosis 434 | 451
mucosa-associated lymphoid tissue lymphoma 430 | 484

Tissue

Endocrine System 16,397 | 18,159
Digestive Tract 16,118 | 17,369
Female tissues 16,118 | 17,400
Skin and soft tissues 16,041 | 17,230
Male tissues 16,005 | 17,142
Nervous System 15,862 | 16,725
Blood and immune system 15,840 | 16,909
Liver and Pancreas 15,793 | 16,750
Urinary Tract 15,744 | 16,678
Respiratory system 15,541 | 16,393
Cardiovascular System 14,656 | 15,192

Target Family

Non-IDG 9,725 | 12,091
Enzyme 3,758 | 4,145
Transcription Factor 1,275 | 1,400
Kinase 611 | 634
Transporter 422 | 473
GPCR 305 | 408
Ion Channel 280 | 344
Epigenetic 233 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 36 | 38
oGPCR 17 | 421

HCA RNA Cell Line

SH-SY5Y 16,707 | 16,707
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50