Development Level

Tbio 9,647 | 10,625
Tdark 4,625 | 7,003
Tchem 1,719 | 1,890
Tclin 529 | 602

Collection

Kinase: IDG Consortium (Targets) 117 | 125
Ion Channel: IDG Consortium (Targets) 86 | 102
GPCR: IDG Consortium (Targets) 82 | 127
Kinase: IDG Consortium (Complete/Control) 35 | 37
GPCR: IDG Consortium (Complete/Control) 23 | 26

IMPC Phenotype

preweaning lethality, complete... 617 | 633
preweaning lethality, incomple... 248 | 260
abnormal behavior 218 | 226
decreased lean body mass 190 | 195
embryonic lethality prior to t... 185 | 187
decreased total body fat amoun... 181 | 186
decreased body weight 169 | 174
decreased bone mineral content 152 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 128 | 131
increased or absent threshold ... 122 | 128
decreased bone mineral density 120 | 126
decreased grip strength 115 | 123
increased circulating alkaline... 115 | 119
abnormal embryo size 107 | 112
decreased circulating glucose ... 107 | 121
decreased body length 106 | 108
hyperactivity 102 | 108
increased lean body mass 102 | 107
abnormal retina morphology 95 | 100
enlarged heart 94 | 111
increased mean corpuscular hem... 90 | 93
increased bone mineral content 88 | 92
increased mean corpuscular vol... 87 | 91
hypoactivity 84 | 89
decreased circulating choleste... 83 | 85
short tibia 81 | 82
decreased circulating triglyce... 78 | 83
decreased circulating HDL chol... 76 | 77
increased grip strength 76 | 83
decreased circulating serum al... 72 | 79
abnormal lens morphology 71 | 73
increased circulating sodium l... 67 | 71
decreased circulating insulin ... 66 | 75
increased fasted circulating g... 63 | 68
prenatal lethality prior to he... 62 | 64
decreased lumbar vertebrae num... 61 | 62
increased sacral vertebrae num... 60 | 62
abnormal retinal pigmentation 59 | 61
abnormal sleep behavior 59 | 63
male infertility 59 | 62
increased circulating HDL chol... 56 | 63
increased total body fat amoun... 55 | 57
abnormal bone mineralization 54 | 55
decreased rib number 54 | 59
abnormal coat-hair pigmentatio... 52 | 54
decreased leukocyte cell numbe... 51 | 54
decreased prepulse inhibition 51 | 52
increased exploration in new e... 51 | 56
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
increased circulating choleste... 50 | 53
abnormal gait 49 | 51
decreased hemoglobin content 49 | 53
improved glucose tolerance 49 | 56
decreased mean corpuscular vol... 48 | 50
decreased startle reflex 47 | 48
decreased caudal vertebrae num... 46 | 49
decreased circulating alanine ... 46 | 53
abnormal behavioral response t... 45 | 52
decreased fasted circulating g... 45 | 49
increased blood urea nitrogen ... 43 | 44
increased hemoglobin content 43 | 45
thrombocytopenia 43 | 46
abnormal heart morphology 42 | 51
abnormal seminal vesicle morph... 42 | 47
decreased erythrocyte cell num... 41 | 43
increased body weight 41 | 42
increased circulating chloride... 41 | 43
decreased circulating total pr... 40 | 41
decreased heart weight 40 | 44
decreased circulating alkaline... 39 | 41
decreased eosinophil cell numb... 39 | 41
abnormal eye morphology 38 | 38
increased rib number 38 | 41
increased startle reflex 37 | 38
abnormal neural tube closure 35 | 37
decreased circulating LDL chol... 35 | 37
decreased circulating free fat... 35 | 39
decreased neutrophil cell numb... 35 | 37
increased heart weight 34 | 37
increased leukocyte cell numbe... 34 | 37
abnormal spleen morphology 33 | 36
small testis 33 | 37
tremors 33 | 34
cardiovascular system phenotyp... 32 | 35
decreased mean corpuscular hem... 32 | 34
increased circulating calcium ... 32 | 32
limb grasping 32 | 35
abnormal cranium morphology 31 | 32
decreased T cell number 31 | 31
increased hematocrit 31 | 36
decreased circulating calcium ... 30 | 33
decreased circulating creatini... 30 | 31
decreased circulating fructosa... 30 | 31
decreased threshold for audito... 30 | 32
abnormal kidney morphology 29 | 30
decreased blood urea nitrogen ... 29 | 31
increased circulating potassiu... 29 | 31
abnormal epididymis morphology 28 | 31

Disease

ovarian cancer 8,074 | 8,491
osteosarcoma 7,397 | 7,933
medulloblastoma, large-cell 5,875 | 6,234
psoriasis 5,847 | 6,685
glioblastoma 5,335 | 5,572
lung cancer 4,286 | 4,473
atypical teratoid / rhabdoid tumor 4,170 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,142 | 3,289
malignant mesothelioma 3,036 | 3,163
Breast cancer 2,952 | 3,098
pilocytic astrocytoma 2,921 | 3,086
primitive neuroectodermal tumor 2,879 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,861 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,836 | 2,956
invasive ductal carcinoma 2,822 | 2,950
oligodendroglioma 2,708 | 2,849
lung carcinoma 2,634 | 2,844
non-small cell lung cancer 2,634 | 2,798
pediatric high grade glioma 2,596 | 2,712
lung adenocarcinoma 2,525 | 2,714
ependymoma 2,395 | 2,514
subependymal giant cell astrocytoma 2,193 | 2,287
pancreatic cancer 2,174 | 2,300
Cancer 2,156 | 2,346
group 3 medulloblastoma 2,140 | 2,254
astrocytic glioma 2,133 | 2,241
interstitial cystitis 2,121 | 2,299
adult high grade glioma 1,998 | 2,148
ulcerative colitis 1,960 | 2,087
Carcinoma 1,934 | 2,147
pituitary cancer 1,872 | 1,972
Pick disease 1,833 | 1,893
group 4 medulloblastoma 1,807 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,710 | 1,795
ductal carcinoma in situ 1,651 | 1,745
cystic fibrosis 1,556 | 1,670
breast carcinoma 1,541 | 1,614
tuberculosis 1,468 | 1,563
astrocytoma 1,453 | 1,493
posterior fossa group B ependymoma 1,439 | 1,530
medulloblastoma 1,437 | 1,524
posterior fossa group A ependymoma 1,430 | 1,511
sonic hedgehog group medulloblastoma 1,426 | 1,482
colon cancer 1,405 | 1,475
adrenocortical carcinoma 1,373 | 1,427
diabetes mellitus 1,372 | 1,663
Multiple myeloma 1,290 | 1,327
primary pancreatic ductal adenocarcinoma 1,227 | 1,271
juvenile dermatomyositis 1,156 | 1,189
acute quadriplegic myopathy 1,129 | 1,157
Rheumatoid Arthritis 1,100 | 1,170
atypical teratoid/rhabdoid tumor 1,046 | 1,095
spina bifida 1,006 | 1,064
nasopharyngeal carcinoma 958 | 1,056
cutaneous lupus erythematosus 957 | 1,056
dermatomyositis 946 | 966
active Crohn's disease 872 | 918
Atopic dermatitis 816 | 944
gastric carcinoma 796 | 832
non primary Sjogren syndrome sicca 764 | 840
acute myeloid leukemia 752 | 785
Waldenstrons macroglobulinemia 746 | 764
primary Sjogren syndrome 738 | 788
esophageal adenocarcinoma 681 | 737
tuberculosis and treatment for 6 months 667 | 686
progressive supranuclear palsy 650 | 674
aldosterone-producing adenoma 648 | 664
Alzheimer's disease 590 | 644
Duchenne muscular dystrophy 579 | 602
Obesity 562 | 616
Intellectual disability 554 | 573
pancreatic carcinoma 545 | 567
hepatocellular carcinoma 534 | 550
fibroadenoma 526 | 557
Down syndrome 523 | 548
Endometriosis 492 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 487 | 499
chronic rhinosinusitis 464 | 512
Prostatic Neoplasms 451 | 471
Schizophrenia 447 | 503
active ulcerative colitis 439 | 477
IGA Glomerulonephritis 437 | 454
mucosa-associated lymphoid tissue lymphoma 427 | 480
Multiple Sclerosis 426 | 498
gastric cancer 413 | 436
Amyotrophic Lateral Sclerosis 412 | 432
Mammary Neoplasms 382 | 410
inflammatory breast cancer 375 | 404
non-small cell lung carcinoma 367 | 413
Neurodegenerative disease 363 | 383
Kidney disease 342 | 397
sarcoidosis 340 | 368
Parkinson's disease 337 | 364
glioblastoma multiforme 325 | 347
Polycystic Ovary Syndrome 315 | 334
Epilepsy 314 | 346
tuberculosis and treatment for 3 months 307 | 327
hereditary spastic paraplegia 305 | 313
urothelial carcinoma 305 | 318
nephrosclerosis 299 | 329

Tissue

Nervous System 16,292 | 18,560
Female tissues 16,265 | 18,646
Digestive Tract 16,257 | 18,472
Endocrine System 16,257 | 18,511
Urinary Tract 16,205 | 18,443
Liver and Pancreas 16,176 | 18,135
Male tissues 16,135 | 17,968
Cardiovascular System 16,121 | 17,957
Blood and immune system 16,104 | 17,994
Skin and soft tissues 16,064 | 18,114
Respiratory system 15,921 | 17,483

Target Family

Non-IDG 9,586 | 11,969
Enzyme 3,730 | 4,146
Transcription Factor 1,272 | 1,400
Kinase 604 | 634
Transporter 422 | 473
GPCR 305 | 408
Ion Channel 277 | 341
Epigenetic 227 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 17 | 421

HCA RNA Cell Line

SH-SY5Y 16,520 | 16,520
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131