Development Level

Tbio 9,824 | 10,625
Tdark 4,824 | 7,003
Tchem 1,747 | 1,890
Tclin 550 | 602

Collection

Kinase: IDG Consortium (Targets) 119 | 125
GPCR: IDG Consortium (Targets) 89 | 127
Ion Channel: IDG Consortium (Targets) 89 | 102
Kinase: IDG Consortium (Complete/Control) 36 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 26

IMPC Phenotype

preweaning lethality, complete... 625 | 633
preweaning lethality, incomple... 253 | 260
abnormal behavior 221 | 226
decreased lean body mass 191 | 195
embryonic lethality prior to t... 187 | 187
decreased total body fat amoun... 182 | 186
decreased body weight 171 | 174
decreased bone mineral content 153 | 157
embryonic lethality prior to o... 148 | 148
abnormal bone structure 129 | 131
increased or absent threshold ... 124 | 128
decreased bone mineral density 120 | 126
decreased grip strength 119 | 123
increased circulating alkaline... 115 | 119
decreased circulating glucose ... 110 | 121
abnormal embryo size 108 | 112
decreased body length 106 | 108
hyperactivity 106 | 108
increased lean body mass 105 | 107
enlarged heart 99 | 111
abnormal retina morphology 96 | 100
increased mean corpuscular hem... 91 | 93
increased bone mineral content 90 | 92
increased mean corpuscular vol... 88 | 91
decreased circulating choleste... 84 | 85
hypoactivity 83 | 89
short tibia 82 | 82
decreased circulating triglyce... 80 | 83
increased grip strength 78 | 83
decreased circulating HDL chol... 76 | 77
decreased circulating serum al... 74 | 79
abnormal lens morphology 71 | 73
decreased circulating insulin ... 68 | 75
increased fasted circulating g... 68 | 68
increased circulating sodium l... 67 | 71
prenatal lethality prior to he... 63 | 64
decreased lumbar vertebrae num... 62 | 62
increased sacral vertebrae num... 62 | 62
abnormal retinal pigmentation 60 | 61
male infertility 60 | 62
increased circulating HDL chol... 59 | 63
abnormal sleep behavior 58 | 63
increased total body fat amoun... 57 | 57
decreased rib number 56 | 59
abnormal bone mineralization 55 | 55
increased exploration in new e... 53 | 56
decreased leukocyte cell numbe... 52 | 54
abnormal behavioral response t... 51 | 52
abnormal coat-hair pigmentatio... 51 | 54
decreased hemoglobin content 51 | 53
decreased prepulse inhibition 51 | 52
improved glucose tolerance 51 | 56
increased circulating choleste... 51 | 53
abnormal gait 50 | 51
decreased mean corpuscular vol... 50 | 50
impaired glucose tolerance 50 | 52
increased bone mineral density 50 | 52
decreased circulating alanine ... 48 | 53
decreased fasted circulating g... 48 | 49
decreased startle reflex 47 | 48
decreased caudal vertebrae num... 46 | 49
thrombocytopenia 45 | 46
increased blood urea nitrogen ... 44 | 44
abnormal heart morphology 43 | 51
abnormal seminal vesicle morph... 43 | 47
increased hemoglobin content 43 | 45
decreased erythrocyte cell num... 42 | 43
decreased circulating total pr... 41 | 41
decreased heart weight 41 | 44
increased body weight 41 | 42
decreased circulating alkaline... 40 | 41
increased circulating chloride... 40 | 43
increased rib number 40 | 41
decreased eosinophil cell numb... 39 | 41
abnormal eye morphology 38 | 38
decreased neutrophil cell numb... 37 | 37
abnormal neural tube closure 36 | 37
decreased circulating LDL chol... 36 | 37
decreased circulating free fat... 36 | 39
increased leukocyte cell numbe... 36 | 37
increased startle reflex 36 | 38
decreased mean corpuscular hem... 34 | 34
increased heart weight 34 | 37
limb grasping 34 | 35
small testis 34 | 37
abnormal spleen morphology 33 | 36
tremors 33 | 34
increased hematocrit 32 | 36
abnormal cranium morphology 31 | 32
cardiovascular system phenotyp... 31 | 35
decreased T cell number 31 | 31
decreased circulating chloride... 31 | 32
female infertility 31 | 34
increased circulating calcium ... 31 | 32
decreased blood urea nitrogen ... 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating creatini... 30 | 31
decreased circulating fructosa... 30 | 31
decreased threshold for audito... 30 | 32
increased circulating potassiu... 30 | 31

Disease

ovarian cancer 8,128 | 8,491
osteosarcoma 7,456 | 7,933
psoriasis 6,037 | 6,685
medulloblastoma, large-cell 5,936 | 6,234
glioblastoma 5,385 | 5,572
lung cancer 4,296 | 4,473
atypical teratoid / rhabdoid tumor 4,228 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,164 | 3,289
malignant mesothelioma 3,061 | 3,163
Breast cancer 2,993 | 3,098
pilocytic astrocytoma 2,962 | 3,086
primitive neuroectodermal tumor 2,930 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 2,874 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 2,845 | 2,956
invasive ductal carcinoma 2,837 | 2,950
oligodendroglioma 2,755 | 2,849
lung carcinoma 2,690 | 2,844
non-small cell lung cancer 2,654 | 2,798
pediatric high grade glioma 2,628 | 2,712
lung adenocarcinoma 2,553 | 2,714
ependymoma 2,432 | 2,514
subependymal giant cell astrocytoma 2,218 | 2,287
pancreatic cancer 2,188 | 2,300
Cancer 2,185 | 2,346
astrocytic glioma 2,169 | 2,241
group 3 medulloblastoma 2,162 | 2,254
interstitial cystitis 2,143 | 2,299
adult high grade glioma 2,015 | 2,148
Carcinoma 2,001 | 2,147
ulcerative colitis 1,957 | 2,087
pituitary cancer 1,908 | 1,972
Pick disease 1,854 | 1,893
group 4 medulloblastoma 1,824 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,719 | 1,795
ductal carcinoma in situ 1,675 | 1,745
cystic fibrosis 1,590 | 1,670
breast carcinoma 1,544 | 1,614
tuberculosis 1,481 | 1,563
medulloblastoma 1,471 | 1,524
posterior fossa group B ependymoma 1,469 | 1,530
astrocytoma 1,461 | 1,493
posterior fossa group A ependymoma 1,448 | 1,511
sonic hedgehog group medulloblastoma 1,440 | 1,482
diabetes mellitus 1,423 | 1,663
colon cancer 1,400 | 1,475
adrenocortical carcinoma 1,383 | 1,427
Multiple myeloma 1,293 | 1,327
primary pancreatic ductal adenocarcinoma 1,234 | 1,271
juvenile dermatomyositis 1,157 | 1,189
acute quadriplegic myopathy 1,126 | 1,157
Rheumatoid Arthritis 1,109 | 1,170
atypical teratoid/rhabdoid tumor 1,055 | 1,095
spina bifida 1,033 | 1,064
nasopharyngeal carcinoma 997 | 1,056
cutaneous lupus erythematosus 968 | 1,056
dermatomyositis 949 | 966
active Crohn's disease 869 | 918
Atopic dermatitis 841 | 944
gastric carcinoma 796 | 832
non primary Sjogren syndrome sicca 779 | 840
acute myeloid leukemia 754 | 785
Waldenstrons macroglobulinemia 743 | 764
primary Sjogren syndrome 738 | 788
esophageal adenocarcinoma 697 | 737
tuberculosis and treatment for 6 months 662 | 686
progressive supranuclear palsy 655 | 674
aldosterone-producing adenoma 650 | 664
Alzheimer's disease 607 | 644
Duchenne muscular dystrophy 576 | 602
Obesity 575 | 616
Intellectual disability 558 | 573
pancreatic carcinoma 545 | 567
Down syndrome 534 | 548
fibroadenoma 534 | 557
hepatocellular carcinoma 530 | 550
Endometriosis 508 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 499
chronic rhinosinusitis 483 | 512
Schizophrenia 459 | 503
Prostatic Neoplasms 454 | 471
active ulcerative colitis 445 | 477
Multiple Sclerosis 442 | 498
IGA Glomerulonephritis 437 | 454
mucosa-associated lymphoid tissue lymphoma 426 | 480
Amyotrophic Lateral Sclerosis 418 | 432
gastric cancer 414 | 436
Mammary Neoplasms 394 | 410
inflammatory breast cancer 377 | 404
non-small cell lung carcinoma 373 | 413
Neurodegenerative disease 370 | 383
Kidney disease 356 | 397
sarcoidosis 347 | 368
Parkinson's disease 341 | 364
glioblastoma multiforme 330 | 347
Epilepsy 326 | 346
Polycystic Ovary Syndrome 318 | 334
hereditary spastic paraplegia 306 | 313
tuberculosis and treatment for 3 months 304 | 327
urothelial carcinoma 302 | 318
nephrosclerosis 301 | 329

Tissue

Nervous System 16,678 | 18,560
Female tissues 16,656 | 18,646
Endocrine System 16,644 | 18,511
Digestive Tract 16,636 | 18,472
Urinary Tract 16,575 | 18,443
Liver and Pancreas 16,520 | 18,135
Male tissues 16,444 | 17,968
Skin and soft tissues 16,438 | 18,114
Cardiovascular System 16,435 | 17,957
Blood and immune system 16,411 | 17,994
Respiratory system 16,192 | 17,483

Target Family

Non-IDG 9,856 | 11,969
Enzyme 3,761 | 4,146
Transcription Factor 1,314 | 1,400
Kinase 610 | 634
Transporter 431 | 473
GPCR 319 | 408
Ion Channel 300 | 341
Epigenetic 231 | 242
Nuclear Receptor 46 | 48
oGPCR 41 | 421
TF/Epigenetic 36 | 38

HCA RNA Cell Line

SCLC-21H 16,945 | 16,945
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Interleukin-9 IL9 Tbio Non-IDG -2.46520 301.6 339
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99