Development Level

Tbio 10,642 | 11,445
Tdark 4,434 | 6,588
Tchem 1,502 | 1,598
Tclin 561 | 613

Collection

RFA-RM-18-021 283 | 328
Kinase: IDG Consortium (Target... 122 | 125
GPCR: IDG Consortium (Targets) 88 | 126
Ion Channel: IDG Consortium (T... 87 | 99
Kinase: IDG Consortium (Comple... 37 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 969 | 979
preweaning lethality, incomple... 482 | 499
abnormal behavior 289 | 298
embryonic lethality prior to t... 277 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 217 | 220
decreased total body fat amoun... 199 | 207
decreased vertical activity 187 | 208
enlarged heart 187 | 210
abnormal bone structure 182 | 187
increased lean body mass 167 | 172
decreased body weight 159 | 161
decreased bone mineral content 145 | 151
abnormal heart morphology 144 | 162
hyperactivity 144 | 148
decreased lean body mass 132 | 135
increased total body fat amoun... 130 | 134
hypoactivity 124 | 132
decreased bone mineral density 119 | 126
male infertility 118 | 123
increased circulating alkaline... 116 | 122
decreased circulating glucose ... 115 | 126
increased startle reflex 110 | 112
decreased grip strength 107 | 116
increased bone mineral content 106 | 108
abnormal seminal vesicle morph... 105 | 114
embryonic growth retardation 105 | 106
decreased body length 98 | 101
increased or absent threshold ... 96 | 101
short tibia 96 | 97
increased mean corpuscular hem... 93 | 96
decreased circulating choleste... 92 | 93
cataract 90 | 92
increased mean corpuscular vol... 89 | 92
prenatal lethality prior to he... 85 | 87
decreased prepulse inhibition 80 | 82
abnormal lens morphology 79 | 81
decreased circulating serum al... 78 | 82
decreased lymphocyte cell numb... 78 | 83
decreased circulating triglyce... 76 | 79
decreased mean corpuscular vol... 76 | 79
increased circulating HDL chol... 74 | 80
increased fasted circulating g... 74 | 76
decreased circulating insulin ... 73 | 76
improved glucose tolerance 73 | 79
impaired glucose tolerance 72 | 75
increased bone mineral density 71 | 72
small superior vagus ganglion 71 | 74
decreased startle reflex 70 | 75
decreased leukocyte cell numbe... 69 | 73
abnormal eye morphology 68 | 68
abnormal retina morphology 68 | 71
abnormal gait 67 | 69
decreased circulating HDL chol... 67 | 68
abnormal sleep behavior 66 | 70
decreased hemoglobin content 66 | 68
increased circulating sodium l... 66 | 71
abnormal behavioral response t... 64 | 66
decreased fasted circulating g... 64 | 65
increased circulating choleste... 63 | 66
abnormal kidney morphology 61 | 65
abnormal coat-hair pigmentatio... 60 | 64
decreased erythrocyte cell num... 60 | 62
increased heart weight 60 | 62
increased monocyte cell number 58 | 63
edema 57 | 59
female infertility 56 | 60
small testis 54 | 58
thrombocytopenia 54 | 56
decreased caudal vertebrae num... 52 | 53
abnormal spleen morphology 51 | 55
decreased blood urea nitrogen ... 50 | 51
decreased mean corpuscular hem... 50 | 50
abnormal skin morphology 49 | 50
hydrometra 49 | 53
decreased circulating total pr... 48 | 49
increased blood urea nitrogen ... 47 | 48
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased circulating alanine ... 45 | 47
increased leukocyte cell numbe... 45 | 47
increased mean platelet volume 45 | 45
decreased hematocrit 44 | 46
increased hematocrit 43 | 46
increased neutrophil cell numb... 43 | 46
increased hemoglobin content 42 | 45
abnormal testis morphology 41 | 43
decreased neutrophil cell numb... 41 | 42
abnormal epididymis morphology 40 | 42
increased circulating triglyce... 40 | 42
limb grasping 40 | 41
decreased red blood cell distr... 39 | 41
enlarged spleen 39 | 41
increased circulating chloride... 39 | 41
tremors 39 | 39
abnormal bone mineralization 38 | 38
decreased circulating LDL chol... 37 | 38
increased grip strength 37 | 41
prolonged QT interval 37 | 38
increased erythrocyte cell num... 36 | 39

Disease

Carcinoma 10,420 | 11,493
ovarian cancer 8,244 | 8,520
osteosarcoma 7,544 | 7,950
psoriasis 6,089 | 6,694
medulloblastoma, large-cell 5,994 | 6,241
glioblastoma 5,643 | 5,792
atypical teratoid / rhabdoid tumor 4,991 | 5,112
ependymoma 4,554 | 4,679
lung cancer 4,544 | 4,740
group 3 medulloblastoma 3,998 | 4,104
adult high grade glioma 3,653 | 3,801
Breast cancer 3,472 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,194 | 3,291
malignant mesothelioma 3,148 | 3,232
Astrocytoma, Pilocytic 2,990 | 3,081
primitive neuroectodermal tumor 2,965 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,898 | 2,989
invasive ductal carcinoma 2,866 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,863 | 2,955
oligodendroglioma 2,782 | 2,850
non-small cell lung cancer 2,759 | 2,890
lung carcinoma 2,707 | 2,843
lung adenocarcinoma 2,575 | 2,716
astrocytic glioma 2,535 | 2,597
Kidney cancer 2,467 | 2,613
Cancer 2,345 | 2,499
pancreatic cancer 2,298 | 2,398
subependymal giant cell astrocytoma 2,238 | 2,287
interstitial cystitis 2,163 | 2,312
pituitary cancer 1,922 | 1,972
tuberculosis 1,911 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,903 | 1,962
Pick disease 1,869 | 1,894
group 4 medulloblastoma 1,813 | 1,855
ulcerative colitis 1,707 | 1,819
ductal carcinoma in situ 1,689 | 1,745
cystic fibrosis 1,626 | 1,696
breast carcinoma 1,578 | 1,638
diabetes mellitus 1,490 | 1,728
colon cancer 1,414 | 1,478
adrenocortical carcinoma 1,401 | 1,428
Autosomal recessive predisposition 1,377 | 1,442
Multiple myeloma 1,308 | 1,332
juvenile dermatomyositis 1,165 | 1,187
Rheumatoid arthritis 1,138 | 1,191
acute quadriplegic myopathy 1,135 | 1,158
astrocytoma 1,130 | 1,146
primary pancreatic ductal adenocarcinoma 1,081 | 1,109
Schizophrenia 1,066 | 1,160
spina bifida 1,053 | 1,074
pediatric high grade glioma 1,038 | 1,064
nasopharyngeal carcinoma 1,004 | 1,058
Intellectual disability 994 | 1,016
cutaneous lupus erythematosus 977 | 1,057
dermatomyositis 954 | 966
active Crohn's disease 879 | 922
Atopic dermatitis 855 | 952
non primary Sjogren syndrome sicca 837 | 891
gastric carcinoma 777 | 807
Epilepsy 768 | 792
acute myeloid leukemia 766 | 783
Waldenstrons macroglobulinemia 750 | 765
Liver Cirrhosis, Experimental 730 | 769
active ulcerative colitis 726 | 764
medulloblastoma 704 | 720
esophageal adenocarcinoma 700 | 737
primary Sjogren syndrome 693 | 735
progressive supranuclear palsy 662 | 676
aldosterone-producing adenoma 655 | 665
Melanoma 639 | 711
Obesity 635 | 678
Dull intelligence 631 | 645
Low intelligence 631 | 645
Mental Retardation 631 | 645
Mental deficiency 631 | 645
Poor school performance 631 | 645
Alzheimer's disease 621 | 658
Bipolar Disorder 614 | 666
Cognitive delay 595 | 608
Global developmental delay 595 | 608
Mental and motor retardation 595 | 608
Duchenne muscular dystrophy 582 | 601
Seizures 580 | 596
Liver cancer 574 | 604
Muscle hypotonia 561 | 571
pancreatic carcinoma 544 | 562
fibroadenoma 538 | 559
hepatocellular carcinoma 529 | 547
Endometriosis 519 | 540
Short stature 514 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 501 | 510
Down syndrome 489 | 499
Multiple Sclerosis 486 | 540
chronic rhinosinusitis 486 | 512
Prostatic Neoplasms 480 | 495
sonic hedgehog group medulloblastoma 459 | 467
posterior fossa group A ependymoma 454 | 468
gastric cancer 441 | 459
Amyotrophic lateral sclerosis 437 | 451
Breast Neoplasms 430 | 445

Tissue

Endocrine System 16,760 | 18,159
Female tissues 16,403 | 17,400
Digestive Tract 16,397 | 17,369
Skin and soft tissues 16,306 | 17,230
Male tissues 16,238 | 17,142
Nervous System 16,074 | 16,725
Blood and immune system 16,068 | 16,909
Liver and Pancreas 15,994 | 16,750
Urinary Tract 15,927 | 16,678
Respiratory system 15,733 | 16,393
Cardiovascular System 14,758 | 15,192

Target Family

Non-IDG 9,996 | 12,091
Enzyme 3,792 | 4,145
Transcription Factor 1,319 | 1,400
Kinase 617 | 634
Transporter 431 | 473
GPCR 319 | 408
Ion Channel 303 | 344
Epigenetic 237 | 242
Nuclear Receptor 46 | 48
oGPCR 42 | 421
TF/Epigenetic 37 | 38

HCA RNA Cell Line

SCLC-21H 17,139 | 17,139
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39