Development Level

Tbio 9,883 | 11,445
Tdark 3,980 | 6,588
Tchem 1,358 | 1,598
Tclin 462 | 613

Collection

RFA-RM-18-021 243 | 328
Kinase: IDG Consortium (Target... 116 | 125
Ion Channel: IDG Consortium (T... 70 | 99
GPCR: IDG Consortium (Targets) 64 | 126
Kinase: IDG Consortium (Comple... 33 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 936 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 274 | 298
embryonic lethality prior to t... 264 | 278
embryonic lethality prior to o... 235 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 186 | 207
enlarged heart 181 | 210
abnormal bone structure 167 | 187
decreased vertical activity 161 | 208
increased lean body mass 153 | 172
decreased body weight 148 | 161
abnormal heart morphology 139 | 162
hyperactivity 136 | 148
decreased bone mineral content 132 | 151
decreased lean body mass 118 | 135
increased total body fat amoun... 117 | 134
hypoactivity 116 | 132
decreased bone mineral density 115 | 126
increased circulating alkaline... 111 | 122
male infertility 110 | 123
decreased circulating glucose ... 106 | 126
decreased grip strength 102 | 116
embryonic growth retardation 102 | 106
increased startle reflex 102 | 112
increased bone mineral content 98 | 108
abnormal seminal vesicle morph... 94 | 114
increased or absent threshold ... 91 | 101
decreased body length 90 | 101
short tibia 90 | 97
increased mean corpuscular hem... 88 | 96
decreased circulating choleste... 86 | 93
increased mean corpuscular vol... 86 | 92
cataract 83 | 92
prenatal lethality prior to he... 82 | 87
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 75 | 82
abnormal lens morphology 74 | 81
decreased lymphocyte cell numb... 74 | 83
decreased mean corpuscular vol... 73 | 79
increased circulating HDL chol... 72 | 80
decreased circulating triglyce... 70 | 79
impaired glucose tolerance 69 | 75
decreased startle reflex 68 | 75
increased bone mineral density 68 | 72
increased fasted circulating g... 68 | 76
abnormal retina morphology 66 | 71
decreased leukocyte cell numbe... 65 | 73
improved glucose tolerance 65 | 79
small superior vagus ganglion 65 | 74
abnormal eye morphology 63 | 68
decreased circulating HDL chol... 63 | 68
decreased circulating insulin ... 62 | 76
abnormal coat-hair pigmentatio... 60 | 64
decreased hemoglobin content 60 | 68
increased circulating choleste... 60 | 66
increased heart weight 59 | 62
decreased erythrocyte cell num... 58 | 62
abnormal gait 57 | 69
abnormal sleep behavior 57 | 70
edema 56 | 59
increased monocyte cell number 56 | 63
abnormal behavioral response t... 55 | 66
decreased fasted circulating g... 55 | 65
increased circulating sodium l... 55 | 71
abnormal kidney morphology 53 | 65
abnormal spleen morphology 52 | 55
decreased caudal vertebrae num... 52 | 53
female infertility 52 | 60
small testis 52 | 58
thrombocytopenia 51 | 56
decreased mean corpuscular hem... 48 | 50
decreased blood urea nitrogen ... 46 | 51
hydrometra 46 | 53
abnormal skin morphology 44 | 50
decreased circulating total pr... 44 | 49
abnormal neural tube closure 43 | 46
decreased circulating alanine ... 43 | 47
increased blood urea nitrogen ... 43 | 48
increased neutrophil cell numb... 43 | 46
decreased circulating alkaline... 42 | 46
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased leukocyte cell numbe... 41 | 47
enlarged spleen 40 | 41
increased hemoglobin content 40 | 45
increased grip strength 39 | 41
increased mean platelet volume 39 | 45
abnormal testis morphology 38 | 43
increased circulating triglyce... 38 | 42
abnormal epididymis morphology 37 | 42
decreased red blood cell distr... 37 | 41
tremors 37 | 39
abnormal bone mineralization 36 | 38
abnormal cranium morphology 35 | 36
decreased circulating LDL chol... 35 | 38
decreased circulating creatini... 35 | 39
limb grasping 35 | 41
decreased neutrophil cell numb... 34 | 42
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,567 | 11,493
ovarian cancer 7,919 | 8,520
osteosarcoma 7,192 | 7,950
medulloblastoma, large-cell 5,565 | 6,241
psoriasis 5,491 | 6,694
glioblastoma 5,224 | 5,792
atypical teratoid / rhabdoid tumor 4,596 | 5,112
lung cancer 4,292 | 4,740
ependymoma 4,149 | 4,679
group 3 medulloblastoma 3,700 | 4,104
adult high grade glioma 3,307 | 3,801
Breast cancer 3,250 | 3,578
malignant mesothelioma 3,020 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 3,010 | 3,291
primitive neuroectodermal tumor 2,726 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,703 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,669 | 2,955
Astrocytoma, Pilocytic 2,664 | 3,081
invasive ductal carcinoma 2,659 | 2,951
non-small cell lung cancer 2,577 | 2,890
oligodendroglioma 2,530 | 2,850
lung carcinoma 2,426 | 2,843
lung adenocarcinoma 2,351 | 2,716
astrocytic glioma 2,317 | 2,597
Kidney cancer 2,189 | 2,613
Cancer 2,176 | 2,499
pancreatic cancer 2,167 | 2,398
subependymal giant cell astrocytoma 2,062 | 2,287
interstitial cystitis 1,979 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,858 | 1,962
tuberculosis 1,798 | 2,010
Pick disease 1,738 | 1,894
pituitary cancer 1,703 | 1,972
group 4 medulloblastoma 1,693 | 1,855
ulcerative colitis 1,586 | 1,819
ductal carcinoma in situ 1,570 | 1,745
cystic fibrosis 1,497 | 1,696
breast carcinoma 1,454 | 1,638
diabetes mellitus 1,356 | 1,728
colon cancer 1,298 | 1,478
Multiple myeloma 1,296 | 1,332
adrenocortical carcinoma 1,294 | 1,428
Autosomal recessive predisposition 1,249 | 1,442
juvenile dermatomyositis 1,112 | 1,187
acute quadriplegic myopathy 1,086 | 1,158
astrocytoma 1,067 | 1,146
Rheumatoid arthritis 1,066 | 1,191
spina bifida 1,028 | 1,074
primary pancreatic ductal adenocarcinoma 1,025 | 1,109
pediatric high grade glioma 973 | 1,064
Intellectual disability 934 | 1,016
dermatomyositis 932 | 966
nasopharyngeal carcinoma 930 | 1,058
Schizophrenia 918 | 1,160
cutaneous lupus erythematosus 873 | 1,057
active Crohn's disease 831 | 922
non primary Sjogren syndrome sicca 800 | 891
Atopic dermatitis 787 | 952
acute myeloid leukemia 749 | 783
Waldenstrons macroglobulinemia 735 | 765
gastric carcinoma 726 | 807
Epilepsy 696 | 792
esophageal adenocarcinoma 682 | 737
active ulcerative colitis 681 | 764
Liver Cirrhosis, Experimental 672 | 769
medulloblastoma 646 | 720
progressive supranuclear palsy 639 | 676
primary Sjogren syndrome 631 | 735
aldosterone-producing adenoma 618 | 665
Dull intelligence 596 | 645
Low intelligence 596 | 645
Mental Retardation 596 | 645
Mental deficiency 596 | 645
Poor school performance 596 | 645
Cognitive delay 574 | 608
Global developmental delay 574 | 608
Mental and motor retardation 574 | 608
Obesity 564 | 678
Alzheimer's disease 552 | 658
Seizures 537 | 596
Bipolar Disorder 531 | 666
Muscle hypotonia 531 | 571
Duchenne muscular dystrophy 529 | 601
Melanoma 520 | 711
pancreatic carcinoma 520 | 562
hepatocellular carcinoma 517 | 547
Short stature 488 | 531
fibroadenoma 485 | 559
Endometriosis 475 | 540
Liver cancer 465 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 456 | 510
Prostatic Neoplasms 455 | 495
Down syndrome 454 | 499
chronic rhinosinusitis 448 | 512
gastric cancer 425 | 459
posterior fossa group A ependymoma 422 | 468
Amyotrophic lateral sclerosis 418 | 451
sonic hedgehog group medulloblastoma 417 | 467
Multiple Sclerosis 415 | 540
Breast Neoplasms 407 | 445

Tissue

Endocrine System 15,408 | 18,159
Digestive Tract 15,232 | 17,369
Female tissues 15,220 | 17,400
Skin and soft tissues 15,171 | 17,230
Male tissues 15,105 | 17,142
Blood and immune system 15,008 | 16,909
Liver and Pancreas 14,953 | 16,750
Urinary Tract 14,942 | 16,678
Nervous System 14,940 | 16,725
Respiratory system 14,777 | 16,393
Cardiovascular System 13,982 | 15,192

Target Family

Non-IDG 9,086 | 12,091
Enzyme 3,611 | 4,145
Transcription Factor 1,218 | 1,400
Kinase 578 | 634
Transporter 388 | 473
Ion Channel 238 | 344
Epigenetic 230 | 242
GPCR 227 | 408
Nuclear Receptor 43 | 48
TF/Epigenetic 36 | 38
oGPCR 28 | 421

HCA RNA Cell Line

RT4 15,683 | 15,683
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39