Development Level

Tbio 10,290 | 11,651
Tdark 3,983 | 6,593
Tchem 1,247 | 1,388
Tclin 495 | 612

Collection

RFA-RM-18-021 252 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 65 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 957 | 979
preweaning lethality, incomple... 465 | 499
abnormal behavior 272 | 298
embryonic lethality prior to t... 271 | 278
embryonic lethality prior to o... 237 | 239
abnormal embryo size 212 | 220
enlarged heart 187 | 210
decreased total body fat amoun... 186 | 207
decreased vertical activity 172 | 208
abnormal bone structure 169 | 187
increased lean body mass 153 | 172
decreased body weight 151 | 161
abnormal heart morphology 147 | 162
decreased bone mineral content 132 | 151
hyperactivity 131 | 148
decreased lean body mass 125 | 135
increased total body fat amoun... 122 | 134
hypoactivity 115 | 132
decreased circulating glucose ... 114 | 126
increased circulating alkaline... 114 | 122
decreased bone mineral density 113 | 126
decreased grip strength 107 | 116
increased startle reflex 106 | 112
embryonic growth retardation 102 | 106
male infertility 101 | 123
abnormal seminal vesicle morph... 100 | 114
increased bone mineral content 99 | 108
decreased body length 94 | 101
increased or absent threshold ... 93 | 101
decreased circulating choleste... 89 | 93
short tibia 88 | 97
increased mean corpuscular hem... 87 | 96
cataract 86 | 92
increased mean corpuscular vol... 84 | 92
prenatal lethality prior to he... 82 | 87
abnormal lens morphology 77 | 81
decreased lymphocyte cell numb... 77 | 83
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 74 | 82
decreased circulating triglyce... 72 | 79
decreased mean corpuscular vol... 72 | 79
decreased startle reflex 70 | 75
increased bone mineral density 70 | 72
small superior vagus ganglion 70 | 74
decreased leukocyte cell numbe... 68 | 73
impaired glucose tolerance 68 | 75
decreased circulating HDL chol... 67 | 68
increased circulating HDL chol... 67 | 80
increased fasted circulating g... 67 | 76
abnormal eye morphology 66 | 68
abnormal retina morphology 66 | 71
decreased circulating insulin ... 66 | 76
improved glucose tolerance 66 | 79
abnormal sleep behavior 64 | 70
increased circulating sodium l... 62 | 71
abnormal coat-hair pigmentatio... 59 | 64
abnormal gait 59 | 69
decreased fasted circulating g... 59 | 65
decreased hemoglobin content 59 | 68
increased heart weight 58 | 62
abnormal behavioral response t... 57 | 66
abnormal kidney morphology 57 | 65
decreased erythrocyte cell num... 57 | 62
edema 56 | 59
increased monocyte cell number 56 | 63
increased circulating choleste... 55 | 66
thrombocytopenia 53 | 56
small testis 52 | 58
abnormal spleen morphology 49 | 55
decreased caudal vertebrae num... 49 | 53
female infertility 49 | 60
hydrometra 48 | 53
decreased mean corpuscular hem... 47 | 50
decreased blood urea nitrogen ... 45 | 51
decreased circulating alkaline... 45 | 46
decreased circulating total pr... 45 | 49
abnormal neural tube closure 44 | 46
abnormal skin morphology 44 | 50
decreased circulating alanine ... 44 | 47
increased blood urea nitrogen ... 43 | 48
decreased hematocrit 42 | 46
increased hematocrit 42 | 46
increased hemoglobin content 42 | 45
increased leukocyte cell numbe... 42 | 47
increased neutrophil cell numb... 42 | 46
increased mean platelet volume 41 | 45
abnormal testis morphology 40 | 43
increased circulating triglyce... 39 | 42
decreased neutrophil cell numb... 38 | 42
increased circulating chloride... 38 | 41
tremors 38 | 39
abnormal epididymis morphology 37 | 42
decreased circulating LDL chol... 37 | 38
decreased red blood cell distr... 37 | 41
increased grip strength 37 | 41
limb grasping 37 | 41
abnormal bone mineralization 36 | 38
enlarged spleen 36 | 41
increased erythrocyte cell num... 36 | 39
increased mean corpuscular hem... 35 | 36

Disease

Carcinoma 9,706 | 11,493
ovarian cancer 8,057 | 8,520
osteosarcoma 7,353 | 7,950
medulloblastoma, large-cell 5,727 | 6,241
psoriasis 5,660 | 6,694
glioblastoma 5,386 | 5,792
atypical teratoid / rhabdoid tumor 4,732 | 5,112
lung cancer 4,393 | 4,740
ependymoma 4,236 | 4,679
group 3 medulloblastoma 3,782 | 4,104
adult high grade glioma 3,450 | 3,801
Breast cancer 3,300 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,103 | 3,291
malignant mesothelioma 3,064 | 3,232
Astrocytoma, Pilocytic 2,808 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 2,802 | 2,989
primitive neuroectodermal tumor 2,794 | 3,035
invasive ductal carcinoma 2,766 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,762 | 2,955
non-small cell lung cancer 2,642 | 2,890
oligodendroglioma 2,615 | 2,850
lung carcinoma 2,518 | 2,843
lung adenocarcinoma 2,436 | 2,716
astrocytic glioma 2,395 | 2,597
Kidney cancer 2,252 | 2,613
Cancer 2,250 | 2,499
pancreatic cancer 2,213 | 2,398
subependymal giant cell astrocytoma 2,142 | 2,287
interstitial cystitis 2,074 | 2,312
tuberculosis 1,876 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,861 | 1,962
Pick disease 1,790 | 1,894
pituitary cancer 1,764 | 1,972
group 4 medulloblastoma 1,747 | 1,855
ulcerative colitis 1,695 | 1,819
ductal carcinoma in situ 1,623 | 1,745
cystic fibrosis 1,540 | 1,696
breast carcinoma 1,524 | 1,638
diabetes mellitus 1,392 | 1,728
colon cancer 1,370 | 1,478
adrenocortical carcinoma 1,346 | 1,428
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,285 | 1,442
juvenile dermatomyositis 1,152 | 1,187
acute quadriplegic myopathy 1,124 | 1,158
Rheumatoid arthritis 1,112 | 1,191
astrocytoma 1,107 | 1,146
primary pancreatic ductal adenocarcinoma 1,062 | 1,109
spina bifida 1,012 | 1,074
pediatric high grade glioma 1,000 | 1,064
Schizophrenia 965 | 1,160
Intellectual disability 948 | 1,016
dermatomyositis 941 | 966
cutaneous lupus erythematosus 939 | 1,057
nasopharyngeal carcinoma 922 | 1,058
active Crohn's disease 858 | 922
Atopic dermatitis 800 | 952
non primary Sjogren syndrome sicca 798 | 891
gastric carcinoma 761 | 807
acute myeloid leukemia 756 | 783
Waldenstrons macroglobulinemia 752 | 765
Epilepsy 714 | 792
Liver Cirrhosis, Experimental 713 | 769
active ulcerative colitis 698 | 764
primary Sjogren syndrome 697 | 735
esophageal adenocarcinoma 671 | 737
medulloblastoma 665 | 720
progressive supranuclear palsy 640 | 676
aldosterone-producing adenoma 633 | 665
Dull intelligence 605 | 645
Low intelligence 605 | 645
Mental Retardation 605 | 645
Mental deficiency 605 | 645
Poor school performance 605 | 645
Obesity 590 | 678
Cognitive delay 585 | 608
Global developmental delay 585 | 608
Mental and motor retardation 585 | 608
Alzheimer's disease 579 | 658
Duchenne muscular dystrophy 568 | 601
Melanoma 565 | 711
Bipolar Disorder 553 | 666
Muscle hypotonia 551 | 571
Seizures 544 | 596
hepatocellular carcinoma 531 | 547
pancreatic carcinoma 528 | 562
Liver cancer 504 | 604
fibroadenoma 504 | 559
Short stature 497 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 485 | 510
Endometriosis 481 | 540
Down syndrome 466 | 499
Prostatic Neoplasms 458 | 495
Multiple Sclerosis 451 | 540
gastric cancer 441 | 459
chronic rhinosinusitis 431 | 512
sonic hedgehog group medulloblastoma 431 | 467
posterior fossa group A ependymoma 430 | 468
Breast Neoplasms 419 | 445
mucosa-associated lymphoid tissue lymphoma 416 | 484

Tissue

Endocrine System 15,712 | 18,159
Digestive Tract 15,538 | 17,369
Female tissues 15,498 | 17,400
Skin and soft tissues 15,456 | 17,230
Male tissues 15,394 | 17,142
Blood and immune system 15,334 | 16,909
Nervous System 15,253 | 16,725
Liver and Pancreas 15,236 | 16,750
Urinary Tract 15,205 | 16,678
Respiratory system 15,055 | 16,393
Cardiovascular System 14,266 | 15,192

Target Family

Non-IDG 9,316 | 12,091
Enzyme 3,664 | 4,145
Transcription Factor 1,206 | 1,400
Kinase 590 | 634
Transporter 390 | 473
GPCR 262 | 408
Ion Channel 259 | 344
Epigenetic 229 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 37 | 38
oGPCR 20 | 421

HCA RNA Cell Line

RPMI-8226 16,015 | 16,015
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
RH-30 15,693 | 15,693
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
UbiA prenyltransferase domain-containing protein 1 UBIAD1 Tbio Enzyme -1.59893 42.5 50