Development Level

Tbio 9,333 | 10,625
Tdark 4,350 | 7,003
Tchem 1,662 | 1,890
Tclin 486 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 77 | 102
GPCR: IDG Consortium (Targets) 66 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 20 | 26

IMPC Phenotype

preweaning lethality, complete... 612 | 633
preweaning lethality, incomple... 242 | 260
abnormal behavior 213 | 226
decreased lean body mass 182 | 195
embryonic lethality prior to t... 182 | 187
decreased total body fat amoun... 172 | 186
decreased body weight 166 | 174
embryonic lethality prior to o... 147 | 148
decreased bone mineral content 146 | 157
abnormal bone structure 121 | 131
increased or absent threshold ... 119 | 128
decreased bone mineral density 116 | 126
decreased grip strength 114 | 123
increased circulating alkaline... 112 | 119
decreased circulating glucose ... 108 | 121
abnormal embryo size 107 | 112
decreased body length 104 | 108
hyperactivity 99 | 108
enlarged heart 96 | 111
increased lean body mass 95 | 107
abnormal retina morphology 94 | 100
increased mean corpuscular hem... 89 | 93
increased bone mineral content 88 | 92
decreased circulating choleste... 84 | 85
increased mean corpuscular vol... 83 | 91
hypoactivity 79 | 89
decreased circulating HDL chol... 76 | 77
decreased circulating triglyce... 76 | 83
short tibia 76 | 82
decreased circulating serum al... 72 | 79
increased grip strength 71 | 83
abnormal lens morphology 70 | 73
decreased circulating insulin ... 65 | 75
increased circulating sodium l... 63 | 71
increased fasted circulating g... 61 | 68
decreased lumbar vertebrae num... 60 | 62
prenatal lethality prior to he... 60 | 64
increased sacral vertebrae num... 58 | 62
abnormal sleep behavior 57 | 63
abnormal retinal pigmentation 56 | 61
decreased rib number 56 | 59
abnormal bone mineralization 53 | 55
male infertility 53 | 62
decreased leukocyte cell numbe... 51 | 54
increased total body fat amoun... 51 | 57
increased bone mineral density 50 | 52
increased circulating HDL chol... 50 | 63
abnormal coat-hair pigmentatio... 49 | 54
decreased prepulse inhibition 49 | 52
decreased hemoglobin content 48 | 53
decreased mean corpuscular vol... 48 | 50
impaired glucose tolerance 48 | 52
increased exploration in new e... 48 | 56
decreased circulating alanine ... 47 | 53
decreased startle reflex 47 | 48
improved glucose tolerance 47 | 56
increased circulating choleste... 46 | 53
decreased fasted circulating g... 45 | 49
abnormal behavioral response t... 44 | 52
thrombocytopenia 44 | 46
abnormal gait 43 | 51
decreased caudal vertebrae num... 43 | 49
abnormal heart morphology 42 | 51
decreased erythrocyte cell num... 42 | 43
increased blood urea nitrogen ... 42 | 44
increased hemoglobin content 41 | 45
decreased circulating alkaline... 40 | 41
increased body weight 40 | 42
increased circulating chloride... 40 | 43
abnormal seminal vesicle morph... 39 | 47
decreased heart weight 39 | 44
decreased circulating total pr... 38 | 41
abnormal eye morphology 37 | 38
decreased circulating LDL chol... 36 | 37
decreased eosinophil cell numb... 36 | 41
decreased neutrophil cell numb... 36 | 37
increased rib number 36 | 41
increased startle reflex 36 | 38
abnormal neural tube closure 35 | 37
decreased circulating free fat... 34 | 39
increased leukocyte cell numbe... 34 | 37
increased heart weight 33 | 37
small testis 33 | 37
tremors 33 | 34
cardiovascular system phenotyp... 32 | 35
decreased mean corpuscular hem... 32 | 34
abnormal cranium morphology 31 | 32
abnormal spleen morphology 31 | 36
increased hematocrit 31 | 36
limb grasping 31 | 35
decreased T cell number 30 | 31
decreased circulating calcium ... 30 | 33
decreased circulating fructosa... 30 | 31
decreased circulating chloride... 29 | 32
female infertility 29 | 34
increased circulating potassiu... 29 | 31
abnormal testis morphology 28 | 30
decreased blood urea nitrogen ... 28 | 31
decreased circulating creatini... 28 | 31
decreased threshold for audito... 28 | 32

Disease

ovarian cancer 7,947 | 8,491
osteosarcoma 7,266 | 7,933
medulloblastoma, large-cell 5,669 | 6,234
psoriasis 5,610 | 6,685
glioblastoma 5,141 | 5,572
lung cancer 4,177 | 4,473
atypical teratoid / rhabdoid tumor 3,998 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,073 | 3,289
malignant mesothelioma 2,982 | 3,163
Breast cancer 2,859 | 3,098
pilocytic astrocytoma 2,779 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 2,778 | 2,988
primitive neuroectodermal tumor 2,759 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 2,744 | 2,956
invasive ductal carcinoma 2,736 | 2,950
oligodendroglioma 2,589 | 2,849
non-small cell lung cancer 2,545 | 2,798
lung carcinoma 2,503 | 2,844
pediatric high grade glioma 2,495 | 2,712
lung adenocarcinoma 2,414 | 2,714
ependymoma 2,324 | 2,514
subependymal giant cell astrocytoma 2,123 | 2,287
pancreatic cancer 2,119 | 2,300
Cancer 2,104 | 2,346
group 3 medulloblastoma 2,068 | 2,254
interstitial cystitis 2,054 | 2,299
astrocytic glioma 2,044 | 2,241
ulcerative colitis 1,935 | 2,087
adult high grade glioma 1,908 | 2,148
Carcinoma 1,815 | 2,147
Pick disease 1,775 | 1,893
pituitary cancer 1,750 | 1,972
group 4 medulloblastoma 1,748 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 1,680 | 1,795
ductal carcinoma in situ 1,608 | 1,745
cystic fibrosis 1,506 | 1,670
breast carcinoma 1,489 | 1,614
tuberculosis 1,438 | 1,563
astrocytoma 1,424 | 1,493
medulloblastoma 1,374 | 1,524
sonic hedgehog group medulloblastoma 1,358 | 1,482
colon cancer 1,356 | 1,475
posterior fossa group A ependymoma 1,336 | 1,511
diabetes mellitus 1,328 | 1,663
adrenocortical carcinoma 1,327 | 1,427
posterior fossa group B ependymoma 1,320 | 1,530
Multiple myeloma 1,294 | 1,327
primary pancreatic ductal adenocarcinoma 1,212 | 1,271
juvenile dermatomyositis 1,144 | 1,189
acute quadriplegic myopathy 1,115 | 1,157
Rheumatoid Arthritis 1,085 | 1,170
atypical teratoid/rhabdoid tumor 1,008 | 1,095
spina bifida 994 | 1,064
dermatomyositis 936 | 966
cutaneous lupus erythematosus 930 | 1,056
nasopharyngeal carcinoma 915 | 1,056
active Crohn's disease 848 | 918
Atopic dermatitis 786 | 944
gastric carcinoma 780 | 832
Waldenstrons macroglobulinemia 745 | 764
acute myeloid leukemia 745 | 785
primary Sjogren syndrome 743 | 788
non primary Sjogren syndrome sicca 739 | 840
esophageal adenocarcinoma 668 | 737
tuberculosis and treatment for 6 months 665 | 686
progressive supranuclear palsy 633 | 674
aldosterone-producing adenoma 628 | 664
Alzheimer's disease 563 | 644
Duchenne muscular dystrophy 562 | 602
hepatocellular carcinoma 531 | 550
Obesity 529 | 616
pancreatic carcinoma 529 | 567
Intellectual disability 527 | 573
Down syndrome 508 | 548
fibroadenoma 500 | 557
autosomal dominant Emery-Dreifuss muscular dystrophy 474 | 499
Endometriosis 470 | 535
IGA Glomerulonephritis 437 | 454
Prostatic Neoplasms 434 | 471
active ulcerative colitis 429 | 477
chronic rhinosinusitis 428 | 512
gastric cancer 414 | 436
mucosa-associated lymphoid tissue lymphoma 413 | 480
Schizophrenia 412 | 503
Multiple Sclerosis 410 | 498
Amyotrophic Lateral Sclerosis 393 | 432
Mammary Neoplasms 384 | 410
inflammatory breast cancer 358 | 404
Neurodegenerative disease 352 | 383
non-small cell lung carcinoma 339 | 413
sarcoidosis 332 | 368
Kidney disease 327 | 397
Parkinson's disease 313 | 364
glioblastoma multiforme 311 | 347
tuberculosis and treatment for 3 months 307 | 327
Polycystic Ovary Syndrome 304 | 334
hereditary spastic paraplegia 304 | 313
nephrosclerosis 297 | 329
Epilepsy 289 | 346
urothelial carcinoma 282 | 318

Tissue

Nervous System 15,585 | 18,560
Female tissues 15,579 | 18,646
Digestive Tract 15,569 | 18,472
Endocrine System 15,558 | 18,511
Urinary Tract 15,516 | 18,443
Liver and Pancreas 15,496 | 18,135
Male tissues 15,475 | 17,968
Blood and immune system 15,453 | 17,994
Cardiovascular System 15,428 | 17,957
Skin and soft tissues 15,378 | 18,114
Respiratory system 15,258 | 17,483

Target Family

Non-IDG 9,181 | 11,969
Enzyme 3,637 | 4,146
Transcription Factor 1,202 | 1,400
Kinase 583 | 634
Transporter 390 | 473
GPCR 262 | 408
Ion Channel 255 | 341
Epigenetic 223 | 242
Nuclear Receptor 42 | 48
TF/Epigenetic 36 | 38
oGPCR 20 | 421

HCA RNA Cell Line

RPMI-8226 15,831 | 15,831
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
RH-30 15,519 | 15,519
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66