Development Level

Tbio 10,108 | 11,651
Tdark 3,856 | 6,593
Tchem 1,233 | 1,388
Tclin 496 | 612

Collection

Kinase: IDG Consortium (Target... 114 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 62 | 126
Kinase: IDG Consortium (Comple... 34 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 950 | 979
preweaning lethality, incomple... 461 | 499
embryonic lethality prior to t... 273 | 278
abnormal behavior 271 | 298
embryonic lethality prior to o... 236 | 239
abnormal embryo size 210 | 220
decreased total body fat amoun... 183 | 207
enlarged heart 181 | 210
abnormal bone structure 169 | 187
decreased vertical activity 165 | 208
decreased body weight 153 | 161
increased lean body mass 151 | 172
abnormal heart morphology 137 | 162
hyperactivity 132 | 148
decreased bone mineral content 131 | 151
decreased lean body mass 120 | 135
increased total body fat amoun... 116 | 134
hypoactivity 114 | 132
decreased circulating glucose ... 110 | 126
increased startle reflex 109 | 112
increased circulating alkaline... 108 | 122
decreased bone mineral density 106 | 126
embryonic growth retardation 102 | 106
decreased grip strength 100 | 116
abnormal seminal vesicle morph... 99 | 114
male infertility 96 | 123
increased bone mineral content 95 | 108
decreased body length 94 | 101
increased mean corpuscular hem... 92 | 96
short tibia 90 | 97
increased mean corpuscular vol... 89 | 92
cataract 86 | 92
increased or absent threshold ... 86 | 101
decreased circulating choleste... 85 | 93
prenatal lethality prior to he... 83 | 87
abnormal lens morphology 75 | 81
decreased prepulse inhibition 75 | 82
decreased lymphocyte cell numb... 74 | 83
decreased mean corpuscular vol... 74 | 79
decreased circulating serum al... 73 | 82
decreased circulating triglyce... 71 | 79
increased bone mineral density 70 | 72
increased circulating HDL chol... 68 | 80
increased fasted circulating g... 68 | 76
decreased startle reflex 66 | 75
impaired glucose tolerance 66 | 75
decreased leukocyte cell numbe... 65 | 73
increased circulating sodium l... 65 | 71
small superior vagus ganglion 65 | 74
abnormal retina morphology 64 | 71
decreased circulating HDL chol... 64 | 68
abnormal eye morphology 63 | 68
abnormal sleep behavior 63 | 70
decreased circulating insulin ... 62 | 76
improved glucose tolerance 62 | 79
decreased erythrocyte cell num... 61 | 62
decreased hemoglobin content 60 | 68
abnormal behavioral response t... 59 | 66
abnormal gait 59 | 69
edema 57 | 59
increased circulating choleste... 57 | 66
increased heart weight 57 | 62
abnormal kidney morphology 56 | 65
increased monocyte cell number 56 | 63
abnormal coat-hair pigmentatio... 55 | 64
decreased fasted circulating g... 55 | 65
small testis 52 | 58
thrombocytopenia 51 | 56
abnormal spleen morphology 49 | 55
decreased caudal vertebrae num... 49 | 53
abnormal skin morphology 47 | 50
decreased blood urea nitrogen ... 46 | 51
decreased mean corpuscular hem... 46 | 50
female infertility 46 | 60
hydrometra 46 | 53
abnormal neural tube closure 45 | 46
decreased circulating total pr... 44 | 49
decreased hematocrit 43 | 46
increased blood urea nitrogen ... 43 | 48
increased leukocyte cell numbe... 43 | 47
decreased circulating alanine ... 42 | 47
decreased circulating alkaline... 42 | 46
increased hematocrit 41 | 46
increased hemoglobin content 41 | 45
decreased red blood cell distr... 40 | 41
increased mean platelet volume 40 | 45
increased neutrophil cell numb... 40 | 46
decreased neutrophil cell numb... 39 | 42
enlarged spleen 39 | 41
increased circulating triglyce... 39 | 42
abnormal bone mineralization 38 | 38
abnormal testis morphology 38 | 43
tremors 37 | 39
increased grip strength 36 | 41
enlarged lymph nodes 35 | 37
increased mean corpuscular hem... 35 | 36
limb grasping 35 | 41
decreased circulating creatini... 34 | 39
increased circulating chloride... 34 | 41
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,613 | 11,493
ovarian cancer 7,964 | 8,520
osteosarcoma 7,283 | 7,950
medulloblastoma, large-cell 5,618 | 6,241
psoriasis 5,553 | 6,694
glioblastoma 5,289 | 5,792
atypical teratoid / rhabdoid tumor 4,644 | 5,112
lung cancer 4,340 | 4,740
ependymoma 4,177 | 4,679
group 3 medulloblastoma 3,732 | 4,104
adult high grade glioma 3,349 | 3,801
Breast cancer 3,267 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,030 | 3,291
malignant mesothelioma 3,029 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 2,741 | 2,989
primitive neuroectodermal tumor 2,738 | 3,035
invasive ductal carcinoma 2,721 | 2,951
Astrocytoma, Pilocytic 2,716 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 2,702 | 2,955
non-small cell lung cancer 2,595 | 2,890
oligodendroglioma 2,533 | 2,850
lung carcinoma 2,465 | 2,843
lung adenocarcinoma 2,364 | 2,716
astrocytic glioma 2,321 | 2,597
Kidney cancer 2,272 | 2,613
Cancer 2,242 | 2,499
pancreatic cancer 2,190 | 2,398
subependymal giant cell astrocytoma 2,093 | 2,287
interstitial cystitis 2,007 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,889 | 1,962
tuberculosis 1,856 | 2,010
Pick disease 1,757 | 1,894
pituitary cancer 1,731 | 1,972
group 4 medulloblastoma 1,711 | 1,855
ulcerative colitis 1,646 | 1,819
ductal carcinoma in situ 1,586 | 1,745
cystic fibrosis 1,525 | 1,696
breast carcinoma 1,476 | 1,638
diabetes mellitus 1,380 | 1,728
colon cancer 1,333 | 1,478
adrenocortical carcinoma 1,327 | 1,428
Multiple myeloma 1,308 | 1,332
Autosomal recessive predisposition 1,290 | 1,442
juvenile dermatomyositis 1,157 | 1,187
acute quadriplegic myopathy 1,123 | 1,158
Rheumatoid arthritis 1,099 | 1,191
astrocytoma 1,092 | 1,146
primary pancreatic ductal adenocarcinoma 1,039 | 1,109
spina bifida 1,009 | 1,074
pediatric high grade glioma 991 | 1,064
Schizophrenia 969 | 1,160
dermatomyositis 941 | 966
Intellectual disability 935 | 1,016
cutaneous lupus erythematosus 919 | 1,057
nasopharyngeal carcinoma 918 | 1,058
active Crohn's disease 818 | 922
non primary Sjogren syndrome sicca 797 | 891
Atopic dermatitis 796 | 952
acute myeloid leukemia 755 | 783
Waldenstrons macroglobulinemia 749 | 765
gastric carcinoma 749 | 807
Liver Cirrhosis, Experimental 707 | 769
Epilepsy 706 | 792
primary Sjogren syndrome 693 | 735
active ulcerative colitis 661 | 764
medulloblastoma 659 | 720
esophageal adenocarcinoma 658 | 737
progressive supranuclear palsy 639 | 676
aldosterone-producing adenoma 628 | 665
Dull intelligence 597 | 645
Low intelligence 597 | 645
Mental Retardation 597 | 645
Mental deficiency 597 | 645
Poor school performance 597 | 645
Obesity 587 | 678
Alzheimer's disease 582 | 658
Cognitive delay 572 | 608
Global developmental delay 572 | 608
Mental and motor retardation 572 | 608
Duchenne muscular dystrophy 570 | 601
Bipolar Disorder 554 | 666
Seizures 542 | 596
Melanoma 536 | 711
Muscle hypotonia 533 | 571
pancreatic carcinoma 533 | 562
hepatocellular carcinoma 531 | 547
Liver cancer 504 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 510
Short stature 485 | 531
fibroadenoma 476 | 559
Endometriosis 472 | 540
Down syndrome 455 | 499
Prostatic Neoplasms 450 | 495
Multiple Sclerosis 448 | 540
chronic rhinosinusitis 441 | 512
gastric cancer 435 | 459
Amyotrophic lateral sclerosis 429 | 451
posterior fossa group A ependymoma 428 | 468
mucosa-associated lymphoid tissue lymphoma 424 | 484
sonic hedgehog group medulloblastoma 419 | 467

Tissue

Endocrine System 15,426 | 18,159
Digestive Tract 15,258 | 17,369
Female tissues 15,244 | 17,400
Skin and soft tissues 15,227 | 17,230
Male tissues 15,113 | 17,142
Blood and immune system 15,072 | 16,909
Liver and Pancreas 15,026 | 16,750
Nervous System 14,997 | 16,725
Urinary Tract 14,980 | 16,678
Respiratory system 14,809 | 16,393
Cardiovascular System 14,108 | 15,192

Target Family

Non-IDG 9,117 | 12,091
Enzyme 3,572 | 4,145
Transcription Factor 1,214 | 1,400
Kinase 595 | 634
Transporter 377 | 473
GPCR 253 | 408
Ion Channel 244 | 344
Epigenetic 224 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 35 | 38
oGPCR 17 | 421

HCA RNA Cell Line

RH-30 15,693 | 15,693
U-2 OS 17,559 | 17,559
EFO-21 17,301 | 17,301
SCLC-21H 17,139 | 17,139
NTERA-2 17,039 | 17,039
U-266/70 16,745 | 16,745
BEWO 16,726 | 16,726
SH-SY5Y 16,707 | 16,707
HMC-1 16,581 | 16,581
NB-4 16,547 | 16,547
HaCaT 16,515 | 16,515
U-2197 16,483 | 16,483
U-266/84 16,440 | 16,440
U-251 MG 16,365 | 16,365
U-87 MG 16,285 | 16,285
U-698 16,279 | 16,279
Karpas-707 16,275 | 16,275
WM-115 16,253 | 16,253
K-562 16,233 | 16,233
T-47d 16,213 | 16,213
U-937 16,180 | 16,180
AF22 16,160 | 16,160
SK-MEL-30 16,142 | 16,142
A-431 16,131 | 16,131
CAPAN-2 16,102 | 16,102
RPMI-8226 16,015 | 16,015
SK-BR-3 16,008 | 16,008
REH 15,960 | 15,960
U-138 MG 15,914 | 15,914
HEK 293 15,853 | 15,853
THP-1 15,833 | 15,833
MOLT-4 15,809 | 15,809
Daudi 15,753 | 15,753
HDLM-2 15,752 | 15,752
HeLa 15,690 | 15,690
RT4 15,683 | 15,683
AN3-CA 15,648 | 15,648
BJ hTERT+ SV40 Large T+ 15,609 | 15,609
BJ hTERT+ SV40 Large T+ RasG12... 15,493 | 15,493
HTCEpi 15,453 | 15,453
BJ 15,448 | 15,448
CACO-2 15,436 | 15,436
PC-3 15,376 | 15,376
BJ hTERT+ 15,353 | 15,353
HEL 15,346 | 15,346
SiHa 15,286 | 15,286
RPTEC TERT1 15,278 | 15,278
MCF7 15,232 | 15,232
HBF TERT88 15,209 | 15,209
Hep G2 15,179 | 15,179
A549 15,174 | 15,174
HL-60 15,041 | 15,041
LHCN-M2 14,989 | 14,989
ASC TERT1 14,842 | 14,842
HUVEC TERT2 14,717 | 14,717
TIME 14,461 | 14,461

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.51747 3.15 91
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Paralemmin-3 PALM3 Tbio Non-IDG -0.66901 5.71 76
COP9 signalosome complex subunit 9 COPS9 Tbio Non-IDG 0.21 0.92 14
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
UDP-glucuronosyltransferase 2B15 UGT2B15 Tbio Enzyme -1.79589 61.5 83
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50