Development Level

Tbio 9,165 | 10,625
Tdark 4,211 | 7,003
Tchem 1,656 | 1,890
Tclin 487 | 602

Collection

Kinase: IDG Consortium (Targets) 112 | 125
Ion Channel: IDG Consortium (Targets) 74 | 102
GPCR: IDG Consortium (Targets) 62 | 127
Kinase: IDG Consortium (Complete/Control) 33 | 37
GPCR: IDG Consortium (Complete/Control) 17 | 26

IMPC Phenotype

preweaning lethality, complete... 613 | 633
preweaning lethality, incomple... 238 | 260
abnormal behavior 212 | 226
embryonic lethality prior to t... 186 | 187
decreased lean body mass 185 | 195
decreased total body fat amoun... 171 | 186
decreased body weight 162 | 174
embryonic lethality prior to o... 148 | 148
decreased bone mineral content 144 | 157
abnormal bone structure 120 | 131
decreased bone mineral density 113 | 126
increased or absent threshold ... 113 | 128
increased circulating alkaline... 110 | 119
abnormal embryo size 108 | 112
decreased grip strength 104 | 123
decreased body length 102 | 108
decreased circulating glucose ... 102 | 121
hyperactivity 99 | 108
enlarged heart 96 | 111
increased lean body mass 95 | 107
increased mean corpuscular hem... 90 | 93
abnormal retina morphology 88 | 100
increased bone mineral content 87 | 92
increased mean corpuscular vol... 87 | 91
decreased circulating choleste... 80 | 85
hypoactivity 80 | 89
decreased circulating triglyce... 75 | 83
short tibia 75 | 82
decreased circulating HDL chol... 73 | 77
increased grip strength 73 | 83
decreased circulating serum al... 71 | 79
abnormal lens morphology 67 | 73
increased circulating sodium l... 64 | 71
decreased circulating insulin ... 62 | 75
prenatal lethality prior to he... 62 | 64
increased fasted circulating g... 61 | 68
decreased lumbar vertebrae num... 60 | 62
increased sacral vertebrae num... 58 | 62
abnormal retinal pigmentation 56 | 61
abnormal sleep behavior 56 | 63
abnormal bone mineralization 55 | 55
increased circulating HDL chol... 54 | 63
decreased rib number 52 | 59
increased total body fat amoun... 52 | 57
decreased prepulse inhibition 49 | 52
abnormal coat-hair pigmentatio... 48 | 54
decreased hemoglobin content 48 | 53
decreased leukocyte cell numbe... 48 | 54
decreased mean corpuscular vol... 48 | 50
increased bone mineral density 48 | 52
increased circulating choleste... 48 | 53
male infertility 48 | 62
abnormal behavioral response t... 47 | 52
increased exploration in new e... 47 | 56
abnormal gait 46 | 51
impaired glucose tolerance 46 | 52
decreased circulating alanine ... 45 | 53
improved glucose tolerance 44 | 56
decreased caudal vertebrae num... 43 | 49
decreased erythrocyte cell num... 43 | 43
decreased startle reflex 43 | 48
thrombocytopenia 43 | 46
increased hemoglobin content 42 | 45
abnormal heart morphology 41 | 51
decreased fasted circulating g... 41 | 49
increased blood urea nitrogen ... 41 | 44
decreased heart weight 40 | 44
increased body weight 40 | 42
abnormal seminal vesicle morph... 39 | 47
decreased circulating total pr... 38 | 41
increased circulating chloride... 37 | 43
increased rib number 37 | 41
abnormal eye morphology 36 | 38
abnormal neural tube closure 36 | 37
decreased circulating free fat... 36 | 39
decreased circulating alkaline... 35 | 41
decreased neutrophil cell numb... 35 | 37
cardiovascular system phenotyp... 33 | 35
decreased eosinophil cell numb... 33 | 41
increased leukocyte cell numbe... 33 | 37
small testis 33 | 37
abnormal spleen morphology 32 | 36
decreased circulating LDL chol... 32 | 37
decreased mean corpuscular hem... 32 | 34
increased heart weight 32 | 37
increased startle reflex 32 | 38
increased hematocrit 31 | 36
tremors 31 | 34
abnormal cranium morphology 30 | 32
decreased T cell number 30 | 31
decreased threshold for audito... 30 | 32
decreased circulating creatini... 29 | 31
decreased circulating fructosa... 29 | 31
increased circulating calcium ... 29 | 32
limb grasping 29 | 35
decreased circulating chloride... 28 | 32
embryonic growth retardation 28 | 28
decreased circulating calcium ... 27 | 33
female infertility 27 | 34
increased circulating potassiu... 27 | 31

Disease

ovarian cancer 7,851 | 8,491
osteosarcoma 7,195 | 7,933
medulloblastoma, large-cell 5,561 | 6,234
psoriasis 5,505 | 6,685
glioblastoma 5,048 | 5,572
lung cancer 4,135 | 4,473
atypical teratoid / rhabdoid tumor 3,937 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 3,000 | 3,289
malignant mesothelioma 2,942 | 3,163
Breast cancer 2,829 | 3,098
intraductal papillary-mucinous carcinoma (IPMC) 2,717 | 2,988
primitive neuroectodermal tumor 2,706 | 3,031
pilocytic astrocytoma 2,691 | 3,086
invasive ductal carcinoma 2,690 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 2,685 | 2,956
oligodendroglioma 2,507 | 2,849
non-small cell lung cancer 2,505 | 2,798
lung carcinoma 2,449 | 2,844
pediatric high grade glioma 2,434 | 2,712
lung adenocarcinoma 2,343 | 2,714
ependymoma 2,279 | 2,514
pancreatic cancer 2,092 | 2,300
Cancer 2,091 | 2,346
subependymal giant cell astrocytoma 2,076 | 2,287
group 3 medulloblastoma 2,039 | 2,254
astrocytic glioma 1,995 | 2,241
interstitial cystitis 1,988 | 2,299
ulcerative colitis 1,878 | 2,087
adult high grade glioma 1,860 | 2,148
Carcinoma 1,822 | 2,147
Pick disease 1,743 | 1,893
group 4 medulloblastoma 1,723 | 1,875
pituitary cancer 1,719 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,707 | 1,795
ductal carcinoma in situ 1,570 | 1,745
cystic fibrosis 1,490 | 1,670
breast carcinoma 1,440 | 1,614
tuberculosis 1,430 | 1,563
astrocytoma 1,384 | 1,493
medulloblastoma 1,363 | 1,524
sonic hedgehog group medulloblastoma 1,322 | 1,482
colon cancer 1,319 | 1,475
posterior fossa group B ependymoma 1,318 | 1,530
diabetes mellitus 1,313 | 1,663
posterior fossa group A ependymoma 1,311 | 1,511
adrenocortical carcinoma 1,308 | 1,427
Multiple myeloma 1,293 | 1,327
primary pancreatic ductal adenocarcinoma 1,190 | 1,271
juvenile dermatomyositis 1,149 | 1,189
acute quadriplegic myopathy 1,114 | 1,157
Rheumatoid Arthritis 1,067 | 1,170
spina bifida 988 | 1,064
atypical teratoid/rhabdoid tumor 977 | 1,095
dermatomyositis 935 | 966
nasopharyngeal carcinoma 912 | 1,056
cutaneous lupus erythematosus 909 | 1,056
active Crohn's disease 809 | 918
Atopic dermatitis 783 | 944
gastric carcinoma 769 | 832
acute myeloid leukemia 743 | 785
Waldenstrons macroglobulinemia 741 | 764
non primary Sjogren syndrome sicca 739 | 840
primary Sjogren syndrome 737 | 788
tuberculosis and treatment for 6 months 658 | 686
esophageal adenocarcinoma 655 | 737
progressive supranuclear palsy 633 | 674
aldosterone-producing adenoma 623 | 664
Duchenne muscular dystrophy 564 | 602
Alzheimer's disease 563 | 644
pancreatic carcinoma 533 | 567
hepatocellular carcinoma 530 | 550
Intellectual disability 528 | 573
Obesity 527 | 616
Down syndrome 496 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 477 | 499
fibroadenoma 472 | 557
Endometriosis 462 | 535
chronic rhinosinusitis 438 | 512
IGA Glomerulonephritis 434 | 454
Prostatic Neoplasms 425 | 471
mucosa-associated lymphoid tissue lymphoma 421 | 480
Amyotrophic Lateral Sclerosis 409 | 432
Multiple Sclerosis 406 | 498
Schizophrenia 406 | 503
gastric cancer 406 | 436
active ulcerative colitis 403 | 477
Mammary Neoplasms 378 | 410
Neurodegenerative disease 352 | 383
inflammatory breast cancer 352 | 404
non-small cell lung carcinoma 339 | 413
sarcoidosis 331 | 368
Kidney disease 330 | 397
Parkinson's disease 305 | 364
glioblastoma multiforme 305 | 347
hereditary spastic paraplegia 302 | 313
Polycystic Ovary Syndrome 299 | 334
tuberculosis and treatment for 3 months 294 | 327
urothelial carcinoma 285 | 318
Asthma 279 | 349
nephrosclerosis 278 | 329

Tissue

Nervous System 15,324 | 18,560
Female tissues 15,297 | 18,646
Digestive Tract 15,296 | 18,472
Endocrine System 15,284 | 18,511
Urinary Tract 15,248 | 18,443
Liver and Pancreas 15,233 | 18,135
Blood and immune system 15,188 | 17,994
Cardiovascular System 15,183 | 17,957
Male tissues 15,183 | 17,968
Skin and soft tissues 15,141 | 18,114
Respiratory system 15,034 | 17,483

Target Family

Non-IDG 8,987 | 11,969
Enzyme 3,548 | 4,146
Transcription Factor 1,211 | 1,400
Kinase 588 | 634
Transporter 377 | 473
GPCR 253 | 408
Ion Channel 241 | 341
Epigenetic 218 | 242
Nuclear Receptor 45 | 48
TF/Epigenetic 34 | 38
oGPCR 17 | 421

HCA RNA Cell Line

RH-30 15,519 | 15,519
U-2 OS 17,365 | 17,365
EFO-21 17,116 | 17,116
SCLC-21H 16,945 | 16,945
NTERA-2 16,845 | 16,845
U-266/70 16,555 | 16,555
BEWO 16,540 | 16,540
SH-SY5Y 16,520 | 16,520
HMC-1 16,393 | 16,393
NB-4 16,359 | 16,359
HaCaT 16,330 | 16,330
U-2197 16,300 | 16,300
U-266/84 16,256 | 16,256
U-251 MG 16,194 | 16,194
U-87 MG 16,105 | 16,105
Karpas-707 16,093 | 16,093
U-698 16,092 | 16,092
WM-115 16,064 | 16,064
K-562 16,048 | 16,048
T-47d 16,036 | 16,036
U-937 15,987 | 15,987
AF22 15,978 | 15,978
SK-MEL-30 15,961 | 15,961
A-431 15,946 | 15,946
CAPAN-2 15,917 | 15,917
RPMI-8226 15,831 | 15,831
SK-BR-3 15,826 | 15,826
REH 15,782 | 15,782
U-138 MG 15,733 | 15,733
HEK 293 15,667 | 15,667
THP-1 15,651 | 15,651
MOLT-4 15,625 | 15,625
HDLM-2 15,578 | 15,578
Daudi 15,574 | 15,574
HeLa 15,515 | 15,515
RT4 15,501 | 15,501
AN3-CA 15,462 | 15,462
BJ hTERT+ SV40 Large T+ 15,429 | 15,429
BJ hTERT+ SV40 Large T+ RasG12... 15,311 | 15,311
BJ 15,276 | 15,276
HTCEpi 15,271 | 15,271
CACO-2 15,254 | 15,254
PC-3 15,203 | 15,203
BJ hTERT+ 15,181 | 15,181
HEL 15,174 | 15,174
SiHa 15,106 | 15,106
RPTEC TERT1 15,101 | 15,101
MCF7 15,048 | 15,048
HBF TERT88 15,032 | 15,032
Hep G2 14,999 | 14,999
A549 14,994 | 14,994
HL-60 14,863 | 14,863
LHCN-M2 14,816 | 14,816
ASC TERT1 14,670 | 14,670
HUVEC TERT2 14,543 | 14,543
TIME 14,296 | 14,296

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Thyroid adenoma-associated protein THADA Tbio Non-IDG -1.50722 29.2 46
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.29593 203.1 88
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.96873 85.2 108
Paralemmin-3 PALM3 Tbio Non-IDG -0.47712 3.44 66
Zinc finger protein Aiolos IKZF3 Tbio Transcription Factor -1.78743 55.0 277
Zinc finger protein 215 ZNF215 Tdark Transcription Factor -0.47111 3.15 74
Epithelial membrane protein 3 EMP3 Tbio Non-IDG -1.64647 44.8 131
UDP-glucuronosyltransferase 2B15 UGT2B15 Tchem Enzyme -1.77071 60.2 66